How 3D printing inside cells paves the way for microscopic machines

Chip-based 3D printers can be pocket-sized and involve no moving parts

Researchers have demonstrated a proof-of-concept version of a chip-based 3D printer that emits visible light onto light-sensitive resin to construct solid shapes. The technology may provide a portable, low-cost solution for future, small-scale fabrication needs.

Microgravity environments improve the success of 3D bioprinting

Gravity can cause gaps, such as those in the chambers of a 3D-printed heart, to collapse before stem cells, hydrogels, and biochemicals bind together during the bioprinting process. Rather than Earth's surface, some bioprinting is done on the International Space Station, where defective organs are also printed to test treatment methods.

3D printers can create nearly any object that can be digitally designed

Limited only by the size of the printer and the properties of the materials used for printing, fabrications, including household items, toys, props, cases, prototypes, and models, can take anywhere from fractions of an hour to several days to make, depending on design complexity, size, color changes, and printer settings.

Prosthetics and orthotics have been 3D printed to improve the lives of animals

Shells for hermit crabs, wheelchairs for guinea pigs and dogs, and horseshoes for improved running performance have been created using 3D printers. Other artificial body parts made using this technology include a jaw for a loggerhead turtle, a beak for a toucan, and a tail for an American alligator.

View a timeline of 3D printing technology through 2019

The first working 3D printing device was invented in 1983 and utilized stereolithography, a process in which a laser triggers a chemical reaction that hardens liquid resin. Powder-based laser sintering technology was patented in 1987, with metal-based powders first being used for 3D printing in 1997.

As of 2025, the Factory of the Future 1.0 is the world's largest 3D printer

Housed at the University of Maine, the machine incorporates AI and can utilize bio-based materials to construct homes exceeding 3,000 square feet in size. Homes made from these materials are fully recyclable, as their components can be deconstructed, ground up, and reused as raw materials for printing.

The secret lives of cells

Cutting-edge microscopy has revealed previously unseen interactions of biological molecules within their cellular environment, enabling scientists to observe and analyze the molecules in a holistic view. This podcast explains the minute advancements made over the last few decades in observing cells, revealing how scientists have come and what the future holds for the field.

The benefits of 3D printing batteries, from safety to sustainability

Rather than using the liquid electrolyte commonly found in lithium-ion batteries, 3D-printed batteries would use a solid layer, which can be custom-built into different shapes, deliver higher energy density by building thinner layers, and be fabricated with fewer raw materials compared to injection molding.

In 2015, the FDA approved the first 3D-printed prescription tablet

Spritam, an epilepsy medication, had been too large and difficult to swallow, particularly due to its inability to dissolve easily. The new pill was designed with porous layers to enhance its dissolvability, paving the way for future 3D printing of drugs.

Watch the engineering challenges overcome in turning a 3D printer into a tattoo machine

The DIY project required reprogramming the printer to operate on a curved, 2D surface rather than making flat layers in 3D, editing replacement firmware to bypass temperature safety checks, and developing a rapid system to stop the tattoo in case of an emergency. The final product printed "LEG" on a volunteer's leg.

Massive 3D printers have been used to build homes by stacking layers of 'concrete toothpaste,' a fire-resistant material that effectively insulates against outside noise.

As of 2025, perfect synthetic replication of natural organs remains elusive

Advancements such as 3D printing muscles, performing vaginal reconstruction with colon tissue, and growing organs in a lab have shown promise, but artificial options and transplanting substitutions continue to exhibit functional and performance limitations compared to their natural equivalents.

Objects can be 3D printed with light by projecting 2D computerized tomography (CT) scans onto rotating cylinders of resin, which solidify upon exposure.

Visualization of printing synthetic DNA

Ever wonder how synthetic DNA is made? Discover how GenScript uses innovative technology to synthesize precise, high-quality DNA at a larger scale than ever before.

The mass of a cell can be measured using hollow, vibrating beams

In 2010, scientists at MIT constructed a U-shaped device that vibrates like a guitar string with an internal fluid channel. As cells and bacteria pass through the device, its rate of vibration shifts, with greater mass creating larger shifts.

Mosquito necroprinting uses an insect's mouthpart as the printer nozzle

Mosquitoes are abundant, and their nozzles are 32-100 times cheaper to harvest than to create from scratch out of metal or glass. By coating the organic nozzle to increase its strength, researchers are employing necroprinting to create tiny structures at better resolutions than commercial alternatives.

How to turn any cell of the body into a stem cell

Scientists have developed techniques allowing them to 'reprogram' any cell in the body into an induced pluripotent stem (iPS) cell, which can be used to create either more stem cells or specialized cells for use in experimental medical treatments. This page gives readers a brief introduction to the history of iPS cells, what researchers are studying with iPS cells, and challenges associated with iPS research.

Watch the iterative process of successfully printing a slice of vegan cheesecake

3D printing food requires integrating ingredients with a variety of properties, which may not all resist the physical stress of stacking. This means successful 3D printing of food may require rethinking how ingredients are layered and modifying ratios of each, potentially sacrificing taste for structural integrity.

Schizophrenia is being studied with pea-sized 'mini-brains'

Brain organoid research is enabling researchers to study distinct electrical firing patterns associated with schizophrenia. These "mini-brains" that are constructed in the lab from patients' cells could lead to better diagnosis approaches and drug development.

Cells cannot grow forever due to escalating inefficiency in transporting chemicals

As cells get larger, their volume grows much faster than the surface area through which nutrients and waste products pass, creating a bottleneck that eventually causes cells to die. This forces nearly all organisms visible to the naked eye to comprise enormous numbers of smaller cells, such as the approximately 30 trillion found in the average adult human.

3-parent baby technique fuels worries of future 'designer babies'

Some critics of this approach worry that any genetic manipulation will both culturally and technologically normalize the idea of "designer babies"—embryos that are manipulated or selected based on physiological characteristics including height, eye color, athletic ability, and intelligence.

Artificial coral reefs have been 3D printed from nontoxic, biodegradable terracotta clay, which coral polyps have used as a foundation for rebuilding marine ecosystems.

The human body in 3D

Zygote Body is a free human anatomy tool that allows users to explore the intricacies of the human body in stunning detail. With the click of a mouse, users can isolate by body system or view anatomical structures from any angle. Check out this...

Swarms of mechanical bees may one day support natural pollination

Engineers are racing to create tiny robot bees that can be programmed to mimic natural bee behavior, helping in specific scenarios such as indoor farming and space agriculture. Battery life challenges may be solved by having these robots accompanied by a nearby "mother" drone power supply.

Research studies can be conducted inside or outside of living samples

While "in vitro" experiments occur outside living organisms for cost-effectiveness, "in vivo" experiments take place inside them, providing real-life insights at a higher cost and with increased ethical concerns. Alternatively, "in silico" methods use computational simulations.

Cell theory originated from microscopic observations of cork and dental plaque

In the mid-1600s, Robert Hooke identified compartment-like structures—which he called cells—in cork, and Anton van Leeuwenhoek discovered bacteria in samples of his dental scrapings. Almost 200 years later, Matthias Schleiden and Theodor Schwann showed that plants and animals, respectively, are composed of cells, proving that cells are the foundation of all living things.

The scientist that biohacked a buff frog

If a tree frog was injected with a DNA mixture containing follistatin, a gene that may influence muscle growth, would it become buff? Josiah Zayner hopes so. By learning how to biohack animals, he hopes people are one step closer to feeling more comfortable "whipping up DIY gene therapy."

Scientists have demonstrated IVF to help critically endangered rhinos

Scientists have used the technique to create embryos from eggs harvested from captive southern white rhinos and implanted into a southern white rhino. They hope to use this proof of concept to eventually use IVF to revive the population of northern white rhinos, which are extinct in the wild and have no living males left, using a precious reserve of frozen embryos and a surrogate southern white rhino mother.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

Larger animals like giraffes, elephants, and blue whales have developed a unique defense against cancer, a phenomenon known as Peto's Paradox

Tattoos remain visible on your skin thanks to immune cells called macrophages

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Planarian flatworms are small, aquatic worms with exceptional regenerative capabilities. When cut, the worms can regenerate multiple bodies in a matter of weeks.

The syncytiotrophoblast is the outer layer of the placenta and the largest human cell, spanning an area about twice that of a king-sized bedsheet.

About 2,000 US babies are born annually without some portion of their limbs, potentially leading to a lifetime of pricey prosthetics.

Sony set the standard for cylinder-shaped batteries when it repurposed manufacturing equipment used to make rolls of magnetic recording tape.

Explore fun facts from the USPS, including unique post office buildings, a stamp that traveled past Pluto, and more.

After NASA's Voyager 1 captured Earth as a single pixel as it left the solar system in 1990, astronomer Carl Sagan used the image to reflect on humanity's fragility and the responsibility to protect 'the only world we've ever known.'

Electrical grids worldwide must double their power delivery capacity by 2050 to meet surging demand from AI and electric vehicles.

Crows are believed to have intelligence on par with a seven-year-old child and demonstrate complex behaviors, from problem-solving with tools to recognizing human faces.

Watch how viruses like Ebola can spill over from animals to humans—and vice-versa.

Watch how deep-sea mining equipment collects and processes polymetallic nodules—metal-rich, potato-shaped rocks—from the ocean floor and creates environmentally damaging plumes of sediments.

In 2019, a laptop loaded with six of the worst malware in history and described as 'an exhibit of historical weaponry' sold for $1.3M.

The first robot in literature may have been a 'mechanical man' in 1907's 'Ozma of Oz,' a book in L Frank Baum's 'Wizard of Oz' series.

Some researchers have labeled nomophobia, the fear of being without your phone, as 'the phobia of the 21st century.'

In 1945, Surrealist artist Salvador Dalí and legendary animator Walt Disney began collaborating on a short film that was not completed until 2003, years after both men had died.

While atoms are normally made of protons, neutrons, and electrons, exotic ones have been built with antimatter—alternate versions of normal matter that live for fractions of a second and are about a billion times as rare.

NBA superstar Victor Wembanyama spent the 2025 summer training with monks in central China to enhance his body and mind.