Rosalind Franklin uncovered the molecular structure of the tobacco mosaic virus

View the model of the tobacco mosaic virus from the 1958 Brussels World's Fair

After she finished analyzing her X-ray diffraction data on DNA fibers, Rosalind Franklin explored plant virus structures. For her work on the TMV, she was invited to build this 5-foot model, modified from earlier versions made of ping pong balls and bicycle handlebar grips.

Rosalind Franklin’s work led to Nobel Prize-winning discoveries in DNA and virology

Her X-ray diffraction imaging helped uncover the structure of DNA, which earned James Watson, Francis Crick, and Maurice Wilkins a Nobel Prize. The same techniques enabled virus imaging, contributing to Aaron Klug's Nobel Prize in chemistry.

Beyond DNA, Franklin's legacy extends into modern virology and steel production

While remembered for her critical but under-credited role in uncovering parameters for the structure of DNA, Rosalind Franklin made significant contributions across coal chemistry and virus structure. Her research helped improve fuel efficiency, wartime protective equipment, and foundational knowledge in molecular biology.

Rosalind Franklin was the long-overlooked contributor to discovering DNA's structure

Though James Watson, Francis Crick, and Maurice Wilkins are credited with discovering the DNA double helix, it incorporated Rosalind Franklin's unpublished data. Photo 51, her famous DNA image, took more than 100 hours to produce and a year’s worth of analysis to interpret.

Explore a 3D model of the experimental setup Rosalind Franklin used to take Photo 51

To capture the X-ray diffraction image of DNA from the thymus of a calf, Franklin built a humidity-controlling camera to isolate the B form of DNA. The exposure lasted 60 hours and produced a cross pattern, indicating a helical structure.

Exploring carbon compound pore structures contributed to improved gas mask filtration

During World War II, the British Coal Utilisation Research Association sought to improve the efficiency of coal as an energy source and studied the effectiveness of charcoal filters to keep soldiers safe. Rosalind Franklin's research there formed the basis of her PhD and led to five scientific papers.

View a collection of historical documents about molecular biology's history

The collection features materials related to those involved in the discovery of DNA and provides historical context for the discoveries of RNA, various viruses, and important bioproteins. The items include photographs, business correspondence, manuscripts, and scientific instruments.

See a timeline of landmark discoveries in the field of genetics

From the first genetic map of fruit fly genes in 1911 through the completion of the Human Genome Project in 2003, scientists have built upon each other's discoveries to further our knowledge of the human body and the genetic instructions that inform our traits and disease risks.

The foundation for computer viruses was published after its creator's death

In the late 1940s, Hungarian American mathematician, scientist, and engineer John von Neumann gave a series of lectures where he explained the theoretical framework for a computer program that could replicate itself—the von Neumann Universal Constructor. His lectures were later compiled and published in 1966, nine years after his death from cancer.

Bacteria helped scientists realize that DNA was the hereditary molecule, not proteins

Until the mid-1900s, most scientists believed genes were made of proteins, which were known to act as enzymes, hormones, and other chemicals that mediated an organism's traits. The Avery-MacLeod-McCarty and that benign bacteria could be made lethal, where the inherited factor that caused bacterial transformation contained DNA.

How the 1918 pandemic spurred developments in virology and vaccines

This article provides an in-depth historical account of the 1918 Spanish Flu pandemic, including its impact on the global population and how its occurrence spurred significant advancements in the study of viruses—laying the groundwork for the...

A technical look at the measles virus and its life cycle

The measles virus is made up of a single strand of RNA, packaged inside an envelope that varies in shape and size. A negative-sense paramyxovirus—the same family as mumps—the virus is encased in proteins that help it attach to immune cells inside the body.

Ernest Rutherford's gold foil and nitrogen experiments revealed nuclear structure

Observing high-angle deflections when alpha particles were fired at gold foil led to an atomic model with a dense, positively charged nucleus. Firing those particles at nitrogen resulted in the emission of hydrogen nuclei—protons—leading to the discovery of the subatomic particle.

The mosquito's role in the transmission of malaria was confirmed in 1897

The British army doctor Ronald Ross, who later won the Nobel Prize for his work, was the first to describe the transmission of malarial parasites by mosquitoes. He had lab mosquitoes suck blood from malaria-infected people and separately found the malaria parasite inside a mosquito's gut, confirming the bug's role in malaria transmission.

The discovery of the first extremophile and how it revolutionized DNA analysis

While investigating samples taken from within and around the hot springs at Yellowstone National Park, microbiologist Thomas Brock discovered Thermus aquaticus, a microorganism that thrived in hot water. It contained an enzyme called Taq polymerase, a critical molecule in polymerase chain reaction—a molecular photocopier that amplifies genetic signals to improve medical diagnostics.

Mosaic is credited for making the World Wide Web accessible to everyday people—not just scientists—for the first time

Mosaic was a web browser that allowed people to more easily access webpages on the World Wide Web. But unlike previous browsers, Mosaic was a graphical browser, which means it displayed images alongside text. This helped turn the web from a place for scientists into a cultural location that captured people's attention.

A moldy cantaloupe supercharged penicillin production

In 1943, a moldy cantaloupe found at a market in Peoria, Illinois, yielded a strain that produced six times more penicillin. Though often credited to lab worker “Moldy Mary” Hunt, accounts differ on who actually brought in the fruit.

Receptors on the cell surface are key to whether a virus is successful

Viral receptors are key regulators of host range, tissue tropism, and viral pathogenesis—basically, the door locks on cells allowing viruses to invade, if they have the right key. How this process works at the microscopic level determines whether a virus is able to trigger a widespread illness in the host.

How MIT researchers have used genetic mutations to improve photosynthesis efficiency

Recognizing that RuBisCO—a protein that binds carbon dioxide to other compounds to produce the building blocks of organic molecules—often mistakenly binds oxygen, scientists performed directed evolution experiments to modify the geometry of a bacterial version of the protein to cause it to preferentially interact with carbon dioxide over oxygen.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

Ebola is a filovirus, meaning it resembles a thread under a microscope

Filovirus is derived from the Latin word 'filum', meaning 'thread.' That term describes its thin, flexible, threadlike appearance. Originally isolated in 1976, the microscopic image of the Ebola virus is now famous, even portrayed in the movie Outbreak. In fact, Ebola's threadlike appearance can vary in both length and degree of twisting, sometimes resembling a bowl of spaghetti.

Ebola is a filovirus, meaning it resembles a thread under a microscope, though it sometimes twists and can resemble a bowl of spaghetti.

Poison ivy was sent to Europe in the 1600s as an exotic, ornamental oddity

The plants were grown in the English royal gardens at Kew, the Faculty of Medicine in Paris, and a few other locations.

Spies working on the Manhattan Project propelled the Soviet bomb program

Soviet infiltration—most notably by Klaus Fuchs—smuggled detailed implosion-design and hydrogen‑bomb data from Los Alamos to Moscow, cutting the USSR’s development time by at least a year and enabling their first atomic test in August 1949.

The origin of the term 'molecular gastronomy' and its first international workshop

The 1992 event was born from a conversation between American cooking instructor Elizabeth Cawdry Thomas and Italian physicist Ugo Valdrè, who agreed on the merits of the science of cooking. The International Workshop on Molecular and Physical Gastronomy was named, in part, after the field of molecular biology to lend it prestige and greater seriousness.

HFMD was first reported in 1957 in New Zealand

The first clinical report involved eight kids with the characteristic sores in New Zealand, and then in the years that followed there were dozens more cases there and also reports of outbreaks in England and Scotland, among other settings, including the US.

There's a West Nile virus prevention rap—and it's amazing

This catchy rap from biologist MC Bugg-Z and the Fairfax County government in Virginia walks people through prevention steps and the dangers of the virus, telling listeners to "rock" insect repellant and talking about the history of the disease in the US.

The Mona Lisa's celebrity status and repeated restorations have obscured what made the painting so revolutionary for its time

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

During the French Revolution, a botanist's letter asking about "dear Rhus" (poison ivy) was intercepted, leading authorities to suspect he was conspiring with the Russians.

The name 'Silicon Valley' arose from the founding of Shockley Semiconductor Laboratory in Fairchild Semiconductor in 1956-57, founded near Stanford University in Palo Alto

Elk Cloner, the first computer virus to spread in public, was written as a practical joke by Richard Skrenta, a Pittsburgh high school student.

The story of Dollree Mapp, whose legal challenge over her 1957 conviction for possessing "obscene material" led to a major strengthening of the Fourth Amendment

English mathematician Ada Lovelace wrote the first computer algorithm a century before computers existed and hypothesized that computing devices would one day be able to compose music—foreseeing the generative AI systems of today.

Sunflowers have long been a symbol of nuclear disarmament because they can extract large amounts of radioactive cesium from soil.

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

Mid-century modern graphic designers, known for their bright colors and bold lines in advertising, also found success with children's books.

While atoms are normally made of protons, neutrons, and electrons, exotic ones have been built with antimatter—alternate versions of normal matter that live for fractions of a second and are about a billion times as rare.

Before humans, the Soviet Union and the United States sent animals—including apes, dogs, and cats—to space during the Space Race.

Some Pokémon have been named after real and fictional organisms, while some real-world species have been named after Pokémon, such as Chilicola charizard and Binburrum zapdos.

Legendary architect Frank Lloyd Wright designed the SC Johnson headquarters in Wisconsin, aiming to make a cathedral-like workplace

Long before Major League Baseball began allowing instant replay for balls and strikes, an umpire reluctantly used the technology to determine whether a hit was a home run, a move that inadvertently ushered in a new era for the sport.

View the ten deadliest tornadoes in US history.

Hear 50 years of iconic hip-hop samples, the genre's foundational looped tracks

'Saturday Night Fever,' the 1977 film that introduced disco to the mainstream, was based on a fabricated magazine story.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

Explore an interactive map built from more than 100,000 survey responses on where people find joy in their lives