What is CAR T-cell therapy?

See how CAR-T cell therapy works to help fight cancer

Short for chimeric antigen receptor T-cell therapy, CAR-T Cell Therapy helps augment the body's own ability to attack cancer cells. It's a cell-based gene therapy that alters the genes in a person's T cells—which are a type of immune cell—to help them beat back cancerous growths.

Teaching immune cells to fight cancer

CAR T-cell therapy is a type of immunotherapy, which involves strengthening the immune system to attack cancer cells. Patient T cells, which manage immune responses and are responsible for killing pathogen-infected cells, are collected and re-engineered to produce surface-level proteins called chimeric antigen receptors. These CARs, now able to bind to specific proteins on cancer cell surfaces, are multiplied into the millions and infused back into the patient.

Why CAR-T therapy has become one of the main focus areas for autoimmune diseases

The therapy, originally targeting cancer, involves taking a patient's own T cells, genetically reprogramming them to recognize and attack a specific target and then infusing them back into patients. For autoimmune diseases, the therapy instead programs them to target immune cells that are causing problems, restoring immune system tolerance.

CAR-T is showing promise for treating lupus—previously thought to be incurable

A small number of lupus patients have remained in complete remission for years after undergoing an experimental CAR-T cell therapy that seems to eliminate enough B cells to fuel a "deep reset" of the immune system. CAR-T therapy is also being used experimentally to treat MS, myositis, and other autoimmune disorders. (Some users may experience a paywall.)

Early research suggests CAR-T therapy might treat scleroderma, reducing skin thickening

Clinical data from a couple patients in 2025 indicated that one experimental CAR-T therapy called rese-cel was able to genetically reprogram T cells to eliminate certain problematic immune B cells that were causing the condition. The therapy reduced skin thickening and allowed the patients to halt using immunosuppressive medications and steroids.

The difference between standard cancer treatments and emerging immunotherapies

If you've ever wondered what the difference was between immunotherapy and chemotherapy, this short video takes you through the steps. Briefly, chemotherapy attacks cancer in tumor cells directly, while immunotherapy encourages your immune system to fight it. There's more to it than that, but this delightful two-and-a-half-minute video provides a good primer.

How medical robots could cure cancer

Medical robots are on the verge of being able to be injected into the body, where they will be responsible for semi-autonomous behavior, such as detecting cancer cells and distributing medication. This six-minute video dives into the science of these nanorobots, which are smaller than blood cells. Applications of these nanobots could range from disease discovery and condition monitoring to tissue repair and artificial blood delivery.

Turning nuclear waste into cancer medications

This video explores Terrapower, a company transforming nuclear waste into lifesaving cancer treatments. This is accomplished through the production and use of Actinium 225, a rare isotope derived from thorium, which is used in targeted alpha therapy to treat cancer.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

A snapshot of progress in cancer treatments

The American Association for Cancer Research's "Snapshot of a Year of Progress" offers an overview of significant advancements in cancer research and treatment over the past year. Take a quick look at the rapid pace of scientific discovery and the translation of research findings into clinical practice. In 2024 alone, health regulators approved 15 new anticancer therapies alone.

How heart transplants work

Heart transplants require an old heart to be removed and a new one to be installed without killing the patient. How does that work? In this easy-to-understand five-minute video, learn each step of the intricate process, from donor matching to the preservative solution a heart is doused in while it is transported.

The inner life of a cell

White blood cells are responsible for protecting the human body from infection. This video uses biophysical data from Harvard researchers to accurately demonstrate what goes on inside one white blood cell as it works within the immune system.

Explaining CRISPR at five levels of technical detail

CRISPR is a new area of biomedical science that enables gene editing and could be the key to eventually curing diseases like autism or cancer. WIRED challenges biologist Neville Sanjana to explain this concept to 5 different people; a 7-year-old, a 14-year-old, a college student, a grad student and a CRISPR expert.

The Armamentarium is a set of new gene therapy tools to fight brain diseases

Research from 29 universities and institutions across North America has resulted in the development of 1,000 tools that provide large-scale, cell-type specific targeting for the first time. These tools may be used to alter the activity of brain cells to address some neurological diseases and sleep disorders.

Watch patient stories describing life with macular degeneration

This video series features patients discussing their experiences with the disorder, family members describing caregiving, and other insights about the disease.

Breaking down how and why 5G will change the world

The jump from 3G to 4G networks was pretty huge, and 4G to 5G is many times greater and is almost difficult to comprehend. This nine-minute video dives into how 5G will transform our world.

The basics behind mRNA vaccines

In this video, Yale experts Saad Omer, MBBS, MPH, PhD; Onyema Ogbuagu, MBBCh; and Akiko Iwasaki, PhD, explain the science behind COVID-19 mRNA vaccines.

Why don't we all have cancer?

The creation of a single cell produces 120,000 genetic mutations that can lead to cancer. This video investigates how our bodies proofread and autocorrect those mistakes.

What conditions can be treated with stem cells?

Stem cell research is a global enterprise, and much of the work is being done in Europe. This page gives readers a good sense of the medical conditions stem cell researchers in Europe focus on, and the specific research challenges they address. This page also offers links to in-depth information about many of the research projects.

See this 201-level explanation about mitochondria and mitochondrial replacement therapy

This 2022 academic presentation from Stanford University's Dr. Gregory Enns offers a detailed overview about mitochondrial therapy approaches. Enns, a pediatric geneticist, explains how well-functioning mitochondria support the human body.

How do tariffs work?

This brief animated video from Time walks through a simple example of a tariff on a single good, illustrating how this would affect the market for the good—both domestically and abroad—and who would eventually bear the cost of the tariff.

Learn how monoclonal antibodies, which mimic the body's antibodies, can fight diseases like Ebola.

Watch what depression does to the brain

This video explores the neurobiology of depression and why unraveling the complexities of this disease and its etiology will potentially improve treatments. Effective depression treatment, as this video highlights, can eventually make a depressed brain look like a healthy one on brain scans.

A guide to YouTube TV

In addition to giving users the ability to watch videos for free, supported by ads, YouTube also offers premium subscription products that include an ad-free version of YouTube—as well as YouTube TV, which lets viewers stream live TV channels over the internet. This CNET overview of YouTube TV explains what viewers get with the service, including which channels and networks, as well as a cloud DVR and the ability to cancel anytime.

Artificial photosynthesis turns CO₂ into sustainable fuel

Carbon conversion focuses on a central perplexing question: if carbon dioxide is a leading driver of climate change, and fossil fuels are made of carbon-based molecules, can we devise a way to convert CO₂ into useful alternatives efficiently? This video breaks down a potential pathway using artificial photosynthesis, which uses sunlight to convert CO₂ into fuel.

See how cholera spreads in a community

This animated video offers a comprehensive look at how cholera spreads. It makes clear why it's so difficult to stamp out this disease in communities around the world. It also details what steps can help control cholera.

How ALS (Lou Gehrig’s Disease) might work, and what scientists are learning about it

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects the nerve cells (neurons) controlling muscle movement. As the motor neurons degenerate, they stop sending signals to the muscles, causing progressive muscle weakness and, eventually, death. This three-minute animation focuses on the mechanisms within the motor neurons that cause them to degenerate. By understanding these mechanisms, researchers hope to one day find a cure for ALS.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Watch the cumbersome, but necessary, precautions healthcare workers must take to care for and protect themselves while caring for Ebola patients.

Children are now three times more likely to say they want to be a YouTuber when they grow up than an astronaut, with some even attending 'YouTube camps' that teach kids how to create content for the platform.

When you complete a CAPTCHA on a website to prove you are human, you may be unknowingly training algorithms for self-driving cars, whose systems require training data to help identify crosswalks, bicycles, and other outdoor objects.

In recent years a child anxiety expert has created and tested a novel phobia and anxiety treatment approach for children, focused on changing how parents respond to the fears.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Tattoos remain visible on your skin thanks to immune cells called macrophages

Learn how your body is, scientifically, like a firework with its own slow, controlled burn.

Objects can be 3D printed with light by projecting 2D computerized tomography (CT) scans onto rotating cylinders of resin, which solidify upon exposure.

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

Venture capital is a form of funding provided to early-stage companies with high growth potential, typically in exchange for an equity (or ownership) stake

In 2025, four executives from large tech companies were given positions in the US Army Reserves—including Palantir Chief Technology Officer Shyam Sankar, which reinforced Palantir's ties with the US military and its role as a leading defense partner.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

When caught in the mouths of cardinal fish, seed shrimp release glowing, bioluminescent chemicals, which alert predators of the cardinal fish, prompting the shrimp's ejection.

Watch a 1934 short film starring jazz legend Cab Calloway, a major figure in the Harlem Renaissance's music scene

Explore the history, structure, and species of Australia's Great Barrier Reef with this interactive journey narrated by Sir David Attenborough.

The first steps to rebuilding your credit score include getting to know exactly what's on your credit report and figuring out how far you are from the '700 club,' or 'good score' range.

20,000 letters to the advice columnist 'Dear Abby' provide insight into prevailing sex, religion, and LGBTQ fears, anxieties, and concerns from the 1950s onward.

Explore an interactive map of battles from the American Revolution, along with detailed summaries of each engagement

Calculate how much of your tax dollars go to each federal program based on your income, filing status, and number of children