Medical advances that manage to resuscitate people from comas and cardiac arrests have enabled new research into the brain activity of people experiencing near-death experiences and a new (contested) explanation about why they occur.

The main criticism of a recent neurophysiological explanation for near-death experiences is that these events are too complex to be explained as a neurochemical response to an oxygen-deprived brain.

The body's response to cardiac arrest has been linked to near-death experiences.

A radiation oncologist has studied near-death experience reports for over 25 years and compiled around 4,000 accounts in the hopes of finding more patterns that would reveal insights about consciousness and humans' final moments before or around death.

What happens in a dying brain?

Near-death experiences usually happen during death or on the border of life and death when a person isn't understood to be conscious. This article details the science of what's going on with the brain during NDEs.

A near-death experience is a phenomenon reported by roughly 5% of the population, typically occurring after a traumatic physical event or a brief clinical death.

A leading expert on near-death experiences, psychiatrist Dr. Bruce Greyson, says that during his decades of research on this topic, this area of research has become far more mainstream and accepted as a rigorous area of inquiry.

Some scientists argue NDEs are constructed by the brain, not actually experienced

Despite the powerful memories associated with NDEs, scientists question the idea that the experiences prove consciousness endures after death, opting instead to find physiological explanations for common reports of out-of-body experiences, euphoric and lucid thinking, and more.

Brain activity sometimes goes into overdrive around the point of death according to researchers' recent analysis of patients' brains before and after they were taken off their ventilators.

Accounts of near-death experiences share similarities with hallucinogens, with reports of mystical-like states of consciousness across both contexts.

NDEs typically change people's outlooks drastically and can prompt depression

The phenomena are regularly categorized as hallucinations, but some specialists are interested in their psychological nuances. Many survivors report feeling less anxiety about death, though some surveys show the experiences can increase physiological sensitivities.

Near-death experiences can be reminiscent of religious visions, yet people across different faiths as well as those with no declared religion have reported them.

The oldest medical report of a near-death experience dates to around 1740.

Meet the Dutch cardiologist who believes consciousness can exist outside the body

Dutch cardiologist Dr. Pim van Lommel conducted one of the largest studies of near-death experiences following cardiac arrest, publishing the results in the prestigous journel The Lancet. He later went on to argue (to significant criticism from peers) that his findings suggest consciousness can exist outside the body.

Scientists are studying dying patients' brain activity in the final moments of life

In the final moments of life there are distinctive bursts of coordinated neural activity. Researchers are interested in parsing that data to better understand the dying process and also exploring how this data relates to our understanding of consciousness.

Psychiatrist Bruce Greyson created a scale to identify and rate NDEs

Researcher Bruce Greyson is one of the world’s leading experts on near-death experiences. This article explores what the field of NDE research has learned over the last five decades, discusses the difficulties of studying such a controversial topic, and outlines what we’ve ruled out as the cause of these events.

Near-death experiences have been reported across cultures for millennia.

The University of Virginia has the nation's most established near-death studies division, but institutions including the University of Southampton, the University of Connecticut, and the University of North Texas have also explored the field.

Four in 10 CPR patients report consciousness not captured by standard measures.

A 'paranormal activity' unit at the University of Virginia studies challenges to mainstream scientific ideas about human consciousness.

Research advances suggest death takes much longer than we realized

Recent research indicates that organs, including the brain, are better at handling a lack of oxygen after the heart stops beating than previously known. Such findings may open up possibilities that include someday reversing certain death processes and expanding the availability of organs available for organ donations. (Some users may experience a paywall.)

Brain death is a uniquely modern problem stemming from modern ventilators.

Terminal lucidity is the phenomenon of sudden, heightened mental clarity when on the verge of death

The "Let's Talk Near Death" podcast explores phenomena around the end of life, inviting guests to recount their own experiences. This episode focuses on the phenomenon known as "terminal lucidity," where patients experience clarity, vivid memory recall, and more, typically following a heart attack, stroke, or other trauma.

Listen to an avowed rationalist discuss his frightening near-death experience visions from 2020 and how it changed his life outlook.

Watch this 2021 video demonstrating a full brain death examination

This video and accompanying article in the peer-reviewed New England Journal of Medicine show the then-standard steps of a full brain death examination—demonstrating the process on a medical dummy to search for pain, blinking, eye movement, cough, gagging, or other forms of responsiveness. (May need to sign up for a free account to view.)

See the 16-question Greyson questionnaire on near-death experiences and how they're scored.

The neuroscience of heartbreak

An analysis of functional MRIs revealed a difficult fact: the active brain areas of people experiencing heartbreak were very similar to those actively in love. This is a major reason why people in the middle of rejection can't accept the reality of their loss. This article breaks down the various changes in neurotransmitters and neural pathways for those enduring that universal experience, heartbreak.

Dream interpretation has evolved from ancient mystical explanations, to dream reports, to tracking electrical activity in the brain and more.

The Lazarus Effect is when a heart begins beating on its own after declared death

Formally called autoresuscitation, this rare phenomenon occurs when someone is declared dead following a cardiac arrest but their heart beats again without help—making it seem like the person came back to life. Doctors don't know the exact cause.

Studies of psychedelic use may help shed light on the nature of consciousness

The nature of consciousness—what it is, where it comes from, and how it manifests as moment-to-moment experience—remains under debate by scientists. Recent studies show psychedelics were found to boost low-frequency brain signals known as delta waves, a behavior also seen during dream states.

Pig brain cellular activity was restarted hours after death in study published in 2019

Yale University scientists restored basic cellular activity and circulatory function in pig brains about four hours after death with a synthetic cocktail of preservatives and nutrients. This work— which didn't restart electricity activity in the brain or consciousness—could help advance future human stroke and brain injury treatments.

The dreaming brain, as understood by scientists

Technology has advanced to where the seemingly separate fields of psychology and neuroscience are asking the same questions about dreams, such as whether they're more closely related to perception or visualization. Some field-intersecting findings include research that shows people with impaired face perception don't dream of faces, those with brain legion-related cognition difficulties deal with similar issues in dreams, and children's dreams change in parallel to their cognitive development.

Neural interfaces offer major medical potential but raise serious ethical concerns

Although brain-computer interfaces can help people recover lost functions and allow direct brain-to-computer communication in the future, surveys have shown little public support for using them to boost abilities like memory or focus in healthy people.

The neurobiology of meaningfulness: the benefits of psychedelics

Psychedelics produce powerful emotions in its users, including a profound sense of meaningfulness. The philosopher William James called this sense "noetic" in the late 19th century, but for decades researchers avoided studying the effects of such drugs on the brain. However, the recent resurgence in psychedelic research has heightened interest in the relationship between this noetic sense resulting from the therapeutic use of drugs. Learn what researchers have found out here.

Thanatology is the study of death and dying.

In 1968, a Harvard Medical School committee issued the first neurological definition of death

The definition set a legal and medical precedent for how we define death, important for issues including organ donation. This 2020 video podcast discusses the history of brain death controversies and the variability in how death has been determined, including discussions in the late 1960s about when patients are considered dead in the context of organ donations.

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

Brain death is a top source of organ donation

Brain death is a significant source of organ donations because patients declared brain dead and hooked up to intensive care unit machines will still have oxygen flowing to organs like the heart, lungs, and kidneys—preserving those organs.

Research suggests the brain maintains connections to lost limbs

Decades-old research suggested brain reorganization after amputations, but brain scans show unchanged limb representations. Phantom limb pain may result from such unchanged brain maps, which may enhance prosthetic limb control in brain-computer interface technology.

Grief rewires the human brain

The human brain handles stress and emotional traumas similarly. In response to the emotional stress of a situation like the death of a loved one, divorce, or abuse, the brain may strengthen or weaken connections between nerves to form new neural connections. Over time, chronic stress can diminish brainpower, reducing overall nerve growth and memory to shift resources to enable elevated fear responses and enable humans to survive.

Why 'spacing out' or dissociating may help reduce trauma awareness

Dissociation may have developed as a defense mechanism in the brain to help navigate intense emotional or physical situations by providing out-of-body experiences that put distance between the mind and the environment. However, in about 1.1% and 1.5% percent of the general population, a severe form of this separation can produce alternate identities, or alters.

Sleep is no longer considered a binary state—scientists are seeking to map a variety of liminal states between sleep and waking, including the hypnagogic state associated with boosts of creativity.

Brain death is a top source of organ donation

Brain death is a significant source of organ donations—approximately 40% of organs in the US and the UK are recovered from people who experience brain death. Patients declared brain dead and hooked up to intensive care unit machines will still have oxygen flowing to organs like the heart, lungs, and kidneys—preserving those organs.

Can physics explain where consciousness comes from?

Consciousness is a complex emergent phenomenon of the brain, which is primarily composed of neurons and glial cells. Since all matter is composed of atoms that follow the laws of physics, there may be quantum processes beyond classical electrochemical interactions that can explain where consciousness comes from.

How can octopuses and MDMA help scientists understand the human brain?

Research shows that psychedelics may induce something called "critical periods" in the adult brain, which can make our brains more open to learning and changing, like they once were back in early childhood. Psychedelics similarly change how social creatures like octopuses behave, which demonstrates that these animals could help us better understand our own neurobiology.

The study of dreams, formally called oneirology, has evolved over the centuries, from anecdotal interpretations to advanced brain imaging.

How seizures (potentially) alter consciousness

Seizures occur when intense electrical activity floods the brain, prompting significant loss of self-control and a variety of sensory disruptions and hallucinations. Cultures interpret the episodes differently, with many contemporary norms viewing them as negative while others characterize them as intense spiritual occasions. Author Fyodor Dostoyevsky viewed his seizures this way, as well as cultures in Mongolia, some Shamanic indigenous religions, and others.

An essay exploring how living day-to-day with a brain implant helps restore a sense of identity

Companies like Neuralink are experimenting with volunteers who have lost control over their bodies. Many of the program's participants claim the most significant benefit from the tool is the ability to perform simple, mundane tasks, such as playing video games or shaking hands, rather than more obvious milestones like walking or eating. This essay explores what it's like, day to day, to use a brain implant.

Researchers have investigated the benefits of extreme pain rituals, exploring how and why we engage in these events when humans generally naturally avoid pain and perceive it as a negative experience.

Brain conditions and surgery can cause some individuals to feel no fear

Fear is a survival mechanism that originates in the brain's amygdala, triggering the body's fight-or-flight response. However, in modern society, without the same natural dangers, fear can lead to anxiety and mental health issues when unnecessarily triggered. Understanding individuals without fear may help identify new methods to treat anxiety disorders.

Explore the biology of pain and why the experience of pain may differ widely from one person to another.