Microbiologists are saving the lives we cannot see

Cutting-edge microscopy has revealed previously unseen interactions of biological molecules within their cellular environment, enabling scientists to observe and analyze the molecules in a holistic view. This podcast explains the minute advancements made over the last few decades in observing cells, revealing how scientists have come and what the future holds for the field.

Superbugs are a very real problem, but researchers around the world are working to advance our understanding of these pathogens and develop new medicines. This podcast talks with several scientists on the frontier of superbug research, offering insight into what we know—and what the future of medicine may look like.

Microbes break down proteins and fats and produce compounds with distinct tastes. These microbes can include bacteria (like the one used to give Swiss its trademark holes), molds (like the ones that give blue cheese its distinctive veining), and countless other tiny organisms.

In 1958, English ecologist Charles Elton suggested that diverse ecosystems should be more resistant to invasive species because gaining a foothold would be more challenging when resources are more thinly spread. However, in lab-grown microbial ecosystems with greater biodiversity, population volatility opened more ecological roles that invasive species could easily fill.

A Stanford microbiologist explores what we don't yet know about the gut microbiome—such as whether we can engineer the bacterial species within it—and the current scientific advances in the field.

Molecules such as DDT, a synthetic insecticide, and PFAS—"forever" chemicals used to make products resistant to heat, water, and grease—have historically been used across various industries but are now known to be harmful. Microbes that can convert some of these substances into nontoxic products, such as water and carbon dioxide, have already been identified, with ongoing research to find others.

Through gene editing and the deployment of artificial cells, scientists can leverage learnings from the genetic sequencing of animals with known resistances to protect endangered species. Gene editing of certain species, such as mosquitoes, can also reduce their ability to spread diseases like malaria between humans.

A bloom estimated to contain about 100 sextillion microbial cells broke down much of the 4.1 million barrels of spilled crude oil into nontoxic compounds in what was one of the most significant bioremediations of a human-made disaster. The microbes involved acted similarly to the first patented genetically modified organism in US history: an oil-eating bacterium engineered in 1971.

Jump to: What is the microbiome? How microbiota benefit the body The role of probiotics Can diet affect one’s microbiota? Future areas of research What is the microbiome? Picture a bustling city on…

Also known as entomoremediation, the novel approach uses larvae and adult insects, including their gut microbiomes and associated enzymes, to extract or degrade pollutants. As of 2025, research has shown that black soldier flies can degrade a wide range of antibiotics, highlighting their potential for bioremediating antibiotic-contaminated organic waste.

Possessing unique biochemicals that can detoxify extreme environments and resilience against the Martian surface that is lethal to humans, scientists are exploring whether colonies of these organisms can transform small areas of the Red Planet into future habitats for humans. Extremophiles may also be best equipped to serve as microscopic factories for the fabrication of essential polymers.

A look at how researchers filtered the air around two zoos and identified genetic material from dozens of species, a technique that could help track and conserve wildlife.

Some species are used to quickly study the effects of human diseases and treatments because they are short-lived and have similar systems to those found in humans. Bacteria, like E. coli, have been used as human proxies given their rapid growth and ease of genetic manipulability.

The increased use of antibiotics combined with an aging population, is projected to result in an almost 50% increase in global deaths from antimicrobial resistance each year. At the same time, antibiotic use for livestock is expected to increase by 30% over the same time frame.

While DNA in soil and water samples has long been used for such analyses, airborne DNA is being incorporated into such efforts to monitor individual species abundance, detect invasive species, measure biodiversity, and determine the success of conservation actions. Future work may include detecting attacks from biological weapons.

These specialized immune cells are first responders during inflammation, responding to a threat or injury and then performing other inflammatory response tasks, including summoning neutrophils to help attack invaders.

In 2024, researchers published an incredibly detailed study aimed at predicting the real-world impact of antimicrobial resistance over the next 25 years. The key findings were clear: the superbug crisis is poised to get much worse and needs to be addressed. This article offers a clear, concise overview of the study, which was published in The Lancet.

How fermented foods shaped the immune system of humans and great apes over time, and why foods like sauerkraut may be important for the human body.

Through biostimulation, Indigenous microbes are provided with moisture, nutrients, or oxygen to prevent their death and ensure optimal progression of their biochemical reactions. Bioaugmentation can introduce new microbial cultures to target specific compounds not natively found in the environment, while landfarming can spread or aerate contaminated soil to improve access to contaminants.

This overview from the National Institutes of Health provides a deeper (but still accessible) look at the different bacteria in the gut, how the microbiome develops through life, its purpose, and more.

A 2002 exhibition at Montana State University-Bozeman placed the bacteria onto petri dishes that served as macroscopic pixels to create images. Once the bacteria finished eating all the food in the sealed dishes, the light slowly faded away, ending the exhibit.

Anna Dumitriu's bioart piece was created to commemorate the 75th anniversary of the first use of penicillin in a human patient and intends to raise awareness about the rapid development of antibiotic-resistant pathogens by using bacteria that have essentially been transformed into their pre-antibiotic era state.

Margaret Talbot spotlights the rise of DIY biology in community labs, where amateur scientists—often outside formal institutions—create everything from insulin to prosthetic prototypes. These grassroots biohackers challenge traditional science by pursuing open, accessible innovation, raising questions about credibility, ethical oversight, and acceptance by mainstream researchers.

Marine plastic pollution has been studied for decades, but the extent and effects of plastic pollution elsewhere is only just beginning to be explored.

The most diverse group of organisms on the planet are in trouble, with recent research suggesting insect populations are declining at an unprecedented rate. Explore this visual interactive on the issue from Reuters Graphics.

Researchers are investigating different strategies to determine if one day they could give people a combination of gut microbes to set them up for fewer allergies. In animal research, scientists have already prevented severe allergic responses in allergy-prone mice—supplying them with gut microbes from healthy, non-allergic human babies.

The gut microbiome is a microscopic ecosystem that runs off the work of microbes in the digestive tract. These workers make getting energy from food possible. What and how that energy manifests depends on what building blocks these microbes have to work with, meaning their composition and functions are strongly influenced by diet. Gut microbes have their own genes, which affect how a person's genes act.

Antimicrobial resistance is a global health threat, driven by the misuse and overuse of antimicrobials in humans, animals, and more. Estimates suggest superbugs could lead to $1T in healthcare costs by 2050, and the world faces a shortage of new drug development to meet the challenge.

The Berkeley Pit, an open-pit copper mine in Butte, Montana, that ceased operations in 1982 and is now filled with highly acidic water, is home to various species of fungi and yeast. These extremophiles produce unique compounds that may have anti-inflammatory benefits and have already been used to create an antibiotic for staph infections.

The presence of microplastics in instruments, surfaces, and air has made accurate measurement of their levels in lab samples difficult, given the high likelihood of contamination. While the use of stainless steel tools in a sealed, clean lab may reduce accidental exposure, existing methods can misidentify biological substances, such as fat, as plastics, further complicating research.

The winners of Nature's 2025 photo competition capture the essence of scientific fieldwork in diverse and challenging environments. From a biologist battling waves for whale research to ice core drilling in polar night conditions, this gallery details the research being each winning photo.

These extremophiles have adapted to biomes with very high concentrations of metals and toxic chemicals by developing mechanisms to isolate these substances within cellular compartments and break them down into less harmful forms with specialized proteins. They have the potential to support the decontamination of metal-rich wastewater and soil, as well as the extraction of rare-earth metals.