Rubisco, the crucial enzyme powering photosynthesis

Why the abundance of RuBisCO in photosynthetic cells may come from its inefficiency

Despite pulling about 115 billion tons of carbon dioxide from the atmosphere to build organic molecules each year, the enzyme instead binds oxygen at least one in five times, needlessly costing cells energy. To compensate for this and its processing of no more than 10 molecules per second—versus thousands processed by a typical enzyme—it's become the most abundant enzyme on Earth.

An overview of oxygenic photosynthesis, which releases oxygen from breaking down water

Within the membranes of chloroplasts, electrons in pigments are energized by light and transferred across a series of molecules until they create the energetic NADPH molecule. This transfer also powers a hydrogen pump, which creates an ion imbalance that, when relieved, produces energetic ATP molecules. Outside the membranes, both NADPH and ATP are used to synthesize G3Ps, which are funneled into other metabolic pathways to produce sugars.

The research pipelines being explored by the RIPE Project to improve photosynthesis

These include engineering plants with faster stomata, which would allow photosynthesis to resume more quickly amid fluctuations in available light due to clouds or shading from other plants, and resolving bottlenecks in the regeneration of RuBP, the molecule to which carbon dioxide is fixed during photosynthesis to initiate the Calvin cycle. (Some readers may experience a paywall.)

An explanation of the Calvin cycle, including why it needs to run six times to create glucose

Each run of this second phase of photosynthesis begins with a five-carbon molecule called RuBP, which gains an additional carbon atom when carbon dioxide (CO₂) is attached. Across six cycles, the six six-carbon molecules—36 carbon atoms in total—are processed into 12 three-carbon sugars, which can be used to generate glucose, and six RuBP molecules, enough for each cycle to restart.

How MIT researchers have used genetic mutations to improve photosynthesis efficiency

Recognizing that RuBisCO—a protein that binds carbon dioxide to other compounds to produce the building blocks of organic molecules—often mistakenly binds oxygen, scientists performed directed evolution experiments to modify the geometry of a bacterial version of the protein to cause it to preferentially interact with carbon dioxide over oxygen.

Understanding the role of photosynthesis as a sink within the carbon cycle

Photosynthetic organisms are net carbon absorbers, pulling carbon dioxide from the atmosphere and storing it in organic compounds and within soil. Approximately one-third of humanity's carbon emissions are stored by these organisms.

Nearly half the oxygen we breathe comes from photosynthetic plankton, not plants

Although the Amazon Rainforest is considered the "lungs of the Earth," it only produces 20% of the planet's oxygen, while phytoplankton, or microalgae, generate more than twice as much, despite making up less than 1% of the total mass of photosynthetic organisms on the planet. Through photosynthesis, microalgae also absorb up to 40% of global carbon emissions.

The three categories of photosynthesis, which each help plants survive in different environments

In the vast majority of plants, C3 photosynthesis produces three-carbon intermediate molecules in the Calvin cycle within the cells of leaves. Plants in hot, dry climates use C4 photosynthesis across two types of cells to produce four-carbon molecules before the Calvin cycle. Plants in drought conditions use CAM to store carbon dioxide as an acid at night, minimizing water loss.

Learn about photoautotrophs, the photosynthetic organisms at the base of the food web

The sun is the ultimate source of energy for the planet, but consumers along food chains, such as herbivores and carnivores, cannot harness this energy themselves and instead rely on consuming plants and other organisms that capture it to build carbohydrates. Besides plants, photoautotrophs include algae and some bacteria that convert solar energy into chemical energy for the biosphere.

How the pigments that absorb light for photosynthesis contribute to plants' green color

Although light energy is captured to power the reactions that produce the building blocks of starch, cellulose, glucose, and other sugars, chlorophyll a and b are most sensitive to violet, blue, orange, and red light, leaving green light mostly unabsorbed. This green light is instead reflected, giving most plants this color appearance.

Artificial photosynthesis turns CO₂ into sustainable fuel

Carbon conversion focuses on a central perplexing question: if carbon dioxide is a leading driver of climate change, and fossil fuels are made of carbon-based molecules, can we devise a way to convert CO₂ into useful alternatives efficiently? This video breaks down a potential pathway using artificial photosynthesis, which uses sunlight to convert CO₂ into fuel.

Visualize the purpose of stomata in photosynthesis

These openings on the underside of leaves can be opened and closed by specialized guard cells to regulate the movement of carbon dioxide into and oxygen out of cells, thus impacting the rate of photosynthesis. At night, when the light-dependent reactions in photosynthesis are not possible, the stomata close to prevent the plant from losing water through transpiration.

Watch underwater photosynthesis make water look like champagne

In shallow waters where sunlight can reach, photosynthetic reactions absorb water and dissolved carbon dioxide, producing bubbles of oxygen at the surface of plants. As these bubbles rise to the water's surface, a fizzy appearance is created.

The Google Doodle honoring Jan Ingenhousz, who discovered oxygenic photosynthesis

Born in 1730, the Dutch scientist expanded on existing knowledge that plants produce and absorb gases in his 1779 paper, which detailed that light was necessary for the biochemical processes that produce oxygen in plant leaves. He also identified that all parts of plants produce carbon dioxide at night.

Explore the efficiency of photosynthesis under various conditions

In this simulation, users can track how the cellular concentrations of ATP, NADPH, glucose, and oxygen vary over time in response to changes in temperature, acidity, carbon dioxide concentration, and the properties of incoming light. Through multiple trials, users can identify the optimal conditions for photosynthetic reactions.

How greenhouse gases and climate change impact the efficiency of photosynthesis

A review in the Journal of Experimental Botany found that higher temperatures reduce the efficiency of enzymes involved in photosynthesis and impair a plant's ability to control water loss and regulate carbon dioxide uptake. While increased carbon dioxide levels are understood to accelerate plant growth by boosting photosynthesis, researchers suggest these effects more than offset the potential gain.

Early Earth lifeforms likely made energy via mineral reactions, not sunlight

Earth's initial atmosphere was filled with carbon dioxide, methane, and water, with most oxygen locked away in the rocky crust. Over time, bacteria evolved to slowly release that oxygen into the atmosphere by breaking down rock.

Explore the water footprint of producing various proteins, fruits, and vegetables

This interactive gallery highlights the various types of water behind the production of biofuels, foods, and materials such as cotton. Diets high in bovine meat, whose production requires 15,415 liters of water per kilogram (1,847 gallons per pound), are among the most water-intensive, whereas every kilogram of vegetables uses 322 liters of water (39 gal/lb) to produce.

How trees transport water from roots to leaves

Trees move water to their extremities via a deft system starting from the roots to the leaves. See how it works in this short video breaking down the process in a Douglas fir.

The surprising science behind Pop Rocks

Have you ever wondered why Pop Rocks makes tiny explosions in your mouth? Well, there’s actually pressurized carbon dioxide bubbles trapped within the sugary candy. This 19-second video shows you what Pop Rocks look like under a microscope.

Bees are crucial for pollination and food security

When animals and insects pick up the pollen of flowers and spread it, they allow plants, including many food crops, to reproduce. The most common pollinator is the bee, but bees are at risk from pollution and pesticides.

The key ingredients to life on Earth—and elsewhere

Life can only arise in incredibly specific conditions, an abundance of certain substances like water and phosphorus, lots of time, and the right proximity to a heat-and-light-providing star. These two experts on evolution of life say above all, life requires luck. Here's a list of eight ingredients to life.

How humans breathe without thinking about it

We breathe without thinking about it thanks to the body’s respiratory system and autonomic nervous system, which controls vital functions. Breathing transports oxygen to the body’s cells to keep them working and clears the body of carbon...

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

How fermentation enables the pickling of food and the production of beer

This process occurs when microbes produce lactic acid, ethanol, or carbon dioxide after consuming sugars. The acid helps preserve vegetables in a brine solution during pickling and gives them a sour taste, while ethanol serves as the inebriant in alcoholic beverages. The acid and carbon dioxide give sourdough bread its taste and texture.

Coral reefs get their colors from zooxanthellae—microorganisms that line corals' digestive tracts and provide them with sugars in exchange for a home within this protective tissue.

CRISPR-Cas9 enables precise genome editing using a simple RNA-guided system

Jennifer Doudna's research uncovered how bacteria use the tool as an immune defense by cutting viral DNA. She and Emmanuelle Charpentier received the 2020 Nobel Prize in chemistry for showing how this mechanism could be engineered to target and edit genes in living cells.

Scientists testing how climate change affects plants found, in a years-long simulation study, that poison ivy grew 70% faster with the resulting extra carbon dioxide.

See how each of the more than two million known species relates to each other—and to common ancestors—in this zoomable tree of life.

See how fireworks are made and learn how metals like magnesium and copper are responsible for different colors.

While the sun's gravity keeps the planets in orbit, their gravity also pulls on the sun, causing it and everything else in the solar system to orbit around a mutual balance point called the barycenter—the true center of the solar system.

Scientists can determine Earth's past climate conditions by analyzing air trapped in microscopic bubbles within ice cores—columns of compressed snow layers that build up over hundreds of thousands of years.

How fusion—which releases energy when two lighter atoms combine to form a heavier atom—differs from fission

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

Some renewable energy sources may weaken the resiliency of electric grids by removing outage buffers provided by coal- and natural gas-fired plants, which provide the system with more time to find a new power source if a plant goes down.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

Watch how deep-sea mining equipment collects and processes polymetallic nodules—metal-rich, potato-shaped rocks—from the ocean floor and creates environmentally damaging plumes of sediments.

All rainbows are 'raincircles' caused by water droplets separating white sunlight into a spectrum of colors, but Earth's surface blocks the bottom half of the circle from our line of sight.

The price of gas is a composite made up of several different factors, with the federal gas tax making up less than 20% of what drivers pay at the pump.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

How Amazon operates a 'flywheel' business model, a self-reinforcing cycle that drives continuous growth

The syncytiotrophoblast is the outer layer of the placenta and the largest human cell, spanning an area about twice that of a king-sized bedsheet.

Pure water does not conduct electricity because this flow of energy requires the movement of charged particles, and water is a neutral molecule.

After NASA's Voyager 1 captured Earth as a single pixel as it left the solar system in 1990, astronomer Carl Sagan used the image to reflect on humanity's fragility and the responsibility to protect 'the only world we've ever known.'

The American cockroach is actually from Africa, an apparent hitchhiker aboard ships carrying enslaved people, with evidence suggesting the bug may have arrived in the New World as early as the 1600s.

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

An initial public offering or 'IPO' is the process of a private company becoming public by putting shares of the company on the stock market for purchase.

Georgia O'Keeffe's flower paintings are often assumed to be sexual, though the artist claimed she was simply interested in highlighting the beauty of flowers that most people neglect

After the Boston Tea Party, colonists switched to coffee, which became the main morning drink for revolutionaries.