Trauma-related amputations are primarily from falls, then car accidents and related traumas, followed by mechanical forces according to analysis based on global burden of disease data in 2017.

Every 3.5 minutes in the US, a limb is amputated due to diabetes.

Amputees must navigate the challenging medical and economic aspects of limb support and replacement, but advances in technology and research may reduce these costs.

Traumatic brain injury is a leading cause of brain death—and TBIs are trending up

Traumatic brain injury-related deaths have generally increased between 2000 and 2023, growing from roughly 49,000 to more than 68,000 in 2023. Firearm-related suicide is the most common cause of TBI-related deaths in the US, according to the Centers for Disease Control and Prevention. People also experience TBIs from falls, motor vehicle crashes, or assaults.

Prehistoric hunter-gatherers performed amputations and appear to have provided post-op care, according to analysis of a recent fossil discovery from almost 31,000 years ago.

Listen to how bionic limbs are reshaping what it means to live as an amputee in this award-winning 2022 podcast series covering the stories of two amputees who struggled with shortcomings in prosthetic technology.

Black patients are losing their limbs at a rate triple that of other groups due in large part to inequities in diabetes care and management.

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

See the global blindness burden by cause and continent

These charts show the estimated number of people worldwide with blindness due to cataract, glaucoma, refractive disorders, age-related macular degeneration, malaria, river blindness, trachoma, and other causes.

Research suggests the brain maintains connections to lost limbs

Decades-old research suggested brain reorganization after amputations, but brain scans show unchanged limb representations. Phantom limb pain may result from such unchanged brain maps, which may enhance prosthetic limb control in brain-computer interface technology.

Non-amputees can be tricked into thinking they have phantom limbs with rubber arm experiments.

Trauma is a primary risk factor for substance use disorder later in life

Studies indicate 75% of people with substance use disorder have experienced at least one traumatic experience in their life. These experiences alter brain function, leading to heightened stress and emotional pain. Substances offer temporary relief, but this often results in dependency.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

This Texas city is having an 'amputation crisis'

Texas has some of the highest rates of diabetes-related amputations in the country. Towering over the rest of the Longhorn state is the city of San Antonio, where men are nearly three times as likely to lose a limb to diabetes than women. This article explains how men in this majority Mexican American city are genetically and culturally at risk of Type 2 diabetes, a disease involving issues with the blood sugar-regulating hormone insulin.

Firework or sparkler burns can have large effects on our hands' range of motion

Dr. Erin Miller, a hand surgeon at Harborview Medical Center in Seattle, describes the range of injuries she's seen from firework injuries in this 2020 video. The damage includes loss of hands, fingers, and tips of fingers. Miller describes how in a recent year she was on-call during the week of the Fourth, and in just five days she saw 30 cases and had to amputate 42 fingers because of fireworks injuries.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

America's top causes of death are heart disease, cancer, accidents, and stroke

Heart disease killed more than 680,000 people in 2023 and cancer killed around 613,000 people that year. Both causes of death are far above the next leading cause of death—accidents, which numbered around 223,000. Provisional data for 2024 indicates the leading causes of death remained the same.

The US had about 155.4 million emergency room visits in 2022

Of those emergency incidents, the largest share of patients were between the ages of 25 and 44 and were in the southern part of the US. More than 43 million of the visits involved injuries, including poisonings.

See what regions report new leprosy cases

This graphic shows the burden of leprosy by region for 2023, based on data provided from the World Health Organization, which collates this information. Southeast Asia leads in the number of cases by region. (Some readers may experience a paywall.)

11 people died from firework injuries in the US in 2024

Most of those deaths involved misuse of the explosives and device malfunctions or misfires. That fatality count doesn't include the almost 15,000 people who received treatment in the emergency room due to firework-related injuries. More than a third of all the injuries in 2024 were burns, underscoring the risks of using these explosive devices.

How trauma gets ‘under the skin’

A study examining the muscle function of older adults who have at least one adverse childhood experience (ACE) suggests that trauma digs itself into muscle cells. Participants who reported childhood trauma were found to have lower maximum levels of cellular energy than people who reported fewer or no ACEs. Such compromised mitochondrial function "doesn't bode well," as it relates to a variety of health and age-related outcomes.

Estimates suggest inactivity contributes to 6% of deaths worldwide

The World Health Organization identifies physical inactivity as the fourth leading modifiable risk factor for global mortality, just behind hypertension, tobacco use, and high blood glucose. Latest estimates are that inactivity contributes to 6% of deaths and significantly increases the burden of chronic diseases like heart disease, diabetes, and cancer.

Phantom limbs aren't just limited to limbs—there are phantom breasts, teeth, and more, and these sensations are often painful.

One in 10 adults worldwide has diabetes

As of 2021, diabetes claimed at least 6.7 million lives and continues to kill one person every five seconds. Nearly one in two adults with diabetes don't know they have the condition, which is expected to increase in prevalence from 537 million in 2021, to 783 million in 2045.

Phantom limb pain may often match the pain or contortion of the injury that led to the limb loss.

See what analysis of one man's amputated leg, donated to The Bone Museum, tells us about his otherwise invisible pain.

See images of medical cases of firework injuries shared on this 'Instagram for doctors'

Included photos include scans of missing or damaged digits, a chunk of missing flesh, a facial injury from a homemade firework in a glass bottle that exploded in the patient's hand before it was thrown, and an injury where a patient's finger bone flew into someone's leg.