The earliest known cardiovascular system dates to 520 million years ago.

Blood has evolved many times over hundreds of millions of years, resulting in different blood colors and compositions—and there are even some organisms that don't need blood at all.

The earliest evidence of cancer was found in a 1.7-million-year-old fossil—discovered in the toe of an ancestor of modern-day humans.

Humans can have brain damage after four minutes without blood flow.

An interactive guide to the cardiovascular system

The cardiovascular or circulatory system moves blood throughout the body, ensuring cells have necessary nutrients and removing any waste. Click through this interactive 3D guide to explore the system as it crisscrosses the body via arteries, veins, and capillaries. This guide also includes similar breakdowns of the body and its other processes.

The strange endurance of consuming blood for health

Blood's importance to humanity is best summarized this way: without it, we die. This importance naturally begets assumptions about its medicinal properties, many of which appear accessible through drinking or eating the fluid connective tissue. This article details the history of blood drinking, from ancient Roman gladiators to modern-day sanguinarians.

Cell theory originated from microscopic observations of cork and dental plaque

In the mid-1600s, Robert Hooke identified compartment-like structures—which he called cells—in cork, and Anton van Leeuwenhoek discovered bacteria in samples of his dental scrapings. Almost 200 years later, Matthias Schleiden and Theodor Schwann showed that plants and animals, respectively, are composed of cells, proving that cells are the foundation of all living things.

The history of blood, as told by a hematologist

Since ancient times, blood has been seen as a semi-magical substance. Alchemists theorized it was a mixture of the four elements. Others proposed it was one of four bodily fluids whose balance dictated health. This 2019 essay by a hematologist reviews blood's reputation across cultures and centuries.

The first appearance of bioluminescence was at least 540 million years ago

After analyzing fossils, genetic data, and statistical methods, scientists believe octocorals were the first organisms to evolve light-producing abilities. As a result of independent evolution across at least 94 species, this phenomenon is connected to a diverse range of behaviors.

The economics of horseshoe crab blood

Horseshoe crabs are older than dinosaurs and have survived five mass extinctions that wiped most life from the planet. But it's only now that their future as a species is in danger. This blood, worth about $60,000 per gallon, is hyper-sensitized to certain bacteria that are fatal to humans. This 17-minute podcast dives into humanity's pursuit of horseshoe crab blood, a "somewhat magical" mixture heavily relied on by the pharmaceutical industry.

Medical recognition of strokes stretches back to ancient Greece

Every minute, 750 milliliters of blood flows to the brain, supplying 20% of the body’s oxygen. A sudden disruption—whether from a clot (ischemic stroke) or a bleed (hemorrhagic stroke)—can be life-threatening. From ancient Greek theories to modern CT and MRI scans, here’s how stroke science has evolved over time.

Fossils suggest tardigrades developed cryptobiosis more than 180 million years ago

As of 2024, three tardigrade fossils have been discovered, all preserved in amber. Analysis suggests different species of the organism existed over 500 million years ago, when marine heterotardigrades and freshwater terrestrial eutardigrades diverged. (Some readers may experience a paywall.)

How the heart achieves its first beat

Scientists observed zebrafish embryos as they grew and isolated the several-second-long initial heartbeats to better understand this crucial moment in every heart's life. The zebrafish's heart starts beating 20 hours into their existence. Each heart cell activates electrically at random, without rhythm. As these cells mature, they become more sensitive to electrical charges; as they all fire, a rhythm is established and a pulse is born.

Evidence suggests the first cells on Earth were bacteria

About 4 billion years ago, these single-celled organisms harvested carbon dioxide and sunlight to produce their own food and oxygen, setting the stage for the evolution of oxygen-breathing life forms. Archaeabacteria, which thrive on inorganic molecules in extreme habitats on Earth today, were also among the earliest organisms.

Human anatomy provides evidence for evolution

Throughout history, scientists have used anatomy to support the Theory of Evolution in three main ways. Homologous structures, or similar physical features in organisms that serve different functions, can help scientists understand common ancestors....

Genetic analysis suggests Anopheles mosquitoes fed on humans some 1.8 million years ago.

When did humans start kissing romantically?

This article explores the ancient roots of romantic kissing. Current archaeological evidence dates sexual and romantic lip kissing to about 2,500 BCE. A Mesopotamian clay tablet from the time shares a tale of two deities locking lips. There's also...

When was the first blood transfusion?

In the 1600s, an English doctor transferred the blood from one dog to another via quills. The procedure ended when one of the dogs died. This article details the early days of blood transfusions, which turned toward humans shortly after the 1666 dog experiment and involved putting the blood of a sheep into a human recipient (who reportedly survived the encounter).

The Antikythera mechanism: The oldest-known analog computer

A device now considered the world's oldest computer was pulled from a shipwreck more than 120 years ago. Known as the "Antikythera Mechanism," it is now believed to have allowed precise tracking of astronomical positions, and its sophistication overturned understanding of Ancient Greek capabilities.

Ancient humans and other early hominins were closer than you might think

Evidence that human ancestors and other early hominins coexisted continues to accumulate, raising the question of just how close these ancient people truly were. This article details how evidence is changing the theory that early hominins like...

Explore the heart in this interactive 3D model

The heart is the fleshy muscle at the heart (pun intended) of the circulatory system. The heart is segmented into four chambers: two for intake (the right side) and two for output (the left side). Controlled via the autonomic nervous system, also known as the involuntary nervous system, the heart typically beats 60 to 100 times per minute, sending nutrient- and oxygen-rich blood throughout the body.

What is cardiovascular disease?

Cardiovascular diseases are a range of related health conditions that develop in the heart and blood vessels. This article and related infographics detail cardiovascular disease types and treatments.

The oldest DNA recovered so far is 2 million years old

The oldest DNA recovered so far is about 2 million years old and has given scientists an unadulterated peek into ancient history. This nine-minute video explores the findings and implications of the DNA, which was pulled from frozen soil in...

Before discovering cells, life was believed to emerge suddenly from inorganic matter

Popularized by Aristotle in the 4th century BCE, spontaneous generation was used to explain phenomena like mice appearing in seemingly sealed grain storage. The invention of the compound microscope in the late 16th century led to the identification of cells as the basic unit of life, but it was not until 1855 that their origin from preexisting cells was established.

Prehistoric hunter-gatherers performed amputations and appear to have provided post-op care, according to analysis of a recent fossil discovery from almost 31,000 years ago.

Pig heart valves have been placed in humans since 1965

The first successful use of a pig heart valve in a human was reported in 1965. This 2015 video details why humans have been able to use pig animal valves for so long with good results and how that differs from what's needed for whole organ transplants.

Human anatomy 101: the body's systems

Human life is made possible by the body's ten major systems, which maintain homeostasis by responding to incoming sensory and biochemical input. Each system must work independently and collaboratively for the body to maintain health and respond appropriately to its internal and external environments. The bones of the skeletal system, for example, give the body its shape and protect organs while also facilitating movement with the muscular system.

Searching for the history of cancer in ancient human bones

Nestled under archaeology lies bioarchaeology, which involves the study of bones, human or animal. This subfield recently birthed another field of study: paleo-oncology. Paleo-oncology looks for cancer and related biomarkers in bioarchaeological remains. This TED article explains how this nascent multidisciplinary field challenges the idea that cancer is modern.

The tongue evolved in animals roughly 350 million years ago

Creatures like fish rely on suction to consume food, flexing their gills to create water currents that vacuum up their meals. The evolution of the tongue enabled vertebrates to completely cut ties with the sea, moving onto land where they could sample new foods and ways to eat them.

Visualize the 5,000-year history of consumer credit in one infographic

Consumer loans for agriculture were likely first used around 3500 BCE, but modern consumer credit took many more centuries to be established. England's credit reporting system, for instance, dates back to the early 1800s when a group of English tailors began swapping information about customers who failed to settle their debts.

Billion-year-old Arctic fossils suggest Earth had fungi far earlier than previously thought

Named Ourasphaira giraldae, this new species of fungus, reported in 2019, was found in the Grassy Bay Formation in the Canadian Arctic. It pushed the fossil record of fungi back by about half a billion years since the oldest previously recognized fungi fossils came from the Rhynie chert, a Scottish site that dates back roughly 400 million years. This fungal discovery also suggests that fungi may have occurred on land much earlier than plants, raising questions about what ancient fungi used for nourishment.

What did the earliest swords look like?

That depends on where you draw the line between daggers and swords. According to current evidence, the first swords appeared 5,000 years ago in what's now Turkey. Unfortunately, evidence of the earliest swords is colored by survivorship bias; It's...

Genetic analysis indicates that every organism on Earth evolved from a single cell

LUCA—the last universal common ancestor—lived about 4.2 billion years ago and likely obtained energy through the conversion of carbon dioxide and hydrogen gas consumed from atmospheric gases at the ocean's surface or hydrothermal vents—openings on the seafloor where fluid warmed and enriched with minerals by Earth's interior is expelled.

Here's how early humans lived

Explore the evidence of early human behavior—from ancient footprints to stone tools and the earliest symbols and art – along with similarities and differences in the behavior of other primate species.

A brief history of human blood groups

The blood group that determines whether you have type A, B, AB, or O blood was discovered near the turn of the 20th century. This short academic article dives into three main theories about the evolution and emergence of blood groups, the exact nature of which remains unclear.

Explore the microscopic composition of blood.

What a tiny marine worm can tell us about our brains

Meet the amphioxus, a small eel-like animal that has a lot to teach us about brain evolution. The genetic roots of our brains can be seen in these unusual creatures. This three-minute educational video focuses on the evolutionary history of the human brain through these odd little critters with a 500-million-year-old history.

Historians estimate that only 1% of shipwrecks have been discovered.

A cave painting might be the oldest illustrated story ever recorded

A nearly 44,000-year-old cave painting may be the oldest story ever recorded, offering viewers a tale of human-like creatures on a hunt. This article details the discovery of the cave and its archaeological implications.