The ancient Romans invented the first known artificial sweetener—it involved lead. (Paywall may apply.)

Multiple sugar substitutes were accidental discoveries when lab workers didn't wash their hands.

Saccharin was widely used in WWI when sugar was rationed

The substance was discovered by chemists in 1878, but its use became more common during World War I and also afterward as a result of sugar rationing. It had become a typical household item in the US and Europe by 1917. During World War II, the artificial sweetener again saw significant popularity.

Aspartame was a surprise discovery from a lab working on gastric ulcers

As with saccharin and cyclamate, the aspartame discovery arose from its discoverer tasting something sweet from his workplace. In 1965, American chemist James Schlatter licked a white powder off his finger as he picked up a piece of paper and was startled to discover it tasted sweet. He applied for a patent for the substance, and received it in 1970. It is now one of the most popular artificial sweeteners. (Some users may experience a paywall.)

Fake sugars may disrupt metabolic health. (Paywall may apply.)

Teddy Roosevelt was once given a daily dose of an artificial sweetener, prescribed by his doctor.

Artificial sweeteners aren't very helpful for weight loss.

Saccharin was banned in Canada in the 1970s, but regulators may allow its use once again

The product, commonly known as Sweet'N Low, was banned in Canada in the late 1970s due to research indicating that the sweetener could cause cancer in lab rats. Subsequent studies have found that the rodent findings didn't hold true for humans, and so Canadian regulators state that they are considering updating their stance to allow the product to be added to certain foods (the product is currently allowed in the US).

Michael Sveda discovered cyclamate by accident

When this lab researcher brought his hands to his lips to smoke his cigarette in 1937, he tasted something sweet, which he called cyclamate. It was quickly used in diet sodas, but it was banned from the US in 1969 after being linked to rodent bladder cancer in lab experiments.

Monsanto got its start in the early 1900s producing saccharin

The company was originally called Monsanto Chemical Works and was founded in 1901 by John Francis Queeny who was then a wholesale drug buyer. He named the company Monsanto for his wife's maiden name. At first, the company began producing saccharin with borrowed equipment and secondhand machines, aiming to produce domestically what was then being imported from Germany. (Some users may encounter a paywall.)

Vanilla was originally thought to be an additive for chocolate

The classic flavor didn't stand on its own until the 17th century, when Queen Elizabeth I's apothecary began intentionally making vanilla sweets.

Ancient Romans helped develop modern cheese production techniques

The ancient Romans loved cheese and experimented with different processes to elevate its flavor, like aging. Some of their innovations, like Pecorino Romano, you can still find today. Others, like the smoked goat-milk Caseus, we only know about through historical records.

The dark side of modern sugar production

Humanity's ancestors evolved to wring more calories from sugary fruits by storing excess sugar as fat, an adaption that's culminated in many peoples' palettes preferring calorie-rich sweet. Now, the desire for sugar has both contributed to a widespread health crisis and been at the center of atrocities around the world.

Sugar alcohols, a type of carbohydrate used as a sweetener, may elevate risk of heart attacks and strokes.

Stevia has been used to treat burns and indigestion

The substance, which is roughly 300 times sweeter than sugar and scientifically known as Stevia rebaudiana, comes from a plant that grows in Paraguay and Brazil. It has long been used medicinally and as a sweetener by indigenous communities in those locations.

See how sugar stacks up against the sweetness of sugar alternatives, which can sometimes be hundreds of times sweeter than their sugar counterparts.

In ancient Rome, toast was added to drinks

Toasted bread crumbs absorbed the acidity of bitter wine and, in some cases, added flavor. Although the term "toasting" was not yet in use, the practice was common. Some say the Roman Senate decreed in the first century CE that all citizens must drink to the honor of Emperor Augustus before every meal, though scholars debate the validity of that claim. Eventually, the literal toast became associated with the tributes.

A look at what was on the menu for ancient Romans

"Delicious Italy" is a website exploring the food culture of various Italian cities and regions, and in this article, the editors explore what is known about the diet of ancient Romans. Olives (and their oil) were a key daily essential, alongside grains like barley, millet, and spelt flour. Where meat was found it was most often ox, pork, deer, lamb, and even pigeons. Middle Eastern fruits like cherries and peaches could last long enough to travel to Roman cities around the Mediterranean, and candy-friendly dates were sourced from Africa. Explore this and much more at Delicious Italy.

Artificial sweeteners may disrupt gut health, throwing off the balance of beneficial bacteria in the gut and shifting the composition of the microbiome.

Aspirin was the first synthesized anti-inflammatory drug

Once used by the ancient Sumarians—extracted from willow bark—but now synthesized in the lab, the active ingredient of this popular medication has been used to treat headaches and pain for thousands of years.

Rome's herbal panacea may not be as extinct as we thought

Silphion: cure-all, aphrodisiac, birth control, tasty seasoning. Nero allegedly ate the last of this miracle plant. This article details how a researcher may have found more. Seven centuries after the yellow-flowered plant was first documented growing in what's now Libya, it vanished. Historians proposed that the loss of Silphion may have been the first recorded extinction of any species.

Listen to how the 1902 'poison squad' experiments changed food safety in America

As part of government research, a group of young men were paid to eat standard American food—replete with food additives like borax and formaldehyde—which revealed the dangers of unregulated food. The work was led by the first FDA commissioner, Harvey Wiley, who helped end the "century of the great stomachache."

Artificial sweeteners are considered safe for most people, but researchers are investigating their effects on gut microbiome health.

Why it's so hard to end the use of toxic lead

Lead was one of the earliest metals mined on Earth, desired for its soft malleability and used in cosmetics, pipework, gasoline, and more. But even though researchers demonstrated its toxicity in the 20th century, much of the world still uses it.

Learn the history of food science breakthroughs from the 20th century

Long after humans developed the means to produce sufficient food to feed civilizations, scientific research focused on a wide variety of objectives, such as developing methods to preserve food quality (accomplished via frozen food), speeding up cooking (leading to the microwave), and lowering the cost of sweetening food, which high fructose corn syrup provides.

Xylitol, a sugar alcohol, is sometimes added to foods at 1,000 times the level seen naturally in foods

This article covers the latest research in sugar alcohols and heart health. Some work indicates that after consuming sugar alcohols erythritol or xylitol people are at an elevated risk of developing blood clots, which can cause heart attacks and strokes. Both substances occur in low levels naturally in fruits and vegetables and are also produced by the human body, but as sweeteners in foods they are present at exponentially higher levels.

The term 'alcohol' has Arabic origins

Linguistic research reveals a lot about the ancient origins of alcohol. For example, studying various languages reveals that "mead," an alcoholic beverage made from honey, came even before wine.

Conversation candy hearts were originally message-free medicinal lozenges

In 1847, a Boston pharmacist invented a machine that automated the production of his pharmacy's medicinal lozenges and then formed the New England Confectionery Company, which later became part of the company now known as NECCO. By the late 1800s, they were producing cookies with Valentine-themed messages and eventually brought the romantic messages to their smaller lozenges, which they later called Sweethearts.

A history of Rome and wine

Wine and winemaking were integral parts of everyday Roman life. Wine was used medicinally and for religious rites, as well as for pleasure. It also contributed to the expansion of the Roman empire as wine and grapes were traded throughout the Mediterranean. Roman winemaking practices spread as the empire grew. Without Rome, wine may never have grown into what it became, and vice versa.

Sugar skulls are more than a sweet snack

The colorful candy combines Indigenous traditions with European confectionery techniques. Its symbolization reminds celebrants that death can be “sweet.”

Eduard Baltzer encouraged 'natural eating' in the 1860s

Historian Corinna Treitel credits the Protestant minister with inventing the concept of “natural eating” in Nordhausen, Germany, in the 19th century. Baltzer believed that people were consuming excessive amounts of schnapps, sugar, and meat, and that this behavior was having a detrimental impact on their lives. He encouraged a diet mostly of fruits and vegetables, though he was not opposed to food grown with artificial fertilizers.

The tradition of drinking Champagne on New Year's is believed to come from ancient Rome

Julius Caesar might not have had sparkling wine, but when the Romans created the now-standard calendar that begins on Jan. 1, they celebrated with a toast. The tradition spread throughout Europe and then the colonies, and so when Champagne became the drink of choice for special occasions, it was only natural that it became the standard New Year’s Eve sip.

Why pickles became a thing

Pickles began in Mesopotamia around 2400 BCE as a way to preserve vegetables amid heat (and spoilage). They spread through Egypt, Greece, and Rome, where Julius Caesar reportedly fed pickles to his soldiers, and brining was treated as a culinary art. The technique is broadly useful, as salt and water can extend the shelf life and deepen flavor for almost anything.

Unlike its Mexican counterpart, American Coca-Cola contains high-fructose corn syrup rather than sugar

There are a few reasons why American Coke turned away from sugar in the 1980s, but none of them are related to consumer health. This Reader's Digest article breaks down the history behind Coke's recipe change, explaining why the company continues using high-fructose cough syrup.

Britain’s bottle innovation saved Champagne

Champagne wouldn’t be where it is today without a surprising partner: 17th-century British glassmakers. An energy crisis caused by deforestation—not enough trees to burn—led to the search for an alternative fuel source. Enter coal. The plentiful resource burned much hotter than wood, creating stronger glass that could stand up to the pressure of the carbon monoxide produced by the wine’s second fermentation and solving one of the fledgling industry’s most vexing problems.

Stevia is a plant-derived sweetener but the plant isn't approved for eating

Steviol glycosides, the sweet-tasting stuff in the plant leaves, are purified and highly processed before they end up in the food or drinks sold in stores. The US Food and Drug Administration does not allow the use of stevia leaf or crude stevia extracts in food, and the agency also bars them from being imported into the US for use as sweeteners.

Cats have a mutation that prevents them from tasting sweetness, but goldfish are covered in taste buds and are ranked among the world's supertasters. (Paywall may apply.)

Gummy vitamins have candy-level sugar—and that sweetness is linked to overdoses

A typical gummy vitamin contains about the same amount of sugar in a single serving as one Sour Patch candy. It's linked to the increase in pediatric overdoses for products including multivitamins and melatonin. Gummy formulations also degrade quickly, so they often include much higher levels of the product in each serving than the label advertises—boosting overdose risks due to this unchecked variability. (Some users may experience a paywall.)

Ancient Rome had an early version of macaroni and cheese

Called placenta (with a hard "c"), the holiday dish consisted of sheets of rolled-out dough layered with cheese. It is the first recipe documenting the combination of the two elements. While there is debate about whether the dough can be called pasta because it's not boiled, many scholars view the dish as a proto-lasagna.