The main criticism of a recent neurophysiological explanation for near-death experiences is that these events are too complex to be explained as a neurochemical response to an oxygen-deprived brain.

Medical advances that manage to resuscitate people from comas and cardiac arrests have enabled new research into the brain activity of people experiencing near-death experiences and a new (contested) explanation about why they occur.

A leading expert on near-death experiences, psychiatrist Dr. Bruce Greyson, says that during his decades of research on this topic, this area of research has become far more mainstream and accepted as a rigorous area of inquiry.

Some scientists argue NDEs are constructed by the brain, not actually experienced

Despite the powerful memories associated with NDEs, scientists question the idea that the experiences prove consciousness endures after death, opting instead to find physiological explanations for common reports of out-of-body experiences, euphoric and lucid thinking, and more.

A near-death experience is a phenomenon reported by roughly 5% of the population, typically occurring after a traumatic physical event or a brief clinical death.

A radiation oncologist has studied near-death experience reports for over 25 years and compiled around 4,000 accounts in the hopes of finding more patterns that would reveal insights about consciousness and humans' final moments before or around death.

The body's response to cardiac arrest has been linked to near-death experiences.

Accounts of near-death experiences share similarities with hallucinogens, with reports of mystical-like states of consciousness across both contexts.

What happens in a dying brain?

Near-death experiences usually happen during death or on the border of life and death when a person isn't understood to be conscious. This article details the science of what's going on with the brain during NDEs.

Psychiatrist Bruce Greyson created a scale to identify and rate NDEs

Researcher Bruce Greyson is one of the world’s leading experts on near-death experiences. This article explores what the field of NDE research has learned over the last five decades, discusses the difficulties of studying such a controversial topic, and outlines what we’ve ruled out as the cause of these events.

NDEs typically change people's outlooks drastically and can prompt depression

The phenomena are regularly categorized as hallucinations, but some specialists are interested in their psychological nuances. Many survivors report feeling less anxiety about death, though some surveys show the experiences can increase physiological sensitivities.

The oldest medical report of a near-death experience dates to around 1740.

See the 16-question Greyson questionnaire on near-death experiences and how they're scored.

Brain activity sometimes goes into overdrive around the point of death according to researchers' recent analysis of patients' brains before and after they were taken off their ventilators.

Near-death experiences can be reminiscent of religious visions, yet people across different faiths as well as those with no declared religion have reported them.

The University of Virginia has the nation's most established near-death studies division, but institutions including the University of Southampton, the University of Connecticut, and the University of North Texas have also explored the field.

Near-death experiences have been reported across cultures for millennia.

Listen to an avowed rationalist discuss his frightening near-death experience visions from 2020 and how it changed his life outlook.

A 'paranormal activity' unit at the University of Virginia studies challenges to mainstream scientific ideas about human consciousness.

Meet the Dutch cardiologist who believes consciousness can exist outside the body

Dutch cardiologist Dr. Pim van Lommel conducted one of the largest studies of near-death experiences following cardiac arrest, publishing the results in the prestigous journel The Lancet. He later went on to argue (to significant criticism from peers) that his findings suggest consciousness can exist outside the body.

Can physics explain where consciousness comes from?

Consciousness is a complex emergent phenomenon of the brain, which is primarily composed of neurons and glial cells. Since all matter is composed of atoms that follow the laws of physics, there may be quantum processes beyond classical electrochemical interactions that can explain where consciousness comes from.

Brain death is a uniquely modern problem stemming from modern ventilators.

Scientists are studying dying patients' brain activity in the final moments of life

In the final moments of life there are distinctive bursts of coordinated neural activity. Researchers are interested in parsing that data to better understand the dying process and also exploring how this data relates to our understanding of consciousness.

Terminal lucidity is the phenomenon of sudden, heightened mental clarity when on the verge of death

The "Let's Talk Near Death" podcast explores phenomena around the end of life, inviting guests to recount their own experiences. This episode focuses on the phenomenon known as "terminal lucidity," where patients experience clarity, vivid memory recall, and more, typically following a heart attack, stroke, or other trauma.

The neurobiology of meaningfulness: the benefits of psychedelics

Psychedelics produce powerful emotions in its users, including a profound sense of meaningfulness. The philosopher William James called this sense "noetic" in the late 19th century, but for decades researchers avoided studying the effects of such drugs on the brain. However, the recent resurgence in psychedelic research has heightened interest in the relationship between this noetic sense resulting from the therapeutic use of drugs. Learn what researchers have found out here.

Watch this 2021 video demonstrating a full brain death examination

This video and accompanying article in the peer-reviewed New England Journal of Medicine show the then-standard steps of a full brain death examination—demonstrating the process on a medical dummy to search for pain, blinking, eye movement, cough, gagging, or other forms of responsiveness. (May need to sign up for a free account to view.)

Research advances suggest death takes much longer than we realized

Recent research indicates that organs, including the brain, are better at handling a lack of oxygen after the heart stops beating than previously known. Such findings may open up possibilities that include someday reversing certain death processes and expanding the availability of organs available for organ donations. (Some users may experience a paywall.)

The dreaming brain, as understood by scientists

Technology has advanced to where the seemingly separate fields of psychology and neuroscience are asking the same questions about dreams, such as whether they're more closely related to perception or visualization. Some field-intersecting findings include research that shows people with impaired face perception don't dream of faces, those with brain legion-related cognition difficulties deal with similar issues in dreams, and children's dreams change in parallel to their cognitive development.

How can octopuses and MDMA help scientists understand the human brain?

Research shows that psychedelics may induce something called "critical periods" in the adult brain, which can make our brains more open to learning and changing, like they once were back in early childhood. Psychedelics similarly change how social creatures like octopuses behave, which demonstrates that these animals could help us better understand our own neurobiology.

How specialized oxygen mixtures like heliox enable deep diving without feeling drunk

Beyond a depth of about 30 meters (98 feet), if divers are breathing surface air, which is about 78% nitrogen, underwater pressure forces more nitrogen into the bloodstream and induces nitrogen narcosis, whose symptoms resemble alcohol intoxication. Through saturation diving, where nitrogen is replaced with helium—an inert gas—deep divers can maintain cognitive function while working for extended periods.

Studies of psychedelic use may help shed light on the nature of consciousness

The nature of consciousness—what it is, where it comes from, and how it manifests as moment-to-moment experience—remains under debate by scientists. Recent studies show psychedelics were found to boost low-frequency brain signals known as delta waves, a behavior also seen during dream states.

Dream interpretation has evolved from ancient mystical explanations, to dream reports, to tracking electrical activity in the brain and more.

Explore the biology of pain and why the experience of pain may differ widely from one person to another.

How science explains déjà vu

Take a fun look at the science explaining the odd experience of déjà vu, which some theories suggest is actually a sign of a healthy brain.

Humans experience the world subjectively. What does that mean for scientific research?

When you close your eyes, do you see static or colorful patterns or an "intrinsic grey" known as Eigengrau in German? This variation of our internal experiences is just the tip of the iceberg, one that scientists are increasingly studying and...

The neuroscience of heartbreak

An analysis of functional MRIs revealed a difficult fact: the active brain areas of people experiencing heartbreak were very similar to those actively in love. This is a major reason why people in the middle of rejection can't accept the reality of their loss. This article breaks down the various changes in neurotransmitters and neural pathways for those enduring that universal experience, heartbreak.

In 1968, a Harvard Medical School committee issued the first neurological definition of death

The definition set a legal and medical precedent for how we define death, important for issues including organ donation. This 2020 video podcast discusses the history of brain death controversies and the variability in how death has been determined, including discussions in the late 1960s about when patients are considered dead in the context of organ donations.

How seizures (potentially) alter consciousness

Seizures occur when intense electrical activity floods the brain, prompting significant loss of self-control and a variety of sensory disruptions and hallucinations. Cultures interpret the episodes differently, with many contemporary norms viewing them as negative while others characterize them as intense spiritual occasions. Author Fyodor Dostoyevsky viewed his seizures this way, as well as cultures in Mongolia, some Shamanic indigenous religions, and others.

What happens to your brain when you burn out?

You've probably heard of burnout, also known as the feeling of exhaustion that happens after a long period of being overwhelmed or stressed. It's often associated with work and careers, but other parts of life, like parenting, can cause burnout, too. Scientists are figuring out what happens, biochemically speaking, in the brain when burnout hits—and spoiler alert, it includes a neurotransmitter called glutamate. Watch this video to learn more.

Why 'spacing out' or dissociating may help reduce trauma awareness

Dissociation may have developed as a defense mechanism in the brain to help navigate intense emotional or physical situations by providing out-of-body experiences that put distance between the mind and the environment. However, in about 1.1% and 1.5% percent of the general population, a severe form of this separation can produce alternate identities, or alters.

Psychedelics set off a flurry of brain activity that may permanently alter it

The brain seems to experience a sharp increase in communication between areas that generally don't interact. New research suggests a thin, sheet-like gray matter structure tucked deep within the brain, between the insular cortex and striatum, may be the key to this change. The area is centrally located and home to many of the receptors that psychedelics target, potentially rewiring the brain and rewriting thought patterns.

Necrosis is the unplanned death of cells and the tissue they comprise

If cells die prematurely due to a lack of blood flow, injury, or disease, they and their organelles can swell, leading to rupture of the surrounding cell membrane. This releases the cell's contents into the surrounding tissue, causing inflammation and damage to neighboring cells.

Examining self-diagnosed synesthesia

A growing number of people on social media claim to have a perceptual condition that lets them smell colors, see music, or taste sounds. But do they really?

Déjà vu is a memory illusion involving brain regions correcting inaccurate memories

Neuroscientists suggest the phenomenon is your brain recognizing that this feeling of familiarity is incorrect, showing off the brain's internal fact-checking system. Younger people experience déjà vu more often because their brains have higher excitatory activity and stronger memory monitoring systems.

Four in 10 CPR patients report consciousness not captured by standard measures.

Neural implants blur the line between personal intention and machine execution

A key ethical dilemma—the contemplation conundrum—explores whether implants might misinterpret mere imagination as intent to act. Neuroscientists have found no brain signal that clearly marks when someone decides to act, making intent hard to detect in neurotechnological systems.

This is the human brain on the world's strongest psychedelic

Within seconds of inhaling a high dose of vaporized synthetic 5-MeO-DMT—a lab-produced substance that otherwise is naturally derived from the glands of the Colorado River toad—it induced slow brain waves. Such waves are typically associated with unconsciousness due to a coma or anesthesia, perhaps explaining why users describe feeling like everything falls away. The compound is currently in clinical trials for treating depression.

Thanatology is the study of death and dying.

The debate on why humans are conscious—and what that means

Understanding what consciousness is, and why and how it evolved, is perhaps the greatest mystery known to science. Watch interviews with the world's leading experts on what it is and whether we'll ever know.

An essay exploring how living day-to-day with a brain implant helps restore a sense of identity

Companies like Neuralink are experimenting with volunteers who have lost control over their bodies. Many of the program's participants claim the most significant benefit from the tool is the ability to perform simple, mundane tasks, such as playing video games or shaking hands, rather than more obvious milestones like walking or eating. This essay explores what it's like, day to day, to use a brain implant.

Individuals with synesthesia experience involuntarily overlapping sensations

Tasting words or seeing colors in music results from the brain retaining extrasensory connections from infancy. While most lose these neural pathways during development, about 4% of people are synesthetes, maintaining them without realizing it's unusual.