There is no robust evidence that topical or oral collagen peptides provide significant benefits for our skin or enhance healing.

Beginning in our 20s, the amount of this protein in our skin, muscles, and connective tissue declines. But independent, high-quality studies—like those that are double-blind—have not yet shown a significant association between their use and evidence of it improving skin elasticity, reducing wrinkles, or combating hair loss. Some collagen supplements do seem to help with joint pain and knee function, but NPR cautions that studies on that purpose are industry-funded.

Eating collagen-rich foods won't lead to more collagen in the body because your digestive system breaks down consumed collagen into amino acids. Instead, eating a healthy diet of proteins and greens helps your body to produce collagen. Collagen supplements derived from animal skin and bones are typically sold in a prebroken-down peptide formulation called hydrolyzed collagen so they can be absorbed through the gut into the bloodstream.

Marketing claims that collagen supplements or drinks will make your hair shiny, thick, and improve hair growth are not backed by scientific evidence.

Skin resurfacing vaporizes the top layer of skin to reveal healthier, new skin, while collagen can give the skin structure and elasticity. Such procedures treat scars and burns, but may leave light spots on the skin.

Watch a board-certified sports medicine therapist detail his thinking about this synthetic peptide; he says it's "promising but unproven." He notes that this product is designed to mimic the natural protein thymosin beta-4, found in human and animal tissues, which promotes wound healing. TB-500 is classified as a research peptide for recovery, meaning it's not approved for human use and has not yet undergone rigorous human trials on its safety and efficacy.

BPC-157, which purportedly helps with tissue repair and muscle growth, can cause concerning side effects, including pain and swelling. TB-500, another experimental peptide, is marketed for wound healing, but it hasn't undergone any clinical human trials, and high levels of this peptide have been linked to tumor growth.

This meta-analysis included available studies on this peptide from 1993-2024, and identified 36 studies. It found 35 preclinical (nonhuman) studies and one retrospective study in humans of musculoskeletal pain following injections of BPC-157 for unspecified chronic knee pain. In that one human study, 7 of 12 patients receiving BPC-157 reported relief after the injections (though many had injuries that often heal on their own over time).

It's an autoimmune disease that disproportionately causes worse complications in African American people for unknown reasons. It causes the body to overproduce collagen after the immune system attacks the body's own connective tissue, leading to excess collagen deposits and restricted blood circulation as small blood vessels are damaged. It can damage various organs, including the lungs.

Vitamins are molecular tools the body needs to carry out regular cellular processes, such as wound healing. This 45-minute video dives into the science behind vitamins and their role in the body. There are 13 essential vitamins that must be...

Cuts to human skin take twice as long to heal compared to chimps and other mammals. Scientists argue this is due to the reduced number of hair follicles on human bodies. Hair follicles contain stem cells which help repair skin cells faster, so as humanity shed its hair over time, so to speak, it also slowed its wound healing.

When muscles contract, they release ‘hope molecules’ (myokines) such as IL-6 and irisin. These proteins then travel through the bloodstream to reduce inflammation, improve insulin sensitivity, and even support brain repair. This piece illustrates how movement triggers a systemic healing cascade throughout the human body.

Clinical data from a couple patients in 2025 indicated that one experimental CAR-T therapy called rese-cel was able to genetically reprogram T cells to eliminate certain problematic immune B cells that were causing the condition. The therapy reduced skin thickening and allowed the patients to halt using immunosuppressive medications and steroids.

Peptide science dates back to the late 1800s with some early peptide synthesis work, but peptides took off in the medical sphere after surgeon Frederick Banting and his colleague's isolation of insulin from dog pancreases in 1921.

Skin cells responsible for healing wounds work more quickly during the daytime, underscoring that the timing of an injury greatly influences recovery time, according to 2017 research. Nighttime burns took an average of 11 days longer to heal than burns incurred during the day.

Research published in 2022 affirmed that vitamin formulations containing vitamins C and E, copper, zinc, lutein, and zeaxanthin—but no beta carotene—can enhance eye health and slow the progression of macular degeneration.

Our ability to build new myelin sheaths for nerves degrades with age. There have been research advances boosting cells that support these processes and clear away debris from degraded myelin, but not yet any medications to boost myelination itself, which would aid nerve signaling and preserve nerve function.

Some scientists have hypothesized that peptides and RNA molecules may have coevolved as a single, mixed "chimeric" molecule, fueling the beginning of protein production and predating a primitive version of the ribosome. All life today uses ribosomes to make peptides.

A 20-year study by the National Cancer Institute involving almost 400,000 people found that daily multivitamins did not help people live longer. In some cases, these vitamins also increased the risk of death. Although some subpopulations—such as those with documented vitamin deficiencies and pregnant individuals—should take vitamins, daily multivitamins should not be taken uniformly by adults. Instead, patients should discuss vitamins with their clinicians and consider baseline vitamin testing before starting vitamin regimens.

In 2013, several researchers declared multivitamins dead, stating that so-called supplements had no clear benefits and might be harmful. But the science isn't so clear-cut. This article explores the question of who would benefit from...

Across human trials, seed oils have not been shown to increase rates of disease or inflammation, with a study of over 800 Swedish men finding that higher seed oil diets were linked to living longer. Reviews of these trials found better health outcomes when saturated fats were replaced with seed oils.

Blood tests and other dietary screening tools by clinicians and nutritionists can indicate whether someone is deficient in needed vitamins or minerals, and those results can then lead to a personalized care plan that may include supplements. Supplements can negatively interact with certain medications, so it's important to speak with your doctor about supplements before taking them.

In the first half of the 20th century, peptides including insulin and adrenocorticotropic hormone were isolated from animals to provide life-saving medicines. ACTH was isolated from the pituitary glands of cows and pigs and insulin was isolated from the pancreas of dogs and cows.

Advancements such as 3D printing muscles, performing vaginal reconstruction with colon tissue, and growing organs in a lab have shown promise, but artificial options and transplanting substitutions continue to exhibit functional and performance limitations compared to their natural equivalents.

The global body has an entire section dedicated to banned peptide hormones, including ones that may stimulate growth hormones and testosterone. BPC-157 was added to the list in 2022.

We're not sure yet. Researchers at the University of California San Francisco are studying why some conditions and behaviors, such as low-oxygen environments and exercise, benefit the aging process, hoping to reveal potential health applications. Some of this research focuses on klotho, a naturally occurring age-regulating hormone named after the Greek Fate Clotho. Animal studies on klotho brain injections found subjects had improved memory recall and age-related degeneration resistance.

A study examining the muscle function of older adults who have at least one adverse childhood experience (ACE) suggests that trauma digs itself into muscle cells. Participants who reported childhood trauma were found to have lower maximum levels of cellular energy than people who reported fewer or no ACEs. Such compromised mitochondrial function "doesn't bode well," as it relates to a variety of health and age-related outcomes.

Explore a reference site that aggregates and summarizes peer-reviewed studies on hundreds of supplements and dietary interventions. It is ad-free and funded by subscriptions, making it a health resource without a financial stake in what you buy.

The protective tissues around skeletal muscles consist of elastic proteins like collagen. Stretching them expands their length while retaining strength, ideal for athletes.