Prolonged stress impairs the prefrontal cortex

How burnout alters your brain

Stress is a normal part of everyday life, and it’s not necessarily all bad. But chronic stress—the kind that leads to burnout—can change the size and functioning of parts of your brain. It can alter the ability to make new brain cells and memories and even potentially modify your DNA.

Stress and the brain

While an acute stress response is a normal bodily function, the effects of chronic stress can be extremely damaging to the human body. This is particularly true with regard to the brain. This article explores the effects of stress on the human brain, including how chronic stress may lead to psychological conditions such as depression and memory loss.

Clinical burnout: prolonged exhaustion, mental distance, and persistent negative feelings

Burnout isn’t just stress—it’s a pervasive feeling of exhaustion that can start in the workplace and seep into everyday life. It causes feelings of dread and cynicism about work tasks. On top of emotional distress, there can be physical symptoms and a tendency towards addictive behavior.

What happens to your brain when you burn out?

You've probably heard of burnout, also known as the feeling of exhaustion that happens after a long period of being overwhelmed or stressed. It's often associated with work and careers, but other parts of life, like parenting, can cause burnout, too. Scientists are figuring out what happens, biochemically speaking, in the brain when burnout hits—and spoiler alert, it includes a neurotransmitter called glutamate. Watch this video to learn more.

Chronic stress affects nearly all parts of the body

Stress is our body’s internal mechanism to deal with changes in our internal balance. As such, the stress response affects nearly every organ system through a cascade of both fast and slow hormonal changes. While short-term stress can be adaptive, long-term stress may cause serious health issues.

Grief rewires the human brain

The human brain handles stress and emotional traumas similarly. In response to the emotional stress of a situation like the death of a loved one, divorce, or abuse, the brain may strengthen or weaken connections between nerves to form new neural connections. Over time, chronic stress can diminish brainpower, reducing overall nerve growth and memory to shift resources to enable elevated fear responses and enable humans to survive.

How we frame stress—as good or bad—seems to alter how it affects us

This podcast discusses research that indicates stress perception may drastically affect how we respond to it. In research exploring if our stress is presented as diminishing our health versus if we're told it enhances our performance, it will lead to differences in how successful participants are at performing tasks—with the enhancers doing better.

Our ancient fight-or-flight response may contribute to modern ailments

Many common modern diseases humans struggle with may in fact have their origins in our ancient fight-or-flight stress response. Long-term effects of the stress hormones cortisol and adrenaline—in this case, triggered by things like workplace stressors—can wreak havoc on the delicate internal balance of our organ systems.

The brain will attempt to rest itself in periods of chronic sleep deprivation

Skimping on sleep lengthens reaction times and blunts decision-making skills. At a certain point, the brain will try to sneak sleep where it can, shifting sections offline even as you remain awake. Going without sleep raises blood pressure, undermines the immune system, and increases one's risk of dementia.

These areas of the brain are hard-hit in depression—but the changes are reversible

Depressed brains can have certain characteristic changes, including an overactive amygdala, reduced hippocampus size, and changes to the thalamus and neuromodulating chemicals in the brain.

Links between long-term caregiving and chronic stress

This Cleveland Clinic overview suggests that around 60% of people caring for family or loved ones with health conditions will experience burnout. Caregivers prepare meals, help with transportation, administer medications, and perform daily tasks for others, all while managing their own lives. This guide may help readers overcome the guilt or frustration of long-term caregiving to seek alternative options.

How aging degrades neural functioning in the brain over time

Aging affects the brain perhaps more than any other organ in the body. Throughout life, the brain experiences radical shifts in the number of neurons, synaptic connections between neurons, and hormone levels that regulate our mood and processing.

Exercise releases chemicals that enhance cognitive function

Neurotransmitters like dopamine, serotonin, and norepinephrine, along with increased brain-derived neurotrophic factor levels, enhance a wide range of brain functions. New research demonstrates a direct link between movement and numerous cognitive benefits, including memory, learning, and stress resilience.

ADHD impairs working memory and limits the ability to form long-term memories

While ADHD is most often recognized for producing struggles with attention and organization, these executive functions are critical for capturing the data that creates memories in the brain. Breaking data into pieces, or chunking, helps address these struggles.

Stress-induced hormones contribute to gray hair

When the body experiences stress, the sympathetic nervous system releases the hormone norepinephrine. This hormone prematurely activates pigment-producing cells (melanocytes) in hair follicles, which depletes the hair's ability to retain color over the long run.

Left versus right brain strokes vary significantly in long-term effects

Due to the high complexity of the brain, the aftereffects of a stroke can have widely different manifestations, ranging from minor temporary impairments to rapid death. Whether a stroke results in paralysis, speech impairments, loss of bodily function, or death will depend on whether it occurs in the left or right hemispheres or the brain stem.

Drug tolerance and withdrawals are consequences of overloading dopamine circuits

Addictive substances or behaviors will typically flood our brains with more dopamine than usual. In response to the overstimulation, our brains will decrease the number of available dopamine receptors. This results in the need for more stimulus for the same response (tolerance) and a rise in negative feelings when the stimulus is absent (withdrawal).

People are experiencing AI 'brain fry' at work

Workers, particularly in marketing, are experiencing mental fatigue in the workplace due to expectations—often unspoken—that they should use AI to multitask beyond their comfort levels. Many feel they are underperforming if they don't embrace this technology. This situation differs from typical burnout. This podcast discussion suggests that this "brain fry" tends to intensify when employees are required to use more than three AI tools.

Some claim breathwork can improve mental health, help process trauma, and more

Research shows people who practice breathing exercises see a decrease in depression and stress levels, and that such exercises are about as effective at treating PTSD as conventional approaches. Even something as simple as extending exhales can slow one's heart rate and activate the parasympathetic nervous system.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Supplements ahead of exertional heatstroke helped protect mice against brain damage

In the lab, mice dosed with probiotics prior to inducing exertional heatstroke, had better cognitive outcomes. This evidence underscores the links between the gut microbiome and the brain, at least in rodents.

PTSD is a long-lasting mental disorder linked to past traumatic events

Posttraumatic stress disorder is a mental health condition arising from traumatic events with four key symptoms: intrusive memories, avoidance behavior, negative moods and thoughts, and changes in emotional and physical reactions.

Circadian rhythm disruption can influence various mental health disorders

This 2020 research overview surveys the relationship between disrupted circadian clocks and disorders including schizophrenia, anxiety, and bipolar disorder. It incorporates findings and therapeutic approaches drawing from human night shift studies and jet lag studies alongside animal research.

Prolonged space travel significantly impacts multiple human body systems

Astronauts can lose 20% of their muscle mass after two weeks and 10% of their bone mass after six months in space. Decreased sharpness of eyesight and changes in neural connectivity, brain structure and gut bacteria have also been observed.

What employers can do about parental stress

The US Surgeon General recently released a formal warning deeming parental stress a public health issue. The advisory also included recommendations for how employers can mitigate the issue. Employers can help their employees access child care, for instance, or provide flexible working hours. To find out more about what the Surgeon General prescribes, read more here.

The myth of multitasking's prestige

In this article, renowned neurologist Richard Cytowic seeks to expose multitasking as a fool’s errand. Cytowic explains how the brain, like a computer, switches between tasks rather than handling multiple tasks at once. He shares that attempting to focus on multiple activities at the same time consequentially decreases the brain's ability to ignore distractions, maintain focus, and organize information. Instead, he suggests, try to focus on completing one thing at a time.

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

Researchers believe the brain consolidates memories, processes emotions, and plans for the future during dream states

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

About 12.5% of US adults experience a phobia in their lifetime, a diagnosis that hinges on the intense fear interfering with daily life and persisting for at least six months.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

Ebola infects and disables immune cells, triggering a cascade of events that leads to small blood clots throughout the body, weakening blood vessels and interrupting blood flow to key organs.

Firework or sparkler burns, even if they cover a relatively small area of skin, can significantly affect our range of motion.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

Some renewable energy sources may weaken the resiliency of electric grids by removing outage buffers provided by coal- and natural gas-fired plants, which provide the system with more time to find a new power source if a plant goes down.

Use this calculator to find the dollar value of your mental load, from meal planning to coordinating after-school care for your children.

Chaos theory—informally known as the butterfly effect—is the reason why weather forecasts are presented with probabilities rather than certainties.

Larger animals like giraffes, elephants, and blue whales have developed a unique defense against cancer, a phenomenon known as Peto's Paradox

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

Astronauts have repaired genetic damage in space using CRISPR—a molecular tool that can make precise changes to DNA and is used in single-celled organisms to attack invasive viruses.

US consumers collectively owe more than $1T to credit card companies—almost as much as they owe in auto loans.

Urushiol, the oily toxin in poison ivy, can remain allergenic on clothing for years.

Netflix profits when you're not watching, and its movies are designed that way—read a detail-rich critical essay exposing lesser-known Netflix takes

When you complete a CAPTCHA on a website to prove you are human, you may be unknowingly training algorithms for self-driving cars, whose systems require training data to help identify crosswalks, bicycles, and other outdoor objects.

Play the role of a student in a game where you try to navigate college and remain debt-free, selecting different income levels, high school experience, race, ethnicity, and more.

Gerrymandering works through two techniques: cracking opposing voters across districts to dilute their power, and packing them into a few to waste their votes in lopsided majorities.

In 2026, Finland was named the world's happiest country for the ninth consecutive year based on its wealth, social safety network, and high life expectancy, among other factors.

Domino's Pizza's 30-minute delivery guarantee was responsible for the chain's 1980s surge, but it was discontinued after the company was found liable for delivery driver accidents.

Existentialist writer Jean-Paul Sartre coined the famous phrase 'Hell is—other people' in his play 'No Exit'