BPC-157 stands for Body Protection Compound-157

A comprehensive review of BPC-157 studies identified no human safety data

This meta-analysis included available studies on this peptide from 1993-2024, and identified 36 studies. It found 35 preclinical (nonhuman) studies and one retrospective study in humans of musculoskeletal pain following injections of BPC-157 for unspecified chronic knee pain. In that one human study, 7 of 12 patients receiving BPC-157 reported relief after the injections (though many had injuries that often heal on their own over time).

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Peptides like BPC-157 are marketed based largely on animal studies, not human research

BPC-157, which purportedly helps with tissue repair and muscle growth, can cause concerning side effects, including pain and swelling. TB-500, another experimental peptide, is marketed for wound healing, but it hasn't undergone any clinical human trials, and high levels of this peptide have been linked to tumor growth. (Some users may encounter a paywall.)

The US FDA issued a 2025 warning about BPC-157 and other popular peptides

BPC-157, which mimics a naturally occurring gut peptide involved in soft tissue repair, has been marketed for various regenerative properties. But the FDA warned in July 2025 that it doesn't have enough data to assess its safety in humans and that such products may also pose risks related to contamination.

Read a deep dive on the 'all-purpose healing' peptide BPC-157

The unapproved peptide—which has received glowing testimonials from bodybuilders, biohackers, popular podcasters, and some in the MAHA movement— is often sourced from China. It has been used for myriad conditions. But scientific questions about the substance abound, including whether it's truly a natural substance produced by the human body, since genetic material that codes for its unique amino acid sequence hasn't been found in the human genome or the gut microbiome. Other unknowns include how it works in the body, which receptors it targets, and its safety, since evidence beyond anecdotes remains scant in humans.

The World Anti-Doping Agency has banned many peptides

The global body has an entire section dedicated to banned peptide hormones, including ones that may stimulate growth hormones and testosterone. BPC-157 was added to the list in 2022.

Early peptide research focused on isolating the substances from animal tissue

In the first half of the 20th century, peptides including insulin and adrenocorticotropic hormone were isolated from animals to provide life-saving medicines. ACTH was isolated from the pituitary glands of cows and pigs and insulin was isolated from the pancreas of dogs and cows.

Diabetes drug GLP-1 is a peptide (that's what the 'P' is for)

Glucagon-like peptide-1, or GLP-1, is one of the most well-known peptides in common use. In 2024, 26.5% of all adults with diagnosed diabetes used the substance. GLP-1 was particularly popular among people with diabetes aged 50-64, followed by younger adults and then seniors aged 65+.

Premarin, the hormone medication derived from pregnant horses, is 'PREgnant MARes urINe'

Scientists in the late 1920s and early 1930s discovered estrogens could be extracted from human placenta, and then isolated it from the urine of pregnant women. But researchers discovered the urine of pregnant horses had similar substances and the horse product was much easier to collect in significant amounts—leading to Premarin.

'Buffy coats': The 1% of blood that helps fight off disease

When blood is centrifuged, white blood cells and platelets form a layer called the buffy coat between the plasma and red blood cells. This layer makes up less than 1% of blood, but its heightened leukocyte concentration makes it useful for toxicology research.

Pharmaceutical companies can use ChatGPT to improve drug development

Moderna has incorporated the tool into its workflows to accelerate analysis and identify optimal drug dosage from clinical data. The company's legal team also uses a custom GPT—Contract Companion—to break down and summarize contracts quickly.

Learn how monoclonal antibodies, which mimic the body's antibodies, can fight diseases like Ebola

Monoclonal Antibodies mimic the antibodies produced naturally by the immune system. These molecules target specific parts of the virus, preventing them from entering cells or interfering with their ability to cause harm or infection.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

How is immunotherapy used to fight cancer?

The Dana-Farber Cancer Institute provides a delightful Science Illustrated animation explaining PD-1/PD-L1 immunotherapy and how it fights cancer. Briefly, the treatment helps T-cells recognize cancerous cells that would ordinarily be "disguised" by proteins and attack. The fight is made more fair and effective by immunotherapy and similar cancer treatments.

The Consumer Financial Protection Bureau is looking closely at BNPL

Given the lack of data around BNPL services in comparison to other financial products such as credit cards, the CFPB has conducted research to better understand BNPL products and how they could harm and benefit consumers.

The most advanced 'bunker-buster' bomb can penetrate 200 feet below soil or concrete

The GBU-57 Massive Ordnance Penetrator is delivered exclusively by the B-2 Spirit stealth bomber, which carries only two at a time. Using GPS-guided fins and a steel alloy casing, it burrows 200 feet underground before detonating.

Why we should care about renaming the hormonal disorder PCOS to PMOS

The new name, polyendocrine metabolic ovarian syndrome, nods to the hormonal disruptions that cause this condition, which affects roughly one in eight women. People with PMOS may have symptoms including irregular periods, trouble conceiving, weight gain, acne, undesired hair growth, and more. The earlier name, polycystic ovary syndrome, was a misnomer because women with the condition don't have cysts in their ovaries. Rather, they have masses that are actually immature follicles. World health experts think the condition often goes undiagnosed.

Critical organic molecules have been found on an asteroid

NASA's OSIRIS-REx mission returned samples containing amino acids and nucleobases from asteroid Bennu. Without Bennu having been destroyed—as is common for asteroids that enter Earth's atmosphere—its samples serve as a time capsule of the solar system's early chemistry.

Distinct plant species evolved to produce caffeine as a pesticide

Although it provides a defense against insects trying to eat caffeine-bearing plants, the molecule is an example of exaptation, where its original function was repurposed over time. Studies show that some plants now produce caffeine-laced nectar to help pollinators move more quickly and pollinate more efficiently.

Some private credit funds trade on the stock market

These funds, which trade at market prices, are called "public BDCs," which stands for "business development companies." For instance, the global alternative investment manager Ares Management Corp. has a public BDC.

What is the Responsibility to Protect?

This website provides an in-depth overview of the Responsibility to Protect. An important global principle, R2P seeks to safeguard populations from genocide, war crimes, crimes against humanity and ethnic cleansing. The website’s ‘What is...

The amount of plastic chemicals in 300 everyday Bay Area foods

Food production is more complicated than it appears, and manufacturing, packaging, and shipping processes can add significant substances to your food. This massive project compiled data on 300 samples of foods delivered to the San Francisco area, testing for the presence of 18 different kind of plastic. Learn how to read the data here with its helpful guides and then explore the table yourself.

Astatine-211 is a radioisotope that can be used for therapeutic cancer treatment

With less than 30 grams in the Earth's crust at any given time, astatine is the rarest naturally occurring element. Its decay produces alpha particles that can damage diseased cells with the same impact as 10,000 electrons.

During the first Biosphere 2 mission, crew members lost 16% of their body weight

Food and oxygen shortages drove the “Biospherians” to split into two factions—one seeking to bring in outside resources and another aiming to maintain isolation for the experiment’s integrity. Psychological stress was exacerbated further by the increasing prevalence of insect pests.

Open brain surgery is not required for BCIs inserted via blood vessel injection

Synchron's brain-computer interface, the Synchron Switch, takes advantage of preexisting medical devices, such as stents and catheters. Cells grow over the device over a 90-day period, incorporating it into the vessel wall and minimizing clots.

The word 'Peloton' comes from the word for the main group of riders in a cycling race

The word itself is French for "ball," but became the inspiration for the word "platoon" in the 17th century to describe a group of soldiers. Now, it's a common cycling term and the main focal point in cycling races.

Dispose of invading viruses while learning about the CRISPR immune system

In this free, easy-to-play game, defend the city of Bacterium by playing the role of Cris Perotein. As you play, you'll learn microbiology and the workings of the mechanisms that CRISPR uses to protect bacteria. (desktop recommended)

Larger animals like giraffes, elephants, and blue whales have developed a unique defense against cancer, a phenomenon known as Peto's Paradox

The 2026 Ebola outbreak in the DRC is spurring new Ebola vaccine development for the Bundibugyo species.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

The syncytiotrophoblast is the outer layer of the placenta and the largest human cell, spanning an area about twice that of a king-sized bedsheet.

In 2025, four executives from large tech companies were given positions in the US Army Reserves—including Palantir Chief Technology Officer Shyam Sankar, which reinforced Palantir's ties with the US military and its role as a leading defense partner.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

Apeirophobia is an overwhelming fear of living forever, perhaps stemming from the brain's inability to conceptualize an infinite life.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

While atoms are normally made of protons, neutrons, and electrons, exotic ones have been built with antimatter—alternate versions of normal matter that live for fractions of a second and are about a billion times as rare.

Massive 3D printers have been used to build homes by stacking layers of 'concrete toothpaste,' a fire-resistant material that effectively insulates against outside noise.

In 2018, 26-year-old missionary John Allen Chau was killed by tribesmen after attempting to reach and evangelize on India's isolated North Sentinel Island

Explore the archaeological treasures of Pompeii, the city buried under volcanic ash when Mount Vesuvius erupted in 79 CE.

Poison ivy's rash-causing compound is found in the plant's roots, stem, and leaves—so coming into contact with any part of the plant can lead to rashes for the 85% of people who are allergic to it.

The USPS spent $3.97B in 2024, accounting for .058% of the federal budget.

SpongeBob exemplifies Aristotle's philosophy for living well because he understands that happiness doesn't come from external factors like money, recognition, or power.

Prince's sexually explicit 1984 track 'Darling Nikki' attracted the ire of the Parents Music Resource Center, an advocacy group that inspired the Parental Advisory sticker, even though the song ends with a Christian message.

The animatronic shark from Steven Spielberg's 'Jaws,' the first modern blockbuster, was a complex underwater apparatus called 'Bruce.'

Power lines are dotted with large, brightly colored balls to improve the visibility of these thin wires to helicopters and small planes and help prevent potential crashes.

Hedge funds, the private investment firms that trade a wide swath of financial assets, make money by imposing steep fees on investors and from the fund's investment performance.

The 1987 Nintendo video game 'Stadium Events' isn't known for being particularly fun, but its scarcity has made it a highly sought-after item that has sold for up to $35K at auction.