Prehistoric hunter-gatherers performed amputations and appear to have provided post-op care, according to analysis of a recent fossil discovery from almost 31,000 years ago.

Surgery before the dawn of anesthesia

The arc toward anesthetics was painfully slow, with early pain mitigation offerings ranging from analgesics—drugs that dim pain but don't block it—and numbing surgical sites with cold water to gassing patients with carbon dioxide or bashing or bleeding them unconscious. Such treatments and the torturous surgery they preceded led many to avoid even life-saving procedures, and those who survived often kept silent about the trauma.

The earliest evidence of cancer was found in a 1.7-million-year-old fossil—discovered in the toe of an ancestor of modern-day humans.

Humanity's reduced body hair slows down wound healing

Cuts to human skin take twice as long to heal compared to chimps and other mammals. Scientists argue this is due to the reduced number of hair follicles on human bodies. Hair follicles contain stem cells which help repair skin cells faster, so as humanity shed its hair over time, so to speak, it also slowed its wound healing.

Trauma-related amputations are primarily from falls, then car accidents and related traumas, followed by mechanical forces according to analysis based on global burden of disease data in 2017.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

See what analysis of one man's amputated leg, donated to The Bone Museum, tells us about his otherwise invisible pain.

The archaeological discovery that shifted scientists' understanding of human evolution

In 2003, archaeologists in Indonesia uncovered the remains of a 3-foot-tall skeleton that appeared to belong to a new type of human. Read this article to learn how the discovery of this 50,000-year-old skeleton upended the idea that human evolution...

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

Neanderthals commonly had surfer's ear, a potential sign of extensive seafood collection

Analysis from 2019 found that about half of the 23 Neanderthal skulls scientists examined seemed to have the bony growths in the inner ear, signifying they had surfer's ear. Those growths suggest our ancient relatives, dating back to between perhaps 100,000 and 40,000 years ago, were potentially hunting fish, mollusks, or other marine resources in chilly waters.

Searching for the history of cancer in ancient human bones

Nestled under archaeology lies bioarchaeology, which involves the study of bones, human or animal. This subfield recently birthed another field of study: paleo-oncology. Paleo-oncology looks for cancer and related biomarkers in bioarchaeological remains. This TED article explains how this nascent multidisciplinary field challenges the idea that cancer is modern.

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

With no textbooks or antibiotics, this WWI surgeon pioneered facial reconstruction

New Zealand surgeon Dr. Harold Gillies made extraordinary advances in the field of reconstructive surgery during World War I and after. This 36-minute NPR podcast interviews historian Lindsey Fitzharris, author of Gillie's biography, The Facemaker, charting how the good doctor reconstructed the faces of numerous soldiers in an age before antibiotics and plastic surgery as we know it today.

The Paranthropus genus, our mysterious extinct cousins

In the last century, skull and jaw fragments have been discovered in East Africa suggesting an ancient hominin species lived, evolved, and died alongside humanity's ancestors. With large, broad skulls and strong jaws, the Paranthropus genus—which includes several related species—is an absorbing case of the effects of niche partitioning, where species coexist by adapting differently to the environment. Paranthropus died out and human ancestors endured. Find out why here.

How do we know what prehistoric humans ate?

Without recourse to ancient menus, how can historians know what our ancient human ancestors—as far as 3 million years ago—ate on a daily basis? Researchers evaluate several factors, including the type of teeth the species had evolved, chemical analysis of the teeth, patterns of wear and tear on teeth, as well as food scraps found in the vicinity of ancient remains. Learn the approach to discovering ancient hominin diets.

Listen to how bionic limbs are reshaping what it means to live as an amputee in this award-winning 2022 podcast series covering the stories of two amputees who struggled with shortcomings in prosthetic technology.

Here's how early humans lived

Explore the evidence of early human behavior—from ancient footprints to stone tools and the earliest symbols and art – along with similarities and differences in the behavior of other primate species.

Cadaver dogs are helping archaeologists uncover decaying history

Archaeologists are increasingly relying on dogs to help find decaying bodies at burial sites, some of them up to thousands of years old. This is helping archaeologists to detect past remains without ever touching a shovel, which means there's less...

The history of skull modification

The ancient Maya people sometimes modified their skulls to appear more conical. Body modification has been a human pastime for literal ages, from piercings to bindings and everything in between. Modifying one's skull shape may have been a way to symbolize status, beauty, belonging, or belief. The health impacts of such practices are still debated. This article explores the history and health impacts of skull modification, also known as artificial cranial deformation.

Amputees must navigate the challenging medical and economic aspects of limb support and replacement, but advances in technology and research may reduce these costs.

What ancient goat teeth reveal about ancient human-animal relationships

About 4,000 years ago, several goats with terrible teeth managed to outlive their better-teethed brethren. With such intense dental damage, the goats were likely fed higher-quality feed than the more dentally gifted herd members, a dietary shift that would've contributed to the difference in life span. These goat teeth underscore the hard truth that humans may inflict harm on the animals they care about most, regardless of intention.

How 'the Iceman' got his tattoos remains a mystery

Ötzi the Iceman, discovered in 1991, is one of the oldest human mummies ever found—and his 61 tattoos remain a mystery. This explainer looks at how researchers believe the tattoos were made, what their placement suggests about ancient medicine and culture, and why we’re still piecing together their true purpose today.

The lifestyles of early humans

For 2.5 million years, humans lived on Earth without leaving a written record of their lives—but they left behind other kinds of remains and artifacts.

The Ishango bone suggests mathematics was born about 20,000 years ago

Ancient civilizations developed mathematical systems for various purposes, including the Egyptians for the construction of the pyramids and the Ancient Greeks for logical reasoning in theorems. However, these systems were predated by the Ishango bone—found in the Democratic Republic of the Congo—whose notches suggest a base ten system, prime numbers, and simple mathematical operations.

The world’s oldest tattoos belong to 'Iceman' Ötzi

Ötzi is the corpse of "the Iceman" found in the Alps along the Italian and Austrian border in 1991. His mummified body was covered with lines and crosses along the “hard-working” areas of his body, signifying their potential application for therapeutic pain management.

Why our ancestors didn't have crooked teeth

The ancient human fossil record is filled with specimens with pretty nice teeth. So why do modern humans have dental problems? Scientists can't be certain, but one hypothesis suggests the evolutionary shrinking of the human jaw crowded our mouths,...

Exploring the link between history, art, and anatomy

Throughout centuries, art has played a vital role in sharing—and furthering—scientific understanding. This largely began in 1543 when physician Andreas Vesalius worked with an artist and engraver to transform learnings from his dissections into...

Experience a century of America's healthcare advances with this medical visualization, tracing a sampling of healthcare innovations from head to toe.

Researchers have investigated the benefits of extreme pain rituals, exploring how and why we engage in these events when humans generally naturally avoid pain and perceive it as a negative experience.

Research suggests the brain maintains connections to lost limbs

Decades-old research suggested brain reorganization after amputations, but brain scans show unchanged limb representations. Phantom limb pain may result from such unchanged brain maps, which may enhance prosthetic limb control in brain-computer interface technology.

The archaeology of human sacrifice

Human sacrifice appears in cultures around the globe. But how do we know that to be true? Scientists can tell the difference between ritual sacrifice and mass graves better explained by war and political instability. Learn how in this article about...

Ancient humans and other early hominins were closer than you might think

Evidence that human ancestors and other early hominins coexisted continues to accumulate, raising the question of just how close these ancient people truly were. This article details how evidence is changing the theory that early hominins like...

How old are stone tools?

The earliest evidence for stone tools currently dates back to 3.3 million years ago, long before modern humans started roaming about. These tools were made by stone flaking, a mode of tool creation that still is used today and is done by striking...

Dinosaurs suffered from cancer, arthritis, and infections seen in modern animals

Using CT scans and advanced pathology techniques, paleopathologists have identified respiratory illnesses, malignant osteosarcoma, and other diseases in dinosaurs. The research has helped show how many of these ailments are not exclusively modern phenomena.

Why surgeons implant teeth into eyes

What if the thing that restored your vision… was your own tooth? That’s exactly what happened to Brent Chapman. After 20 years without sight, a bizarre surgery using his tooth as a lens restored his vision.

The medical profession has a dark history of 'body snatching' for education

This term originally referred to secretly removing corpses from graves for sale—usually to medical schools where they were used for education. The practice dates back at least to the 1300s but still—much more rarely—persists today.

A Roman-era cemetery in York may hold the remains of gladiators

A burial ground in York, used from the 1st to the 4th centuries CE, contained around 80 skeletons of unusually tall and muscular young men. Many show fatal combat wounds, including one with a bite mark from a large predator.

Santa Barbara's Channel Islands revealed the oldest skeletal remains in North America

IN 1959, archaeologists found a human femur jutting out from a rock face on Santa Rosa Island. Using the then-new technology of radiocarbon dating, they measured the age of the remains at 13,000 years—the oldest in the continent.

The earliest known cardiovascular system dates to 520 million years ago.

Nonamputees can be tricked into thinking they have phantom limbs with rubber arm experiments.

A cave painting might be the oldest illustrated story ever recorded

A nearly 44,000-year-old cave painting may be the oldest story ever recorded, offering viewers a tale of human-like creatures on a hunt. This article details the discovery of the cave and its archaeological implications.

Read why one man agreed to get a pig kidney in 2025 to replace his own failing organ

The 68-year-old New Hampshire man told USA Today that a motivator for the experimental surgery was his belief that he was going to die anyway, and other people suffering from kidney disease could gain valuable insights. Yet the surgery bought him time—he lived 271 days with a pig organ and later received a human kidney transplant. Clinical trials began in 2026 to test the pig xenotransplants in more people.

Phantom limb pain may often match the pain or contortion of the injury that led to the limb loss.

Every 3.5 minutes in the US, a limb is amputated due to diabetes.

Black patients are losing their limbs at a rate triple that of other groups due in large part to inequities in diabetes care and management.

Recreating ancient faces: where art meets archaeology

Artistic renderings and reconstructions of ancient people are one way to bring the past to life, providing viewers with insights into and empathy for those who came before. This article details how modern artists and archaeologists work together to...

Look through this WWI stretcher bearer's bag

While it was indeed the first industrialized war, medical science had yet to catch up on the battlefield. This nearly eight-minute video sorts through the contents of a World War I stretcher-bearer's satchel. A modern doctor and ex-officer assesses the bag's various medical tools for performing first aid on the battlefield.

Chinese scientists transplanted a pig lung into a human being in 2025—but it had to be removed.

Why human brains were bigger 3,000 years ago

Our modern civilisation may be the most advanced to ever exist on Earth, but around 100 generations ago, our ancestors had brains that were larger than our own.

Read the 1866 story in The Atlantic that put phantom limbs on the map, a fictional story by a Civil War surgeon that was mistaken for being a true account by many readers.

Genetic analysis suggests Anopheles mosquitoes fed on humans some 1.8 million years ago.