Increasing contact between humans and wild animals is driving zoonotic threats

Animal-to-human pathogens constitute 75% of emerging infectious diseases

Zoonotic diseases encompass more than 200 diseases transmitted from animals to humans, wherein humans are usually accidental hosts. Ranging from rabies to HIV to monkeypox, this overview lists some of the most common viral threats.

Watch how viruses like Ebola can spill over from animals to humans—and vice-versa

More than 70% of all new infectious diseases originate in animals. Referred to as zoonotic diseases, these are diseases that originate in animals and occasionally spill over or jump from animals to humans. Bats, mosquitoes, and primates have all been linked to spillover events. As human populations push further into previously uninhabited wilderness, animal-human contact increases, and disease spillover is inevitable.

Zoonotic diseases: Pathogens that jump from animals to humans

Such diseases may be caused by a variety of pathogens—viruses, bacteria, fungi, or parasites—and can originate in creatures ranging from ticks and mosquitoes to pigs and bats. Because they develop in animals and are often new to human immune systems, zoonotic diseases have severe consequences for public health.

Watch how viruses like Ebola can spill over from animals to humans—and vice-versa.

What are zoonotic diseases?

Interspecies interactions are a breeding ground for disease transmission. This basic background information on zoonotic disease from the Centers for Disease Control and Prevention (CDC) chronicles the different ways humans can get sick, identifies what groups are particularly vulnerable, and offers links to other resources.

Chimpanzees are dying from human colds

For some great apes, the threat of human-borne diseases outweighs poaching or habitat loss. This article details the danger of reverse zoonoses, which refers to diseases that spread from humans to animals.

Vector-borne diseases kill more than 700,000 people globally each year—and are growing

The diseases with the greatest potential to spread widely aren't the ones that quickly kill human hosts. Instead, the best hosts or reservoirs for vector-borne diseases would be chronically ill over the long term, increasing the likelihood that the pathogen could be transmitted to others.

Climate change is influencing the spread of disease

Rising temperatures and water levels are forcing animals and pathogens beyond their typical boundaries. This article and its data visualizations explore the proliferation of climate-driven diseases.

Rabies kills more than 50,000 worldwide each year

Rabies transmission to humans typically comes from an infected animal, and death was very common before recent protocols were developed (post-exposure prophylaxis). The virus is neurotropic, which means it has an affinity for nerve tissue, and moves quickly from broadly infecting the body to destroying the brain.

Mosquito-borne illnesses have killed captive orcas at SeaWorld

After two SeaWorld orcas died from viruses carried by mosquitoes, scientists warn that mosquito-borne illnesses may be a bigger threat to these captive animals than previously known. Captive orcas spend a lot of time stationary, close to the surface, unlike their wild counterparts. Researchers saw mosquitoes landing on the animals' backs, heads, and dorsal fins, supping on their blood.

From 1970 to 2017, invasive species have caused $1.28T in damage globally

The costliest species were the Asian tiger and yellow fever mosquitoes ($149B), which arrived in the US from Asia and sub-Saharan Africa, respectively. The bulk of their damage came from their transmission of diseases such as Zika, chikungunya, and dengue. (Some readers may experience a paywall.)

Invasive species are the third biggest threat to Earth's biodiversity

According to the World Wildlife Fund's Living Planet Report 2020, changes in land and sea use account for about half of all recorded threats to the diversity of the planet's species. Species overexploitation is the second-largest proportional threat at 24%, while invasive species make up 13%.

Explore 3D models of some of the most dangerous viruses

Everyone has come in contact with common viruses—typically something like influenza (the common flu)—but sometimes they encounter more dangerous strains. While we're familiar with the symptoms that manifest, it wasn't until the advent of advanced microscopy that scientists could pin down the exact structure and behavior of various viruses.

Watch an expert's take on the rare disease hantavirus—and why it's not of great concern to the general population

This rare zoonotic disease, transmitted to humans primarily through infected rodent droppings, urine, or saliva, is rarely spread between people. The disease was of particular concern in spring 2026, when an outbreak occurred on a 150-person cruise ship, prompting a flurry of action, including contact tracing for passengers in their home countries. The disease can be fatal. But early care—primarily oxygen support—can help patients survive.

Human-to-human transmission of hantavirus remains extremely rare, so the 2026 hantavirus cruise ship outbreak doesn't mean we're facing a COVID-style pandemic risk.

'Sloth fever' is an emerging health threat, especially to pregnant women

This disease, caused by the Oropouche virus, is found in animals including sloths, primates, and birds. It primarily spreads through the bite of midges—insects commonly called "no-see-ums." It's endemic to the Amazon region, but US travelers are increasingly contracting it internationally.

Three Ebola species are responsible for most large outbreaks of the disease, yet the only approved Ebola vaccine is known to work against just one of them.

The seven viruses that cause human cancers

Certain viruses have been linked to the development of human cancers. These viruses account for up to 20% of cancers worldwide, causing cancer by interacting with host proteins, proliferating within weak immune systems, and commandeering susceptible human cells. Unlike other viruses, human tumor viruses don't kill host cells, allowing them to establish persistent infections. The seven viruses include the Epstein-Barr Virus, the Human Papillomaviruses, and more.

West Nile virus found in the UK for the first time

The West Nile virus, which mainly spreads between birds and mosquitoes, was detected in the UK for the first time. While no evidence exists for any human infections, climate change may be expanding mosquitoes—and the diseases they carry—farther north.

Antimicrobial resistance is responsible for 1.3 million deaths each year

Antimicrobial resistance is a global health threat, driven by the misuse and overuse of antimicrobials in humans, animals, and more. Estimates suggest superbugs could lead to $1T in healthcare costs by 2050, and the world faces a shortage of new drug development to meet the challenge.

19 fungal pathogens are of key concern to world health officials

In 2022, this global health body issued its first-ever list of top fungal threats to human health. It said fungal threats are spreading and occurring more frequently. The WHO’s list included 19 fungal pathogens to watch, and said that the most dangerous ones to public health are Cryptococcus neoformans, Aspergillus fumigatus, Candida albicans, and Candida auris. There are only a handful of classes of medication currently available to combat fungal pathogens, with few others in the pipeline even though antimicrobial resistance is growing.

The Chinese market for donkey hides has created a new source of diseases

Since 1992, China’s donkey population has dropped more than 80 percent. This report examines how China’s booming demand for a traditional medicine known as e-jiao, made from collagen from donkey hides, is leading to the slaughter of 6 million African donkeys annually, and providing a new source for zoonotic diseases.

Major genetic shifts in flu viruses can spark global pandemics

Antigenic shift happens when two different influenza viruses infect the same host and swap genetic material. The result is a brand-new subtype of influenza which, if easily spread among people, can trigger a worldwide pandemic.

Zoo animals have developed allergies, too

Although scientists do not know if allergies manifest among wild animals—and if animals can survive with them—in a zoo setting, veterinarians have observed zoo animals with common allergy symptoms, including itchiness, crusty skin, and runny eyes. Veterinarians have identified Asian elephants with pollen allergies and at least one jaguar with an allergy to fleas.

Some animals have little or no bacterial populations in their gut

Gut microbiomes are essential to human health, but many animals have a much smaller, transient, or even nonexistent microbiome. The discoveries have advanced our understanding of the evolution of the human microbiome.

Only one strain of wild poliovirus continues to infect humans

Three strains of polio used to regularly infect humans, but two of the strains were declared eradicated in 2015 and 2019, respectively. In 2019, world health leaders estimated complete polio eradication—if achieved—would save $14B by 2050.

Biologists believe over 5,000 coyotes inhabit LA as of 2025

Panic and fear of coyotes spread in the 1980s after the first recorded instance of a human killed by the animal in American history, but LA and Chicago residents today are learning to live alongside the animal. Research shows that coyotes can even benefit urban ecosystems by helping to control populations of geese and deer, and by improving songbird survival through preying on cats.

Restaurants are where most of us contract food poisoning in the US

From 2014 to 2022, most reported foodborne illness cases occurred at restaurants. Between 2020 and 2022—when COVID-19 also likely influenced restaurant eating habits and tracking—there were only 238 foodborne illness outbreaks linked to restaurants, down from 714 the prior two years. Still, restaurants were behind most reported outbreak cases. (Some readers may experience a paywall.)

Animal phobias are likely the most common type of phobias, followed by an extreme fear of heights.

Larger animals like giraffes, elephants, and blue whales have developed a unique defense against cancer, a phenomenon known as Peto's Paradox

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

See how each of the more than two million known species relates to each other—and to common ancestors—in this zoomable tree of life.

Before humans, the Soviet Union and the United States sent animals—including apes, dogs, and cats—to space during the Space Race.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Poison ivy will likely become both larger and more resilient due to climate change.

Some Pokémon have been named after real and fictional organisms, while some real-world species have been named after Pokémon, such as Chilicola charizard and Binburrum zapdos.

Coral reefs get their colors from zooxanthellae—microorganisms that line corals' digestive tracts and provide them with sugars in exchange for a home within this protective tissue.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

Fireworks-related ER visits are on the rise—in 2024, they increased by 52% as compared to the prior year.

The American cockroach is actually from Africa, an apparent hitchhiker aboard ships carrying enslaved people, with evidence suggesting the bug may have arrived in the New World as early as the 1600s.

The deadliest aspect of volcanic eruptions is often not lava, but pyroclastic flows—avalanches of ash, gas, and rock that can move more than half the speed of sound.

In 2018, 26-year-old missionary John Allen Chau was killed by tribesmen after attempting to reach and evangelize on India's isolated North Sentinel Island

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

Radioactive elements can introduce software errors because the ionizing radiation they produce can detach electrons from atoms, and computer code relies on the distribution of electrons.

US housing costs have risen by roughly 175% between 1991 and 2026—but a growing number of Gen Zers are becoming homeowners anyway. In 2025, 4% of homebuyers were Gen Z, up from 3% the year before.

Electrical grids worldwide must double their power delivery capacity by 2050 to meet surging demand from AI and electric vehicles.

The Russia-Ukraine conflict is the largest ground war in Europe since World War II in casualties, forces mobilized, and displacement of civilians.

Chaos theory—informally known as the butterfly effect—is the reason why weather forecasts are presented with probabilities rather than certainties.

The US dollar is the most widely circulated currency in the world, and is involved in nearly 90% of global transactions

In 2019, a laptop loaded with six of the worst malware in history and described as 'an exhibit of historical weaponry' sold for $1.3M.