Monsanto got its start in the early 1900s producing saccharin, the artificial sweetener.

In 1856, a chemist accidentally discovered mauveine, the world's first synthetic dye, while trying to make quinine to treat malaria. The synthetic dyes that followed helped reveal germs under microscopes, paving the way for modern imaging techniques and breakthrough treatments, such as antibiotics.

Long after humans developed the means to produce sufficient food to feed civilizations, scientific research focused on a wide variety of objectives, such as developing methods to preserve food quality (accomplished via frozen food), speeding up cooking (leading to the microwave), and lowering the cost of sweetening food, which high fructose corn syrup provides.

As part of government research, a group of young men were paid to eat standard American food—replete with food additives like borax and formaldehyde—which revealed the dangers of unregulated food. The work was led by the first FDA commissioner, Harvey Wiley, who helped end the "century of the great stomachache."

In 1943, a moldy cantaloupe found at a market in Peoria, Illinois, yielded a strain that produced six times more penicillin. Though often credited to lab worker “Moldy Mary” Hunt, accounts differ on who actually brought in the fruit.

In 1847, a Boston pharmacist invented a machine that automated the production of his pharmacy's medicinal lozenges and then formed the New England Confectionery Company, which later became part of the company now known as NECCO. By the late 1800s, they were producing cookies with Valentine-themed messages and eventually brought the romantic messages to their smaller lozenges, which they later called Sweethearts.

The Poison Squad tells the story of government chemist Dr. Harvey Wiley who, determined to banish these dangerous substances from dinner tables, took on the powerful food manufacturers and their allies.

How harmful are today’s herbicides for us humans, and for the environments they’re seeping into? And do we really need weedkillers to feed the world?

Health food stores began opening in the ‘50s, though they were primarily focused on vitamins and holistic supplements. Natural food stores, however, provided pesticide-free produce and often relied on local farmers for their products. One of the first was New Age Natural Foods, in San Francisco’s Haight-Ashbury neighborhood, which opened in 1965.

The company's chemists were attempting to synthesize a substance that could compete with an existing patent for the best clot medicine of that time, hydrastinine. MDMA was the byproduct of that effort.

The compound monosodium glutamate has been identified in dairy, meats and vegetables, and provides an "umami"—Japanese for "tasty"—flavor to food. Studies in the late 1960s characterized MSG as harmful, but only when testing doses hundreds of times greater than what would be consumed in a typical diet.

Nylon, one of the most ubiquitous materials in the world, was invented in 1935. Chemist Wallace Carothers was hired by American conglomerate DuPont to perform research. After seven years of work he produced nylon, the first wholly synthetic fabric. Carothers’ life ended tragically, but his contributions revolutionized everything from military equipment to women’s fashion.

Monosodium glutamate myths originate from a 1968 letter to the New England Journal of Medicine, in which unpleasant symptoms after eating Chinese food were dubbed Chinese restaurant syndrome without medical data. Subsequent studies show this savory flavor enhancer—found in tomatoes, mushrooms, and other foods—is safe in moderation.

While many traditional histories credit German immigrant George Schneider with founding the Bavarian Brewery in 1852, an investigation from St. Louis Magazine found that it was actually started in 1857 by a fascinating German physician named Dr. Adam Hammer.

Humanity's ancestors evolved to wring more calories from sugary fruits by storing excess sugar as fat, an adaption that's culminated in many peoples' palettes preferring calorie-rich sweet. Now, the desire for sugar has both contributed to a widespread health crisis and been at the center of atrocities around the world.

And it's been that way for a long time—both of the sodas were created in the late 1800s in the South. Pepsi was created by Caleb Bradham, and was originally called "Brad's Drink."

Once used by the ancient Sumarians—extracted from willow bark—but now synthesized in the lab, the active ingredient of this popular medication has been used to treat headaches and pain for thousands of years.

Randy Constant sold nonorganic feed to other farmers, who fed it to their animals, which were then sold as organic meat. The scheme began sometime in the mid-2000s and ended after a tip, likely from one of Constant’s competitors, to the US Department of Agriculture. Constant pleaded guilty and was sentenced to 10 years in prison, but died by suicide before serving time.

In the 1830s, farmers were skeptical of new technology, so McCormick demonstrated the machine—described as a cross between a plow, a chariot, and a flying object—to prospective buyers. Long before modern sales norms existed, he divided the market into territories operated by agents who provided service on the machines, financing to expand the customer base, and product iteration based on feedback from regional agents.

Peptide science dates back to the late 1800s with some early peptide synthesis work, but peptides took off in the medical sphere after surgeon Frederick Banting and his colleague's isolation of insulin from dog pancreases in 1921.

The product was marketed toward women and framed excessive sweating as a medical disorder that needed to be addressed with the product.

Her 1962 book, “Silent Spring,” inspired many people to consider the chemicals used to grow their food, but Carson didn’t think that manufactured fertilizers needed to be banned from farming, writing that “The ultimate answer is to use less toxic chemicals so that the public hazard from their misuse is greatly reduced.” When she testified to Congress in 1963, she said, “I think chemicals do have a place.”

Jane Maas started as a copywriter at the advertising agency Ogilvy & Mather in 1964. She’s known for working on the famous "I Heart NY" tourism campaign alongside artist Milton Glaser. This interview provides a glimpse into what life was like for women like her on Madison Avenue.

From "Yankee cheddar" to Kraft Singles, American cheese has a long history shaped by innovation and economics. Originally a cheddar export, it evolved into the processed slices we know today—thanks to a 1916 patent. And in the 1980s, it became “government cheese,” distributed to millions.

Those involved in the predecessor of the modern scientific discipline engaged in experimentation to develop recipes that would transform ordinary matter into gold and to create medicines, cosmetics, dyes, and alloys. Over the course of centuries, scientists identified unique elements, organized them based on their properties in the periodic table, and eventually developed the technology to discover the internal structure of atoms.

Most modern processed foods rely on a number of preservatives to stay fresh from production to our plates. The most common include citric acid (preservative and flavor), sodium benzoate (preservative), xanthan gum (thickening and stabilizing), carrageenan (thickening), and red dyes 3 and 4 (for color).

In 1912, biochemist Kazimierz Funk, often anglicized as Casimir Funk, proposed that there existed an essential nutrient in food that could prevent deficiency diseases, such as scurvy or rickets. This article explores the origin of the multivitamin, an invention that has garnished...

For centuries, Type 1 diabetes was fatal. The 1920s "discovery" of insulin netted two of its creators—Frederick Banting and his boss, John Macleod—a Nobel prize. Separately, the German doctor Georg Zuelzer synthesized an effective version of the life-saving drug years earlier but was interrupted by World War I.

This investigative report examines how the Sackler family built its fortune through Purdue Pharma’s aggressive marketing of OxyContin, a highly addictive painkiller. Through 2017, the drug had generated more than $30B in sales for Purdue Pharma, controlled by the Sacklers.

A "patent medicine" is a proprietary medicine that is ostensibly created and marketed under a patent, and, crucially, is available without prescription.

Mars, Incorporated manufactures some of the world’s favorite treats, including M&M’s, Snickers, and Milky Way bars. Despite their success, you’ve probably not heard of them. The privately held company is largely unknown to the world despite being owned by the second-richest family in the US. This podcast discusses the mysterious Mars family and their remarkable entrepreneurial feat. Listen to uncover more.