US West Nile case numbers were up 40% in 2025 across the United States though theories vary to explain this surge.

West Nile was reported in 47 states in 2025, with more than 1,400 people severely affected

Tracking numbers from the CDC indicate that the virus spread widely that year, with more than 2,000 reported human cases and many states seeing more than 25 sickened people. More than 1,400 people had neuroinvasive cases of the disease—meaning the virus had entered the nervous system, which can cause severe, potentially life-threatening illness.

Most cases of West Nile virus are asymptomatic in people

About 1 in 5 infected people develop symptoms from West Nile, including symptoms such as fatigue, head and body aches, and vomiting. But around 1% of patients develop severe complications such as encephalitis or meningitis, which can be life-threatening. Those who are most likely to become severely ill are people over age 60.

There's no cure for West Nile virus—and infection can leave patients with permanent symptoms.

West Nile virus found in the UK for the first time

The West Nile virus, which mainly spreads between birds and mosquitoes, was detected in the UK for the first time. While no evidence exists for any human infections, climate change may be expanding mosquitoes—and the diseases they carry—farther north.

Nearly 5,500 crows died during four months in 1999 from West Nile in NYC.

How a scientist discovered West Nile is spread by birds

Listen to Tracey McNamara, former chief pathologist at the Bronx Zoo, detailing her surprising late 1990s discovery that established West Nile virus is spread by birds. Financing animal disease surveillance studies, she says, saves human lives and surveillance gaps may fuel missed opportunities to identify dangerous diseases before they jump between species.

West Nile is named after the district in Uganda where it was first isolated from a patient

In 1937, scientists isolated the virus from a woman in the West Nile District of Uganda. It's since been detected in much of Africa, Eastern Europe, West Asia, the Middle East, and was first detected in US patients during an outbreak in 1999.

West Nile virus was detected in UK mosquitoes for the first time in 2023

Fragments of the virus were detected in mosquitoes that were being collected in Britain for the first time in 2023, but the UK government considers the overall risk to people to be low. As of spring 2026, there have never been detected locally-acquired cases of the disease.

Dead birds are often the warning sign health officials look for as a sign of West Nile danger.

Long-term memory issues among West Nile survivors may be from the body's immune response, not the viral infection.

Horses account for about 96% of known mammalian cases of West Nile virus infection beyond humans.

West Nile Virus is maintained in nature, even without human infections

Mosquitoes pick up the virus when they feed on birds, and then pass it to other birds with their bite, delivering it via virus-laden saliva. Hundreds of different North American bird species can harbor the virus—even if they don't all get sick from it.

Robins are a major host for West Nile in North America, even though other species more readily spread the disease.

West Nile Virus has been detected in American alligators, and outbreaks have led to substantial economic losses on alligator farms.

Hear from a NYC public health official who led the first US investigation into West Nile about the challenges investigators faced and their working theories about that outbreak.

Protecting yourself from West Nile involves avoiding getting bites and clearing standing water.

10 locally acquired malaria cases were reported in the US in 2023—a surprise

The cases, reported in Florida, Texas, Maryland, and Arkansas, broke a 20-year streak since there had been no reported locally acquired mosquito-transmitted malaria in the country since 2003, when there was a case in Florida.

Horses can—rarely—get West Nile, too

The animals can contract the virus via infected mosquito bites, but for horses there are four vaccines available. Though West Nile's often asymptomatic or mild in horses, the disease can sometimes be deadly, killing via severe neurological inflammation. There are no reported instances of people becoming sickened by infected horses or vice-versa.

Horses have four licensed West Nile vaccines—but humans have none

A major hurdle for West Nile vaccine development is the lack of a market for it since so many people are symptomatic for the infections. Still, a growing number of infections, including a 40% spike in 2025, may change that calculation.

Powassan virus, a rare tick-borne disease named after the Canadian town where it was discovered in 1958, is on the rise in the northeastern United States, and it kills roughly 10% to 15% of patients with symptomatic disease.

More than 20 mosquito-borne and tick-borne diseases are found in the US

Children, older adults, and people with compromised immune systems are at particular risk of poorer health outcomes from these diseases. But dog owners and outdoor enthusiasts are among those at particular risk of contracting these illnesses, which include Lyme disease, Zika, and the condition Alpha-gal Syndrome.

Environmental conditions, shifting immunity, and viral strain could help explain 2025 spike

The surge in HFMD in the summer and early fall of 2025 in the mid-Atlantic could be the result of a confluence of factors, including a more virulent strain of disease-causing virus, good environmental conditions for the virus to spread—hot, humd—and a potential immunity gap among kids due to milder HFMD outbreaks the previous year.

Scientists found that if cats ate infected rodents, they could get West Nile in lab experiments.

Mosquito-borne illnesses have killed two captive orcas at SeaWorld since they became water park attractions.

There's a West Nile virus prevention rap—and it's amazing

This catchy rap from biologist MC Bugg-Z and the Fairfax County government in Virginia walks people through prevention steps and the dangers of the virus, telling listeners to "rock" insect repellant and talking about the history of the disease in the US.

Lyme disease is the most common vector-borne illness in the US

In the US, ticks account for 90% of all disease transmission from bites, including mosquitoes. And Lyme disease is the most common vector-borne disease in the US overall, with estimates suggesting there are about 475,000 Lyme cases annually across the nation.

A malaria case in Maryland stumped doctors in 2023—leading to the wrong treatment and underscoring the challenge of physicians being mindful of tropical diseases in our interconnected world.

Florida reports 71 imported malaria cases annually—4% of all the US cases.

See the total number of Lyme cases per state in 2023

New York, Pennsylvania, and Massachusetts had the highest total number of Lyme disease cases in 2023. New York had more than 22,000 cases that year. Maine had one of the highest Lyme incidence rates of disease that year—213 per 100,000 people—but only 2,942 cases overall.

Zika virus shocked scientists because the mosquito-borne disease causes birth defects

This revelation, confirmed in 2016, marked the first time that a mosquito-borne disease was known to cause birth defects. Fetuses exposed to the Zika virus during pregnancy sometimes suffer from neurological complications and microcephaly, a small-headed condition associated with neurological development issues and impairment.

There may be 500,000 additional malaria deaths by 2050 according to peer-reviewed research published in 2026.

Wolbachia: the bacteria that could eliminate dengue fever

Dengue fever, transmitted by mosquitoes, kills more people annually than all types of natural disasters combined. However, mosquitoes that host Wolbachia bacterium have their ability to transmit the virus naturally suppressed, offering a route to eliminating nearly 25,000 deaths annually.

See the incidence of Lyme disease across all 50 states in 2023

The US states with the highest rate of Lyme disease—meaning cases per 100,000 people—were Rhode Island, Vermont, and Maine, in 2023. Rhode Island had 260 cases per 100,000 people, based on cases reported to the US Centers for Disease Control and Prevention. (Some users may encounter a paywall.)

Discover the latest information on US measles cases in the US from official outbreak tracking figures.

Explore this database to discover Lyme disease incidence in your county.

California condors have been vaccinated against West Nile to protect their limited population

The condors became endangered in the 20th century primarily due to lead poisoning from consuming animals shot with lead bullet fragments inside them, so condors in captivity and in the wild are vaccinated against diseases including highly pathogenic avian flu and West Nile.

Heat-related deaths may have climbed by more than 50% over 20 years

Between 2000 and 2009 one study suggests annual heat deaths averaged around 2,670, but between 2010 and 2020 that figure was likely more than 4,000. Researchers studied 54 million death records from the contiguous US and created mathematical models to arrive at these figures, noting that a combination of aging populations and climate change drove that increase.

See MS prevalence by region in the United States

This map underscores that people in the northeastern United States have more cases of the disease as compared to the south, west, and midwest. On an individual level, these numbers may still differ based on genetic makeup and other factors irrespective of where people live.