Watch actress Kristen Bell discuss her challenges with depression and anxiety.

Major depressive disorder is a clinical diagnosis and is not a lifestyle choice. Those who struggle with depression can express persistent feelings that are difficult to process and make sense of for friends and family. This guide walks through some counterintuitive perspectives, including resisting the urge to force a depressed person to do the things that would make them feel better.

Henson describes the importance of finding culturally competent therapists because mental health struggles, including her depression, are so stigmatized in the African-American community. She said that Black Americans feel the need to appear strong, which leads to self-medication and untreated illness that can "weigh you down."

"Entertainment is always the first priority," the director of medical research for "Grey's Anatomy" and "Private Practice" explained in this Newsweek article. But, medical consultants and dedicated groups like the University of Southern California's Hollywood, Health, and Society program, can help inform shows' characters, actions, and sensitivities on subjects like mental illness.

Worrying about past events and upcoming challenges is not a pleasant experience, but a reasonable amount of stress can bring a lot of good into our lives. In this episode of "The Happiness Lab" with Dr. Laurie Santos, two psychology experts offer tips for resetting one's relationship with stress. Listen and learn how to make stress a positive tool rather than a debilitating emotion.

Jennifer Moss founded a tech company, had a baby in the middle of the start-up process, and crashed after months of rising exhaustion and disconnection from a career she once felt passionate about. She shared her story of burnout and the techniques she used to turn her life around and repair her relationships in this piece.

Activities like exercise, even at low levels, have been shown to alleviate some of depression's symptoms for some people. However, depression saps energy levels, making it particularly difficult to motivate oneself to take helpful action.

People differ in how they respond to setbacks. Famed psychologist Martin Seligman outlines three key pillars for resilience: developing mental toughness by interpreting failures as external and temporary, recognizing and using one’s signature strengths, and cultivating strong relationships that offer support and meaning.

- Actress Florence Henderson (1934–2016)

Applegate discusses with Conan O'Brien how ignorance about the disease and fake cure information continue to proliferate. Sigler, known for her role on HBO's Sopranos, also discusses how she is now prioritizing roles that will have a disability, like her.

This podcast discusses research that indicates stress perception may drastically affect how we respond to it. In research exploring if our stress is presented as diminishing our health versus if we're told it enhances our performance, it will lead to differences in how successful participants are at performing tasks—with the enhancers doing better.

This prevalence trend mirrors the broader incidence of depression among women and is well-documented. Researchers suggest the disparity stems from differences in hormones, social role expectations, coping mechanisms, and more. Men may also present with depression differently, and seek help less.

Individual solutions for burnout, often called “self-care,” can be helpful for managing stress. Harvard researcher Aditi Nerurkar’s 2024 book The Five Resets details a road map for burnout recovery. In this interview she suggests, among other tactics, gaining focus on what matters the most in one’s life, taking breaks from both work and the internet, and making time for practices that strengthen the mind-body connection.

This first-person account of a woman diagnosed with autism at age 31 covers her experience of why it was useful for her to receive her diagnosis as an adult and how it helped her to understand her life and her feelings of 'being an imposter.'

Described as having therapy with someone who knows you well, documenting one's thoughts and feelings aids in information processing and can reveal personal issues. Methods include bullet journaling and gratitude, which a 2024 study linked to a longer lifespan.

Menopause has long been a topic left out of film and TV. But some shows, like "The Change," and celebrities, like Jennie Garth, are now openly talking about it. This article breaks down how Hollywood is starting to come around to the menopause conversation and how celebrities are talking about their own personal experiences, as well as advocating on Capitol Hill.

The understanding that comes from meeting others who have similar experiences can provide hope that life can get better, the solace of affirmation, and make navigating a new diagnosis or a rare illness, in particular, much easier.

The American Psychiatric Association's DSM-5—used for defining diagnoses—says a person must be experiencing five or more symptoms of depression most of the day over at least two weeks. Research indicates older people are less likely than younger people to meet that depression benchmark, though this article says they still often have at least several of the depression symptoms.

Interdisciplinary artist Kristina Wong sees parallels between the early days of the COVID-19 pandemic and some of the “worst performance art” she’s encountered in her career. Wong’s sharp sense of humor and clever writing mean that she gets in some good digs at the more ridiculous side of performance art, but don’t let her funny fool you: this is an incisive piece on the role of performance, empathy, trauma, and art in all our lives.

A large analysis of existing studies published in 2021 found that systemic inflammation is associated with fatigue, appetite changes, and sleep disruption, rather than some of depression's broader symptoms including hopelessness about the future, or feeling fearful. This may suggest that inflammation influences specific symptoms of the condition, rather than the disease as a whole.

- Singer Tina Turner (1993–2023)

-American beach volleyball star Kerri Walsh Jennings (1978-present)

Founding a company comes with more than just logistical challenges—it's a daunting emotional task, too. In this article, a psychologist breaks down how first-time founders can prepare for the mental pressure of starting a company.

A study led by a team from Stanford University showed that MR can help people with depression by providing pathways to engage in activities such as digital board games and dancing. Participants saw reduced symptoms of depression that made their overall treatment plans more successful.

This podcast offers insights on how to effectively talk to others when they're experiencing powerful emotions, and how to simultaneously protect yourself in those situations.

After reaching superstar status by the 1970s, Minnelli was often mired in gossip, with reporters asking questions about nonexistent pregnancies or commenting on her appearance. Thanks to her upbringing in the industry, she often took these interactions in stride.

In this 2025 interview, the artist speaks candidly about her traumatic childhood, her enduring interest in exploring pain and pleasure, and how performance taught her to control her pain.

Donning headphones that play a track mimicking the auditory hallucinations common in schizophrenia, Cooper finds he is very distracted, disconcerted, and frustrated. The auditory track aims to help listeners build empathy with patient populations by understanding the challenges they face in daily life.

Dr. Roland Griffiths helped lead the revival of psychedelic research, often prescribing the use of psilocybin to address severe depression or anxiety in patients. This podcast explores how Griffiths leaned on his own career after being diagnosed with cancer and facing the prospect of death.

This short narrative video describes the ups and downs of a woman's experience with progressive MS, and her husband's experience supporting her while navigating his own relapsing-remitting MS.

After Amanda Riley was diagnosed with cancer, her social media followers rallied to raise funds to ensure their favorite religious influencer could afford one miracle after another. As more than $100,000 of donations poured in, Riley shared glimpses into her health struggles, posting evidence as fake as her diagnosis. Pulling from years of journalistic investigation, this eight-episode podcast series dives into Riley's reality.

Depressed brains can have certain characteristic changes, including an overactive amygdala, reduced hippocampus size, and changes to the thalamus and neuromodulating chemicals in the brain.

The perennial debate on how to be happy involves various aspects of life, and one of the most essential is our psychological attitudes toward experiences. This piece lists and explains four basic tools to strengthen your "psychological immune...

Developing psychological flexibility, or an ability to adapt during change and stressful situations, can help leaders manage pressure while maintaining their wellbeing. A leader who can embrace discomfort and navigate hard times can earn greater respect, increase team satisfaction, manage distress effectively, and stay focused on priorities. Read this article for a further understanding on how to develop and sharpen this skill.

Workers, particularly in marketing, are experiencing mental fatigue in the workplace due to expectations—often unspoken—that they should use AI to multitask beyond their comfort levels. Many feel they are underperforming if they don't embrace this technology. This situation differs from typical burnout. This podcast discussion suggests that this "brain fry" tends to intensify when employees are required to use more than three AI tools.

Psychological research presents some unsurprising wisdom about how to make big decisions without regret: focus on people, don’t miss opportunities, and stay true to yourself.

This engaging TEDx talk from addiction researcher Jacki Hillios explores addiction recovery through a transformative lens and Phoenix Multisport—an innovative program helping people rebuild their lives through active lifestyles. By living out its core message that people are not defined by their disease, the program demonstrates the power of social support in recovery.

A clinical trial participant with severe epilepsy described becoming “one” with her implant after it gave her unprecedented control over her seizures. When the device was removed due to the company shutting down, she experienced deep emotional trauma and a sense of personal loss.

Watch this podcast discussion from Weill Cornell Medicine about the emotional journey of infertility for couples and individuals and hear advice about how to navigate the feelings of loss of control, grief, anger, and despair, including suggested tips for supporting individuals struggling with infertility.

Some research shows that menopause can fuel anxiety and also that preexisting anxiety can boost the chances of experiencing other menopause symptoms, including hot flashes, insomnia, and brain fog. But treatments—including hormone replacement therapy, breathing exercises, and other forms of exercise—can alleviate some of these symptoms.