Common hormone therapies to treat menopausal symptoms

Menopause hormone therapy infuses the body with estrogen after the body's natural levels drop

The treatments can treat symptoms like hot flashes and vaginal dryness at varying doses. Progestogen, another hormone, is also typically prescribed with estrogen because estrogen alone can thicken the uterus lining, which elevates the risk of developing endometrial cancer.

There are multiple HRT options to treat menopause and perimenopause symptoms

This lengthy video features a board-certified OB/GYN based in Texas who provides a thorough overview of the different formulations for HRT, used to treat symptoms including hot flashes, vaginal dryness, and mood swings, and the pros and cons of each. She also discusses modern synthetic options versus the older formulation extracted from the urine of confined pregnant horses.

Menopause and perimenopause symptoms may affect both the mind and body

Women going through these aging transitions may experience some common physical and mental symptoms to varying degrees, including hot flashes, bladder control issues, brain fog, and vaginal dryness. This article dives into some of the most common symptoms women might expect during perimenopause, plus what they can do to relieve them.

27% of US menopausal women used estrogen in 1999, but by 2020 that number was under 5%

The fallout of studies in the early 2000s linking hormone therapy for menopause and elevated cancer, stroke, and other health risks meant that even decades later—yet before the FDA removed its black box warning in 2025—use of HRT remained extremely uncommon. (Some users may experience a paywall.)

How menopause affects mental health

Menopause, a natural biological process, occurs in three stages: perimenopause (hormone fluctuations), menopause (end of menstrual cycles), and postmenopause (12 months without menstruation). Hormonal shifts during this time can affect neurotransmitters, increasing the risk of mood disorders.

It's never too late to start hormone replacement therapy for menopause symptoms

This board-certified gynecologist discusses how it's ideal to start estradiol as soon as possible after menopause to maximize its benefits, but that if older women have healthy hearts they can still start these medications later, in consultation with their doctors, and the products could be useful if women are continuing to suffer from symptoms of menopause or want to fight bone loss.

HRT patches are popular partly because they have lower blood clotting risks than oral estradiol

Women taking estradiol for menopause or perimenopause are sometimes told oral HRT is not an option for them because it increases blood clot risks. But a large analysis in 2019 concluded that other forms of the HRT, such as the patch, creams, and gel, do not.

Menopause can exacerbate anxiety

Some research shows that menopause can fuel anxiety and also that pre-existing anxiety can boost the chances of experiencing other menopause symptoms, including hot flashes, insomnia, and brain fog. But treatments including hormone replacement therapy, breathing exercises, and other forms of exercise can alleviate some of these symptoms.

What is medical menopause?

Medical menopause is when menopause is induced from either surgery or medicine. Chemotherapy and radiation, as well as oophorectomy (a surgical procedure that removes the ovaries) and a radical hysterectomy can cause a woman to become menopausal. Women that go through medical menopause experience the same symptoms as women that experience natural menopause. Learn more about the medical condition here.

HRT for menopause may not help with mental health or sleep says a large 2026 analysis

A recent analysis investigating the effects of menopause and HRT use on mental health, cognition, and brain health suggested HRT did little or nothing to aid with mental health and sleep. But the researchers caution that, among other data gaps, they didn't have information on which HRT formulations were used among their nearly 125,000 participants, so results may have varied by drug treatment.

The gaps in menopause research and their effects

Nearly all studies (99%) researching the biology of aging don’t consider menopause in their setup. A Harvard professor noted that about 75% of aging-related diseases are likely influenced by menopause. In this article, she discusses how gaps in research are negatively impacting how the medical system can effectively treat aging women. Read her analysis of the issue here.

Gender-affirming hormone therapy cues changes similar to puberty

When HRT is part of gender affirmation care, people receive regular doses of estrogen or testosterone to alter hormone levels to more closely align with those of cis individuals of that biological sex. HRT may affect voice pitch, body hair, bone density, and more. Many of those changes are not reversible with the cessation of therapy, though the effects may diminish.

Menopause may become a $600B industry

Companies marketing products and supplements to alleviate menopause symptoms and make life easier during this life stage have become a gold mine. This 2022 article explores how and why companies have swooped into this space, and whether you should trust them or not.

Health problems are being misdiagnosed as perimenopause symptoms

Symptoms of menopause and perimenopause (the premenopause period) can be varied enough that clinicians dismiss them in patients in their mid-30s and onward as just a symptom of hormone level change. In this story, a woman's itching was dismissed as a hormonal change, but after two years and 11 separate doctor consultations, was diagnosed as cancer. (Some users may experience a paywall.)

MS Drugs reduce inflammation, helping reduce relapses and slow disease progression

Disease-Modifying Drugs calm the body's inflammatory response to help stave off relapses—when new or existing MS symptoms show up for a day or longer. Avoiding smoking, exercising, reducing stress via mindfulness, checking for vitamin D deficiencies, drinking more water and eating well, all can slow disease progression. [The jury's still out on if HRT around the time of menopause may reduce dementia risk](https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(25)00122-9/fulltext) Estrogen can reduce inflammation and support neural growth in the brain, and some research has suggested that beginning hormone replacement therapy around menopause—versus later in life—reduces Alzheimer's disease risk. Still, a recent systematic review concluded that taking HRT didn't affect dementia risk, regardless of when women started taking it, so the science remains unsettled.

Menopause, once not discussed in polite company, is now a plot point in some television shows

Menopause has long been a topic left out of film and TV. But some shows, like "The Change," and celebrities, like Jennie Garth, are now openly talking about it. This article breaks down how Hollywood is starting to come around to the menopause conversation and how celebrities are talking about their own personal experiences, as well as advocating on Capitol Hill.

Estrogen is a really important hormone for men, too

Many people may be familiar with the idea that too much estrogen can cause infertility and other complications, including erectile dysfunction, but too little estrogen is also a significant medical concern because it can result in a reduced sex drive and limit overall growth.

The word allergy is partly derived from the Greek word 'allos' for 'other'

For people with allergies, their immune systems recognize substances as a harmful "other"—cuing an inflammatory response. This podcast explores allergy details and related topics, including how scientists are interested in if the same allergic response mechanisms could underpin other health issues, including severe, painful symptoms around the time of menstrual cycles. Since estrogen acts on white blood cells called mast cells, which leads to the release of histamines—similar to what happens during allergic responses—an understudied question is whether the same process is fueling some of the uncomfortable symptoms around menstruation. An allergist guest notes this raises questions about if antihistamine medications like Pepsid might alleviate them, something that hasn't yet been explored in clinical trials.

See this searchable resource about herbal therapies, including evidence and drug interactions

Memorial Sloan Kettering Cancer Center has created this searchable resource of herbal supplements to inform the public about the purported uses of herbal therapies, the existing evidence about them, their mechanism of action, and any concerns about potential herbal supplement and drug interactions.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

Mifepristone, approved in 2000, is used to end early pregnancies

The drug works by blocking progesterone, a hormone that is needed to support pregnancy. Mifepristone is typically used in combination with a second drug, misoprostol, because this regimen often causes less cramping and bleeding than just using misoprostol alone.

Antidepressants alone may fail to help an estimated one-third to one-half of depressed patients

There are three major categories of antidepressants—tricyclic antidepressants, monoamine oxidate inhibitors, and selective serotonin reuptake inhibitors. This podcast notes these first-line depression drugs are not effective for many patients and may also come with concerning side effects. Other therapeutic approaches—either in combination with medication or as an alternative—include therapy, meditation, and consistent exercise.

Opioids are a class of drugs including fentanyl, heroin, oxycodone, and more

Since the dawn of pain, living things have sought ways to mitigate this evolutionary warning signal. One of nature's most effective painkillers is opium, a highly addictive, milky latex extracted from poppy plants. This forms the basis of one of the most prescribed classes of modern drugs.

There's no cure for tinnitus, but sometimes it goes away on its own

Though there's no cure, treatments and management approaches can significantly reduce symptoms and improve quality of life. Hearing aids, sound generators, and other steps can help some people with this condition. But sometimes tinnitus resolves within hours or days for reasons that remain unclear.

Unlike milder fears, phobias may get in the way of proceeding with your life

Clinicians may recommend exposure therapy—exposing oneself to the thing triggering fears in some doses—as one way to help overcome a fear.

'Men's groups' seek to offer deeper authenticity and personal growth

These formalized gatherings of men involve meaningful check-ins and sharing of daily experiences with the goal of personal growth. They are typically founded with the intention of bringing together men who want to examine their life and relationships, seek personal growth, and explore their ongoing relationship with masculinity and manhood.

Doctors differentiate between a phobia and fear by asking patients whether their fear interferes with their day-to-day activities.

To reduce wrinkles in clothing, research recommends gentle wash cycles with more water and tumble drying with smaller loads and longer times.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Experimental hantavirus vaccines and therapies, still under development, have long been funded by the US military.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

20,000 letters to the advice columnist 'Dear Abby' provide insight into prevailing sex, religion, and LGBTQ fears, anxieties, and concerns from the 1950s onward.

Memecoins are a type of cryptocurrency—a form of digital currency with a wide variety of uses—created around popular 'memes,' or viral internet jokes.

For centuries, it was common to sleep in two shifts: a few hours at the beginning of the night, and a longer period beginning around midnight

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Brandi Chastain, the star of the 1999 US victory over China in the 1999 Women's World Cup, was a last-second choice to take the penalty kick that sealed the victory.

Some renewable energy sources may weaken the resiliency of electric grids by removing outage buffers provided by coal- and natural gas-fired plants, which provide the system with more time to find a new power source if a plant goes down.

Poison ivy is in the same family as mangoes, cashews, and pistachios—and they all produce oily urushiol in their raw, unprocessed state—but they are typically prepared in ways to avoid causing human discomfort.

Hedge funds, the private investment firms that trade a wide swath of financial assets, make money by imposing steep fees on investors and from the fund's investment performance.

See photos of Meteora, a mountainous site in central Greece, home to 14th-century monasteries perched atop soaring outcroppings.

Shooting stars, or meteors, are fragments of asteroids and comets that burn up as they enter Earth's atmosphere, creating streaks in the sky called meteor showers.

Explore an interactive map built from more than 100,000 survey responses on where people find joy in their lives

'Silent' fireworks have gained more interest in recent years as a quieter celebratory option.

Play the role of a student in a game where you try to navigate college and remain debt-free, selecting different income levels, high school experience, race, ethnicity, and more.

When a Paris department store hesitated to sell Estée Lauder's perfume, she 'accidentally' broke a bottle, causing the smell to spread throughout the store and shoppers to start asking to buy the scent.

Gerrymandering works through two techniques: cracking opposing voters across districts to dilute their power, and packing them into a few to waste their votes in lopsided majorities.

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

Artificial coral reefs have been 3D printed from nontoxic, biodegradable terracotta clay, which coral polyps have used as a foundation for rebuilding marine ecosystems.