Traumatic childhood experiences heighten the risk of developing schizophrenia

Schizophrenia symptoms, like psychosis, often first emerge among young adults

A combination of genetics, significant brain changes to the frontal cortex, and hormonal changes during young adulthood—late teens to early 30s—result in schizophrenic symptoms often showing up during this period. The stress of life changes at that age may also be a contributing factor.

People with schizophrenia typically die 9 years earlier than the general population

The syndrome, which affects roughly 1 in 233 adults, is often associated with other serious health issues, including cardiovascular, metabolic, and infectious diseases, which may contribute to early deaths. The side effects of long-term antipsychotic medications also may influence the mortality timing—weight gain, for example, is a common side effect of the drugs and can contribute to cardiovascular issues.

Some data links schizophrenia to older paternal age and birth complications

Yet both associations are not yet considered firm enough to definitively be causative. Schizophrenia is a multi-causal syndrome and a mixture of factors, including genetics, are widely believed to be behind its development.

80% of schizophrenia cases may be inherited

Some research suggests that anywhere between 60% and 80% of people with schizophrenia had genes that predisposed them to the syndrome. That high rate has fueled interest in further exploration of what environmental and lifestyle factors cause some people with that genetic risk to develop the disease when others with the same genetic risks do not.

People with schizophrenia have triple the risk of developing diabetes

It remains contentious if something inherent about the disease or antipsychotics' side effects (weight gain) are mostly to blame. Some newly diagnosed schizophrenia patients already have insulin resistance, raising questions about if patients' brains are getting enough energy from glucose, and if dietary changes—like a high-fat, low-carbohydrate, moderate-protein diet—may help alleviate symptoms.

Schizophrenia increases heat death risks in several complex ways

Evidence shows that people with schizophrenia have an inherently harder time regulating internal body temperatures. They may also struggle to find safe shelter during extreme heat, and their prescribed antipsychotic medications often have dehydrating effects, collectively elevating the risk of heat-related illness and death, as illustrated by this article that focuses on the final days of Stephan Goodwin's life in 2022. (Some users may encounter a paywall.)

People with schizophrenia are excluded from psychedelic research

Individuals with this mental health condition are routinely eliminated from any psychedelic research due to concerns about triggering or worsening psychosis. Yet there is little high-quality research in this area, raising questions about if further research into this question is warranted as interest grows in using psychedelics for therapeutic purposes.

Trauma is a primary risk factor for substance use disorder later in life

Studies indicate 75% of people with substance use disorder have experienced at least one traumatic experience in their life. These experiences alter brain function, leading to heightened stress and emotional pain. Substances offer temporary relief, but this often results in dependency.

Schizophrenia is challenging to diagnose and treat

The disorder is diagnosed by a clinician who observes behaviors and medical history and may run additional tests to rule out other explanations for symptoms including physical injury or other mental health disorders. But, ultimately, it's largely a diagnosis of exclusion—since there is no definitive test for the disease. Antipsychotic medications can help control its symptoms for some patients, but there is no cure for schizophrenia.

What happened to thousands of teens from the 1990s?

Scientists followed thousands of teenagers from 1997 into their 30s, cataloging their adverse experiences along the way via nearly three decades of interviews. Teens who grew up dealing with poverty, uninvolved parents, and other childhood stressors and traumas racked up an ACE score. These adverse childhood experiences have lifelong impacts on one's health, relationships, financial security, and "pretty much everything else," making them more likely to suffer premature death.

How trauma gets ‘under the skin’

A study examining the muscle function of older adults who have at least one adverse childhood experience (ACE) suggests that trauma digs itself into muscle cells. Participants who reported childhood trauma were found to have lower maximum levels of cellular energy than people who reported fewer or no ACEs. Such compromised mitochondrial function "doesn't bode well," as it relates to a variety of health and age-related outcomes.

The term schizophrenia was coined by Swiss psychiatrist Eugen Bleuler in 1908

He launched the word during a lecture at the German Psychiatric Association in Berlin. In his talk he focused on the splitting of psychic functioning as a defining feature of the disease and noted it wasn't associated with dementia or factors like early puberty onset.

Deinstitutionalization in the 20th century unintentionally led to the incarceration of schizophrenia patients

Activism to shut down problematic asylums in the mid-20th century led to the community release of many patients with severe mental illnesses, including schizophrenia, but without adequate support, this deinstitutionalization in the 1960s and 1970s led to a significant increase in patients with schizophrenia ending up in prisons and homeless shelters.

PTSD is a long-lasting mental disorder linked to past traumatic events

Posttraumatic stress disorder is a mental health condition arising from traumatic events with four key symptoms: intrusive memories, avoidance behavior, negative moods and thoughts, and changes in emotional and physical reactions.

The sibling of someone with autism has a 20% chance of developing ASD

The disorder is strongly linked with inheritance, and research suggests that if one child has ASD, there's a one in 5 chance the next child will develop autism, which is seven times more likely than the general population.

Repeated head injuries can lead to CTE and early dementia

Chronic traumatic encephalopathy is a progressive neurodegenerative disease caused by repeated trauma to the head. The condition has become a particular concern in sports like football and soccer, from youth to professional leagues, where repeated low-level concussive events are likely.

An intense fear must persist for at least six months to be diagnosed as a phobia

Research suggests that both environmental and genetic factors can contribute to the onset of these intense, irrational fears. Often, they can stem from an early traumatic experience, but not always.

What the research says about the link between lead pollution and crime

The lead-crime hypothesis links childhood lead exposure to impulsivity and aggression as an adult, traits typically associated with higher crime risk. A 2022 meta-analysis found that reducing lead may explain up to 28% of the US homicide decline, but not the broader crime drop.

SAD uniquely affects people with attention-deficit hyperactivity disorder

Those with ADHD—chronic issues with attention and executive function—are primed for SAD. Many are disproportionately evening chronotypes (more awake in the evening), have a delayed sleep phase, and have low sensitivity to light in the morning. This podcast explores the overlap between these two groups.

Consuming true crime media can increase stress and anxiety

Consuming true crime media can activate one's sympathetic nervous system, which controls the fight-or-flight response. Staying in this heightened state of vigilance can lead to stress-related illnesses, including hypertension, and mental conditions, including depression and anxiety. Additionally, people who actively consume crime news, whether they consider it to be entertainment or educational in nature, report being more fearful of crime, regardless of actual crime rates.

What happens when you can't trust your therapist?

When Marty Markowitz first stepped into his new psychiatrist's office, he triggered a three-decade spiral of abuse that robbed him of his autonomy, relationships, and wealth. Markowitz isn't the only client to lay allegations of abuse at the feet of Dr. Isaac “Ike” Herschkopf, an accomplished New York practitioner with a rolodex of celebrity clients who has since lost his license to practice.

About 12.5% of US adults experience a phobia in their lifetime, a diagnosis that hinges on the intense fear interfering with daily life and persisting for at least six months.

Exposure to ionizing radiation from nuclear accidents can damage DNA

The damage can increase the risks of cancer, cataracts, heart disease, and other illnesses based on exposure times and intensities. Contaminated food, water, air, or soil from near nuclear accidents can further prolong one's exposure.

Many of Spielberg's films were inspired by childhood experiences

Steven Spielberg was inspired to make “Saving Private Ryan” after seeing the toll war took on his father’s generation. Similarly, he felt called to direct “Schindler’s List” by the Holocaust survivors he met when he was only three years old.

The body's response to cardiac arrest has been linked to near-death experiences

Most people who report near‑death experiences experience events like out‑of‑body sensations, altered cognition, emotional and spiritual shifts, or even supernatural phenomena, particularly during cardiac arrest. Research suggests many such experiences may be linked to brain-generated sensory distortions that can be experimentally replicated, suggesting a physiological rather than mystical cause.

Secondary complications from measles in children range across the whole body

The most serious effects of a measles infection, particularly in young children, come from its attack on the immune system. This leaves the whole body vulnerable to follow-on diseases, with some of the most serious including respiratory conditions, encephalitis, and more.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

Salvador Dalí believed he was his own dead brother, who had died nine months before he was born

Firework or sparkler burns, even if they cover a relatively small area of skin, can significantly affect our range of motion.

Children are now three times more likely to say they want to be a YouTuber when they grow up than an astronaut, with some even attending 'YouTube camps' that teach kids how to create content for the platform.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Astronauts have repaired genetic damage in space using CRISPR—a molecular tool that can make precise changes to DNA and is used in single-celled organisms to attack invasive viruses.

Chaos theory—informally known as the butterfly effect—is the reason why weather forecasts are presented with probabilities rather than certainties.

Larger animals like giraffes, elephants, and blue whales have developed a unique defense against cancer, a phenomenon known as Peto's Paradox

Crows are believed to have intelligence on par with a seven-year-old child and demonstrate complex behaviors, from problem-solving with tools to recognizing human faces.

US housing costs have risen by roughly 175% between 1991 and 2026—but a growing number of Gen Zers are becoming homeowners anyway. In 2025, 4% of homebuyers were Gen Z, up from 3% the year before.

A Yale student wrote a profound essay about the consulting industry's influence on elite college students that was published in a book of her writing after she died in a post-graduation car accident.

An investigation suggests a Scottish island became awash in forever chemicals via seafoam and seaspray—raising questions about what that means for the safety of other coastal areas.

Use this calculator to find the dollar value of your mental load, from meal planning to coordinating after-school care for your children.

See 33 images that became central to huge scandals, including a young Charles and Camilla, Michael Jackson's baby on a hotel balcony, and Hugh Grant's mugshot.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

Dirty lightning is a thunderstorm created from friction between rising and falling flows of ash and smoke during volcanic eruptions.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

Discover the catastrophic consequences of a failure of the US electrical grid—something that is more likely than many Americans think.

Abraham Lincoln was almost assassinated weeks before his inauguration as he traveled from Illinois to DC through Baltimore in 1861; it took two independent claims for Lincoln to be convinced the threat was real

Objects can be 3D printed with light by projecting 2D computerized tomography (CT) scans onto rotating cylinders of resin, which solidify upon exposure.

The US first hosted the World Cup in 1994, a tournament that lives in soccer infamy for its poor planning and the murder of Colombian player Andres Escobar, who'd accidentally scored on his own net.