The body's sleep-wake cycle is one of its many circadian rhythms

Studies suggest when you sleep is as important as how much you get

"Molecular clocks" made of timekeeping proteins and genes help regulate the body and its processes, meaning the disruption of one cog will impact another. Those who live in sync with their circadian rhythms report less fatigue, clearer thoughts, greater medication benefits, and better long-term health outcomes.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

Temperature and certain medications can also affect your circadian rhythms

Although light and dark have the largest influence on circadian rhythms, temperature, stress, and certain medications are among the factors that also play a role. Persistent trouble sleeping or staying asleep may signal it’s time to see your doctor to get a better sleep-wake schedule.

Parasites have circadian rhythms, too

Researchers are working to unravel how circadian rhythms of parasites and their hosts affect one another. They’re investigating how to potentially target and disrupt those clocks for disease treatments.

The REM cycle happens around four to six times per night

Sleep is a natural process that is critical to maintaining life—a process conserved throughout evolution across just about any animal with a brain. Generally speaking, the first three stages involve increasingly deep phases of non-REM sleep, followed by a roughly 90-minute period of REM sleep that repeats throughout the night.

Circadian rhythms shift as we age—making older adults want to go to bed earlier

Throughout our lives our internal biological clocks shift. Early-to-rise toddlers become hard-to-wake teens and eventually early-to-sleep seniors. Circadian rhythm fluctuations throughout our life cycle explain some of these changes.

Genetics play a role in the reliability of the body's biological clocks

Growing evidence suggests genetics influence when, how long, and how well one sleeps, meaning insomnia may have a genetic component. While exact insomnia biomarkers have yet to be determined, some genes, including those related to psychiatric disorders, have been implicated.

What happens when we sleep

Sleep is a highly specialized and complex process that begins via signals from a region of the brain called the hypothalamus. As explained in this overview video from The Economist, the hypothalamus maintains our circadian rhythm by using light cues from our environment to regulate sleep via a compound known as melatonin. Once asleep, the brain begins the "sleep cycle" and progresses through the four stages of sleep over and over again each night.

Chronobiologists study the effect of time on biological cycles

Circadian rhythms were first observed in the 1700s, when French astronomer Jean-Jacques D'Ortous de Mairan put a plant in a dark room and watched it still respond to day and night cycles, setting off further studies about specific light-dark biological cycles, an area of inquiry that continues today with the human "clock proteins" at the molecular level.

Circadian rhythm disruption can influence various mental health disorders

This 2020 research overview surveys the relationship between disrupted circadian clocks and disorders including schizophrenia, anxiety, and bipolar disorder. It incorporates findings and therapeutic approaches drawing from human night shift studies and jet lag studies alongside animal research.

Sleep is often viewed individually, when its impact and meaning may be more communal

At any given point, roughly 2 billion people may be asleep on Earth. The typical scientific description of sleep focuses on its individual impact, but the phenomenon shapes whole cultures and eons. This essay prompts a fresh rethinking of the importance of sleep for humanity.

The body's master clock has 20,000 neurons

The suprachiasmatic nucleus, the master clock in mammals, has 20,000 neurons that help maintain the light-dark cycle in the body. Among its jobs: It receives light input information from the retina and then signals peripheral body clocks to act on this information, driving everything from body temperature to hunger.

Emulating Earth’s light-dark cycle is important for astronaut health and safety

Astronauts aboard the International Space Station experience 16 daily sunrises, but scientists have learned to try to promote circadian rhythms by phasing through several light settings aboard the ISS to improve astronauts’ sleep and productivity.

What it's like to live with insomnia

The biological process Shakespeare referred to as the chief nourisher of life's feast is necessary for the body and mind to rest and repair from the activities of daily life. As sleep evades the exhausted, sufferers also lose emotional stability, mental clarity, social connections, and more while simultaneously gaining waves of interrupted biological processes that can lead to disease and death.

Babies don't develop a circadian rhythm right away

Newborns don't develop circadian rhythm until they are a few months old, which helps to explain their erratic sleep schedules. When they're around three months old they begin to release melatonin, which influences sleep, and around the same time they develop more regular sleeping routines.

Single-cell organisms have circadian clocks that direct daily biochemical routines

Cyanobacteria, a type of light-sensitive bacteria, use this clock to signal when to alternate between making organic compounds through photosynthesis and when to convert atmospheric nitrogen into usable ammonia. Upregulating photosynthetic machinery before dawn helps ensure efficient photosynthesis.

SAD disrupts melatonin secretion, producing it longer in the morning

The hormone is secreted from the pineal gland in the brain and is key to the timing of sleep. However, the substance does not generate sleep itself. With seasonal affective disorder, the body misperceives the photoperiod—the time with light—and the cycle of sleeping and waking gets off-phase, leading to issues with circadian rhythms.

'Zeitgebers' like light are external cues for the circadian clock

German for "time giver" or "time cues," common external zeitgebers include sunlight, food, and physical activity. The timing of these external influences can shift circadian clocks or lead to irregularities: A 2018 study, for example, found that later light exposure and meals were linked to later timing of peak activity and bedtimes.

Similarities between human and animal sleep

Have you ever noticed the wide-ranging differences in sleep between humans and animals? Sleep as a necessity is present amongst all animal species, but the specific patterns of sleep vary widely. Just think of the differences between how an owl, a whale, and a horse might sleep. This helpful resource from the Sleep Foundation explores the relations between human and animal sleep, complete with some fascinating statistics about sleep patterns throughout the animal kingdom!

Sleep disorders can exacerbate neurological and other health conditions

Brain regions that control sleep sit adjacent to those that regulate the autonomic nervous system, which controls involuntary bodily functions like heart and breathing rates. These neighbors influence each other, meaning poor sleep can impair or negatively impact the ANS, further disturbing sleep.

In 2017, researchers won a Nobel Prize for their work controlling fruit fly circadian rhythms

This detailed circadian rhythm infographic breaks down a day in the biological life of a fly, providing a peek at some of the groundbreaking work that elicited a Nobel Prize in Physiology or Medicine.

For centuries, it was common to sleep in two shifts: a few hours at the beginning of the night, and a longer period beginning around midnight

Neural rhythms shape how we move, focus, remember, and interact with the world

Millions of neurons in the brain produce rhythmic electrical signals, or brain waves, that guide physical movement and help form and store memories. Researchers also use these rhythms to create brain-computer interfaces, letting people control devices using only their thoughts.

Narcolepsy occurs when the brain loses its ability to control its sleep-wake cycle

Narcolepsy not only makes people fall asleep at random moments, but it can also cause hallucinations, insomnia, and sleep paralysis. The disorder is tied to cells in the brain’s hypothalamus called hypocretin, which are neuropeptides responsible for keeping you awake and controlling your dreaming from coming on too quickly.

Social jetlag—differing weekend and weekday schedules—is physiologically similar to jet lag

Recovering from schedules that drastically differ between weekends and weekdays, something that was first described in academic work in 2006, is a growing concern in public health as more research shows that consistent daily routines are important for human health.

Human anatomy 101: the body's systems

Human life is made possible by the body's ten major systems, which maintain homeostasis by responding to incoming sensory and biochemical input. Each system must work independently and collaboratively for the body to maintain health and respond appropriately to its internal and external environments. The bones of the skeletal system, for example, give the body its shape and protect organs while also facilitating movement with the muscular system.

Researchers believe the brain consolidates memories, processes emotions, and plans for the future during dream states

Learn how your body is, scientifically, like a firework with its own slow, controlled burn

This NPR video makes clear that there are surprising similarities between how our bodies and fireworks function. Fireworks and our bodies are both packed with carbon atoms, and have controlled releases of energy that create heat—keeping the human body warm or fueling fireworks' heat, respectively. What's more, the human body even emits a tiny bit of light somewhat similar to fireworks—though it's not visible to the human eye.

Learn how your body is, scientifically, like a firework with its own slow, controlled burn.

All rainbows are 'raincircles' caused by water droplets separating white sunlight into a spectrum of colors, but Earth's surface blocks the bottom half of the circle from our line of sight.

Crows are believed to have intelligence on par with a seven-year-old child and demonstrate complex behaviors, from problem-solving with tools to recognizing human faces.

While the sun's gravity keeps the planets in orbit, their gravity also pulls on the sun, causing it and everything else in the solar system to orbit around a mutual balance point called the barycenter—the true center of the solar system.

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

How Amazon operates a 'flywheel' business model, a self-reinforcing cycle that drives continuous growth

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Chaos theory—informally known as the butterfly effect—is the reason why weather forecasts are presented with probabilities rather than certainties.

The syncytiotrophoblast is the outer layer of the placenta and the largest human cell, spanning an area about twice that of a king-sized bedsheet.

Ebola infects and disables immune cells, triggering a cascade of events that leads to small blood clots throughout the body, weakening blood vessels and interrupting blood flow to key organs.

The US dollar is the most widely circulated currency in the world, and is involved in nearly 90% of global transactions

Coral polyps reproduce via broadcast spawning, where entire reefs simultaneously release reproductive cells for about one hour, once a year.

Explore an interactive map built from more than 100,000 survey responses on where people find joy in their lives

Poison ivy can cause rashes year-round since all parts of the plant contain urushiol, the oil that triggers our allergic response.

Some researchers have labeled nomophobia, the fear of being without your phone, as 'the phobia of the 21st century.'

Some renewable energy sources may weaken the resiliency of electric grids by removing outage buffers provided by coal- and natural gas-fired plants, which provide the system with more time to find a new power source if a plant goes down.

Some Pokémon have been named after real and fictional organisms, while some real-world species have been named after Pokémon, such as Chilicola charizard and Binburrum zapdos.

NBA superstar Victor Wembanyama spent the 2025 summer training with monks in central China to enhance his body and mind.

The American cockroach is actually from Africa, an apparent hitchhiker aboard ships carrying enslaved people, with evidence suggesting the bug may have arrived in the New World as early as the 1600s.

Objects can be 3D printed with light by projecting 2D computerized tomography (CT) scans onto rotating cylinders of resin, which solidify upon exposure.

See how Budweiser's famous Clydesdales spend their days at Warm Springs Ranch, where roughly 70 to 80 of the beer brand's giant horses can be found at any given time.

The Ramones' 'Pet Sematary,' the theme song for the Stephen King novel of the same name, was written while the band was admiring the writer's collection of horror memorabilia.