How weight loss drugs could reduce obesity costs

GLP-1 helps reduce obesity through a number of mechanisms

Clinical studies show GLP-1 drugs, including semaglutide, promote weight loss through a number of effects. These include reduced appetite, slower emptying of the digestive tract, increased insulin production, and more.

The potential for weight loss drugs to transform the economy

In 2023, Americans spent more than $50B on weight loss drugs, a number expected to triple by the end of the decade. However, because of the wide range of obesity-linked health issues, widespread adoption of the treatments could transform the wider economy.

Semaglutides trigger the release of the appetite-suppressing hormone incretin

We've all heard about these new weight loss drugs. But what are they actually doing inside the human body to help people manage their weight? Health news site STAT has created a clear, concise video that explains what GLP-1 RAs are and how semaglutide works.

How to properly use semaglutides

This podcast with a nutritionist and a medical doctor discusses how useful semaglutide can be for weight loss. It also outlines the need for patients to set reasonable expectations and to make changes to both diet and exercise as part of an overall weight management strategy. The experts note that failure to make meaningful changes outside of using semaglutide may mean patients need to stay on the drug in order to keep the weight off.

How semaglutides are both better and worse than we know

The drugs were developed for use treating diabetes and, later, weight loss, but they have proven helpful with the heart, kidneys, and colon. On the flipside, it may slow digestion and lead to gastroparesis, or stomach blockages, and unexpected babies resulting from the slow effect of birth control pills.

Research suggests Ozempic has benefits beyond weight loss

Semaglutide, the key ingredient in Ozempic, is proving to be more than just a diabetes and weight loss drug. Research suggests it may also help prevent strokes, improve heart health, and slow Alzheimer’s.

Companies developing new weight loss drugs

In recent years, weight loss drugs made a tremendous amount of money for Novo Nordisk and Eli Lilly. Other companies are developing new drugs to break into the market. This piece is a concise overview of companies creating and testing new drugs, how far along they are, and what Novo Nordisk and Eli Lilly are doing to compete with these emerging rivals.

See which GLP-1 drugs are currently approved (along with their cost)

Around 75% of prescriptions for GLP-1 drugs are used to treat diabetes, while the remainder is used for weight loss. This overview from GoodRX includes a list and overview of currently available options along with prices for each.

12% of adults were taking injectable GLP-1 for weight loss according to 2025 survey

Weight loss injectable use rose sharply between 2024 and fall 2025. The percentage of adults who reported taking this class of medicine specifically for weight loss increased to 12.4%, compared with 5.8% in February 2024 when Gallup first measured it.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

Genetic drug matching, called pharmacogenomics, can help avoid dangerous drug reactions

Certain gene variants can affect how quickly or slowly medications are broken down in the body, affecting drug effectiveness and the risk of drugs failing. Such testing is often not covered by insurance companies though research indicates if these tests were performed for more than six drugs across the US population, avoided ailments would likely climb into the hundreds of thousands. (Some users may encounter a paywall.)

Artificial sweeteners aren't very helpful for weight loss

Research published in 2014 from a randomized controlled study found that, on average, people only lost about two pounds if they switched to consuming artificial sweeteners instead of sugar. Some individuals using artificial sweeteners also have gained weight. Scientists theorize one potential explanation for this is that the sweeteners alter gut microbiomes in ways that reduce beneficial flora that would help promote digestion.

Overmedication has put type 2 diabetics at risk of low blood sugar

Type 2 diabetics in the US risk dying from low blood sugar, an epidemic traced to a decades-old, multi-million-dollar drug industry campaign encouraging an average blood sugar level below 7%. Contemporary research correlated such levels with reduced risk of eye, nerve, and kidney damage and increased hypoglycemia risk.

Estimates suggest inactivity contributes to 6% of deaths worldwide

The World Health Organization identifies physical inactivity as the fourth leading modifiable risk factor for global mortality, just behind hypertension, tobacco use, and high blood glucose. Latest estimates are that inactivity contributes to 6% of deaths and significantly increases the burden of chronic diseases like heart disease, diabetes, and cancer.

A financial analysis of space trash cleanup strategies identified long-term benefits

Despite significant initial costs, a NASA report found that removing small debris would provide savings from preventing mission-ending damage, which would offset expenses within a decade. Financial benefits would also come from using less fuel for maneuvers to avoid collisions with debris.

Bupropion is the only antidepressant approved for the preventive treatment of SAD

Clinical trials showed a 44% reduction in risk for recurrence of SAD for those who took the drug compared to a placebo group. Bupropion is a norepinephrine–dopamine reuptake inhibitor, which increases dopamine (other common antidepressants, known as selective serotonin reuptake inhibitors, sometimes can suppress dopamine, but not always).

How meal timing factors into health outcomes

The world is trending toward weight gain, a development that comes with a corresponding rise in risk for health conditions, including diabetes and heart disease. This article explores how meal timing has become a factor in nutrition and weight maintenance.

The typical US household could lower its household costs by 6.4% by using coupons

The study looked at coupons for food, household items, entertainment, and clothing, as well as other expected expenses. The grocery store category offered the largest amount of savings at around $316 annually.

DBS effectiveness in treating addiction remains uncertain amid inconsistent results

Critics argue that deep brain stimulation should be considered a last resort and not a scalable solution, given its high costs and trials limited to small samples. However, it has helped some patients manage severe opioid use disorder when conventional methods didn’t work.

As of 2025, extensive research studies do not support fears about seed oils

Across human trials, seed oils have not been shown to increase rates of disease or inflammation, with a study of over 800 Swedish men finding that higher seed oil diets were linked to living longer. Reviews of these trials found better health outcomes when saturated fats were replaced with seed oils.

Digital healthcare is helping emerging economies

In a world that is rapidly becoming more digitized, low and middle-income countries (LMICs) are trailblazing a path to cohesive digital healthcare ecosystems. This article from McKinsey & Company analyzes the different digital healthcare strategies...

Insurance denials prevent lifesaving care for patients with eating disorders

A patient living with anorexia nervosa was told by her insurance company that she wasn't sick enough to receive needed care. Her experience highlights how some insurers across Washington state focus on less useful metrics like body mass index and weight to gauge sickness instead of psychiatric symptoms that may better illustrate the urgency of receiving care.

Self-driving vehicles have the potential to cut ride costs by 40-50% and eliminate thousands of road deaths

Author Andrew Miller argues that widespread adoption of self-driving vehicles is no longer a distant promise, as Waymo expands into over 15 cities. However, he warns the technology's biggest remaining hurdles are political: liability, labor, and whether cities embrace or resist the shift.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Annual flu shots remain the best defense against influenza

Flu vaccination typically reduces the risk of medical visits by 30 to 60% and lowers hospitalization rates by around 40%. Between 2023 and 2024, in the US alone, vaccines prevented an estimated 120,000 hospitalizations and nearly 7,900 deaths.

How one autoimmune disease patient is questing for inflammation cures

This article's writer, who has Hashimoto's Disease and characteristic symptoms from her body attacking her thyroid—like exhaustion, hair loss, and brain fog—shares big take-aways from an anti-inflammatory retreat in Italy. The writer suggests that a holistic approach to eating, sleeping, and stress management, are the only sustainable ways to lower inflammation.

Health savings accounts are designed to alleviate upfront costs for high-deductible health plans

High-deductible insurance plans often have low monthly premiums, but require policyholders to meet a set spending threshold on medical expenses each year before the insurance kicks in. Health savings accounts give high-deductible plan holders a tax-free savings account to balance the high upfront costs that come with an HDHP.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

About 2,000 US babies are born annually without some portion of their limbs, potentially leading to a lifetime of pricey prosthetics.

See the evolution of Ebola vaccine and treatment development.

Calculate how much of your tax dollars go to each federal program based on your income, filing status, and number of children

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

Larger animals like giraffes, elephants, and blue whales have developed a unique defense against cancer, a phenomenon known as Peto's Paradox

Hedge funds, the private investment firms that trade a wide swath of financial assets, make money by imposing steep fees on investors and from the fund's investment performance.

An investigation suggests a Scottish island became awash in forever chemicals via seafoam and seaspray—raising questions about what that means for the safety of other coastal areas.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

US housing costs have risen by roughly 175% between 1991 and 2026—but a growing number of Gen Zers are becoming homeowners anyway. In 2025, 4% of homebuyers were Gen Z, up from 3% the year before.

Astronauts have repaired genetic damage in space using CRISPR—a molecular tool that can make precise changes to DNA and is used in single-celled organisms to attack invasive viruses.

To reduce wrinkles in clothing, research recommends gentle wash cycles with more water and tumble drying with smaller loads and longer times.

Stanford built a Google Maps for the Roman Empire, revealing how much it cost to travel in the ancient world

In 2026, Finland was named the world's happiest country for the ninth consecutive year based on its wealth, social safety network, and high life expectancy, among other factors.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

Up to a million Girl Scouts sell about 200 million cookie boxes every spring, generating $800 million, largely because refusing a child is frowned upon

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

Lesser-known phobias include turophobia, or the fear of cheese, and nomophobia, the fear of being without your cell phone.

The most expensive ad of all time was for Chanel No. 5 perfume and cost roughly $33M to produce in 2004—about $57M in today's dollars.

Memecoins are a type of cryptocurrency—a form of digital currency with a wide variety of uses—created around popular 'memes,' or viral internet jokes.

The Russia-Ukraine conflict is the largest ground war in Europe since World War II in terms of casualties, forces mobilized, and displacement of civilians.

A Yale student wrote a profound essay about the consulting industry's influence on elite college students that was published in a book of her writing after she died in a post-graduation car accident.

'Shogun,' a 1980s TV series, helped popularize sushi in the US by stimulating an American interest in Japanese culture.