Fast, cheap, and deadly: How fentanyl replaced heroin and hooked America

Why are drug dealers putting fentanyl in everything?

A few grains of fentanyl, a synthetic opioid far more potent than heroin or morphine, are enough to kill a typical adult human. It's made its way into other, less lethal street drugs, where it may be used to increase the highs experienced by unknowing users, increasing their likelihood of addiction and overdose.

From prescriptions to street drugs: Opioids trajectory across America

Exclusive data obtained by The Washington Post from the Centers for Disease Control and Prevention shows how individual counties moved through three waves of the opioid crisis, each wave paving the way for the next. Between 2011 and 2017, the drug responsible for the majority of overdose deaths shifted from prescription pills to heroin to fentanyl. Together, oxycodone, hydrocodone, heroin, and fentanyl have been major drivers in declining life expectancy in the US.

Fentanyl can be up to 100 times more potent than morphine

A synthetic opioid, fentanyl is highly addictive and incredibly fast-acting—a fatal dose is equal to a few grains of table salt. Once it enters the body, fentanyl floods naturally occurring opioid receptors, which can cause the body to shut down its breathing reflex, leading to a fatal overdose.

Fentanyl is better at crossing the blood-brain barrier than other opioids

Among opioids, fentanyl is uniquely adept at crossing the blood-brain barrier—the brain's security fence against harmful substances. This enables a lightning-fast high. It ends just as quickly, sometimes within minutes (where a heroin high lasts hours), and still results in the same withdrawal symptoms.

Opioids are a class of drugs including fentanyl, heroin, oxycodone, and more

Since the dawn of pain, living things have sought ways to mitigate this evolutionary warning signal. One of nature's most effective painkillers is opium, a highly addictive, milky latex extracted from poppy plants. This forms the basis of one of the most prescribed classes of modern drugs.

See how DOJ prosecutors took down a pharmaceutical company's executives over the opioid crisis

This FRONTLINE documentary follows federal prosecutors as they used anti-racketeering laws to convict executives at Insys Therapeutics, a pharmaceutical company that bribed doctors to overprescribe a fentanyl painkiller.

The US war on drugs, explained

The United States has been fighting a global war on drugs for decades. By making drugs more expensive and less available, the US has sought to reduce drug use and inhibit the international drug trade. However, increasing prison populations,...

How El Chapo’s sons built a fentanyl empire poisoning America

Los Chapitos are the four sons of El Chapo, the infamous leader of Mexico’s Sinaloa Cartel. Once dismissed as “narco brats,” the Chapitos are now key figures in the Sinaloa Cartel, accused by the US Drug Enforcement Administration (DEA) of pioneering the “manufacture and trafficking of the deadliest drug [the USA] has ever faced.” Read Reuters’ special report to chronicle the rapid rise of the Sinaloa Cartel’s new generation.

​Why heroin became associated with the grunge world

The drug was popular with several Seattle acts in the early 1990s, with artists like Hole's Courtney Love even publicizing her use in a magazine profile. A 1992 New York Times story on Seattle said the city's principal drugs were "espresso, beer, and heroin."

An interactive investigation into drugs and migration in San Francisco

This interactive article investigates the connection between the boom in US migration from Honduras and drug dealing in San Francisco. A high concentration of Hondurans are fleeing Siria Valley, where poverty and national murder rates run high...

How the Myanmar coup fueled a rise in illegal drugs

According to the UN, Myanmar remains the world’s second-largest producer of heroin. Inside Myanmar, almost all the drugs come from one place: Shan state in the Golden Triangle region, south of China, where Myanmar meets Thailand and Laos. The...

Prince died in 2016 from an accidental fentanyl overdose

The music legend was found dead in an elevator at his Paisley Park residence on April 21, 2016. The cause of death was an accidental overdose from taking pills he believed to be Vicodin, but were actually counterfeit pills laced with fentanyl. Law enforcement was unable to determine who provided him with those pills. He was 57 at the time of his death.

The federal agents who followed Billie Holiday

After the success of "Strange Fruit," the Federal Bureau of Narcotics began surveilling Holiday on suspicion that she was using heroin. Jimmy Fletcher, an agent tasked with following her to clubs and parties, later said that they became quite close. "She was the type who would make anyone sympathetic because she was the loving type," he was reported as saying.

The story of Marie Nyswander, the woman who co-discovered methadone maintenance

Methadone, an opioid with distinct effects from heroin, revolutionized heroin addiction in the 1960s. Marie Nyswander was a psychoanalyst who helped discover the treatment process which is still in use today. Here's a podcast episode examining her life and role in the field of addiction treatment.

How Western psychedelics research fell to the wayside

Psychedelics' modern era began when LSD was discovered in the 1930s. By the 1950s, clinical trials were underway. US user experimentation outside of medical settings (and high-profile violence, like the Manson murders) inspired negative attitudes toward psychedelics, leading to use restrictions that prohibited companies from patenting psychedelic compounds. This strangled psychedelics' profitability until the 1990s when the government loosened its grip and psychedelics research began seeing a resurgence.

Hormone and peptide compounds imported from China soared in 2025

US customs data indicates that these imports doubled to $328M in the first three quarters of 2025, from $164M in the same period of 2024. The imports include GLPs, among other products. (Some users may experience a paywall.)

Silk Road, the dark web's first widely used market, proved the real-world utility of bitcoin

Named after the ancient intercontinental trade network between China and the Roman Empire, the anonymous market was active from early 2011 to October 2013. Before it was shut down, approximately 10,000 products—70% of which were illegal and controlled prescription drugs—were bought and sold using the cryptocurrency.

A Netflix docuseries turned the sport into a national obsession

Throughout much of its history, Formula 1 racing was a European sport that failed to ever find a major audience in the US. That changed with the “Drive to Survive,” the Netflix docuseries that premiered in 2019. This analysis from two communications professors unpacks how the series has successfully presented the sport for an American audience and cultivated a dedicated fanbase in the process.

The US dollar is the most popular note to counterfeit

Counterfeit operations are often controlled by rogue governments, drug cartels, and more. These organized crime rings often sell counterfeit bills wholesale, for anywhere between 40 and 70 cents per dollar.

When America's deadliest serial killer went undetected

Samuel Little, who, for years, washed in and out of the justice system on violent charges eroded into lesser offenses, ultimately admitted to killing 93 people, mostly women, over more than 30 years. He tended to target those on the fringes of society—runaways, drug users, sex workers—people whose deaths were more likely to go unnoticed, he remarked, referring to them as fruits to be plucked at will.

The federal government allowed toxic chemicals into alcohol during Prohibition

Industrial alcohol was still legal during Prohibition, and was often used by bootleggers. In an attempt to disrupt the black market, the government required toxic additives to be included in industrial alcohol, leading to more than one death.

Pizza's popularity has waned in the 2020s

The food remains popular, but it has lagged behind the growth of other fast food spots like coffee shops and Mexican restaurants. It ranked sixth in US food sales from restaurant chains in 2024; it was in the second slot throughout the 1990s. (Some readers may experience a paywall.)

Penicillin was hailed as a 'wonder drug' upon its release

When penicillin became widely available in the 1940s, newspapers and doctors alike celebrated it as a “wonder drug” that could cure infections once considered fatal.

Some experts equate prediction markets to the new crack cocaine of gambling addiction

An addiction psychiatrist at UCLA says betting apps are far more potent than traditional gambling, citing a 19-year-old patient who lost $180,000 and hadn't left campus in a year, cycling through sports bets, crypto, meme stocks, and prediction markets on his phone. This interview explores the extreme edge of the nascent industry.

Trump's H-1B fee hike could reshape US industries and global talent flows

Analysts warn the new H-1B fee could trigger labor shortages in tech, medicine, and universities; push firms to offshore more work; and drive skilled Indian workers and students toward other countries—weakening America's innovation edge.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

11 people died from firework injuries in the US in 2024.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Experimental hantavirus vaccines and therapies, still under development, have long been funded by the US military.

Domino's Pizza's 30-minute delivery guarantee was responsible for the chain's 1980s surge, but it was discontinued after the company was found liable for delivery driver accidents.

See how Ebola tore through Guinea, Sierra Leone, and Liberia in 2014-2016.

While the first exchange-traded fund (a 'basket' of different assets that can be bought and sold on a stock exchange) in the US only launched in 1993, the global ETF market has grown to more than $10T in the short time since.

Hear 50 years of iconic hip-hop samples, the genre's foundational looped tracks

How fusion—which releases energy when two lighter atoms combine to form a heavier atom—differs from fission

The most expensive ad of all time was for Chanel No. 5 perfume and cost roughly $33M to produce in 2004—about $57M in today's dollars.

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

Art theft is the third-largest source of criminal revenues worldwide, thanks in part to the subjective nature of valuing a work of art.

'Saturday Night Fever,' the 1977 film that introduced disco to the mainstream, was based on a fabricated magazine story.

The price of gas is a composite made up of several different factors, with the federal gas tax making up less than 20% of what drivers pay at the pump.

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

A Yale student wrote a profound essay about the consulting industry's influence on elite college students that was published in a book of her writing after she died in a post-graduation car accident.

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

The US first hosted the World Cup in 1994, a tournament that lives in soccer infamy for its poor planning and the murder of Colombian player Andres Escobar, who'd accidentally scored on his own net.

For centuries, Niagara Falls has been a magnet for daredevils seeking to conquer one of nature's most powerful wonders, with its 200-foot drop and water rushing at 32 feet per second with 280 tons of force.

Some researchers have labeled nomophobia, the fear of being without your phone, as 'the phobia of the 21st century.'

A vending machine run with Anthropic's AI went out of business after it was convinced to give away items for free and sell a video game console.

Some coin denominations have ridges etched on their sides, partly to prevent counterfeiting, in a practice called 'reeding.'

Massive 3D printers have been used to build homes by stacking layers of 'concrete toothpaste,' a fire-resistant material that effectively insulates against outside noise.