The Cincinnati Enquirer's Pulitzer-winning look at the opioid epidemic

From prescriptions to street drugs: Opioids trajectory across America

Exclusive data obtained by The Washington Post from the Centers for Disease Control and Prevention shows how individual counties moved through three waves of the opioid crisis, each wave paving the way for the next. Between 2011 and 2017, the drug responsible for the majority of overdose deaths shifted from prescription pills to heroin to fentanyl. Together, oxycodone, hydrocodone, heroin, and fentanyl have been major drivers in declining life expectancy in the US.

The story of the Sackler empire behind highly addictive OxyContin

This investigative report examines how the Sackler family built its fortune through Purdue Pharma’s aggressive marketing of OxyContin, a highly addictive painkiller. Through 2017, the drug had generated more than $30B in sales for Purdue Pharma, controlled by the Sacklers.

One person dies from opioids every 7 to 8 minutes

This collection of infographics by the National Institute for Health Care Management helps put the crisis into perspective. The opioid epidemic has had three waves. Opioid-related deaths increasingly involve synthetic versions of the drug class, contributing to 83 percent of all opioid-related deaths in 2020. Use these infographics to learn more about the crisis.

See how DOJ prosecutors took down a pharmaceutical company's executives over the opioid crisis

This FRONTLINE documentary follows federal prosecutors as they used anti-racketeering laws to convict executives at Insys Therapeutics, a pharmaceutical company that bribed doctors to overprescribe a fentanyl painkiller.

Synthetic opioids: a historical and clinical review

In the 19th century, researchers began synthesizing and isolating poppy plant alkaloids, leading to the invention of morphine, codeine, heroin, oxycodone, and others. These highly addictive variants eventually gave rise to illicit use and a widespread underground market, laying the foundation for the current opioid crisis.

Learn about the US opioid crisis in this free course

Where did the US opioid crisis come from, and how did it spread? Learn this and more in this free, online Harvard University course. Learn about the disease model of addiction treatment and management, and get up-to-date with public health and law enforcement's current harm reduction practices. This free resource gives users a greater understanding of opioid addiction and the epidemic still haunting the US.

Opioid epidemic 101: lawsuits and settlements

State and local governments trying to address the opioid epidemic have sued organizations they believe started and supported the crisis. Companies that made, distributed, or contributed to sales of the highly addictive painkillers are expected to pay more than $50B in settlements. These settlements specifically state that at least 85% of settlement funds must be spent on addressing the epidemic, though where exactly the money is going is unclear.

USA Today asked readers about their grief—and received more than 700 responses

The submissions included one moving story of two women whose sons died by drug overdose. The duo wrote that they found each other in a support group and decided to navigate their respective difficult situations by starting a podcast together called "Two Moms with Two Dead Kids," which focused on what life was like in the years following the deaths of their children.

Barbara Kingsolver's 'Demon Copperhead' reframes Dickens for the opioid crisis

The 2022 novel is a retelling of Dickens' autobiographical coming-of-age novel "David Copperfield." Kingsolver moves the story from Victorian England to contemporary Appalachia, where the opioid crisis is raging. The book won the 2023 Pulitzer Prize for Fiction.

The Washington Post's Janet Cooke returned her Pulitzer

When Washington Post reporter Janet Cooke published her profile of a 8-year-old heroin addict named Jimmy in 1980, it created an instant uproar. Social workers, police officers, and even the mayor of Washington, DC all jumped into action to try to get the child help, but no one could find him. Within hours of Cooke receiving a Pulitzer for the piece, everything began to unravel as it was revealed that she had fabricated not just Jimmy's story, but her own as well. She eventually returned the award.

A podcast detailing the drug markets of East and Southern Africa

The African continent plays a critical role in the global illicit drug market. Often forgotten when discussing drug trafficking, organized criminal networks in Africa have established relationships with other criminal organizations around the world....

Investigating 'the city that kills women'

For nearly three decades, thousands of women have disappeared near Ciudad Juarez, Mexico. Some were mutilated in ways that led authorities to suggest it the work of a serial killer, some were trafficked into slavery, and others have never been found. Opening with a hail of bullets, this 10-part podcast series hopes to uncover those responsible for the femicides.

Who was behind the fatal 1982 Tylenol poisonings?

In 1982, an unknown suspect laced Tylenol packages with potassium cyanide in a Chicago pharmacy. Seven people were killed, and the case led to a nationwide panic, as well as the development of tamper-resistant packaging. No one was ever charged with the deaths, and the lead suspect died in 2023 after serving time in prison for trying to extort $1 million from a manufacturer to "stop the killing."

The East Palestine, Ohio, train derailment explained

A train transporting a number of potentially dangerous chemicals derailed near the Ohio–Pennsylvania border in early February 2023. The extent of the leak has caused a number of environmental concerns and required a controlled burn to clear most...

This American Life explored Ohio's gerrymandering battle

In 2022, Ohio lawmakers repeatedly drew congressional districts that the state Supreme Court ruled unconstitutional. This defiance violated a voter-approved reform intended to prohibit partisan gerrymandering.

Reporting on the Santa Cruz storms

The Pulitzer on the Road podcast interviews prizewinners for insights on their work and takes a deep dive into issues relevant to the awards. This episode focuses on Lookout Santa Cruz, a digital California-based outlet that won the Pulitzer Prize for Breaking News for its coverage of the devastating storms the region faced in early 2023. Lookout’s reporters discuss the importance of local news coverage.

A 49-year-old American died at an ibogaine clinic in Mexico, underscoring its risks

The man had sought out the drug to help him overcome his substance abuse disorder. Though anecdotal reports indicate potential promise, there's been no large-scale clinical trials on ibogaine's safety and efficacy. The plant is derived from a root bark named iboga and has been used for centuries by indigenous communities in Gabon, but first entered scientific consciousness in 1901 after its alkaloid was isolated from Iboga.

‘The Kentucky Derby Is Decadent and Depraved’ signaled the birth of Gonzo Journalism

The 1970 essay opens with a crude conversation between Hunter S. Thompson, the author, and a man at an airport bar. Thompson’s first-person account places him as an active participant. Instead of focusing on the race itself, Thompson paints vivid details of his experience with the hedonistic scene surrounding it.

Some Ozempic users lose their desire to eat

This essay follows a writer whose Ozempic journey involves a dramatic loss of appetite, leading them to stop compulsive snacking and even lose some of the joy of eating. As a result, he becomes fixated on watching food videos and eventually tries to "beat" an all-you-can-eat steak buffet. The experience leaves him feeling disappointed and lacking in desire.

Seven of America's cheapest and safest towns are in Ohio

Combining data on low crime rates and affordable housing, this GoBankingRates survey found New Philadelphia, Ohio, to be the safest and most affordable town in America as of 2025.

'20 Days in Mariupol' is a firsthand look at a siege from the war's front lines

The award-winning documentary "20  Days in  Mariupol" follows a Ukrainian AP team trapped in Mariupol during the first weeks of Russia's 2022 invasion—documenting the bombing of a hospital, mass graves, and civilians under siege. Note: graphic content.

Hundreds of vulnerable Chicago residents died in 1995 during a long-lasting heat wave

Eric Klinenberg wrote a book diving into the specifics of the heat wave. His book, detailing the stories and context fueling more than 700 deaths during just one summer week, helps readers understand how social infrastructure lapses, power outages, and ineffective heat responses led to so many deaths.

The promises and perils of using at-home genetic tests for your health

A primer on genetic testing, personalized medicine, and the promise of pharmacogenomics–the use of genetics to predict an individual's response to a drug.

Overwork contributes to thousands of worker deaths

Can work really kill you? The World Health Organization and the International Labor Organization have estimated that long work hours contribute to thousands of death from strokes and heart attacks each year. This BBC article argues that the culture of overwork and burnout is leading to a public health crisis in desperate need of solutions.

The inside story of the 1969 murder of coal union leader Jock Yablonski

In 1969, Jock Yablonski challenged the longtime president of the United Mine Workers, Tony Boyle. On New Year's Eve of that year, Yablonski, his wife, and their daughter were brutally murdered in their beds.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

View the ten deadliest tornadoes in US history.

See images of medical cases of firework injuries shared on this 'Instagram for doctors.' (Warning: Graphic content)

Louisiana's 'Cancer Alley' is infamous for having some of the highest industrial pollution, toxic air emissions, and cancer risks in the US.

A Yale student wrote a profound essay about the consulting industry's influence on elite college students that was published in a book of her writing after she died in a post-graduation car accident.

Cultural norms about how to handle the bodies of loved ones in communities in West Africa have hampered Ebola responses.

The tragic Pulitzer Prize-winning image 'The Vulture and the Little Girl' (1993) generated controversy, raised concerns about ethics in photography, and eventually led to the photographer's death.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

The story of Dollree Mapp, whose legal challenge over her 1957 conviction for possessing "obscene material" led to a major strengthening of the Fourth Amendment

20,000 letters to the advice columnist 'Dear Abby' provide insight into prevailing sex, religion, and LGBTQ fears, anxieties, and concerns from the 1950s onward.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

About 2,000 US babies are born annually without some portion of their limbs, potentially leading to a lifetime of pricey prosthetics.

Poison ivy can cause rashes year-round since all parts of the plant contain urushiol, the oil that triggers our allergic response.

In 2009, the nation was gripped by the story of a missing young boy who was believed to be floating over Colorado in a homemade balloon, until it was revealed that he was at home the whole time.

Hear about the 250-year history of the United States Postal Service, complete with some of its strangest deliveries, important innovations, and the figures that made it an American institution.

Explore an interactive map built from more than 100,000 survey responses on where people find joy in their lives

A small portion of The Winstons' 'Amen, Brother,' an obscure '60s gospel record, is the basis for thousands of hip-hop tracks, making it one of the most sampled records ever that's informally known as 'the Amen break.'

In 1963, a basement renovation in Turkey revealed a passageway to a hidden, multilevel underground city that once housed as many as 20,000 people

Netflix profits when you're not watching, and its movies are designed that way—read a detail-rich critical essay exposing lesser-known Netflix takes

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

The Russia-Ukraine conflict is the largest ground war in Europe since World War II in casualties, forces mobilized, and displacement of civilians.

US intelligence allegedly pursued more than 600 schemes to assassinate Cuban revolutionary Fidel Castro.

The price of gas is a composite made up of several different factors, with the federal gas tax making up less than 20% of what drivers pay at the pump.