See what analysis of one man's amputated leg, donated to The Bone Museum, tells us about his otherwise invisible pain.

Readers thought the fictional Civil War vet George Dedlow, a character suffering from phantom limb pain in an 1866 story in The Atlantic, was real—and sent donations and stopped by the hospital to meet him.

Listen to an amputee describe what it was like in the aftermath of his partial foot amputation and how his chronic, extreme pain fueled his depression and his decision to attempt to alleviate the pain with the radical surgery.

Amputees must navigate the challenging medical and economic aspects of limb support and replacement, but advances in technology and research may reduce these costs.

Listen to how bionic limbs are reshaping what it means to live as an amputee in this award-winning 2022 podcast series covering the stories of two amputees who struggled with shortcomings in prosthetic technology.

Read the 1866 story in The Atlantic that put phantom limbs on the map, a fictional story by a Civil War surgeon that was mistaken for being a true account by many readers.

Prehistoric hunter-gatherers performed amputations and appear to have provided post-op care, according to analysis of a recent fossil discovery from almost 31,000 years ago.

Learn how a doctor successfully treated a patient's phantom limb pain with a mirror, tricking his brain into thinking his still-present arm was the missing paralyzed left one.

Hear Aristotle Domingo, a bilateral amputee athlete, discuss his amputation journey.

Nonamputees can be tricked into thinking they have phantom limbs with rubber arm experiments.

Phantom limb pain may often match the pain or contortion of the injury that led to the limb loss.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

Hear about life as an amputee and how mirror box therapy helped.

Palliative care physician BJ Miller describes his phantom limb pain and itching after losing both legs and half an arm in an accident. Mirror box therapy eventually helped him, alongside physical therapy. This podcast also features neuroscientist VS Ramachandran who explains how he developed mirror box therapy in the 1990s.

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

Black patients are losing their limbs at a rate triple that of other groups due in large part to inequities in diabetes care and management.

Every 3.5 minutes in the US, a limb is amputated due to diabetes.

Breaking down the knee's anatomy

The human knee is a remarkably complex structure carrying the full weight of the body throughout a person's life while allowing a number of complex twists, flexes, and extensions. It's also one of the body's biggest weaknesses—the location of chronic pain and replacement surgeries for millions of Americans.

Phantom limbs aren't just limited to limbs—there are phantom breasts, teeth, and more, and these sensations are often painful.

Research suggests the brain maintains connections to lost limbs

Decades-old research suggested brain reorganization after amputations, but brain scans show unchanged limb representations. Phantom limb pain may result from such unchanged brain maps, which may enhance prosthetic limb control in brain-computer interface technology.

This Texas city is having an 'amputation crisis'

Texas has some of the highest rates of diabetes-related amputations in the country. Towering over the rest of the Longhorn state is the city of San Antonio, where men are nearly three times as likely to lose a limb to diabetes than women. This article explains how men in this majority Mexican American city are genetically and culturally at risk of Type 2 diabetes, a disease involving issues with the blood sugar-regulating hormone insulin.

An experimental bionic knee has been directly integrated into the user's muscle and bone—not an external socket—marking a significant prosthetic advancement.

The man who turned his leg into a hotspot

Biohacker Michael Laufer recently had a 512GB drive implanted in his leg, which can store data, stream music or movies, and power a hot spot and mesh network. It's called the PegLeg, and WIRED's Daniel Oberhaus spoke with Laufer about the device and the field of biohacking.

Limb regeneration research may lead to treatments for arthritis

For scientists pursuing the cure for arthritis, the holy grail of discoveries lies in how to regrow healthy cartilage inside human joints. While this feat has so far resisted our best scientific attempts, there are plenty of other human tissues—such as the liver and fingertips—that will successfully regenerate.

Tommy John surgery, which can save a pitcher's career, reconstructs a torn ligament in the inner side of the elbow that would otherwise stabilize the elbow during throws.

Read why one man agreed to get a pig kidney in 2025 to replace his own failing organ

The 68-year-old New Hampshire man told USA Today that a motivator for the experimental surgery was his belief that he was going to die anyway, and other people suffering from kidney disease could gain valuable insights. Yet the surgery bought him time—he lived 271 days with a pig organ and later received a human kidney transplant. Clinical trials began in 2026 to test the pig xenotransplants in more people.

Watch real knee surgery footage to see what arthritis looks like up close.

Skull bone marrow may be playing a key role in chronic pain.

You can sign up to donate your body to science

It's a separate process to donate your body for medical research; you usually must contact a whole-body donation program directly. Bodies can be donated for medical research, for forensic analysis research, or for medical students to work with as they learn anatomy and surgery, among other purposes. Learn more about numerous accredited organizations that provide human bodies, organs, and tissues to medical researchers and students.

A human joint is any place in the human body where two bones connect, providing structure and stability.

Exploring the link between history, art, and anatomy

Throughout centuries, art has played a vital role in sharing—and furthering—scientific understanding. This largely began in 1543 when physician Andreas Vesalius worked with an artist and engraver to transform learnings from his dissections into...

Visualizing a joint under attack from rheumatoid arthritis

A particularly difficult arthritis subtype is rheumatoid arthritis, a painful condition provoking a vicious cycle of joint inflammation, destruction, and dysfunction. It begins with a misfiring of the patient’s own immune system—for unknown reasons, it identifies joint and cartilage cells as foreign, initiating an attack to eliminate the supposed "invaders."

Experience a century of America's healthcare advances with this medical visualization, tracing a sampling of healthcare innovations from head to toe.

The surgeon who tried to save John Lennon says he can’t forget that night

Frank Veteran was a resident in 1980 on the night John Lennon was shot in New York. For years afterward, he tried to process the sight of seeing the Beatle dying in the hospital, including through art, but he says that the memories from the experience are still vivid.

Watch this video letter (via Facebook) from a kidney recipient to his donor

A kidney recipient named Justin reads a letter he wrote to his deceased donor about how the person's generous kidney donation saved his parents from having to watch him suffer and his brother from having the pressure of perhaps being his only shot at a life-saving transplant.

Medical imaging allows 3D printers to create patient-matched devices

With imaging data on a person's anatomy, external prostheses and implants, such as cranial plates or hip joints, can be custom-printed to better match a patient's body. Fabrication of porous structures can promote bone growth, leading to longer-lasting implants.

Trauma-related amputations are primarily from falls, then car accidents and related traumas, followed by mechanical forces according to analysis based on global burden of disease data in 2017.

This Indiana medical school encouraged students to get to know their cadavers' families

The school's anatomy professor instructed medical students to think of the cadavers they worked with as their "first patients"—using their names to acknowledge that this was a person and to exchange letters with the cadaver's family members if they agreed to participate. At the conclusion of the course, families were invited to a lab-based memorial service.

Learn about the point of the physical and emotional experience of pain, which has three broad categories that help determine treatment approaches.

An essay exploring how living day-to-day with a brain implant helps restore a sense of identity

Companies like Neuralink are experimenting with volunteers who have lost control over their bodies. Many of the program's participants claim the most significant benefit from the tool is the ability to perform simple, mundane tasks, such as playing video games or shaking hands, rather than more obvious milestones like walking or eating. This essay explores what it's like, day to day, to use a brain implant.

Why Men's Legs Were Everything

From codpieces to cotton hose, here's the surprisingly loaded history of men's legs, and why 18th-century Europe couldn't stop staring at them.

One man lived with a gene-edited pig kidney for 271 days, setting a record, before he received a human kidney.

See haunting images of the plaster casts of Pompeii’s victims

The plaster casts preserve victims’ final moments in striking detail—from their poses to the expressions frozen on their faces. This piece explains how 19th-century archaeologist Giuseppe Fiorelli devised the method long after the bodies had decomposed.

See images of medical cases of firework injuries shared on this 'Instagram for doctors.' (Warning: Graphic images.)

Whose bodies are held inside the American Museum of Natural History?

The American Museum of Natural History holds the remains of at least 12,000 people collected via purchase, donation, or expedition. This article by a professor of art crime details their attempt to identify the individuals whose remains the museum held. Amid questioning, AMNH announced it would change its human remains policy. At the time of the article's publication in October 2023, AMNH had few human remains on public display.

Some medical schools have phased out human cadavers for digital alternatives

AI-based anatomy tools and digital cadavers are increasingly used to teach students, bypassing the ethical and consent concerns around the use of real bodies. Digital cadavers have also become less expensive than real ones, though the tactile and sensory experiences of real dissection may be irreplaceable.

Explore the basics of arthritis in this 1440 Original video with orthopedic surgeon Dr. Nick Golinvaux.

The subjectivity of pain means that one person's kidney stones may be another's childbirth, but most sources of pain do have objective, underlying causes.

Dorothea Lange contracted polio when she was 7, something she said informed her approach to photograph.

Researchers have investigated the benefits of extreme pain rituals, exploring how and why we engage in these events when humans generally naturally avoid pain and perceive it as a negative experience.

Dinosaurs suffered from cancer, arthritis, and infections seen in modern animals

Using CT scans and advanced pathology techniques, paleopathologists have identified respiratory illnesses, malignant osteosarcoma, and other diseases in dinosaurs. The research has helped show how many of these ailments are not exclusively modern phenomena.