UNOS oversees the entire US organ donation system

3 US maps illustrate transplants, donors, and organ waitlist additions—by state

National UNOS tracking data feeds into these US maps that record all the transplants, donors, and waitlist additions in the last 12 months. California, for example, had the most transplantations in 2025—totaling about 5,200—but it also has the longest waiting list, with more than 20,000 additions in that same period.

In the US, you must actively sign up to donate your organs

The US has an opt-in donation system for organ donation—meaning people must provide consent to proceed with any donation. Locations including Spain, the United Kingdom, and Argentina have an opt-out donation system, which means individuals are presumed to be donors unless they actively refuse consent.

NSF-funded research into matching algorithms improved the success of organ transplants

Investigations in game theory, including concepts focused on creating mutually beneficial partnerships—matching theory—led to the design of computer systems that efficiently matched kidney recipients and live donors, resulting in higher-quality matches. By 2019, these matching algorithms were used for multi-organ exchanges.

Brain death is a top source of organ donation

Brain death is a significant source of organ donations because patients declared brain dead and hooked up to intensive care unit machines will still have oxygen flowing to organs like the heart, lungs, and kidneys—preserving those organs.

Thousands of donated human kidneys are thrown away annually

Ten donated kidneys are thrown away daily even though thousands of people are awaiting a kidney transplant. Listen to a kidney doctor and a 2012 economics Nobel laureate discuss why this happens and how the organ transplantation system may be improved. Transplant centers are penalized for low transplant survival rates, they note, and that contributes to why hospitals may decide certain organs are just too risky to use.

Immunosuppressants enable organ transplants, but come with severe side effects

This drug cocktail helps to lower your body's natural response to attack a transplanted organ. Such medications usually need to be taken for a lifetime after receiving an organ and can come with serious side effects including high blood pressure, diabetes, increased risk of some cancers, and high cholesterol, among others.

More than 40 states have passed versions of the Uniform Declaration of Death Act

The 1981 model law, now enacted in most states, is the legal basis for death in the US. There have been many efforts to amend this law, citing the need for more transparency to improve trust between families and the medical profession, though none have moved forward. Alterations to the law could have implications for organ donations and removing life support.

How did segregation in the US affect blood donations?

When the US established its first nationwide network of blood banks in 1941 with the hopes of restoring the dwindling reserves of military members, it was quick to emphasize blood donated by Black Americans wouldn't coat the veins of white servicemen. Historians say this policy was meant to appease white Southerners who believed Black blood was inferior to their own.This policy was leaked to the press that same year.

International organizations exploit ultimate beneficial owner policies in different countries to shield bad actors

UBO policies help determine who owns businesses by evaluating who is making the decisions, regardless of the listed owner.

UNICEF collects donations for children at Halloween

For generations, Trick-or-Treat for UNICEF has been one of the main ways American children are introduced to the work of the United Nations. The Halloween campaign encourages them to collect donations for children in need—instead of just candy.

The UN's primary goal is to promote peace and cooperation

The UN's self-proclaimed mission is to promote peace, protect human rights, and tackle global challenges like poverty and climate change. The About Us page on the UN's website is a good entry point to understand how this international organization works and its impact in today's world.

View the ecosystem of global services, organizations, and agencies behind the internet

Through an open, transparent, and collaborative model built on open standards development and shared global ownership, the internet is kept freely accessible amid evolving international policies. Key organizations, such as IANA, which allocates IP addresses and fulfills administrative functions for the Domain Name System, function as non-profit organizations.

The United States is one of only around two dozen countries with a fully federal system of government, in which power is divided between national and state governments.

College endowments FAQ

​The National Association of College and University Business Officers (NACUBO) is a membership organization representing chief administrative and financial officers at colleges and universities. This page addresses 10 common questions about college endowments, including their purposes, management, and spending policies. Learn more about how endowments support institutional missions and financial sustainability.

Human anatomy 101: the body's systems

Human life is made possible by the body's ten major systems, which maintain homeostasis by responding to incoming sensory and biochemical input. Each system must work independently and collaboratively for the body to maintain health and respond appropriately to its internal and external environments. The bones of the skeletal system, for example, give the body its shape and protect organs while also facilitating movement with the muscular system.

Understanding how non-profit entities manage electric grids to ensure supply-demand balance

Independent System Operators in smaller areas and Regional Transmission Organizations that operate across multiple states run wholesale electricity markets. Electricity suppliers can submit competitive bids to meet estimated demand in day-ahead markets while keeping consumer costs low. ISOs and RCOs also inform markets of deviations in these estimates so that suppliers can adjust how much power they generate, which is then bought and sold in real time.

Federal systems are a minority among the United Nations' 193 members

Of the United Nations' 193 member countries, roughly two dozen use a federal system, dividing power constitutionally between national and subnational governments. This group includes the United States, India, Canada, Germany, and more. The video walks through examples of how these states operate.

The Office of Water protects the nation's rivers, lakes and drinking supplies

The office develops national standards for safe drinking water, regulates wastewater treatment, and enforces the Clean Water Act. It partners with states and tribes to monitor pollution, protect wetlands, and restore aquatic ecosystems across the United States.

The US is one of two countries that abide by a predetermined borrowing limit

When the Treasury hits this “debt ceiling,” Congress has to pass a bill increasing the borrowing threshold. Failure to do so may lead to a financial crisis.

Narcan is an opioid antagonist that can rapidly reverse overdoses

Naloxone, also known by the brand name Narcan, is an opioid-overdose reversal medication that typically begins working within a few minutes. An opioid antagonist, the treatment attaches to opioid receptors without activating them, forcing opioid molecules out of their respective receptors and allowing users' breathing rates to normalize.

USA Today asked readers about their grief—and received more than 700 responses

The submissions included one moving story of two women whose sons died by drug overdose. The duo wrote that they found each other in a support group and decided to navigate their respective difficult situations by starting a podcast together called "Two Moms with Two Dead Kids," which focused on what life was like in the years following the deaths of their children.

USP-verified label on supplements means a nonprofit confirmed what's in the bottle

The black-and-yellow USP-verified program seal on a dietary supplement bottle means that the nonprofit US Pharmacopeia tested a sample of the product and verified that it was made in a facility with good manufacturing practices and that it will dissolve in the body. Their certification also means they tested to confirm that the product contains the ingredients listed on the bottle at the specified levels, and that it doesn't contain harmful levels of certain dangerous contaminants.

A 'designated survivor' stays away from the State of the Union to ensure continuity of government

During major events like the State of the Union, one Cabinet member is kept at a secure location. This "designated survivor" would assume the presidency if a catastrophe eliminated those higher in the line of succession.

Norovirus is the leading cause of food poisoning in the US

The illness is typically transmitted when virus-laden feces gets into another person’s mouth. That occurs when people do not properly wash their hands, contaminating food or surfaces.

The International Space Station is made up of two incompatible segments

Before collaborating due to financial difficulties, Russia and the US had independently been working on developing their own space stations. A specialized adapter was created to connect the Zarya and Unity modules and create the foundation for the ISS.

USB connectors for universal data transfer debuted in 1996

Since the introduction of USB 1.0 by a consortium of companies, data transfer speeds have steadily increased from 1.5 megabits per second to 40 gigabits per second as of 2019. Variations in USB connector types enable them to be used for applications and devices that require different speeds and power.

The US dollar is the most widely circulated currency in the world, and is involved in nearly 90% of global transactions

The USPS spent $3.97B in 2024, accounting for .058% of the federal budget.

Experimental hantavirus vaccines and therapies, still under development, have long been funded by the US military.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

Cultural norms about how to handle the bodies of loved ones in communities in West Africa have hampered Ebola responses.

An initial public offering or 'IPO' is the process of a private company becoming public by putting shares of the company on the stock market for purchase.

About 2,000 US babies are born annually without some portion of their limbs, potentially leading to a lifetime of pricey prosthetics.

The US first hosted the World Cup in 1994, a tournament that lives in soccer infamy for its poor planning and the murder of Colombian player Andres Escobar, who'd accidentally scored on his own net.

Domino's Pizza's 30-minute delivery guarantee was responsible for the chain's 1980s surge, but it was discontinued after the company was found liable for delivery driver accidents.

See how each of the more than two million known species relates to each other—and to common ancestors—in this zoomable tree of life.

The syncytiotrophoblast is the outer layer of the placenta and the largest human cell, spanning an area about twice that of a king-sized bedsheet.

Discover the catastrophic consequences of a failure of the US electrical grid—something that is more likely than many Americans think.

Most of the observable universe's volume consists of voids and supervoids—enormous regions of space with little to no galaxies, stars, or light.

While the sun's gravity keeps the planets in orbit, their gravity also pulls on the sun, causing it and everything else in the solar system to orbit around a mutual balance point called the barycenter—the true center of the solar system.

Watch how deep-sea mining equipment collects and processes polymetallic nodules—metal-rich, potato-shaped rocks—from the ocean floor and creates environmentally damaging plumes of sediments.

Up to a million Girl Scouts sell about 200 million cookie boxes every spring, generating $800 million, largely because refusing a child is frowned upon

Sunflowers have long been a symbol of nuclear disarmament because they can extract large amounts of radioactive cesium from soil.

This site reaches millions of visitors who are tired of AI chatbots and seeking human connection. Pretend to be an AI chatbot and ask questions, provide answers, and draw for people in real time.

'Shogun,' a 1980s TV series, helped popularize sushi in the US by stimulating an American interest in Japanese culture.

In 2018, 26-year-old missionary John Allen Chau was killed by tribesmen after attempting to reach and evangelize on India's isolated North Sentinel Island

A small portion of The Winstons' 'Amen, Brother,' an obscure '60s gospel record, is the basis for thousands of hip-hop tracks, making it one of the most sampled records ever that's informally known as 'the Amen break.'

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

The Beatles' US label rejected the band's first two singles, 'Please Please Me' and 'From Me to You,' with one executive calling the band 'dead in the water.'