The history of blood, as told by a hematologist

The strange endurance of consuming blood for health

Blood's importance to humanity is best summarized this way: without it, we die. This importance naturally begets assumptions about its medicinal properties, many of which appear accessible through drinking or eating the fluid connective tissue. This article details the history of blood drinking, from ancient Roman gladiators to modern-day sanguinarians.

Seven things you might not know about blood

The red stuff currently pumping throughout your body is a type of connective tissue that is both a solid and a liquid. The liquid portion—plasma—acts as a carrier for the solid portion, which includes blood cells and their biological brethren. Your body is constantly refreshing its supply of blood, creating new cells to replace those that have expired or died. This article overviews some lesser-known facts about blood (and why it's not always red).

A brief history of human blood groups

The blood group that determines whether you have type A, B, AB, or O blood was discovered near the turn of the 20th century. This short academic article dives into three main theories about the evolution and emergence of blood groups, the exact nature of which remains unclear.

Blood has evolved many times over hundreds of millions of years, resulting in different blood colors and compositions—and there are even some organisms that don't need blood at all.

Without the option of modern blood transfusions, some doctors in the mid-1800s tried to help save cholera patients by injecting them with cow's milk, hoping it would boost their nutrition and hydration.

Explore the microscopic composition of blood.

Each second, the human body produces 2 million to 3 million new red blood cells.

When was the first blood transfusion?

In the 1600s, an English doctor transferred the blood from one dog to another via quills. The procedure ended when one of the dogs died. This article details the early days of blood transfusions, which turned toward humans shortly after the 1666 dog experiment and involved putting the blood of a sheep into a human recipient (who reportedly survived the encounter).

An interactive explanation of blood transfusion

The antigens and Rh factors of blood cells (which determines your blood type) must be compatible with your immune system—which is why blood transfusions between patients must have matching types. In a mismatch, the immune system will attack and destroy donor blood cells, triggering a potentially fatal reaction.

A list of five scientific theories that were accepted and later disproved

Humoral theory held that everyone's personality derived from different combinations of four bodily fluids: blood, phlegm, yellow bile, and black bile. The phlogiston theory stated that all combustible materials possessed a fire element—phlogiston—that was released and absorbed by the air during burning. When the air became saturated with phlogiston, the fire would go out.

Explore this blood type interactive to learn more about how the 8 most common blood types are defined.

Why don't we synthesize blood?

We're trying. Scientists are currently working on creating viable synthetic blood, an alternative to the presently relied-upon donations that manage to fall short of demand. More than half of the world's nations struggle to meet their population's need for blood. This article details current and historical efforts to develop synthetic blood, a venture that started more than 400 years ago.

What does blood do?

Blood's primary purpose is to ferry oxygen and nutrients to cells in need while collecting cell waste and byproducts for removal. It also enables the body's repair and immune systems to traverse our internal landscape to address cell damage or external invaders, such as viruses and parasites. Zooming out from the exact roles of blood's various cells, the fluid connective tissue also assists with maintaining homeostasis via temperature regulation and pH balance.

The economics of horseshoe crab blood

Horseshoe crabs are older than dinosaurs and have survived five mass extinctions that wiped most life from the planet. But it's only now that their future as a species is in danger. This blood, worth about $60,000 per gallon, is hyper-sensitized to certain bacteria that are fatal to humans. This 17-minute podcast dives into humanity's pursuit of horseshoe crab blood, a "somewhat magical" mixture heavily relied on by the pharmaceutical industry.

Medical recognition of strokes stretches back to ancient Greece

Every minute, 750 milliliters of blood flows to the brain, supplying 20% of the body’s oxygen. A sudden disruption—whether from a clot (ischemic stroke) or a bleed (hemorrhagic stroke)—can be life-threatening. From ancient Greek theories to modern CT and MRI scans, here’s how stroke science has evolved over time.

One doctor argued vampires were based on a real disease

At a conference in 1985, Canadian biochemist David H. Dolphin posited that stories of vampires and werewolves had a real-world origin. He argued that porphyria could have caused sufferers to seek out blood, as well as experience light sensitivity and an aversion to garlic. More than one article in the 1990s discredited this take.

New blood cells are created by hematopoietic stem cells

Blood is made up of several cells with various functions and short lifespans, so the body must have a constant supply of replacements. These replacements are created by hematopoietic stem cells, rare cells that live in bone marrow and can regenerate themselves and blood cells.

How did segregation in the US affect blood donations?

When the US established its first nationwide network of blood banks in 1941 with the hopes of restoring the dwindling reserves of military members, it was quick to emphasize blood donated by Black Americans wouldn't coat the veins of white servicemen. Historians say this policy was meant to appease white Southerners who believed Black blood was inferior to their own.This policy was leaked to the press that same year.

The earliest known cardiovascular system dates to 520 million years ago.

The proteins and sugars on the surface of your blood cells determine your blood type.

Exploring the link between history, art, and anatomy

Throughout centuries, art has played a vital role in sharing—and furthering—scientific understanding. This largely began in 1543 when physician Andreas Vesalius worked with an artist and engraver to transform learnings from his dissections into...

Blood color differs across the animal kingdom, with some animals producing blood that appears green (a group of lizards in New Guinea) or blue (horseshoe crabs).

Humans can have brain damage after four minutes without blood flow.

'Golden blood' is the rarest blood type in the world—fewer than 50 people are known to have it.

The history of ghosts, explained

The afterlife has perplexed humans across different periods, cultures, and belief systems. The desire to understand what comes next is often explored through the telling of ghost stories. Learn more about the spooky phenomena here.

A 'buffy coat' is the roughly 1% of blood that includes multiple types of white blood cells and plays a key role in fighting off disease.

The plasma-selling industry is expected to reach $50B by the end of the decade

About 55% of your blood volume is plasma, the liquid part of blood created from water, proteins, minerals, and salts absorbed through the digestive tract. This 49-minute podcast episode explores the business of plasma—part of a global industry expected to be worth $50B by 2029.

The history of chemistry up to World War I, from alchemists seeking gold to probing atomic structure

Those involved in the predecessor of the modern scientific discipline engaged in experimentation to develop recipes that would transform ordinary matter into gold and to create medicines, cosmetics, dyes, and alloys. Over the course of centuries, scientists identified unique elements, organized them based on their properties in the periodic table, and eventually developed the technology to discover the internal structure of atoms.

The Hungarian countess rumored to have bathed in blood

According to legend, Hungarian countess Elizabeth Báthory killed up to 600 women to bathe in their blood and preserve her youth. Such allegations have been challenged since the 1980s when Slovakian archivist Josef Kocis published a book detailing new aspects of Báthory's life and included possible evidence of a conspiracy meant to undermine her power as part of Transylvania's ruling dynasty.

Blood clotting is critical to maintaining life, but dysfunctional clots can be fatal.

A primer on human tears

Tears are one of the many behaviors that differentiate humans from the rest of the animal kingdom. Why do we cry? This comprehensive and well-written essay explores various theories about why we cry, observes tear fluid as the only one that does not elicit disgust, and attempts to interpret the meaning of tears in different circumstances. See what all the fuss is about here.

The history of germ theory, which explains that illnesses are caused by microorganisms

For centuries, the miasma theory, which held that illnesses were caused by clouds of "bad air" produced by decaying organic matter, was the accepted explanation for the spread of disease. The development of microscopes and the subsequent technology to isolate bacteria and test disease spread in mice greatly contributed to contagionists overturning miasmatists.

Bone marrow generates roughly 500 billion new blood cells each day.

The word 'vampire' appeared in the English-speaking world in the 1730s

However, earlier mentions of creatures with similar characteristics existed throughout Medieval Europe. For example, people often spoke of revenants—restless dead creatures who tormented the living. Historians believe these stories grew in popularity in part because of influence from the Catholic Church, which was emphasizing the idea of purgatory. These older revenant stories eventually influenced modern vampire folklore.

The inner life of a cell

White blood cells are responsible for protecting the human body from infection. This video uses biophysical data from Harvard researchers to accurately demonstrate what goes on inside one white blood cell as it works within the immune system.

Tattoos, explained

Tattoos last because immune cells trap ink beneath the skin—but there's more to the story. This overview looks at how ancient cultures used tattoos for status, spirituality and punishment; how technology like the electric tattoo machine transformed the art form, and where innovations like smart tattoos could take it next.

Explore the abundance of different types of cells in the human body

Lacking a nucleus and other organelles to maximize space for oxygen-carrying hemoglobin and enhance maneuverability through narrow capillaries, there are about four times as many red blood cells and platelets as all other cell types in the body combined. However, about half of the body's cell biomass consists of skeletal myocytes, or muscle fibers.