The Ancient Egyptians developed the first pregnancy test—and scientists tested it in the 1960s and discovered it was accurate about 70% of the time.

Read the 1963 study testing out an ancient Egyptian pregnancy urine test

The study sought to test out the ancient Egyptian approach of having a woman urinate on barley and wheat seeds to ascertain pregnancy status. Surprisingly, the research concluded that pregnant women's urine did promote growth of cereal grains the majority of the time; nonpregnant women's urine did not. Unfortunately, the sex of the child could not be accurately predicted based on which crop grew.

Modern pregnancy tests detect a specific hormone in a woman's urine or blood

They pick up human chorionic gonadotropin, in either blood or urine. The hormone is produced by a woman's reproductive tissues during pregnancy.

The first prenatal screen for disease was developed in 1961

Scientist Robert Guthrie created a method to test newborns for a metabolic defect called phenylketonuria, or PKU. This blood test didn't look for gene variants—it hunted for excess phenylalanine in the blood. The disorder is caused by an inability to digest the amino acid phenylalanine, leading to excess phenylalanine in the body. PKU results in intellectual disability, seizures, and other symptoms if it isn't caught early and treated with a specialized diet.

Many of the new prenatal genetic tests for rare genetic conditions are inaccurate

Established screening tests for Down syndrome in utero are reliable and accurate. But a New York Times investigation into expanded prenatal genetic tests for very rare diseases—much rarer than Down syndrome—found that more than 80 percent of the positive test results turned out to be wrong based on follow-up testing. These expanded tests for rare diseases are performed from a blood draw at 10 weeks of pregnancy and aim to detect chromosomal abnormalities linked to rare diseases. Companies that offer these controversial tests counter that it's only a screening test—not a diagnosis—picking up true positives and noting that patients can and should be counseled about what the findings mean. (Some users may encounter a paywall.)

The first successful IVF pregnancy was in the United Kingdom in 1978

Gynecologist Patrick Steptoe and his collaborator Robert Edwards, a biologist, attempted to fertilize a human egg cell in a petri dish 101 times before finally succeeding. This resulted in the birth of Louise Brown—at the time referred to as a "test tube" baby—in 1978, who was born into the spotlight.

Scientists first observed a sperm and an egg uniting in 1876

Throughout human history, scholars and researchers have speculated on the origin of human reproduction. It wasn't until the late-19th century that the physical process of egg fertilization via sperm cells was observed (in sea urchins), forming the basis for modern fertility research.

The pregnancy test industry is worth roughly $769M

The inventor of the at-home pregnancy test, Margaret Crane, largely hasn't taken credit for her invention until recently.

Only about 0.0001% of sperm, on average, successfully reach the uterine cavity

We've evolved to make pregnancy a complex and difficult process. From the initial development of the blastocyst, to the energy and nutrients needed to grow a new human, our bodies are both fighting and supporting fetal development.

Due date is calculated from the first day of the last menstrual period—not when sex occurred

The standard counting system considers a woman pregnant from the first day of her last menstrual period, which means someone may technically—for the purposes of measurement—have become pregnant even before she had sex. This standard starting point is used because it reliably marks when the body began preparing for pregnancy—even though it's typically two weeks before conception. On average, most women are pregnant for 280 days from the last menstrual period.

The history of ectogenesis and artificial wombs

While the science of artificial wombs is new, the idea goes back to a 1923 Heretics Society of the University of Cambridge lecture where an English biologist was one of the first people to propose an egg could be fertilized outside the womb. This...

Ancient Egyptian papyrus from 16th century BCE seems to reference tinnitus

Ancient Egyptians wrote that they treated "bewitched ear" with herbal concoctions that involved frankincense and other ingredients, which were placed in the ear.

Reconstructing an average day in ancient Egypt

Egyptologists can reconstruct the intimate details of everyday life in the ancient civilization by studying the archaeological material preserved in tombs, monuments, and partially intact neighborhood layouts. Watch a comprehensive tour of the daily habits and lifestyles of ancient Egyptians with expert Dr. Joann Fletcher.

Premarin, the hormone medication derived from pregnant horses, is 'PREgnant MARes urINe'

Scientists in the late 1920s and early 1930s discovered estrogens could be extracted from human placenta, and then isolated it from the urine of pregnant women. But researchers discovered the urine of pregnant horses had similar substances and the horse product was much easier to collect in significant amounts—leading to Premarin.

Two dogs were able to detect prostate cancer in 98% of patients in one study

In this small study published in 2015, two highly trained German Shepherd dogs sniffed hundreds of urine samples and were able to accurately detect prostate cancer—sniffing out certain volatile organic compounds—in almost every single case. One dog was correct 98% of the time and the other correctly identified patients 100% of the time. (Some users may encounter a paywall.)

The earliest record of dream interpretation dates to Ancient Sumer, an analysis of a Sumerian priest king's dream around 2700 BCE.

Genetic blood test offers an estimated clock on when Alzheimer's symptoms may appear

The 2026 research finding from researchers at Washington University School of Medicine in St. Louis—if validated in broader populations—suggests that an already available blood test could estimate when Alzheimer's symptoms may begin within a margin of several years. The test detects a protein called p-tau217 found in blood plasma and the researchers incorporated the findings from that blood test into a statistical model to come up with the symptom timeline predictions.

Modern genetic testing stems from a 1950s discovery about the cause of Down syndrome

Scientists found that an additional copy of chromosome 21 causes the disease and developed an approach to stain chromosomes so they could be manually sorted and counted, which is called karyotyping. The breakthrough discovery by Marthe Gautier, a young French doctor and cytogenetics researcher, was appropriated by a male colleague, who listed himself as the lead author of the study reporting the finding.

The Ishango bone suggests mathematics was born about 20,000 years ago

Ancient civilizations developed mathematical systems for various purposes, including the Egyptians for the construction of the pyramids and the Ancient Greeks for logical reasoning in theorems. However, these systems were predated by the Ishango bone—found in the Democratic Republic of the Congo—whose notches suggest a base ten system, prime numbers, and simple mathematical operations.

Silicon Valley startups Orchid, Nucleus, and Genomic Prediction are selling so-called polygenic tests for prospective parents

These tests claim to show how at-risk a hypothetical baby would be for genetic syndromes. The newfound industry has prompted ethical and medical debates, with critics questioning their accuracy and highlighting the potential problems behind pursuing the perfect baby.

Pregnancy at older ages increases the chances of fetal abnormalities

Chromosomal irregularities are more likely at older maternal ages so genetic testing for a fetus of mothers-to-be at age 35 and older is often recommended. Conditions that can be screened for in utero include cystic fibrosis, Tay-Sachs disease, sickle cell disease, Down syndrome, spina bifida, Duchenne muscular dystrophy, and more.

How women grow tiny humans inside of them

Pregnancy is a complex biological journey, lasting about 40 weeks. When a sperm fertilizes an egg, that event triggers intricate cellular and hormonal processes, driven by hardwired cellular instructions, which lead to cell division, differentiation, and development—ultimately culminating in the birth of a baby.

Without mummies, ancient Egyptians feared their souls would perish

The ancient Egyptians placed major importance on mummification because of their beliefs about the afterlife. They believed a preserved body was essential for the soul’s survival, as it needed a physical form to return to. Without it, they feared the soul would perish.

Nail art can be traced back to 5,000 BCE

Archaeologists discovered Egyptian mummies with nail art and henna-tinted fingertips. The trend would continue informally for centuries until Revlon introduced modern nail polish in 1932.

Why are archaeologists brewing ancient beers?

Archaeologists have managed to brew beer from yeast found inside jugs abandoned thousands of years ago. This article explores why scientists are recreating these ancient beverages and what they hope to learn. People have been drinking beer for...

Ancient Egyptians played Senet, a board game where players threw sticks or bones as dice.

An Egyptologist answers questions from the internet

Professor of Egyptology and Archaeology Laurel Bestock answers your questions about ancient Egypt from X. What did ancient Egyptians sound like? Why is King Tut so enduringly popular? What ancient Egyptian medicine and tools do we still use in modern times?

Calculate your chance of success for IVF treatments

The efficacy of in vitro fertilization procedures varies widely based on age, health history, genetics, and more. This CDC calculator provides an estimate of success rates based on your personal information, relying on thousands of reported outcomes across the US.

Trials ongoing for a 99% accurate, AI-powered blood test

The UK's National Health Service has launched a trial for a blood test that can detect a dozen types of cancers with just ten drops of blood. An AI tool looks for genetic material known to be released by tumors, allowing for cancer detection before tumors are large enough to be imaged.

Researchers once thought Stonehenge functioned as a precise astronomical computer

In the 1960s, scientists used early computers to analyze the stone layout at Stonehenge, arguing it could predict eclipses and other celestial events. This BBC Sky at Night Magazine piece explains how the theory arose—and why scholars now doubt it.

The ultrarare 'Er' blood type has been documented only about 40 times

In 2022, the tragic loss of a pregnancy led researchers to the discovery that the rare "Er" blood type could potentially cause a mismatch in blood types between mother and fetus during pregnancy, with devastating consequences. (Some users may encounter a paywall.)

Four astronomical discoveries from ancient Greece

Modern astronomy relies on making discoveries without being present on the planets, stars, galaxies, and other objects studied. Imagine the difficulty the ancient Greeks had studying them without computers and telescopes. Yet somehow they calculated precise measurements of planetary distances, sizes, and more. Read this page to learn more about early triumphs in astronomical science.

A timeline of key events during each period of Egyptian history

This timeline shows the dates, periods, dynasties, and significant events in the history and art of ancient Egypt from the Predynastic Period (before 3100 BCE) to the end of the Roman Period (395 CE).

The Rosetta Stone praised the Pharoah Ptolemy V in the 196 BCE

Since its discovery in 1799, 27 other copies have been found throughout Egypt, the most recent in 2011. Dr. Ilona Regulski, curator of ancient writing at the British Museum, discusses the crucial artifact and its specific content.

The Royal Game of Ur, which dates back as far as 2600 BCE, is believed to be one of the oldest board games in the world.

The ancient Egyptians built prototypes of the modern Suez Canal

The idea to facilitate trade between the Mediterranean Sea and the Red Sea and connect the Eurasian continent was apparent even to pharaohs in the second millennium BCE. Though no physical traces remain, contemporary accounts attest to early, shorter versions of the canal, including from Herodotus.

Tour the ancient world via beer

What did the people of yesterday make of beer, and how exactly did they make it? Explore the timeless beverage in this guide to ancient beers from around the world. Archaeological evidence suggests the rise of beer brewing may have coincided with humanity's shift from hunters to farmers. According to this article, beer was first enjoyed in ancient Mesopotamia, where paintings, poems, and myths glorified the porridge-like brew.

A particle accelerator allowed researchers to noninvasively examine a mummy

The mummy hailed from the Faiyum oasis, where Egyptian and Roman cultures intersected, and was analyzed using the Advanced Photon Source at Argonne National Laboratory. The device used high-energy X-rays to probe the material composition of numerous objects embedded deep inside the mummy without damaging its remains.

Scientists are reconstructing ancient smells—including a 3,500-year-old ancient Egyptian mummy

Researchers explain how they have recreated the scent of ancient Egyptian mummies and enabled museum-goers to experience that scent on specialized cards. The exhibit will be at the Royal BC Museum in Canada in June 2026.