Henrietta Lacks' tumor cells became the first recognized 'immortal' cell line about 75 years ago, but researchers are still investigating the specific mechanisms that enabled the cells to continuously grow and divide in the laboratory.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

60 years after seeing Henrietta Lacks as a patient, her doctor still remembered the unique cervical tumor that gave rise to the 'immortal' cell line now commonly used in biomedical research—it was purple, shiny, and soft—an appearance he said is very different from a typical tumor.

'Immortal' HeLa cells—cancerous cells widely used in biomedical research after they were nonconsensually taken from a Black woman named Henrietta Lacks—proliferate easily, causing millions of dollars of damage annually by contaminating lab cell cultures.

More than 100,000 scientific publications between 1953 and 2018 reported using HeLa cells—the cancerous cells nonconsensually taken from a Black woman named Henrietta Lacks in 1951.

Read an excerpt from 'The Immortal Life of Henrietta Lacks,' the story of the Black woman whose nonconsensually sampled cancerous cells underpin thousands of research papers and several Nobel Prize-winning works.

The HPV vaccine reduces cervical cancer rates by about 90%.

It's been 75 years since doctors took Henrietta Lacks' cells without her consent or knowledge in 1951 and used them for research, creating an 'immortal' cell line that's still used today—but modern policies and legislation around patient consent remain complex.

Novartis settled with the family of Henrietta Lacks in 2026 for an undisclosed sum after using Lacks' cancerous cells in numerous patents decades after Lacks' cancerous cells were taken without her knowledge or consent.

Roughly 1 in 5 cancers are caused by viruses

About 20% of cancers are caused by viruses, with seven specific oncoviruses causing between 10% and 15% of cancers worldwide. These include human papillomavirus and hepatitis B and C viruses, which can lead to diseases such as cervical and liver cancer. Understanding the mechanisms of these viruses is crucial for prevention and treatment strategies.

The seven viruses that cause human cancers

Certain viruses have been linked to the development of human cancers. These viruses account for up to 20% of cancers worldwide, causing cancer by interacting with host proteins, proliferating within weak immune systems, and commandeering susceptible human cells. Unlike other viruses, human tumor viruses don't kill host cells, allowing them to establish persistent infections. The seven viruses include the Epstein-Barr Virus, the Human Papillomaviruses, and more.

A scientist successfully treated her own breast cancer by injecting the tumor with lab-grown viruses.

See the trailer for the 2017 HBO movie 'The Immortal Life of Henrietta Lacks' starring Oprah Winfrey, who plays the daughter of the Black woman whose cancer cells were taken without her knowledge or permission, and now underpin numerous scientific discoveries.

HeLa cells, 'immortal' cancerous cells that continuously divide, were sent into space in 1960 on both Soviet and American missions—the samples were shared by American researchers as an example of scientific diplomacy amid the Cold War.

Up to 8% of the human genome consists of ancient viral DNA

Human endogenous retroviruses are remnants of infections that affected human primate ancestors millions of years ago and were passed on by infiltrating sperm and egg cells. Studies have shown that this DNA may play a role in immune responses and in placental formation.

Before vaccines, there was 'variolation': what was it?

Before the technology behind vaccinations was discovered, some keen observers of medicine around the globe noticed how previous infections could impact future ones. Learn about the techniques early physicians used before they had vaccines.

The immune system is in a constant fight to detect and eliminate cellular mutations.

HIV sidelines your immune system by destroying T cells, eventually rendering the body unable to fight off even minor illnesses.

mRNA vaccines alter immune response, not DNA, to combat diseases like cancer.

Timeline of cancer research milestones

While cancer remains incurable, there's been so much progress in its treatment over the last two decades. Nature provides an abridged history of milestones and major triumphs in cancer research and treatment. Start in the year 2000, and see how much has changed in the first quarter of the new millennium

Many cancers arise from genetic mutations inherited from your parents

These mutations may happen in response to environmental or lifestyle factors, or may be passed down through family members. Genetic testing can be important in catching certain family cancers early and ensuring patients receive the right treatment for their disease.

Why don't we all have cancer?

The creation of a single cell produces 120,000 genetic mutations that can lead to cancer. This video investigates how our bodies proofread and autocorrect those mistakes.

Cells become cancerous if checkpoints in the cell cycle are damaged

Before cells divide, a protein called p53 can halt the cell cycle if damaged DNA is identified, preventing the fault from propagating to daughter cells. If p53 and other tumor-suppressing molecules cannot function due to mutations or other instabilities, damage can accumulate over successive generations until nothing stops cells from dividing uncontrollably, creating tumors.

Explore global maps of cancer prevalence, with incidences that reflect various risk factors, including smoking rates, HPV infections, sunscreen use, and alcohol consumption.

A new type of immunotherapy focuses on healthy cells hijacked by tumors

Purdue University scientists are at work on a new cancer treatment that attacks immune system cells that feed and protect cancer cells rather than attacking them. The immunotherapy process promises to become a universal treatment for solid tumors. Thus far, the treatment has been tested and shown to work on human tumor cells in the laboratory and animal models.

The earliest evidence of cancer was found in a 1.7-million-year-old fossil—discovered in the toe of an ancestor of modern-day humans.

Variola: the second-deadliest virus on Earth

Because it was declared eradicated in 1980, many forget smallpox is one of history's deadliest diseases—in its final century, it's estimated to have claimed 500 million lives. This 11-minute video from production studio Kurzgesagt takes a look at...

How race science influences breast cancer research

Despite researchers' and physicians' pushback, race is still used in studies and clinics to categorize human differences in health conditions and treatment responses. This article explores how race has influenced breast cancer research. Considering race as a factor in cancer research, diagnosis, and treatment can lead to racial inequalities. Sociocultural factors, including food access and air pollution, greatly influence health outcomes.

About 40% of cancer cases are linked to preventable risk factors

Maintaining a healthy weight, engaging in regular physical activity, and consuming a balanced diet can lower cancer risk. Research indicates that about 40% of US cancer cases are linked to preventable factors, including poor diet and inactivity. Understanding these mechanisms empowers individuals to adopt healthier lifestyles for cancer prevention.

A 1954 outbreak at a Boston boarding school allowed scientists to isolate the measles virus

While measles was described as early as the 9th century, humanity lacked the medical technology to fight the disease until the mid-20th century. Vaccine development from the Boston outbreak in the 1960s and 1970s led to one of the most effective inoculation campaigns in history.

After the patient died, a latent pig virus was discovered inside his xenotransplant

Researchers studying the death of David Bennett Sr., the first gene-edited pig heart transplant patient, discovered potential factors that may have contributed to his demise. One finding is that there was a latent virus, called porcine cytomegalovirus (PCMV), in the pig heart, which may have contributed to dysfunction of the transplant.

Cancer is a group of diseases characterized by the uncontrolled growth of abnormal, mutated cells that can spread throughout the body.

Low cell division rates in heart cells make heart cancer particularly rare

The heart's location in the chest also offers protection from external cancer-causing factors. The disease affects about 3 in every 10,000 people, though most cases arise from metastasis from other body parts.

Every virus is classified into 7 groups based on genetic differences

Viruses infecting humans have been named based on symptoms ("chickenpox") or the location or animal in which they were first discovered ("Bolivian Haemorrhagic Fever" and "Monkeypox"). For clarity among scientists and to reduce stigma, virologists classify the 15,000 known viruses (270 of which infect humans) by their basic genetic material.

Large animals like giraffes and elephants have evolved unique cancer defenses.

Live virus vaccines predated polio—that's how we vaccinate against smallpox

Since 1796, smallpox vaccines have used a live poxvirus related to smallpox. Yellow fever vaccines have used a live weakened form of the virus responsible for yellow fever since 1937.

Only one strain of wild poliovirus continues to infect humans

Three strains of polio used to regularly infect humans, but two of the strains were declared eradicated in 2015 and 2019, respectively. In 2019, world health leaders estimated complete polio eradication—if achieved—would save $14B by 2050.

Herd immunity works by slowing down viral transmission until it dies out

Herd immunity refers to a population whose vaccination rates against a given virus are high enough that transmission dies out before the bug can find the next unvaccinated person to infect. Rates needed to achieve this depend on how contagious a virus is. This video gives a quick visual explanation of how it works.

Searching for the history of cancer in ancient human bones

Nestled under archaeology lies bioarchaeology, which involves the study of bones, human or animal. This subfield recently birthed another field of study: paleo-oncology. Paleo-oncology looks for cancer and related biomarkers in bioarchaeological remains. This TED article explains how this nascent multidisciplinary field challenges the idea that cancer is modern.