Forever chemicals are so common that experts concluded in 2022 that it's uncertain whether limiting consumer exposure would truly reduce one's exposure to these substances, and noted it would still take years for the body to clear them.

Used since the 1940s, 'forever chemicals' include thousands of different types of substances routinely integrated into industry and consumer products, yet research suggests they can accumulate in the body over time.

Watch 'Last Week Tonight' explore the risks of 'forever chemicals,' a group of human-made chemicals used in everyday products to make them resistant to water, stains, grease, and heat. (Warning: language.)

Per- and polyfluoroalkyl substances (PFAS) are a group of human-made chemicals used in a wide range of products due to their unique properties. However, because they can persist in the body and environment for thousands of years, they've earned the moniker "forever chemicals"—and have been linked with numerous health risks.

See this interactive global map that highlights which forever chemicals have been detected in specific wildlife species, drawing together numerous research datasets to provide data on hundreds of species exposed to these hard-to-breakdown substances.

Most of the 86,000 consumer chemicals registered with the US EPA have never received rigorous toxicity testing, though not all those are still in current use.

Explore this interactive EPA map, which shows 'forever chemical' testing results for public water systems—with brown spots indicating testing above national limits.

Why bacterial bioremediation may help counter the negative effects of past chemical solutions

Molecules such as DDT, a synthetic insecticide, and PFAS—"forever" chemicals used to make products resistant to heat, water, and grease—have historically been used across various industries but are now known to be harmful. Microbes that can convert some of these substances into nontoxic products, such as water and carbon dioxide, have already been identified, with ongoing research to find others.

A remote Scottish island is awash in forever chemicals even though there are no obvious industrial sources nearby, and scientists suspect the toxic substances are accumulating via seaspray.

Explore how close you live to some of the most contaminated places in the US

Known as Superfund sites, these toxic locations undergo long-term cleanup to remove hazardous waste, protect health, and restore land for safe reuse. As of 2025, the EPA lists around 1,300 active Superfund sites on its National Priorities List, with more than 450 cleaned and removed since 1980.

BPA-free plastics often contain other harmful 'forever chemicals.'

Many chemicals used in fracking fluid have been classified as toxic

Although the fluid has been known to leach into drinking water supplies, raising health concerns, fracking is exempt from federal clean water regulations due to a loophole in the Energy Policy Act of 2005 championed by former US Vice President Dick Cheney.

Microplastics are entering human food chains through carrots, wheat, and other foodstuffs grown in farmlands fertilized by sewage sludge.

The FDA claims microplastics have not yet been shown to pose a health risk

Although microplastics and nanoplastics are found in many foods and environments, their presence does not violate regulations. Additionally, as of 2025, the administration believes evidence does not confirm that detected levels harm humans.

How existing technology could prevent nearly 80% of plastic pollution

More than 28 million tons of plastic enters the environment each year, where it harms animals and damages habitats. A study co-authored by researchers at The Pew Charitable Trusts found that this flow can be reduced by nearly 80% in the next 20 years using existing waste management and recycling technology.

Fluorinated molecules are the most impactful, longest-lasting greenhouse gases

Developed as replacements for ozone-depleting substances in refrigeration and air conditioning systems, these compounds are released through leaks in and ongoing use of these appliances, as well as from various industrial processes. They can remain in the atmosphere for thousands of years and have warming potentials that are a thousand to tens of thousands of times greater than those of carbon dioxide.

Find fracking wells where you live and what chemicals operators are using

Fracturing fluid recipes are largely proprietary, but FracFocus has maintained a database of chemical disclosures since 2011. Today, the Department of Energy-affiliated nonprofit has more than 240,000 disclosures, along with a searchable database of fracking wells by state, county, and city.

Stainless steel and cast-iron pans should be used over older nonstick cookware

Although modern nonstick pans avoid forever chemicals like PFOA, they were previously used in the manufacturing of Teflon coatings and have been linked with certain types of cancer, infertility, and other adverse health outcomes. Vintage plastic utensils should also be avoided due to the leeching of contaminants in early formulations of plastic.

Some faucets in regions near fracking wells run flammable water

A 2011 study found methane contamination as much as 3,000 feet away from wells, although there was no evidence of fracking chemicals in tested wells. Water with low methane concentrations is not harmful to drink, but it becomes flammable when mixed with air.

Microplastics from sewage sludge persist in farmland soil for decades

A 25-year study in Scotland found that sewage sludge used as fertilizer introduces various microplastics into soil, where they remain and degrade into smaller particles that worsen soil quality. Dyes found in microplastics may also be leaching into the environment, causing additional toxic effects.

The Office of Chemical Safety and Pollution Prevention regulates toxic substances

This office evaluates and manages risks from industrial chemicals and pesticides. It reviews new chemicals before they enter the market, restricts hazardous substances, and promotes safer alternatives to protect human health and the environment.

The amount of plastic chemicals in 300 everyday Bay Area foods

Food production is more complicated than it appears, and manufacturing, packaging, and shipping processes can add significant substances to your food. This massive project compiled data on 300 samples of foods delivered to the San Francisco area, testing for the presence of 18 different kind of plastic. Learn how to read the data here with its helpful guides and then explore the table yourself.

Volatile chemical contamination can last in burn areas long after urban wildfires

Lead, arsenic, asbestos, and other chemicals have been found trapped in smoke-exposed rugs, couches, pillows, and other furniture that appeared otherwise undamaged from the 2025 LA wildfires. The gradual release of these substances has produced dangerous indoor air concentrations and contributed to increased emergency room visits and abnormal blood tests.

Why a Montreal Protocol amendment cut back on the replacements for CFCs

Hydrofluorocarbons were introduced in the 1990s as ozone-safe substitutes for chlorofluorocarbons and hydrochlorofluorocarbons. However, scientists later found that they trap thousands of times more thermal energy in the atmosphere than carbon dioxide does, prompting a 2016 amendment to the Protocol to phase them out.

Supplements often have issues with impurities, toxins, and inaccurate labels

Consumer Reports' tests of more than 20 supplement powders and shakes in 2025 found that more than two-thirds of them contain unsafe levels of lead. Some contained 10 times the amount of lead that's considered acceptable to ingest in a day. The levels they found, in some cases, were even higher than when they tested the products 15 years earlier.

The five most common chemicals found in modern food

Most modern processed foods rely on a number of preservatives to stay fresh from production to our plates. The most common include citric acid (preservative and flavor), sodium benzoate (preservative), xanthan gum (thickening and stabilizing), carrageenan (thickening), and red dyes 3 and 4 (for color).

Why it's so hard to end the use of toxic lead

Lead was one of the earliest metals mined on Earth, desired for its soft malleability and used in cosmetics, pipework, gasoline, and more. But even though researchers demonstrated its toxicity in the 20th century, much of the world still uses it.

Microplastics are infiltrating the human body with unclear but concerning effects

Scientists have linked microplastics to immune system damage, hormone disruption, inflammatory diseases, and even cancer—yet most of their health impacts remain unknown due to limited research. Studies suggest we ingest about a credit card's worth of plastic weekly.

Pollution from lead battery recycling has led to widespread contamination

Many small-scale operations worldwide remain unregulated, bypassing environmental regulations and causing increasing health threats, primarily to children. A 2020 report by UNICEF found that one-third of the world's children are being poisoned by lead from recycled batteries, among other sources.

Microplastics are everywhere and pose growing risks to wildlife and ecosystems

These tiny plastic particles come from intentionally small items and the breakdown of larger plastic debris, ending up in soil, air, and water. A study of 37 US National Park beaches found microfibers at every site, making up 97% of all microplastic debris.

The Love Canal disaster exposed the dangers of buried toxic waste

In the late 1970s, residents of Niagara Falls, New York, discovered their neighborhood was built atop 20,000 tons of chemical waste. Leaking toxins caused illness and birth defects, sparking nationwide outrage and leading to the creation of the EPA's Superfund cleanup program in 1980.

Microplastics 101: What we know about the contaminants invading our bodies

Fifty-one trillion particles of microplastics float in our oceans. Yet there is very little science of how this affects our health. This quick 2-minute video explains the dangers of microplastics.

The US FDA recently tried to regulate the expanded prenatal genetic tests

The agency proposed a new rule in 2023 to make it explicit that these types of tests are devices under existing law and clarify that that the agency could move to regulate them. They finalized a regulatory change in 2024 that added the words "including when the manufacturer of these products is a laboratory" to an existing law, but a federal district court vacated that edit in March 2025—returning the law to as it was before.

Learn why the Montreal Protocol may help prevent millions of cancer deaths

By restoring the ozone layer and reducing ultraviolet exposure, full implementation of the Montreal Protocol is expected to prevent about 443 million cases of skin cancer, 2.3 million skin cancer deaths, and 63 million cases of cataracts among Americans born from 1890 to 2100.

The US FDA issued a 2025 warning about BPC-157 and other popular peptides that are marketed for various regenerative properties.

The ozone layer is on track to recover to pre-1980 levels by mid-century

Thanks to the Montreal Protocol, the ozone layer is steadily recovering and, according to a 2022 assessment, is expected to return to 1980 levels by 2040 globally, 2045 over the Arctic, and 2066 over Antarctica.

How amendments to the Montreal Protocol have expanded global ozone protections

Since 1990, five major amendments—London, Copenhagen, Montreal, Beijing, and Kigali—have accelerated chemical phase-outs, added new substances, such as hydrochlorofluorocarbons, and tightened enforcement.

The history of the Montreal Protocol, the only universally ratified treaty in UN history

Mario Molina and F. Sherwood Rowland discovered that chlorofluorocarbons released chlorine atoms that could break down molecules making up the protective ozone layer. Despite attempts to discredit scientists and economic concerns raised by politicians, the agreement to phase out ozone-depleting substances was signed in 1987.

Rachel Carson didn't argue for wholly organic farming

Her 1962 book, “Silent Spring,” inspired many people to consider the chemicals used to grow their food, but Carson didn’t think that manufactured fertilizers needed to be banned from farming, writing that “The ultimate answer is to use less toxic chemicals so that the public hazard from their misuse is greatly reduced.” When she testified to Congress in 1963, she said, “I think chemicals do have a place.”

Dietary supplements are regulated like foods

This hour-long 2016 documentary from Frontline, the Canadian Broadcasting Corporation, and The New York Times examined the safety of dietary supplements. It noted that this then-$30B industry (it's at least doubled since then) suffers from irregularities and impurities. It warned that many Americans are unaware of the lack of regulatory oversight over these products.

Rachel Carson's 'Silent Spring' exposed the harmful effects of pesticides on food

The 1962 book warned against the use of DDT, a pesticide often sprayed over fields of crops, cautioning that it could be harmful if ingested in excessive amounts by humans. Some credit Carson’s book with inspiring the modern environmental movement and with encouraging the US to establish the Environmental Protection Agency in 1970 and ban the domestic sale of DDT in 1972. (Some readers may experience a paywall.)

Since 2022, two-thirds of data centers have been built in water-stressed areas

In residential evaporative cooling systems, 10% of consumed water is lost to evaporation compared to 80% in data centers. Although some companies have pledged to become water-positive—replenishing more freshwater than they consume—by 2030 through a transition to air cooling, only 10% of data center operators track water use across all their facilities.

How a government chemist founded the FDA—by poisoning people

The Poison Squad tells the story of government chemist Dr. Harvey Wiley who, determined to banish these dangerous substances from dinner tables, took on the powerful food manufacturers and their allies.

The Montreal Protocol helped prevent significant quantities of greenhouse gas emissions

By phasing out ozone-depleting chemicals between 1990 and 2010, the Montreal Protocol prevented emissions equal to 135 gigatons of CO₂—avoiding an estimated 0.5 to 1 degrees Celsius of additional global warming by 2100.

As of 2026, the majority of US states have unsafe radon exposure levels

Alaska, South Dakota, Pennsylvania, Ohio, and Washington top the list of states with exposure levels above 4 picocuries per liter for this naturally occurring radioactive gas. While these state-level averages vary from one county, municipality, and home to another, the EPA encourages those in the highest-risk states to test their homes.

Learn why water can take millions of years to be recycled via the hydrologic cycle

While a single drop of water spends an average of nine days in the atmosphere before precipitating back to Earth, it can spend thousands of years in the ocean before evaporating, and hundreds of thousands of years deep in rock layers before being released as steam in volcanic eruptions. Some water molecules have been trapped in Antarctic ice sheets for millions of years since they last moved through the water cycle.

Review Congress's 2025 report on the history of US critical mineral policy

For decades, supply chains for critical minerals have grown increasingly vulnerable due to reliance on imports. In 2022, the US Geological Survey expanded the list of critical minerals to 50 to better reflect growing industrial needs, exacerbating this vulnerability.

Fracking rates may increase with the construction of new data centers

In Pennsylvania, plans to build at least five new facilities supported by gas-fired power plants are expected to escalate public health risks through surges in air and water pollution. Data center water demands are expected to further strain local resources.

When signing the Paris Agreement, almost 200 nations committed to pursuing efforts to limit global warming to 1.5 degrees Celsius above preindustrial levels, based on guidance from the Intergovernmental Panel on Climate Change.

Listen to how the 1902 'poison squad' experiments changed food safety in America

As part of government research, a group of young men were paid to eat standard American food—replete with food additives like borax and formaldehyde—which revealed the dangers of unregulated food. The work was led by the first FDA commissioner, Harvey Wiley, who helped end the "century of the great stomachache."

Food companies usually issue recalls voluntarily and you can be automatically notified about them

Protecting yourself from food poisoning means staying on top of food recall announcements. Notices about these from the US government, which you can automatically receive after signing up at this link, note what products have been recalled by food companies. Companies alert the US Food and Drug Administration or the US Department of Agriculture when they issue recalls so the public can stay informed.

Why helium helped preserve the US' founding documents, but was later replaced

In 1951, the Charters of Freedom were stored in glass and metal cases filled with helium, which would not chemically react with the documents. After microscopic cracks were identified in the glass through which helium could leak out of and—experts feared—pollutants could infiltrate, new encasements made of aluminum, titanium, and argon replaced the old system in 2003.