A deeper (nontechnical) dive into how CRISPR works

CRISPR is a gene-editing tool that lets scientists cut out and replace damaged DNA

Originally a bacterial defense system against viruses, CRISPR uses guide RNA and a protein called Cas9 to identify and cut specific DNA sequences. Scientists can repurpose this system to switch off faulty genes, insert new ones to treat genetic diseases, or modify organs grown in other animals so that they appear less foreign to a human immune system.

Explaining CRISPR at five levels of technical detail

CRISPR is a new area of biomedical science that enables gene editing and could be the key to eventually curing diseases like autism or cancer. WIRED challenges biologist Neville Sanjana to explain this concept to 5 different people; a 7-year-old, a 14-year-old, a college student, a grad student and a CRISPR expert.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

Visualize how CRISPR works at the molecular level

CRISPR is a revolutionary gene-editing technology already making a real-world impact in helping to treat several diseases and conditions. This simulation provides a microscopic view to help easily visualize the complex science.

CRISPR technology has improved crop resistance to pests and diseases

The gene editing tool is a modern version of the genetic modification that has been done on crops for centuries to create plants with preferred traits. Other applications of CRISPR include creating plants with higher yields and better resistance to climate challenges, as well as foods with improved shelf life and nutrition.

CRISPR-Cas9 enables precise genome editing using a simple RNA-guided system

Jennifer Doudna's research uncovered how bacteria use the tool as an immune defense by cutting viral DNA. She and Emmanuelle Charpentier received the 2020 Nobel Prize in chemistry for showing how this mechanism could be engineered to target and edit genes in living cells.

CRISPR turns 10 years old

When Dr. Jennifer Doudna and colleagues released a paper in 2012 demonstrating the ability to harness the cell's natural immunity machinery to edit DNA, it received little fanfare. A decade later, the gene editing technology has led to innovations in medicine, evolution, and agriculture—and raised profound ethical questions about altering human DNA.

Advances in agriculture are being powered by CRISPR to boost carbon capture

Researchers are using CRISPR to test thousands of plant gene edits, aiming to speed up breeding and maximize carbon retention in soil. By engineering drought tolerance, they also aim to increase crop yields and expand the environments where crops can grow.

Restoring vision in impaired patients via CRISPR

Since CRISPR was revealed as a gene editing tool in 2012, it has been on an accelerated track to real-world applications. Among other clinical demonstrations, doctors have now injected a CRISPR treatment directly into eye cells, helping vision-impaired patients see shapes and colors again.

Astronauts have repaired genetic damage in space using CRISPR—a molecular tool that can make precise changes to DNA and is used in single-celled organisms to attack invasive viruses.

Despite its potential, CRISPR still fails 15% of the time

Biochemists from UIC found that persistent Cas9 binding to double-strand breaks impacts DNA repair efficiency and the effectiveness of the gene editing tool. RNA polymerase collisions also dislodge Cas9, which affects the efficiency of the tool.

TIGR may supplement CRISPR by providing more refined DNA targeting

The tandem interspaced guide RNA is primarily found in viruses—unlike CRISPR, which is bacterial in origin—and is smaller than CRISPR, making it easier to deliver into cells. The TIGR-Tas system appears to read both sides of the DNA double helix and opens a smaller segment of DNA for repairs, improving the precision of single letter modification.

CRISPR can't fix faulty mitochondria

Gene editing via CRISPR could theoretically fix many issues in biology, but editing the mitochondrial genome has remained challenging. In recent years, there has been some progress reaching these cellular powerhouses. (Some users may experience a paywall.)

Gene therapy, a hope of the Human Genome Project, saves a baby's life

A baby with a rare genetic disorder received a bespoke gene-editing treatment using CRISPR technology. The case highlights the potential of personalized medicine for rare diseases, building on the foundation set by the Human Genome Project.

Genetic engineering will change everything forever

Designer babies, the end of diseases, genetically modified humans that never age. Outrageous things that used to be science fiction are suddenly becoming reality. As scientists increasingly understand how specific genes cause disease, the possibility of engineering our genes to not only "fix" problems but enhance our natural ability grows.

Research on bacterial cultures used in yogurt production led to CRISPR's discovery

Scientists learned it was a microbial immune system that could be repurposed to protect dairy cultures from viruses. Today, nearly all yogurt is made with CRISPRized bacteria, as are genetically modified crops like herbicide-resistant corn, wheat, and soy.

As of February 2025, there are more than 150 clinical trials using CRISPR technology

The clinical trials are designed to determine whether experimental CRISPR-related therapies are safe and effective. The majority of trials involve treatments for blood disorders, including beta thalassemia.

Dispose of invading viruses while learning about the CRISPR immune system

In this free, easy-to-play game, defend the city of Bacterium by playing the role of Cris Perotein. As you play, you'll learn microbiology and the workings of the mechanisms that CRISPR uses to protect bacteria. (desktop recommended)

De-extinction techniques create new species from existing organisms

Rather than recovering a genetic sample of a lost species and editing it with that of living creature—as has been depicted in science fiction—scientists begin with living cells from close genetic relatives and use tools like CRISPR to swap in extinct versions of specific traits to create new hybrid species.

Scientists create the first CRISPR-modified spider to enhance its silk proteins

A research group at the University of Bayreuth used CRISPR-Cas9 to genetically modify spiders to produce glowing red silk. Spider silk is five times stronger than steel by weight, and this research paves the way for developing new silk functionalities.

Is synbio really cool, really scary, or both?

There’s always been a divide between technology, the inanimate stuff that we build, and biology, the living stuff that nature builds. Synthetic biologists are trying to figure out how to close the gap by building living things.

Women's wartime suit features silk dyed with CRISPR-modified bacteria

Anna Dumitriu's bioart piece was created to commemorate the 75th anniversary of the first use of penicillin in a human patient and intends to raise awareness about the rapid development of antibiotic-resistant pathogens by using bacteria that have essentially been transformed into their pre-antibiotic era state.

How epigenetics blurs the line between nature and nurture

An exploration of the study of how behaviors and environment affect the way genes work — and how that complicates the nature-versus-nurture debate.

An overview of extremophiles and the biochemical adaptations employed by various types

These organisms thrive in environments that would normally be inhospitable to most living things by using molecules that help counter deadly environmental factors. These include antifreeze-like proteins that prevent psychrophiles from freezing and rupturing in polar regions, and osmoprotectants that prevent some extremophiles from losing water to salty environments.

What makes food crispy, and how science can be used to maximize this property

The fracturing texture experienced when biting into vegetable tempura, fried chicken, pastry crusts, and other foods comes from having a dehydrated, porous surface. When frying food in hot oil, trapped water vaporizes and escapes, creating tunnels and pores in the food as it dehydrates. Breading, particularly with the large, irregular shapes of panko, and leaveners can help create more air spaces.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

The economics of horseshoe crab blood

Horseshoe crabs are older than dinosaurs and have survived five mass extinctions that wiped most life from the planet. But it's only now that their future as a species is in danger. This blood, worth about $60,000 per gallon, is hyper-sensitized to certain bacteria that are fatal to humans. This 17-minute podcast dives into humanity's pursuit of horseshoe crab blood, a "somewhat magical" mixture heavily relied on by the pharmaceutical industry.

The case that willfully being 'cringe' can be antisocial

While noting the prevalence of "cringe" in recent media discourse, the author argues that willfully engaging in cringe behaviors—an overzealous earnestness or awkward rupture of social norms, in many cases—is selfish and forces others to experience discomfort. The essay offers an interesting meditation on how artists often explore cringe as a concept to critique social norms, while others who encourage people to "embrace cringe" are promoting individual freedom over relational harmony.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

Radioactive elements can introduce software errors because the ionizing radiation they produce can detach electrons from atoms, and computer code relies on the distribution of electrons.

Watch how algorithms can be designed to train themselves and self-improve without human input, to the point where the optimized code is too complex for programmers to understand.

The history of many kitchen appliances involves unexpected discoveries and applications, including wartime radar turned hamster defroster and replacing an 'ice king' with heat-stealing boxes.

How fusion—which releases energy when two lighter atoms combine to form a heavier atom—differs from fission

Fast-casual restaurant Chili's is experiencing a resurgence, with its parent company recently reporting a nearly 32% increase in sales, thanks to passionate Gen Z fans on TikTok.

Fear or disgust related to clusters of holes and cracks, called trypophobia, may stem from evolutionary processes to help us avoid pathogens.

Long before Major League Baseball began allowing instant replay for balls and strikes, an umpire reluctantly used the technology to determine whether a hit was a home run, a move that inadvertently ushered in a new era for the sport.

Gerrymandering works through two techniques: cracking opposing voters across districts to dilute their power, and packing them into a few to waste their votes in lopsided majorities.

Crows are believed to have intelligence on par with a seven-year-old child and demonstrate complex behaviors, from problem-solving with tools to recognizing human faces.

The American cockroach is actually from Africa, an apparent hitchhiker aboard ships carrying enslaved people, with evidence suggesting the bug may have arrived in the New World as early as the 1600s.

Some Pokémon have been named after real and fictional organisms, while some real-world species have been named after Pokémon, such as Chilicola charizard and Binburrum zapdos.

Prince's sexually explicit 1984 track 'Darling Nikki' attracted the ire of the Parents Music Resource Center, an advocacy group that inspired the Parental Advisory sticker, even though the song ends with a Christian message.

Venture capital is a form of funding provided to early-stage companies with high growth potential, typically in exchange for an equity (or ownership) stake

Objects can be 3D printed with light by projecting 2D computerized tomography (CT) scans onto rotating cylinders of resin, which solidify upon exposure.

Poison ivy will likely become both larger and more resilient due to climate change.

Search a massive database of over 4 decades of clues from the TV quiz show 'Jeopardy!'

Coral polyps reproduce via broadcast spawning, where entire reefs simultaneously release reproductive cells for about one hour, once a year.

Chaos theory—informally known as the butterfly effect—is the reason why weather forecasts are presented with probabilities rather than certainties.

The Mona Lisa's celebrity status and repeated restorations have obscured what made the painting so revolutionary for its time