In the original 2004 blue zones study, which sought to verify the ages of long-lived, healthy populations in Sardinia, Italy, researchers hypothesized that inbreeding in these isolated communities may have helped promote their longevity. (Paywall may apply.)

One biologist is leading the blue zone criticisms—both questioning the original recordkeeping for these purported longevity-prone locations and pointing to recent research showing declining numbers of healthy seniors in several official blue zone regions.

Blue zones are regions with unusually high numbers of centenarians

Factors thought to contribute to longevity in these regions include diet and social connections, but their legitimacy is often questioned due to a lack of rigorous scientific methodology and potential record inaccuracies.

Blue zones are geographic locations, such as Sardinia, Italy, where there have appeared to be disproportionately high numbers of healthy centenarians, perhaps due to factors including genetics, diet, social connections, and more.

Most self-reported claims of exceptional longevity are exaggerated, but read how demographers verify age claims and why some of the original blue zone demographers say blue zone regions are real and worth studying.

Read the main paper criticizing the concept of blue zones, which argues recordkeeping errors, pension fraud, and natural disasters likely explain the high numbers of purported healthy centenarians in certain locations.

Visit these 'blue zones,' where people live the longest

Blue zones, a term coined in 2004 by National Geographic Fellow Dan Buettner, are regions in the world where people live the longest and healthiest lives. Researchers have identified a few key aspects defining the culture of these areas—physical activity, diet, purpose-driven lives, and more. Explore the top five blue zones from across the world here.

Watch the trailer for journalist Dan Buettner's popular Netflix documentary series 'Live to 100: Secrets of the Blue Zones' which focuses on longevity insights from populations around the world.

Blue zone cooking—a concept that journalist Dan Buettner developed from his reporting on centenarian populations—emphasizes cooking with simple, fresh ingredients and echoes themes of the well-known Mediterranean diet.

Dan Buettner, the journalist who popularized the term blue zones, fires back at criticisms of blue zones in this 2026 letter to the editor published by STAT News.

The formula behind super agers—those possessing health and cognitive skills of people decades younger

A study of about 1,400 super agers did not identify any underlying genetic mechanism for longevity. While researchers instead emphasized that sustainable habits involving positive social connections, sleep, mood, diet, exercise, and personal fulfillment help reduce long-term risks, there is no one-size-fits-all formula for everyone.

Multiple new research paths may lead to slowing (or even reversing) aging

Aging has always been inevitable, but fasting, epigenetic reprogramming, and parabiosis seem to help people stay young. By studying centenarians, memory, and even the humble roundworm, scientists are looking for the genetic basis to live not just a long life, but a healthy one.

Helping support others in older age linked to longer life

Analysis of findings from a long-term study of older couples first interviewed in 1987 and then followed for the next five years found that individuals who lend support to friends, neighbors, and relatives live longer. Non-helpers were more than twice as likely to die as helpers during the five-year period. That's even after controlling for factors including age, gender, and physical and mental health.

Super-agers: seniors 80 and above with the memory ability of people in their 50s

Studies show the number one indicator of whether someone is a "super-ager" is not diet or genetics, but the extent of their social relationships. Moreover, scans reveal noticeable physical differences in certain parts of the brain in patients with extensive social networks.

Environment and genetics explain why animals have widely different lifespans

Both environmental conditions and genetic factors shape how long various animals live. For some creatures, colder conditions allow for less energy use and slower aging. Larger animals have fewer predators. While humans don't live the longest, we are a rare species that successfully lengthened its average lifespan over time.

The Dog Aging Project uses information from over 50,000 dogs to explore longevity

The study gathers health, lifestyle, and genetic data to understand what helps dogs live longer, healthier lives. Findings could also provide human health insights due to our shared surroundings and biology.

Perceived isolation ages you

Mounting evidence suggests that socialization is a vital component of maintaining good health. Research published in 2024 from Mayo Clinic researchers analyzed the social lives of more than 280,000 adults and concluded that individuals that weren't likely to participate in extracurricular social activities and get-togethers were more likely to have a biological age older than their actual age—meaning that you may be 60 but health indicators would suggest you're older.

The disparity in life expectancy between wealthy and impoverished nations has notably narrowed

In 1950, people in Norway lived to age 72, on average, while those in Mali lived to just 26. By 2015, the countries with the worst conditions had made such significant progress that the global average life expectancy had surpassed the rate of any nation in 1950.

Global life expectancy has more than doubled since the 1850s

The human species experienced a dramatic increase in expected lifespan over the past 150 years. Antibiotics, improved sanitation, and better worldwide food distribution are a few factors contributing to this rapid transformation. Use this interactive resource to explore longevity gains over time and compare these improvements across the globe.

Can humans delay or reverse old age?

We're not sure yet. Researchers at the University of California San Francisco are studying why some conditions and behaviors, such as low-oxygen environments and exercise, benefit the aging process, hoping to reveal potential health applications. Some of this research focuses on klotho, a naturally occurring age-regulating hormone named after the Greek Fate Clotho. Animal studies on klotho brain injections found subjects had improved memory recall and age-related degeneration resistance.

Inflammaging appears to differ across global populations

Chronic, low-grade inflammation linked to aging is a byproduct of our industrialized lifestyles, according to recent research. The work compared two industrialized populations with two Indigenous, non-industrialized populations in Bolivia and Malaysia, and found that inflammation levels in the Indigenous groups—unlike the industrialized ones—did not seem to differ by age.

Moving your body every day is key to longevity

In an era of biohacking, where millionaires subject themselves to draconian routines and tests to de-age themselves, one study suggests a super simple key predictor of mortality: more than any other trait, how much subjects moved determined how long they'd live. Movement mattered even more than age in predicting overall life longevity. Researchers suggest this means we should all simply get outside a bit more. Read more about the study here.

At-home genetic testing results commonly led users to healthier lifestyles

Italian research that aimed to investigate what people do longer-term after receiving direct-to-consumer genetic test results indicated that whether the results were positive or negative, people tended to adopt a healthier diet after receiving the results, and they'd still maintained it a year after receiving their results. Some users also reported an overall reduction in stress over their health concerns. (Some users may encounter a paywall.)

Analysis finds dementia was rare in ancient Greece

Ancient medical texts seldom mention severe cognitive decline, suggesting that such conditions were uncommon. This scarcity is attributed to factors like shorter lifespans and active lifestyles, implying that modern environmental and lifestyle changes—along with longer life expectancy—contribute to the current prevalence of dementia.

The quest to find natural ways to extend lifespan

Tales of searching for the Fountain of Youth persist. Our modern-day version is marked by promises of pharmaceutical miracles and a proliferation of viral "biohacking" routines. One doctor’s quest to unlock the keys to longevity stimulated much of this renewed fervor, though his ideas are often taken out of context.

Scientists have not yet answered what the evolutionary benefit may be of menopause

Few animals are known to experience menopause, raising questions about why it would be evolutionarily advantageous to have women survive past their reproductive years. One leading hypothesis is the grandmother hypothesis—older women and other species known to experience menopause, like whales, can aid families and pass down knowledge to future generations.

Some data links schizophrenia to older paternal age and birth complications

Yet both associations are not yet considered firm enough to definitively be causative. Schizophrenia is a multi-causal syndrome and a mixture of factors, including genetics, are widely believed to be behind its development.

Health span: The number of years one is active and disease-free

As scientific advances continue to extend the average human lifespan, many are now turning their attention toward extending "health span." The ultimate goal would be to extend one's health span to match one's lifespan, which would necessitate a shift in focus toward the pursuit of healthy aging. (Some users may experience a paywall.)

Why Hawaiians live longer

Hawaii has the longest life expectancy at birth out of all 50 states, according to the US Centers for Disease Control and Prevention. Key factors include strong healthcare, lots of sunlight, and active lifestyles.

Doctors shift focus from extending lifespan to lengthening health span

As scientific advances extend the average human lifespan, many are turning their attention toward extending "health span." Health span refers to the number of years one is active and disease-free. The ultimate goal is to extend one’s health span to match one’s lifespan.

Child mortality rates since ancient Rome

One of the great achievements of modern humanity has been the sea change in child mortality rates—the chance that a newborn eventually lives past puberty. For thousands of years, children had a 50% chance of not entering adulthood. About 300 years...

People with schizophrenia typically die 9 years earlier than the general population

The syndrome, which affects roughly 1 in 233 adults, is often associated with other serious health issues, including cardiovascular, metabolic, and infectious diseases, which may contribute to early deaths. The side effects of long-term antipsychotic medications also may influence the mortality timing—weight gain, for example, is a common side effect of the drugs and can contribute to cardiovascular issues.

The lack of diversity in DNA databases limits their applications

European ancestry dominates genetic research, hindering the usage of genetic databases for precision medicine for other groups, including African Americans, who face higher health risks due to genetic variants. Many Indigenous communities have also resisted genetic research due to past exploitation. (Some readers may experience a paywall.)

The genetic diversity of dogs is greater within Chernobyl than in surrounding areas

A 2023 study identified that packs of dogs located just 16 kilometers (10 miles) apart within the exclusion zone were more genetically different from one another than from stray dogs hundreds of kilometers away. Rather than radiation, this is likely the result of inbreeding within isolated packs.

MS risk is shaped by geography, not just genes

Latitude—and related vitamin D exposure—seems to affect MS risk. People who migrate from a high-risk MS latitude (like northern Europe or the northern US) to a lower-risk latitude (like tropical areas) before age 15 tend to adopt the lower risk of their new country—suggesting there's a critical window for environmental exposure.

Santa Barbara's Channel Islands revealed the oldest skeletal remains in North America

IN 1959, archaeologists found a human femur jutting out from a rock face on Santa Rosa Island. Using the then-new technology of radiocarbon dating, they measured the age of the remains at 13,000 years—the oldest in the continent.

Large animals like giraffes and elephants have evolved unique cancer defenses

One may expect the larger an animal is, the more likely it is to develop cancer—simply because there are more cells and more chances for a dangerous mutation. However, some large animals show cancer rates almost 10 times lower than humans—a phenomenon known as Peto's Paradox.

Caucasians are at the greatest risk of developing macular degeneration

A 2016 analysis across ethnic groups found, among other things, that white participants had the highest incidence of the disease, followed by Chinese, Hispanic, and Black participants. This study did not answer why that may be the case.

Read a study documenting how 'old people' smell increases with age

Analysis of body odors from individuals aged 26 to 75 confirmed that 2-nonenal, an unsaturated aldehyde with an unpleasant, greasy, and grassy odor, was detected only in subjects aged 40 and older.

The last Pinta Island tortoise died in 2012 at over 100 years old

Unfortunately, different animal species continue to go extinct. See a list of these recent extinctions, and learn the story of Lonesome George, who died without finding a mate in the Galapagos Islands.

Each part of the human body experiences aging differently

With global average life expectancy cresting at 73 years, understanding how the body ages is imperative to effective medical treatment and maintaining a desired quality of life. This 13-minute video dives into how the body and its organs age "from head to toe."

Climate determinism wrongly linked human traits and societal progress to geography

Historically rooted in Greek philosophy, its ideas used the latitudes where people were located to justify racial hierarchies, casting tropical peoples as lazy or inferior. These biases still influence how media and research portray people in climatically disadvantaged regions. (Some readers may experience a paywall.)

80% of schizophrenia cases may be inherited

Some research suggests that anywhere between 60% and 80% of people with schizophrenia had genes that predisposed them to the syndrome. That high rate has fueled interest in further exploration of what environmental and lifestyle factors cause some people with that genetic risk to develop the disease when others with the same genetic risks do not.

South Korea has the lowest fertility rate in the world

If current birthing trends persist, every hundred South Koreans today will have only six great-grandchildren between them. This crisis is a result of high expenses, harsh work-family trade-offs for women, declining marriage rates, and other societal factors. Some newer policies are helping to build incentives for having children, but larger issues also need to be addressed.

Learn how colorectal cancer is linked to the American diet and chronic inflammation

A University of South Carolina colon cancer researcher offers insights from his own research and notes that more exercise, social support, and eating fruits, vegetables, legumes, and foods like fish and olive oil—often called the Mediterranean diet—are associated with better health—and could improve our colons.

Explaining why animals don't cross this invisible line in Indonesia

Although the distance separating the two regions is small, East and West Indonesia have starkly different species, puzzling scientists for decades. Biogeographers use the theory of plate tectonics to explain the phenomenon, arguing the two regions...

Almost 80% of people diagnosed with autoimmune diseases are women

Yet it's still unanswered what may account for that difference. To better understand this disparity researchers are exploring factors including hormonal changes that occur around puberty, pregnancy, and menopause, as well as gut microbe differences, and aspects of X-chromosome protein-coding genes. (Some users may encounter a paywall.)

How Seabiscuit's DNA made him a winner

Seabiscuit's sudden success in the sport has been framed as a classic against-the-odds sports story. One Binghamton University molecular physiologist wanted to go a bit deeper, though, to see how much genetics played a role in the horse's legendary career. Using the horse's silvered hooves, his research team discovered that Seabiscuit's genotype was typically associated with late bloomers, a finding confirmed by the horse's track record.

The love lives of pygmy seahorses

Inch-long pygmy seahorses live fascinating lives in the Coral Triangle of Southeast Asia, where the tiny sea creatures thrive. They are one of the few species in the world where the male carries its progeny to term, in this case, after receiving an egg from the female, who keeps busy checking in on her two male mates, one of whom is always pregnant. Dive into the marine romance in this fascinating essay.

Gladiators followed a mostly vegetarian, high-calcium diet

Analysis of skeletons from a gladiator cemetery at Ephesus by researchers at the Medical University of Vienna found little meat consumption but unusually high calcium levels—likely from drinking wood ash mixed with water to promote weight gain and protect vital organs.

The world’s oldest tattoos belong to 'Iceman' Ötzi

Ötzi is the corpse of "the Iceman" found in the Alps along the Italian and Austrian border in 1991. His mummified body was covered with lines and crosses along the “hard-working” areas of his body, signifying their potential application for therapeutic pain management.