Polygenic scores aim to predict traits based on the contributions of many genes

What the heck is a polygenic risk score?

Being able to predict an individual’s risk of common conditions is regarded by many as the holy grail. So, where are we now?

Aurea's father came upon polygenic risk scores after reading a news article about it

Rafal Smigrodzki, a neurologist with a PhD in genetics, first heard of the polygenic risk score offering after reading about it in a 2017 MIT Technology Review feature that focused on the company they eventually used, Genomic Prediction.

Silicon Valley startups Orchid, Nucleus, and Genomic Prediction are selling so-called polygenic tests for prospective parents

These tests claim to show how at-risk a hypothetical baby would be for genetic syndromes. The newfound industry has prompted ethical and medical debates, with critics questioning their accuracy and highlighting the potential problems behind pursuing the perfect baby.

Genetic drug matching, called pharmacogenomics, can help avoid dangerous drug reactions

Certain gene variants can affect how quickly or slowly medications are broken down in the body, affecting drug effectiveness and the risk of drugs failing. Such testing is often not covered by insurance companies though research indicates if these tests were performed for more than six drugs across the US population, avoided ailments would likely climb into the hundreds of thousands. (Some users may encounter a paywall.)

Selecting an embryo based on polygenic score is illegal in the UK, Israel, and swaths of Europe

Though their use for embryo selection is illegal in many locations, private clinics in the US may offer polygenic scores to inform embryo selection. The US Food and Drug Administration has not banned their use—instead the tests are regulated like supplements, meaning they are not regulated before they come to market but consumers can file complaints and then the agency may take action.

Many of the new prenatal genetic tests for rare genetic conditions are inaccurate

Established screening tests for Down syndrome in utero are reliable and accurate. But a New York Times investigation into expanded prenatal genetic tests for very rare diseases—much rarer than Down syndrome—found that more than 80 percent of the positive test results turned out to be wrong based on follow-up testing. These expanded tests for rare diseases are performed from a blood draw at 10 weeks of pregnancy and aim to detect chromosomal abnormalities linked to rare diseases. Companies that offer these controversial tests counter that it's only a screening test—not a diagnosis—picking up true positives and noting that patients can and should be counseled about what the findings mean. (Some users may encounter a paywall.)

Genetic tests aren't always actionable, which is one reason genetic counselors are so vital

This podcast interview with a Harvard Medical School professor focused on cancer genetics and prevention discusses the specifics of genetic testing and insights and the challenges of processing the outcomes of the testing and what may be actionable—or not.

Around 5 million of our 3 billion DNA letters differ between individuals

Genetic testing examines gene variants to help explain disease symptoms. It explores how genetic differences between individuals can be used to understand risks of developing diseases like Huntington's Disease or passing variants linked to disease onto offspring.

Why genetic testing for Alzheimer's risk may not be right for you

Medical experts warn that completing Alzheimer's testing for late-onset versions of the disease can be fraught, in part because there's a shortage of genetic counselors to help navigate the findings and their potential implications, including for one's finances. Learning you have one or two copies of the APOE4 gene variant, which elevates Alzheimer's risk, can be panic-inducing, but an elevated risk for the disease is not the same as saying it definitely will develop.

Personality tests use the Barnum effect, where vague flattery makes generic descriptions feel specific

A 1949 experiment by psychologist Bertram Forer showed that students rated identical, generic personality profiles as highly personalized. This is the same approach used in horoscopes, Myers-Briggs personality types, and fortune tellers. Even well-resourced tests like Myers-Briggs show poor test-retest reliability, with up to half of retakers getting different results.

Even if you have some ASD-linked gene variations you may not develop ASD

Individual environment and life experiences affect how genes perform in the body, potentially adding methyl groups to DNA that affect their function and turning genes on and off—which may heighten or reduce disease risk.

Biological aging tests assess the breakdown of physiological systems

Known as aging clocks, these tests compare various metrics, like DNA methylation patterns and protein profiles, to healthy baselines. However, the non-uniformity of these baselines across individuals limits testing accuracy and prevents their clinical use.

Carrier screening enables individuals without symptoms to see if they carry a gene for disease

Some conditions are autosomal recessive—meaning a person may carry a gene for that condition, but not have symptoms. Cystic fibrosis, sickle cell disease, and Tay-Sachs disease are examples of autosomal recessive diseases in which a person must inherit two copies of a nonfunctioning gene—one from each parent—to develop disease.

Scientists identify hundreds of genes responsible for OCD

Researchers analyzed the DNA of more than 53,000 people with OCD and identified 30 areas in the genome linked to the disease, containing 249 genes of interest. Of those, several were linked to other brain disorders, paving the way for genetic treatments of various mental illnesses.

What's your ACE score, and what does that mean for your health?

An ACE score is a way of measuring adverse childhood experiences, which can negatively impact health outcomes. Take this quiz to determine your score and what that means for your health. The Centers for Disease Control and Prevention and Kaiser...

Allergy tests identify antibodies, but not whether allergy symptoms may appear

Skin prick tests and blood tests, the two most common allergy tests, both detect the presence of allergen-specific antibodies. But just because the body has those antibodies doesn’t mean that a person is “allergic” to a substance or that they will develop symptoms of an allergy when encountering the substance. Allergists work with families to interpret the results and sometimes combine that data with approaches including exposure challenges—giving someone a tiny bit of the food or substance they may be allergic to—under medical supervision.

Stroke risk doubles each decade after age 55

While age is the greatest risk factor, genetics, diet, and overall health play a prominent role in determining individual stroke risk. Prevention focuses heavily on modifiable risk factors. High blood pressure is the single most important controllable risk factor, contributing to both types of stroke.

Could all mental health disorders have a unifying 'p-factor'?

Some researchers have argued in the past couple decades that all mental health disorders may have a unifying dimension—a theoretical "p-factor" that is common across mental illness, but life experiences and behaviors influence if and how illness manifests. Proponents point to similarities across different disorders, while detractors argue that such connections are largely exaggerated.

Genes are the basic units of heredity

These segments of DNA—long molecules made of nucleotides that coil into chromosomes—code instructions for making specific proteins, which correspond to different traits. Approximately 98 to 99% of human DNA is non-coding, with functions beyond protein synthesis.

A man’s genes can predict his hairline

There’s actually some truth to the idea that you should look at your mother’s father. But genetic research tells us that the full picture is somewhat more complicated. An interesting read on how to use genetics to figure out if you'll go bald (with illustrations).

Genetics may account for nearly 67% of mosquito attractiveness

In a mosquito attraction study published in 2015, identical twins appeared equally attractive to mosquitoes in lab tests, whereas some nonidentical twins were far less likely to be bitten than their siblings. Other work related showed that body odor is also more similar between identical twins.

As of February 2025, there are more than 150 clinical trials using CRISPR technology

The clinical trials are designed to determine whether experimental CRISPR-related therapies are safe and effective. The majority of trials involve treatments for blood disorders, including beta thalassemia.

Problem solving, problem recognition, and learning ability makes up intelligence

Psychologists have several theories from which the concept of intelligence is explained, including general and multiple intelligences. Although IQ is used to quantify intelligence, issues like its cultural biases have spurred debate.

See how a good VantageScore and a good FICO score can differ

While VantageScores and FICO scores both offer credit scores between 300 and 850 and consider the same core factors, they weigh those factors differently, and specific numbers can have different meanings depending on the type of score.

Blood Pressure and Diabetes

New meta-analysis shows blood pressure reductions with ACE inhibitors and ARBs are associated with a lower diabetes risk, but other types of antihypertensive agents have the opposite effect.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

Use this tool to calculate the dollar value of your parental mental load, from meal planning to coordinating after-school care, then see resources that help generate solutions.

The first steps to rebuilding your credit score include getting to know exactly what's on your credit report and figuring out how far you are from the '700 club,' or 'good score' range.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

Play the role of a student in a game where you try to navigate college and remain debt-free, selecting different income levels, high school experience, race, ethnicity, and more.

When you complete a CAPTCHA on a website to prove you are human, you may be unknowingly training algorithms for self-driving cars, whose systems require training data to help identify crosswalks, bicycles, and other outdoor objects.

Larger animals like giraffes, elephants, and blue whales have developed a unique defense against cancer, a phenomenon known as Peto's Paradox

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

The 2026 Ebola outbreak is hampered by a lack of vaccine against the species of the virus, heightening the need for rapid tests to aid in disease control.

Explore an interactive map built from more than 100,000 survey responses on where people find joy in their lives

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

Chaos theory—informally known as the butterfly effect—is the reason why weather forecasts are presented with probabilities rather than certainties.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

The price of gas is a composite made up of several different factors, with the federal gas tax making up less than 20% of what drivers pay at the pump.

US housing costs have risen by roughly 175% between 1991 and 2026—but a growing number of Gen Zers are becoming homeowners anyway. In 2025, 4% of homebuyers were Gen Z, up from 3% the year before.

Doctors differentiate between a phobia and fear by asking patients whether their fear interferes with their day-to-day activities.

Clever Hans was a 1900s horse that was believed to be able to solve math equations, tell time, and read and comprehend German, until a psychology student discovered how he got his answers.

The power and influence of the American presidency have expanded significantly over time—far beyond what the founders envisioned.

Dozens of S&P 500 stocks, including Coca-Cola and Walmart—known as the dividend aristocrats—have increased dividends every year for 25 years

Gerrymandering works through two techniques: cracking opposing voters across districts to dilute their power, and packing them into a few to waste their votes in lopsided majorities.

Memecoins are a type of cryptocurrency—a form of digital currency with a wide variety of uses—created around popular 'memes,' or viral internet jokes.

The Great Salt Lake's distinct dual coloration results from high-salinity organisms that only live in the northern portion and produce a purple protein.