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The main criticism of a recent neurophysiological explanation for near-death experiences is that these events are too complex to be explained as a neurochemical response to an oxygen-deprived brain.

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A recent theory to explain why near-death experiences occur was put forth in 2025 in the journal Nature Reviews Neurology. It posits that NDEs are “episodes of disconnected consciousness" due to oxygen deprivation in the brain. The explanation is called the Neurophysiological Evolutionary Psychological Theory Understanding Near-Death Experience, or NEPTUNE.
An academic critique of NEPTUNE, published in a peer-reviewed journal by two leading near-death experience researchers, including Bruce Greyson who created the Greyson scale for defining NDES, argues that NEPTUNE falls short because NDEs don't seem like typical neurological hallucinations—they are multi-sensory and aren't easily forgotten.
Another aspect of NEPTUNE suggests that the out-of-body feeling common in near-death experiences results from a flood of neurotransmitters that activate a region of the brain called the temporoparietal junction.
Critics contend that though temporoparietal junction activation can result in feelings of disembodiment, visual perception would remain normal, and people experiencing NDEs report seeing inexplicable things, including standing above their own bodies.
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