Influenza

Unlike the common cold, influenza attacks suddenly with fever, body aches, and fatigue. Seasonal strains circulate worldwide, infecting up to a billion people each year and causing hundreds of thousands of deaths despite vaccines and treatments.

In their flu episode, cohosts Erin Welsh and Erin Allmann Updyke unpack influenza’s biology, history, and impact—explaining everything from past pandemics to modern vaccines, all with their trademark mix of science and storytelling.

Influenza viruses carry two key surface proteins: hemagglutinin (H), which lets them enter cells, and neuraminidase (N), which helps them escape and spread. These proteins are the basis for the names of flu subtypes like H1N1 and H3N2

In Renaissance Italy, epidemics were thought to result from the influence of natural disasters or celestial bodies. The illness was named "influenza", meaning “influence” in Italian.

The 1580 influenza pandemic, traced from Asia to Africa and into Europe, became the first flu outbreak clearly documented across the continent—killing tens of thousands and highlighting influenza’s potential for rapid global spread.

The rapid global spread of H5N1 bird flu—from remote Antarctic islands to US farms—shows how animal spillover, driven by human activity and ecological disruption, is accelerating pandemic risk across species long before sustained human transmission begins.

The 1957 H2N2 pandemic spread from East Asia, killing more than 1M globally, while the 1968 H3N2 pandemic began in Hong Kong and caused a similar toll, with both strains rapidly moving across continents.

First detected in Mexico, the 2009 “swine flu” pandemic infected up to 1.4B people worldwide. While mortality rates were lower than earlier pandemics, the outbreak still caused more than 150,000 deaths.

In 1933, British researchers dripped filtered nasal fluids from a sick colleague into ferrets, which quickly developed “ferret flu.” This experiment proved influenza was viral, not bacterial, and established the basis for modern flu vaccines.

The World Health Organization estimates that seasonal influenza causes about 1B cases annually, including 3 to 5M severe illnesses and between 290,000 to 650,000 deaths.