How to properly use semaglutides

Risks of GLP-1s include health side effects, counterfeit drugs, and more

This episode interviews researchers and patients who have used semaglutide to explore some of the potential risks associated with using the drug to lose weight. These include insurance challenges, health scares related to counterfeit versions of these drugs, and some users lose their ability to enjoy food.

How semaglutides are both better and worse than we know

The drugs were developed for use treating diabetes and, later, weight loss, but they have proven helpful with the heart, kidneys, and colon. On the flipside, it may slow digestion and lead to gastroparesis, or stomach blockages, and unexpected babies resulting from the slow effect of birth control pills.

Semaglutides trigger the release of the appetite-suppressing hormone incretin

We've all heard about these new weight loss drugs. But what are they actually doing inside the human body to help people manage their weight? Health news site STAT has created a clear, concise video that explains what GLP-1 RAs are and how semaglutide works.

How quickly does semaglutide work?

While semaglutides begin working almost right away, it may take days or even weeks to notice physical effects. Here, three patients describe their own personal experience with the medications, side effects, benefits, and more.

GLP-1 helps reduce obesity through a number of mechanisms

Clinical studies show GLP-1 drugs, including semaglutide, promote weight loss through a number of effects. These include reduced appetite, slower emptying of the digestive tract, increased insulin production, and more.

How weight loss drugs could reduce obesity costs

A detailed analysis from finance giant ING finds semaglutide and other weight loss drugs could significantly drive down global costs stemming from heart disease and other health problems associated with obesity. The benefits will vary, depending on each country’s demographics and drug and healthcare costs.

Tirzepatide: A GLP-1 drug that also acts on separate receptors to promote weight loss

Tirzepatide, like semaglutide, is a GLP-1 drug used in diabetes treatment and for weight loss. Unlike semaglutide, it also acts on glucose-dependent insulinotropic polypeptide receptors, proving a second route to reducing appetite as a means to treat diabetes and promote weight loss.

What do people do once GLP-1 medications succeed at weight loss?

The drugs have been adopted by 1 in 8 Americans, with many achieving their prescribed weight loss. They now face the question of how to keep the weight off, the key issue with any weight loss program that researchers have known about for decades. Each case is unique. Some folks continue to use GLP-1s like Ozempic in minuscule doses, while others taper them off over time.

Research suggests Ozempic has benefits beyond weight loss

Semaglutide, the key ingredient in Ozempic, is proving to be more than just a diabetes and weight loss drug. Research suggests it may also help prevent strokes, improve heart health, and slow Alzheimer’s.

Compounding pharmacies make custom drug formulations during drug shortages

Compounded semaglutide refers to customized versions of the medication prepared by pharmacies, especially during shortages of FDA-approved products like Ozempic and Wegovy. While compounded forms of brand-name medications can make it easier to access the drugs, the quality of such medications often varies.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

Can we speed up our metabolisms?

Listen to this 31-minute podcast to better understand what science knows and doesn't know about metabolism, as well as the only thing that seems capable of changing it. Scientists understand that the difference between a so-called “fast” and “slow” metabolism does not affect one’s ability to lose weight.

Infertility is often not discussed, forcing women and families to grieve privately

Watch this podcast discussion from Weill Cornell Medicine about the emotional journey of infertility for couples and individuals and hear advice about how to navigate the feelings of loss of control, grief, anger, and despair, including suggested tips for supporting individuals struggling with infertility.

See the differences between the Wegovy pill and injection

Examine this chart that compares and contrasts the oral and injectable Wegovy formulations. The differences include how they are absorbed by the body (through the digestive tract versus subcutaneously), their dosages, and the required timing (the pill is taken daily and has specialized timing requirements, while the injected form is administered once a week). Importantly, the pill form is also approved to treat fewer conditions.

How meal timing factors into health outcomes

The world is trending toward weight gain, a development that comes with a corresponding rise in risk for health conditions, including diabetes and heart disease. This article explores how meal timing has become a factor in nutrition and weight maintenance.

Antidepressants alone may fail to help an estimated one-third to one-half of depressed patients

There are three major categories of antidepressants—tricyclic antidepressants, monoamine oxidate inhibitors, and selective serotonin reuptake inhibitors. This podcast notes these first-line depression drugs are not effective for many patients and may also come with concerning side effects. Other therapeutic approaches—either in combination with medication or as an alternative—include therapy, meditation, and consistent exercise.

'Menobelly' is real, with more fat stored around the abdomen as estrogen levels drop

The way fat is carried in the body shifts with menopause, with those pounds increasingly settling around the abdomen instead of the hips and thighs. Exacerbating this phenomenon, muscle mass also begins to decline, so calories stick around longer than usual. Resistance training, including push-ups and planks, alongside a heavier protein diet can help.

Listen to how medical error affected an emergency physician's approach

Emergency physician Dr. Sarah Gray discusses her worst medical error, what she learned from it, and how medical error and the culture around it lead to physician burnout. In addition to lawsuits, medical errors can lead to guilt, shame, anxiety, and fears of embarrassment, so this podcast discusses how sharing such errors and teaching about them can improve care.

How supplements and alternative medicine are being used to treat MS

MS patients often use complementary and alternative medicine approaches for MS, including acupuncture, yoga, specific diets, herbs like turmeric, and cannabis. Information on integrative approaches often come from support groups and online communities. Complementary care is typically used in conjunction with traditional medicines.

Early research suggests CAR-T therapy might treat scleroderma, reducing skin thickening

Clinical data from a couple patients in 2025 indicated that one experimental CAR-T therapy called rese-cel was able to genetically reprogram T cells to eliminate certain problematic immune B cells that were causing the condition. The therapy reduced skin thickening and allowed the patients to halt using immunosuppressive medications and steroids.

Insurance denials prevent lifesaving care for patients with eating disorders

A patient living with anorexia nervosa was told by her insurance company that she wasn't sick enough to receive needed care. Her experience highlights how some insurers across Washington state focus on less useful metrics like body mass index and weight to gauge sickness instead of psychiatric symptoms that may better illustrate the urgency of receiving care.

Umami synergy—combining glutamates and nucleotides—can amplify a meal

While glutamates are known for triggering the umami taste through specific taste receptors, nucleotides like IMP and GMP can bind alongside glutamates to enhance the receptor's response. This union explains why certain classic food combinations like bacon and eggs taste exceptionally savory.

The science of addiction treatment

A helpful resource from the National Institute on Drug Abuse (part of the NIH). This article examines addiction treatment and recovery through the science behind several accepted methods. The guide draws helpful comparisons with other chronic disease treatments. In particular, it discusses the overlap between medications and therapeutic treatments, and the understanding that relapse doesn’t indicate treatment failure—only a need for continued or modified care.

Tips for reducing the risk of antimicrobial resistance

Antimicrobial resistance is bad news. But there are lots of things you can do to both protect yourself from superbugs and help keep the problem of antimicrobial resistance from getting worse. This page from the CDC offers clear, straightforward guidelines that can help keep you—and your loved ones—healthy.

A doctor answers the internet's burning questions about the gut

Gastroenterologist Dr. Ugo Iroku answers the internet’s burning questions about digestion and bowel movements. Get the lowdown on what it means when your stuff is super dark, the impact of coffee on evacuating bowels, and much more.

Why might someone want to stay in psychosis?

Author Abigail Gosselin writes that her verbal auditory hallucination, often assumed by others to be harmful or threatening in nature, offered a salve to loneliness, even as it told her to kill herself. This perceived benefit and others Gosselin shares offer insight into why people in psychosis may struggle to adhere to treatment and medication plans.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

Watch the cumbersome, but necessary, precautions healthcare workers must take to care for and protect themselves while caring for Ebola patients.

Doctors differentiate between a phobia and fear by asking patients whether their fear interferes with their day-to-day activities.

When caught in the mouths of cardinal fish, seed shrimp release glowing, bioluminescent chemicals, which alert predators of the cardinal fish, prompting the shrimp's ejection.

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

See images of medical cases of firework injuries shared on this 'Instagram for doctors.' (Warning: Graphic content)

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Sunflowers have long been a symbol of nuclear disarmament because they can extract large amounts of radioactive cesium from soil.

Learn how to read a prospectus, the juicy document that any company must file with the SEC before going public.

'Shogun,' a 1980s TV series, helped popularize sushi in the US by stimulating an American interest in Japanese culture.

Use this tool to calculate the dollar value of your parental mental load, from meal planning to coordinating after-school care, then see resources that help generate solutions.

Watch how algorithms can be designed to train themselves and self-improve without human input, to the point where the optimized code is too complex for programmers to understand.

Objects can be 3D printed with light by projecting 2D computerized tomography (CT) scans onto rotating cylinders of resin, which solidify upon exposure.

Hotels in Cannes, the glamorous city on the French Riviera, hire hawks to ward off seagulls during the city's famous film festival.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

The syncytiotrophoblast is the outer layer of the placenta and the largest human cell, spanning an area about twice that of a king-sized bedsheet.

The first steps to rebuilding your credit score include getting to know exactly what's on your credit report and figuring out how far you are from the '700 club,' or 'good score' range.

Memecoins are a type of cryptocurrency—a form of digital currency with a wide variety of uses—created around popular 'memes,' or viral internet jokes.

Gerrymandering works through two techniques: cracking opposing voters across districts to dilute their power, and packing them into a few to waste their votes in lopsided majorities.

The Russia-Ukraine conflict is the largest ground war in Europe since World War II in terms of casualties, forces mobilized, and displacement of civilians.