How burnout alters your brain

Prolonged stress impairs the prefrontal cortex

Burnout isn't just a feeling—it physically affects the brain. Prolonged stress impairs regions of the brain responsible for decision-making, emotional control, memory, and more. It can also lead to chemical imbalances, like reduced dopamine and norepinephrine levels, that worsen these effects.

What happens to your brain when you burn out?

You've probably heard of burnout, also known as the feeling of exhaustion that happens after a long period of being overwhelmed or stressed. It's often associated with work and careers, but other parts of life, like parenting, can cause burnout, too. Scientists are figuring out what happens, biochemically speaking, in the brain when burnout hits—and spoiler alert, it includes a neurotransmitter called glutamate. Watch this video to learn more.

Stress and the brain

While an acute stress response is a normal bodily function, the effects of chronic stress can be extremely damaging to the human body. This is particularly true with regard to the brain. This article explores the effects of stress on the human brain, including how chronic stress may lead to psychological conditions such as depression and memory loss.

Protect employees from chronic stress

Burnout doesn’t just affect employees’ health. It also increases turnover, reduces productivity, and leads to illness. What kinds of changes can employers make to reduce burnout in the workplace? This white paper encourages employers to modify their cultures to reduce burnout, including offering clear feedback and support, creating more flexible workplaces, and reducing unreasonable workloads.

The biology of stress in your body

Stress is a normal human response that has evolved over millions of years to handle changes or threats in our environment. This article is a helpful overview of the biological basics of this response. While it is not harmful to our physiology in the acute setting, chronic stress can lead to damaging changes in the human body over many years.

Grief rewires the human brain

The human brain handles stress and emotional traumas similarly. In response to the emotional stress of a situation like the death of a loved one, divorce, or abuse, the brain may strengthen or weaken connections between nerves to form new neural connections. Over time, chronic stress can diminish brainpower, reducing overall nerve growth and memory to shift resources to enable elevated fear responses and enable humans to survive.

How burnout creep has spread across various areas of life

Burnout primarily refers to the feeling of being overwhelmed at work and is officially considered an occupational hazard, but colloquially people have started referring to other areas of burnout, including workouts or television shows.

Key symptoms of burnout can be both mental and physical

Burnout can be accompanied by several symptoms, including low energy and chronic fatigue, trouble concentrating, difficulty sleeping, and depression. It may even manifest physically as musculoskeletal pain, headaches, stomach and intestinal pain, and more. More intense cases have been linked to cardiovascular and mental health disorders.

How we frame stress—as good or bad—seems to alter how it affects us

This podcast discusses research that indicates stress perception may drastically affect how we respond to it. In research exploring if our stress is presented as diminishing our health versus if we're told it enhances our performance, it will lead to differences in how successful participants are at performing tasks—with the enhancers doing better.

Are you burned out? Take this quiz

Have you ever wondered if what you’re experiencing is burnout, or just stress? This Psychology Today quiz may help you decide if you need to explore more mental health resources. You don’t have to create an account to take the quiz. Simply answer the questions and provide your ZIP code.

Stress can be contagious—and scientists want to learn more about it

Researchers have shown that being around someone who is stressed can trigger a stress response in your body, such as elevated cortisol levels and elevated heart rate. One way this was recently studied was by having people watch stressful activities, like a recorded job interview or solving challenging math problems, and then sampling hormones in observers' spit.

Links between long-term caregiving and chronic stress

This Cleveland Clinic overview suggests that around 60% of people caring for family or loved ones with health conditions will experience burnout. Caregivers prepare meals, help with transportation, administer medications, and perform daily tasks for others, all while managing their own lives. This guide may help readers overcome the guilt or frustration of long-term caregiving to seek alternative options.

How artificial intelligence, which detects patterns, can identify burnout

Researchers are training AI to detect stress-related symptoms, helping physicians and other medical workers recognize and reduce stress from overwork and potentially avoid burnout.

Heatstroke can reprogram your DNA, putting survivors at risk of future health problems

Severe illness from extreme heat exposure can alter DNA through epigenetics—turning genes "on" or "off" to shape disease risk. These changes can place an organism at greater risk of future health complications—unlike the epigenetic changes produced by moderate, repeated heat exposures.

Completing the stress cycle to avoid burnout

Emily and Amelia Nagoski cowrote the book "Burnout: The Secret to Unlocking the Stress Cycle." In this podcast, they discuss their own experiences with burnout, how emotional and mental stress wreak havoc within the body, and societal barriers that intensify burnout.

Chronic drug use can cause neurological changes in the brain

Neuroscientist Judy Grisel breaks down the biology of addiction, examining how drugs hijack the brain’s natural reward system and create lasting neural changes. The physiological and neurological impacts of chronic drug use require a multifaceted treatment approach.

Exercise releases chemicals that enhance cognitive function

Neurotransmitters like dopamine, serotonin, and norepinephrine, along with increased brain-derived neurotrophic factor levels, enhance a wide range of brain functions. New research demonstrates a direct link between movement and numerous cognitive benefits, including memory, learning, and stress resilience.

How to build curiosity

Change and uncertainty induce stress, but reframing the unknown into an opportunity for discovery has tangible benefits. Approaching change with curiosity enhances activity in the hippocampus and promotes neuroplasticity, promoting learning and serving as a barrier against anxiety. A neuroscientist explains how embracing the unknown, trying small experiments, and other techniques build curiosity.

DNA damage and chemical stress causes cellular aging

While outward signs of aging, like gray hair and wrinkles, are easy to spot, aging changes at the cellular level are less obvious. The decline within cells stems from numerous sources, including DNA damage, oxidative stress, and accumulated waste.

A brain scientist's experience with a stroke

What happens when a leading brain scientist has a stroke of her own? Dr. Jill Bolte Taylor recounts moment by moment watching her brain function slow and then cease, followed by a prolonged recovery. Through this experience, she details what she learned about the phenomenon of stroke and how it has impacted her research ever since.

How frontotemporal dementia changes your personality

Significant changes in personality later in life are often attributed to psychological factors. But Dr. Bruce Miller, long-time researcher of FTD, argues this shift is most often attributable to changes in the brain.

How science explains déjà vu

Take a fun look at the science explaining the odd experience of déjà vu, which some theories suggest is actually a sign of a healthy brain.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Menopause affects the brain in complex ways

Lisa Mosconi, a neuroscientist studying the impact of menopause on the brain, explains in this video how menopause directly impacts a woman's brain health and explores why this is an important and often overlooked area in menopause and women's aging healthcare discussions.

Just a 10-minute mental health break can yield benefits

The US CDC offers recommendations for alleviating stress in daily life. Short 10-minute breaks can significantly improve mental health, especially when used for activities like deep breathing, dancing, or writing down things you are grateful for. Building meaningful relationships, termed "social connectedness," can also alleviate stress and promote resilience.

A framework for the various potential causes of insomnia

Insomnia typically occurs in people dealing with life stressors and physical or mental health conditions, though the exact cause continues to elude researchers. Generally, the factors can be broken down into external (such as stress, medication, etc.) or internal (neurological) factors.

Learn how your body is, scientifically, like a firework with its own slow, controlled burn.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

Researchers believe the brain consolidates memories, processes emotions, and plans for the future during dream states

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

Doctors differentiate between a phobia and fear by asking patients whether their fear interferes with their day-to-day activities.

Astronauts have repaired genetic damage in space using CRISPR—a molecular tool that can make precise changes to DNA and is used in single-celled organisms to attack invasive viruses.

Ebola infects and disables immune cells, triggering a cascade of events that leads to small blood clots throughout the body, weakening blood vessels and interrupting blood flow to key organs.

Scientists testing how climate change affects plants found, in a years-long simulation study, that poison ivy grew 70% faster with the resulting extra carbon dioxide.

Use this calculator to find the dollar value of your mental load, from meal planning to coordinating after-school care for your children.

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

Before writing 'Walden,' transcendentalist Henry David Thoreau nearly burned down his hometown with a campfire that grew out of control.

Chaos theory—informally known as the butterfly effect—is the reason why weather forecasts are presented with probabilities rather than certainties.

Some renewable energy sources may weaken the resiliency of electric grids by removing outage buffers provided by coal- and natural gas-fired plants, which provide the system with more time to find a new power source if a plant goes down.

Volcanoes 'die' when their supply of magma runs out, if they are shifted away from their underlying magma reservoir, or if they get clogged by collapsing or their magma cooling back into rock.

Explore an interactive map built from more than 100,000 survey responses on where people find joy in their lives

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

When you complete a CAPTCHA on a website to prove you are human, you may be unknowingly training algorithms for self-driving cars, whose systems require training data to help identify crosswalks, bicycles, and other outdoor objects.

The first steps to rebuilding your credit score include getting to know exactly what's on your credit report and figuring out how far you are from the '700 club,' or 'good score' range.

A Yale student wrote a profound essay about the consulting industry's influence on elite college students that was published in a book of her writing after she died in a post-graduation car accident.

Some Pokémon have been named after real and fictional organisms, while some real-world species have been named after Pokémon, such as Chilicola charizard and Binburrum zapdos.

The power and influence of the American presidency have expanded significantly over time—far beyond what the founders envisioned.

According to the physics of black holes, our 4D reality may be a hologram—a projection of information coded on a 2D surface on the edge of the universe.

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

Gerrymandering works through two techniques: cracking opposing voters across districts to dilute their power, and packing them into a few to waste their votes in lopsided majorities.