The history of chemistry up to World War I, from alchemists seeking gold to probing atomic structure

The history of the periodic table and how it hinted at atoms possessing internal structure

In 1869, more than two decades before the discovery of electrons, Russian chemist Dmitrii Mendeleev organized known elements by atomic weight and chemical properties using index cards. His organization revealed previously undiscovered elements and identified patterns in the reactivity of elements, which would later be linked to each element's outermost electron shell. (Some readers may experience a paywall.)

The history of molecular gastronomy, from thickening yolks with alcohol to making art with food

Before understanding why they worked, humans used scientific principles, including designing solutions and analyzing outcomes, to develop preservation methods like curing meat and fermenting vegetables. By the 20th century, the application of industrialized food preparation to smaller kitchens set the stage for the subdiscipline of food science.

Scientists turn alchemists, transforming transform lead into gold

Fulfilling alchemists' dreams, scientists at the Large Hadron Collider (LHC) transmute lead into gold. While the 86 billion gold nuclei produced were short-lived, the experiment sheds light on how electromagnetic fields can play a critical role in nuclear transmutation.

Create anything from the elements in Little Alchemy 2

Various ancient cultures believed the most abundant substances in the world were its basic elements: earth, water, air, and fire. We may know better now, but you can make almost anything from those four things. Little Alchemy 2 is a fun, cartoonish game that allows users to create more complex items from simple substances.

The history of metallurgy: an interactive timeline

Humans have long been shaping metals into useful tools and aesthetic accessories. By 8,700 BCE, humans already had mastered four types of casting copper. Within a few thousand years, people were combining metals to make the alloy bronze and had...

The simple grandeur of atomic theory

Is the universe made up of a continuous substance, or a finite amount of tiny, indivisible atoms? The atomic hypothesis, largely vindicated in the 20th century, was forgotten for nearly 2,000 years after first being formulated by the Greek philosopher Democritus. Learn more about the theory and its implications for science and human life with this reflective essay.

Exploring World War I technology on the battlefield

Industrialization brought massive changes to warfare during the Great War. Newly-invented killing machines begat novel defense mechanisms, which, in turn spurred the development of even deadlier technologies. Nearly every aspect of what we would consider modern warfare debuted on World War I battlefields. Starting with soldiers on horseback carrying lances and ending in poison gas, machine guns, and aerial battles, this gallery shows the first tools of modern warfare.

The pharmaceutical industry evolved, in part, from the discovery of synthetic dyes

In 1856, a chemist accidentally discovered mauveine, the world’s first synthetic dye, while trying to make quinine to treat malaria. The synthetic dyes that followed helped reveal germs under microscopes, paving the way for modern imaging techniques and breakthrough treatments, such as antibiotics.

Building the first atomic bomb required unprecedented coordination

Creating the first atomic bombs demanded breakthroughs in physics, engineering, and logistics—uniting elite scientists with tens of thousands of workers across the US. This in-depth history explains how the Manhattan Project overcame those challenges.

Gold's electrical conductivity, reflectivity, and catalytic capabilities make it scientifically valuable

Although gold has been prized since its use in 40,000 BCE for decorative purposes, it has more recently served as a replacement for mercury in the production of PVC plastic. Because gold does not react with air or corrode, it has remained in circulation and reused in electronics and biomaterials.

When did people start making and using glass?

This article details the search for the ancient origins of glass, a now-common item through which archaeologists can spot histories of trade and innovation. Bronze Age glass was made from crushed quartz instead of sand, and artisans could color glass with materials such as cobalt. These trace metallic add-ons have given scientists a vital clue into the origins of glass, which is currently debated as either Egypt or the Near East.

The origin of atmospheric science while testing nuclear weapons during the Cold War

The arms race between the US and the Soviet Union saw both countries stockpiling and detonating hundreds of bombs underground, underwater, and in the atmosphere. To better predict where nuclear fallout would travel after these tests, scientists developed models that would serve as a foundation for those used to explain atmospheric circulation.

Radioactive elements can generate electricity, sterilize products, and date artifacts

Since their discovery in the 1890s, these substances have been incorporated throughout our daily lives, from treating food packaging and improving microbial safety to their presence in smoke detectors and gauges for ice cream aeration.

Learn more about the history of fireworks, which date back to an accidental invention during an alchemist's quest for information about immortality

When bamboo in China was tossed into fire in 200 BCE, there was an explosion. About 1000 years later, around 800 CE, an alchemist searching for secrets to immortality mixed sulfur, charcoal, and potassium nitrate together, leading to gunpowder. That mixture was then packed into bamboo or paper tubes, leading to fireworks.

The history of soap and how it forms bathtub scum and white spots in old oil paintings

Soap has been produced since at least 2,200 BCE via a chemical reaction between fats or oils and a base. This creates salts that act as molecular bridges, helping water lift dirt and grease from surfaces. The same chemistry produces scum when metals in hard water bind to soap molecules, as well as white spots in paintings when metal ions in pigments react with fatty acids in the oil binder.

Ernest Rutherford's gold foil and nitrogen experiments revealed nuclear structure

Observing high-angle deflections when alpha particles were fired at gold foil led to an atomic model with a dense, positively charged nucleus. Firing those particles at nitrogen resulted in the emission of hydrogen nuclei—protons—leading to the discovery of the subatomic particle.

View the most expensive materials on Earth, led by those forged in particle accelerators

Californium-252—valued at $27.8M per gram, as of 2025—is far rarer and more valuable than gold, silver, or diamonds due to production and transportation costs. The most expensive substance ever found or created is antimatter, costing approximately $62.5T per gram.

Oxford scientists turned Fleming’s mold discovery into medicine

In 1939, a team at Oxford—including Howard Florey, Ernst Chain, and Norman Heatley—revived Fleming’s forgotten discovery. Using makeshift equipment like bedpans and milk churns, they purified enough penicillin to prove it could treat deadly infections.

How a government chemist founded the FDA—by poisoning people

The Poison Squad tells the story of government chemist Dr. Harvey Wiley who, determined to banish these dangerous substances from dinner tables, took on the powerful food manufacturers and their allies.

A list of five scientific theories that were accepted and later disproved

Humoral theory held that everyone's personality derived from different combinations of four bodily fluids: blood, phlegm, yellow bile, and black bile. The phlogiston theory stated that all combustible materials possessed a fire element—phlogiston—that was released and absorbed by the air during burning. When the air became saturated with phlogiston, the fire would go out.

The origin of the National Science Foundation and why World War II led to its founding

Before World War II, research institutions were funded by endowments or private companies whose priorities stifled the curiosity-driven science that fueled significant breakthroughs and innovation. The NSF was established in 1950 to promote independent scientific progress through basic research, which is focused on knowledge acquisition rather than commercial applications, conducted at national colleges and universities.

The history of blood, as told by a hematologist

Since ancient times, blood has been seen as a semi-magical substance. Alchemists theorized it was a mixture of the four elements. Others proposed it was one of four bodily fluids whose balance dictated health. This 2019 essay by a hematologist reviews blood's reputation across cultures and centuries.

World War I brought attention to US reliance on mineral imports

Domestic stockpiles were inadequate for the extended trade disruptions caused by the four-year war. In response, the US Geological Survey increased its geological mapping to help search for important metals alongside new oil fields for fuel.

How scientists determine elemental composition based on the light emitted by cooling atoms

When electrons within an atom drop to a lower energy level closer to the nucleus, they lose energy and produce light with energy equal to the difference between the two energy levels. Because these levels and the corresponding emitted light are unique to each element, the light serves as a unique signature that can be compared to known lab samples for identification.

English chemist Rosalind Franklin (1920 - 1958) on the importance of science

"Science and everyday life cannot and should not be separated. Science, for me, gives a partial explanation of life."

Build atoms to learn about atomic number, mass number, and charge notations

In this simulation, users can add protons, neutrons, and electrons to create atoms, view their stability and atomic configurations, and identify how the amounts of these subatomic particles are detailed around the abbreviation for the resulting element using AZE notation.

Before discovering cells, life was believed to emerge suddenly from inorganic matter

Popularized by Aristotle in the 4th century BCE, spontaneous generation was used to explain phenomena like mice appearing in seemingly sealed grain storage. The invention of the compound microscope in the late 16th century led to the identification of cells as the basic unit of life, but it was not until 1855 that their origin from preexisting cells was established.

Why it's so hard to end the use of toxic lead

Lead was one of the earliest metals mined on Earth, desired for its soft malleability and used in cosmetics, pipework, gasoline, and more. But even though researchers demonstrated its toxicity in the 20th century, much of the world still uses it.

Two-thirds of antibiotic classes were made between the 1940s and 1960s

The vast majority of bacterial treatments were developed during the "Golden Age of Antibiotics," an era of rapid innovation and drug discovery that led to the reduction of millions of deaths worldwide. Since 1970, only eight new antibiotic classes have been discovered.

The cosmic dark ages: before stars existed

The theories behind the Big Bang suggest the process of the universe beginning to the creation of stable, neutral atoms took just half a million years. But the transition from such atoms to star formation took surprisingly much longer, upwards of 100 million years. Why? This deep dive explores the science behind the unique physical composition of the so-called cosmic dark ages.

Exploring carbon compound pore structures contributed to improved gas mask filtration

During World War II, the British Coal Utilisation Research Association sought to improve the efficiency of coal as an energy source and studied the effectiveness of charcoal filters to keep soldiers safe. Rosalind Franklin's research there formed the basis of her PhD and led to five scientific papers.

X-rays earned the very first Nobel Prize in physics for revealing hidden worlds

In 1895, Wilhelm Conrad Röntgen discovered X-rays, which could pass through solid objects and make unseen structures visible. Today’s X-ray tools continue to advance science and medicine, including capturing real-time images of proteins.

How chemical bonds between atoms form molecules and large geometric structures

In ionic bonding, one atom transfers at least one electron to another atom, forming two atoms of opposite charge. These atoms attract one another and can stack up in a 3D grid called a lattice. Covalent bonding, where electrons are instead shared, can produce enormous molecules, such as the two found in human chromosome 13, which each contain 37 billion atoms.

View historical records of solar observations and discoveries, from telescopes in the early 1600s revealing sunspots to NASA's Parker Solar Probe photographing the sun from within its outer corona in 2025.

The origins of our fascination with time travel

Humans have been captivated by the prospect of leaping forward and backward in time for thousands of years. Georgia Institute of Technology Science Fiction Studies Professor Lisa Yaszek recounts how the concept has been utilized by storytellers from 400 BCE to modern-day to explore our relationship with the supernatural, technology, and the past. In a way, this historical recounting is a journey through time.

The ancient Romans invented the first known artificial sweetener—it involved lead

The product was known as "sugar of lead." It was made by boiling wine in lead pots, concentrating the grapes' natural sugars and adding sweetness from the lead that leached into the grapes. The substance was used until roughly the 1880s for medicinal purposes and also to sweeten wine. (Some users may encounter a paywall.)

The chemistry of ancient tacos

This 16-minute podcast explores the chemistry of Mesoamerica's corn tortillas, which involve a 3,500-year-old chemical process called nixtamalization that releases vitamins, including niacin, one of the essential B vitamins. This process also makes the tortillas softer and more delicious. Corn tortillas were a staple in Mesoamerica, and the archaeologist interviewed in this podcast argues cultures like the Aztecs and Maya wouldn't have thrived without nixtamalization.

LSD (better known as acid) was created in 1938 by Swiss chemist Dr. Albert Hofmann

Lysergic acid diethylamide, better known as LSD or acid, was first developed synthetically in 1938 by Swiss chemist Dr. Albert Hofmann. It's since become a linchpin for an entire aesthetic, fueled a counterculture movement, and is being studied for potential therapeutic uses.

Alfred Nobel invented dynamite and later used his fortune to fund peace prizes

Nobel stabilized dangerous nitroglycerin to create dynamite, revolutionizing construction and mining in the 19th century. Despite his success with explosives, he was deeply disturbed by their destructive potential and redirected his legacy toward rewarding human progress.

Scientists used mass spectrometry to determine the materials in a 1690 painting

Previously used to map the distribution of molecules on biological tissue samples, researchers combined the technique with machine learning to uncover six layers of pigments, binders, and a thin gold leaf layer within *The Marriage of the Virgin*, from a collection in the Metropolitan Museum of Art. The technique may help identify and track artists' material use to learn about pieces of unknown provenance. (Some readers may experience a paywall.)

Robert Koch won the Nobel for his tuberculosis work, but he also pioneered cholera research

Koch was one of the first scientists to isolate the bacterium that causes cholera while investigating an outbreak in Egypt in 1883. He went on to advise about rules to control cholera outbreaks, which formed the basis of the disease control approaches and water hygiene techniques still used today.

A look at the giants of quantum mechanics

German physicist Max Planck publishes his groundbreaking study of the effect of radiation on a “blackbody” substance, and the quantum theory of modern physics

Wilhelm Wundt's place in the history of psychology

While ancient philosophers considered the central problems of psychology, it was Wilhelm Wundt who first called himself one. Here's a quick video overview of his contribution.

A collective effort from multiple scientists and inventors led to the light bulb

While Thomas Edison's thin carbon filament design made light bulbs commercially viable, prior contributions, such as Joseph Swan's development of the first successful incandescent filament electric lamp, made its eventual invention possible.

How scientists earned themselves a Nobel Prize by discovering what destroyed ozone

In 1974, chemists Mario Molina and F. Sherwood Rowland showed that chlorofluorocarbons—then used as aerosol propellants, refrigerants, and industrial solvents—rise into the stratosphere and, upon being struck by ultraviolet radiation, release chlorine atoms, which break apart ozone molecules. Their work earned them the Nobel Prize in chemistry in 1995.

The birth of the multivitamin

In 1912, biochemist Kazimierz Funk, often anglicized as Casimir Funk, proposed that there existed an essential nutrient in food that could prevent deficiency diseases, such as scurvy or rickets. This article explores the origin of the multivitamin, an invention that has garnished...

A short history of space exploration

Let us to take you back through the timeline of space exploration and its rich, fascinating history, starting in 1946, with a rudimentary German military rocket.

The theory of chemtrails originated from misinterpreting a US Air Force paper

The document proposed a future weather modification system to achieve military objectives, but clarified that such a system "does not reflect current military policy, practice, or capability." Past testing of biological and chemical weapons has accelerated conspiracies about streaks of condensation trailing aircraft to be harmful chemical agents.

Chromium contaminants in a ruby crystal gave the world's first laser its red color

The red light originates from a long-lasting excited electron state in the element's atomic structure. The brittle gray metal has historically been used in pigment production, the manufacturing of rust-resistant stainless steel, and the creation of durable coatings with long-lasting shine for metals, wood, and leather.

The 2019 Nobel Prize in Chemistry was awarded for lithium-ion battery development

Stanley Whittingham developed the first functional lithium battery in the early 1970s, while John Goodenough doubled its electrical potential in 1980 by replacing the cathode, thereby enhancing its commercial viability. Five years later, Akira Yoshino developed an anode using carbon material, reducing the risk of flammability.