Some research suggests that the gut microbiome influences our risk of heatstroke, with elevated exercise levels raising body temperature to unsafe levels and increasing gut permeability—causing a "leaky" gut.

Exercise causes diet-independent changes in the gut microbiome

Cardiovascular exercise has been found to boost the gut's population of beneficial bacteria, and exercise overall decreases the likelihood of developing a "leaky gut," a condition in which a porous gut lining allows bacteria to leak into the bloodstream and cause inflammation.

Supplements ahead of exertional heatstroke helped protect mice against brain damage

In the lab, mice dosed with probiotics prior to inducing exertional heatstroke, had better cognitive outcomes. This evidence underscores the links between the gut microbiome and the brain, at least in rodents.

How heatstroke—from overexertion or extreme heat—affects the body

When core body temperature soars to 104 degrees Fahrenheit or higher and remains there for about 30 minutes, it sets off a cascade of problems in the body. Proteins and cell membranes can degrade and begin to leak, potentially leading to liver damage, blood clots, GI tract damage, and organ failure, among other issues.

Heatstroke can reprogram your DNA, putting survivors at risk of future health problems

Severe illness from extreme heat exposure can alter DNA through epigenetics—turning genes "on" or "off" to shape disease risk. These changes can place an organism at greater risk of future health complications—unlike the epigenetic changes produced by moderate, repeated heat exposures.

Exertional heatstroke is a top killer of athletes and soldiers-in-training

Often characterized by collapsing while exercising in the heat with intense sweating, this type of heatstroke among otherwise healthy people occurs when the body loses the ability to cool itself during intense exercise and the body's core temperature has risen to 104 degrees Fahrenheit or higher and cannot cool itself. If treated quickly, it's often survivable, though it can cause lasting damage.

The reason some people love exercise may be because of their microbiome

Certain gut microbes in mice trigger dopamine release and drive motivation to exercise more. Scientists are investigating whether humans carry similar microbial patterns that influence our natural inclination towards movement, exploring how unseen microbial ecosystems may shape mammalian fitness behavior and reinforce innate reward pathways. (Some users may experience a paywall.)

The gut microbiome may play a major role in autoimmune disease and symptom flare-ups

Certain unhealthy foods can promote gut bacterial growth and inflammation in the lining of the gut, potentially disrupting its lining—leading to a leaky gut that may allow pathogens to dribble out into the bloodstream, fueling further inflammation that can both cause disease flare-ups and set the stage for future disease development.

Certain medications that affect blood flow or mood boost the risk of heatstroke

Drugs that narrow blood vessels, beta blockers that regulate blood pressure, diuretics, antidepressants, and antipsychotics can all affect the body's ability to regulate its internal body temperature, and so individuals taking these medications need to take special care in extreme heat and when exercising in hot conditions.

How the microbiome affects your health

The gut microbiome is so influential to overall human health that some researchers consider it a separate organ. Its conditions, influenced by environmental and lifestyle factors such as medication and exercise, contribute to immunity, metabolism, inflammation, medical treatment efficacy, brain development and function, and the development of disorders and diseases, including asthma, depression, inflammatory bowel disease, and Alzheimer's.

Can the gut microbiome drive addiction?

New research suggests an imbalance of gut microorganisms may influence the likelihood of addiction and addictive behaviors by increasing the severity of withdrawal symptoms, triggering brain inflammation in regions of impulse control, and more.

Heat-related complications are of greater concern for distance runners than cardiac threats

Analysis of more than 130,000 runners in Tel Aviv events during a seven-year period indicated that the runners were 10 times more likely to experience heatstroke than serious cardiac problems. Scientists suggest that runners should take 10 to 14 days to acclimate to a hot climate before tackling a serious run.

Extreme weather conditions heighten cholera risks in settings like refugee camps

Runoff from sewage—exacerbated by situations like flooding or extreme rains—heightens this threat. Increasing temperatures also create the ideal conditions for the bacteria to reproduce, increasing transmission risks.

Research links the gut microbiome and rheumatoid arthritis

Arthritis is a potentially disabling joint condition that currently affects nearly one in five adults across the globe. Doctors still don't know what causes rheumatoid arthritis, but the answer may be partly determined by chemicals produced by bacteria in the gut.

Heatstroke treatment guidelines were built almost exclusively on research in men

Protocols for the standard treatment recommendation for heatstroke—whole-body cold water immersion—were built based on studies almost entirely in men. The research wasn't replicated in women, who typically cool faster than men during cold water immersion, raising questions about standard protocol safety for women, due to the risk of overcooling.

Most fungal pathogens can't survive the heat of our bodies

Fungal pathogens typically struggle to survive human body temperatures, but researchers hypothesize that global warming conditions will force fungi to adapt to hotter temperatures, with implications for their ability to also survive within our bodies. That type of evolutionary adaptation would lead to more dire health threats for humans.

Extreme heat is neurologically impairing animals

Dog bites increase in summer, birds struggle to learn, and goats pick more fights. Scientists are unraveling new details about how heat impairs animals' neurological systems.

Sickle cell trait can put people at elevated risk of heat-related illness

This hereditary blood disorder affects the shape and function of red blood cells. A US military study found that among recruits the incidence rate of exertional heat-related illness was 48% higher among those who had sickle cell trait as compared to those without. Easing into intense exercise and gradually increasing exertional frequency and intensity is recommended.

We can get food poisoning from spending time in swimming pools, lakes, rivers, and ponds

Some of the same pathogens that may sicken us in food or water may also sicken us in recreational swimming environments. Bacteria can rub off of people’s (or animal’s) bodies or contaminate the water through a diarrheal episode. Washing your hands for at least 20 seconds before eating food if you are at the beach, pool, or other similar environments and being sure not to swallow the water are ways to help keep safe.

Climate shifts are projected to cause more cases of food poisoning

Research published in 2024 suggests that with more severe heatwaves and natural disasters, scientists expect there to be a rise in foodborne disease, especially in Africa and Asia. Already, there are an estimated 600 million food poisoning cases and 420,000 deaths annually. Diarrhea is the most common cause of those deaths.

How to maintain a healthy gut

Approximately 40 trillion microbes reside in the human gut, forming a unique microbiome, containing hundreds of millions of neurons in what is often called a "mini-brain". A healthy gut is characterized by an effective mucus-lined barrier that prevents unwanted substances from entering the bloodstream. So how do you attain such an ideal gut? This guide outlines a healthy approach to protecting your gut.

Schizophrenia increases heat death risks in several complex ways

Evidence shows that people with schizophrenia have an inherently harder time regulating internal body temperatures. They may also struggle to find safe shelter during extreme heat, and their prescribed antipsychotic medications often have dehydrating effects, collectively elevating the risk of heat-related illness and death, as illustrated by this article that focuses on the final days of Stephan Goodwin's life in 2022. (Some users may encounter a paywall.)

Korey Stringer, of the Minnesota Vikings, died of heat-related illness in 2001

In response, the NFL overhauled its heat approach and no other player has since died from heat-related illness. Even at the high school level, research suggests safety measures should include: mandating water breaks, keeping a cool tub available, and having athletes acclimate to high-temperature playing conditions for a week or longer before donning the full set of protective equipment.

Extreme heat puts people at risk of developing kidney stones

It's essential to remain hydrated in summer weather to keep your body healthy, but one reason is to help dilute minerals that naturally build up if they aren't excreted in our water-fueled urine. Doctors recommend people generally drink 64 ounces of water a day and also eat foods with salt to help ward off dehydration.

Fake sugars may disrupt metabolic health

Alternative sweeteners such as stevia and sucralose are 100 times sweeter than common table sugar. New research suggests these "high-intensity" sweeteners significantly disrupt the composition of the gut microbiome, affecting overall health. (Some users may encounter a paywall.)

Fear (and stress) can be contagious via pheromones secreted by the body

While seeing someone else in a panicked state may induce a stress response, researchers have found stress can be literally contagious—chemicals contained in sweat and other secretions can trigger stress hormone release in others. Theories suggest this feature is an evolutionary adaptation to protect groups from danger.

How greenhouse gases and climate change impact the efficiency of photosynthesis

A review in the Journal of Experimental Botany found that higher temperatures reduce the efficiency of enzymes involved in photosynthesis and impair a plant's ability to control water loss and regulate carbon dioxide uptake. While increased carbon dioxide levels are understood to accelerate plant growth by boosting photosynthesis, researchers suggest these effects more than offset the potential gain.

Heat-related deaths may have climbed by more than 50% over 20 years

Between 2000 and 2009 one study suggests annual heat deaths averaged around 2,670, but between 2010 and 2020 that figure was likely more than 4,000. Researchers studied 54 million death records from the contiguous US and created mathematical models to arrive at these figures, noting that a combination of aging populations and climate change drove that increase.

Sweat doesn't smell, but bacteria multiply in moist environments—and cause an odor

Body odor is associated with sweat, but odor actually arises from the bacteria that multiply in moist environments on your skin. Hormones, medications, food, and body hair can all affect body odor.

Eating competitions can ruin a stomach's elasticity

Competitive eaters make room for all that food by toying with the stomach's ability to expand and contract. Still, doctors warn that repeated stress can destroy that ability, leading to further issues.

Scientists seeking gut insights are attaching flatulence sensors to volunteers' underwear

This fart-tracking device detects gas generated in the gut, providing insights about gut microbial activity. The underwear sensors measure a component of what is technically called flatus—digestive system gas.

Cold water swimming can induce positive stress

The tradition of cold water swimming (or taking a cold plunge, or even a cold shower) has been shown to release the same hormones triggered during a stress response. This can have the effect of increasing blood flow, improved mental acuity, and more.

Microtears in muscles from exercise cause fibers to grow back larger

Placing muscle under increased load or stress causes damage that requires rest to repair, leading to stronger, more enduring muscle over time. Muscles adapt to such increasing demands by improving their efficiency with approaches that include increasing the number of mitochondria housed in hundreds of thousands of muscle cells.

Swimming boosts the risk of contracting swimmer's ear by fivefold

The term swimmer's ear is a bit of a misnomer since other factors including scratches to your ear from Q tips, trapped perspiration inside the ear when you sweat, and living in tropical climates can elevate the risk of contracting this outer ear infection. But swimming poses the greatest risk: widely cited research has found that swimming elevates the risk of contracting this infection fivefold.

What's next for gut microbiome science?

A Stanford microbiologist explores what we don't yet know about the gut microbiome—such as whether we can engineer the bacterial species within it—and the current scientific advances in the field.

Strengthening your butt muscles can help protect against running injuries

More than 28 million people may go running in the US every week, yet people often get hurt—especially with knee injuries—and this podcast explores the science on what happens to our bodies when we run and the effects on our muscles and joints. It also discusses safety tips, including the need to only add more distance to your runs in tiny increments, and that strengthening glute muscles via single-leg glute bridges may be particularly protective against injuries.

We're breathing microplastics

White blood cells can't fight off microplastics and that sparks inflammation and bigger health risks. They're in our food, water, even the rain. What does that mean for us?

Short-term cortisol spikes can boost the immune system

Elevated acute levels can enhance the immune system's ability to fight off infection or respond to injury. Chronic heightened cortisol levels, however, can lead to inflammation that harms cells and tissues over time.

Extreme temperature resilience appears to be temporary for tardigrades

Although often considered indestructible, scientists observed these creatures could endure temperatures near 150°C for only a few minutes in their tun state. Outside this state, only half the samples in a Danish study survived 37.1 degrees Celsius (98 degrees Fahrenheit) for 24 hours, making tardigrades extremotolerant rather than extremophiles.

What is a heat dome?

The world is seeing regular heat waves with multiple causes, including so-called "heat domes," a term rising in use in recent years. A heat dome occurs when the atmosphere traps hot ocean air like a lid or cap, creating stifling conditions and resulting in extended periods of heat. See an illustration of this phenomenon and read how it works with this brief explainer.

Developing adaptable brain-body systems lets athletes thrive beyond 30

Success in high-level sports after age 30 relies on physical fitness and building brain resilience through deliberate training, recovery, and stress regulation. This creates a feedback loop where body and mind reinforce each other.

City structures cause localized heat zones hotter than nearby rural areas

Urban materials like asphalt and concrete trap heat, while cities lack cooling features like trees and water. Due to hot runoff, urban streams can heat up by as much as 18°F more than forested streams.

Research suggests the cleanliness of the ISS may make astronauts unhealthy

The International Space Station's sterile conditions deprive astronauts of the opportunity to strengthen their immune systems through microbial exposure. To address this problem, future missions may use probiotic-based cleaners and foster diverse microbes in space habitats.

How water pressure affects the body

The extreme conditions of the deep sea include increasing amounts of pressure as explorers and organisms descend into its depths. The major danger for both fish and humans is the way pressure changes how body tissues absorb chemical molecules...

Some claim breathwork can improve mental health, help process trauma, and more

Research shows people who practice breathing exercises see a decrease in depression and stress levels, and that such exercises are about as effective at treating PTSD as conventional approaches. Even something as simple as extending exhales can slow one's heart rate and activate the parasympathetic nervous system.

Tick bites can fuel an allergy to a sugar molecule in red meat

Alpha-gal syndrome is on the rise globally as ticks spread due to climate shifts. Bites from some ticks can trigger a sensitivity to a sugar molecule called alpha-gal found in mammal meat, which can lead to allergic responses to hamburgers and steak, among other products. Listen to an expert’s tips for avoiding this allergy, including quickly removing any ticks to limit exposure to their saliva or vomit.

How trauma gets ‘under the skin’

A study examining the muscle function of older adults who have at least one adverse childhood experience (ACE) suggests that trauma digs itself into muscle cells. Participants who reported childhood trauma were found to have lower maximum levels of cellular energy than people who reported fewer or no ACEs. Such compromised mitochondrial function "doesn't bode well," as it relates to a variety of health and age-related outcomes.

What happens to your brain when you burn out?

You've probably heard of burnout, also known as the feeling of exhaustion that happens after a long period of being overwhelmed or stressed. It's often associated with work and careers, but other parts of life, like parenting, can cause burnout, too. Scientists are figuring out what happens, biochemically speaking, in the brain when burnout hits—and spoiler alert, it includes a neurotransmitter called glutamate. Watch this video to learn more.

MS risk is shaped by geography, not just genes

Latitude—and related vitamin D exposure—seems to affect MS risk. People who migrate from a high-risk MS latitude (like northern Europe or the northern US) to a lower-risk latitude (like tropical areas) before age 15 tend to adopt the lower risk of their new country—suggesting there's a critical window for environmental exposure.

An estimated 1% of DNA mutations in bacteria can produce more dangerous strains

Researchers have developed a technique to monitor these mutations in real time. Using this technology, scientists found that mutations occur at a steady rate, with 1% leading to potentially deadly changes.

Read the 2012 study about captive orcas and the threat of mosquito-borne illness

Written by orca trainers who went on to become scientists, it states mosquitoes bite orcas at night when the animals hang out close to the surface. What's more, antibiotics used to keep captive orcas healthy also may depress their immune response, boosting the risks of them being unable to fight off diseases like West Nile Virus and encephalitis, which have killed orcas at US water parks.