In 1970, Pittsburgh Pirates' pitcher Dock Ellis threw a no-hitter—a rare feat that was just the 174th in MLB history—while high on LSD.

Some say baseball's drug problem goes back to the late 1800s

At age 32, pitcher James “Pud” Galvin was feeling tired and decided to take "the Brown-Séquard elixir," which contained a testicular fluid from dogs and guinea pigs, believed to invigorate tired bodies. It might've worked: Galvin pitched a two-hit shutout the next day.

In 1985, New York Mets star Keith Hernandez said 40% of his MLB peers used cocaine, highlighting an open secret about drug use in the league.

100 moments that shaped baseball history

Published in 2018 by baseball historian Jacob Kornhauser, this list examines the defining moments throughout more than a century of play on the field, from Pittsburgh Pirates pitcher Dock Ellis purportedly throwing a no-hitter while on acid to Jackie Robinson breaking the color barrier.

Before 1920, during the Deadball Era, a single baseball was used throughout a Major League game, leading to a notoriously dirty style of play.

LSD was discovered accidentally after its inventor touched his face and hallucinated.

An eephus is a high-arc pitch usually thrown by position players filling in for pitchers in blowout games.

In 1951, a small French town was overtaken by the fungus that ultimately led to LSD

During the summer of 1951, the French town of Pont-Saint-Esprit appeared to go mad. Hundreds were treated for hallucinations and delirium, with some reporting ongoing hallucinations a month after the LSD-like symptoms appeared. Some historians argue it was a case of ergotism, better known in the Middle Ages as "burning disease" and "St. Anthony's Fire."

How to make LSD

Lysergic acid diethylamide, often shortened to LSD, comes from ergot, a parasitic fungus that can be found in grains. Chemists rearrange the fungus' chemical structure or the structure of an ergot derivative through complex chemical reactions, transforming it into the hallucinogenic bicycle-shaped LSD crystal. Due to the partially synthetic drug's criminalization, many of the details of modern LSD crafting honed by "underground chemists" are kept secret.

LSD fueled a countercultural movement before evolving into a potential therapeutic

As the use of recreational psychedelics became common, authorities were quick to claim LSD had lasting adverse effects, criminalizing the drug and halting scientific study for decades. Over time, LSD's reputation shifted from a potential source of enlightenment to a dangerous drug that could dim a person's future, and back to a possible therapeutic compound.

An LSD scientist's role in a US mind control project

Within a decade of LSD's discovery, the US government had launched a secret initiative involving hypnosis and hallucinogens. LSD researcher Louis Jolyon West conducted experiments for the CIA's MKUltra project, which focused on the potential of mind control. He later took part in a criminal trial that hinged on testimony whose sourcing was seemingly inspired by MKUltra experiments. This article explores light shed by West's personal archive.

What does LSD have to do with Bicycle Day?

Bicycle Day, generally celebrated on April 19, doesn't have much to do with the two-wheeled, human-powered vehicle as the name would imply. Instead, it's a celebration of the world's first acid trip. On April 19, 1943, Albert Hofmann took an experimental dose of LSD at his lab before trying to return home via bike. This article includes comics from a graphic novel detailing Hofmann's trip.

LSD (better known as acid) was created in 1938 by Swiss chemist Dr. Albert Hofmann

Lysergic acid diethylamide, better known as LSD or acid, was first developed synthetically in 1938 by Swiss chemist Dr. Albert Hofmann. It's since become a linchpin for an entire aesthetic, fueled a counterculture movement, and is being studied for potential therapeutic uses.

A history of the rare, chaotic moments when MLB batters charge the pitcher on the mound

They typically occur when a pitcher has slung a pitch a little too close to the batter—though the exact causes vary, from quick tempers to longstanding grudges. No definitive account of these infrequent but highly visible incidents has existed, so sportswriter Jon Bois compiled data on 264 such moments between 1950 and 2025. The resulting 23-minute video explores the rich narratives leading to these charged events.

Ken Caminiti exposed steroid use around the league

In 2002, newly retired Ken Caminiti was the first to admit to using steroids as a player, citing how common PEDs were in the league, something that had long been rumored, especially after the single-season home run record was broken in 1998 by Mark McGwire.

MLB pitchers were charged with benefiting from sports betting

In November 2025, two pitchers for the Cleveland Guardians were charged with coordinating with sports bettors to enrich themselves and others. In many instances, they shared the kinds of pitches they would throw at specific points in the game. Bettors then placed money on those actions.

A Bay Area lab was supplying MLB players with steroids

The Bay Area Laboratory Co-operative, also known as BALCO, began as a modest vitamin shop, but by the 1990s it was at the center of a doping scheme that rocked Major League Baseball and other professional sports.

Baseball legend Joe DiMaggio's hitting streak, which ended at 56, cost him a sponsorship deal with Heinz.

Visualize how changes to lineups, driven by modern analytics, could have changed one of MLB's most iconic moments.

Ibogaine, a psychedelic substance, can be used to treat mental illness

Although the substance is banned in the US, it's legal in Mexico. Americans who have traveled there for treatment, including the NFL's Braden Smith, say the drug helps deal with conditions like obsessive-compulsive disorder.

The first MLB All-Star Game was designed by a sports journalist who believed the spectacle would boost baseball's reputation during the Great Depression.

How Western psychedelics research fell to the wayside

Psychedelics' modern era began when LSD was discovered in the 1930s. By the 1950s, clinical trials were underway. US user experimentation outside of medical settings (and high-profile violence, like the Manson murders) inspired negative attitudes toward psychedelics, leading to use restrictions that prohibited companies from patenting psychedelic compounds. This strangled psychedelics' profitability until the 1990s when the government loosened its grip and psychedelics research began seeing a resurgence.

LSD was derived from natural compounds produced by the ergot fungus

Ergot is a fungus that slowly infects and replaces individual grains on grasses, including rye and wheat. Ingesting ergot can cause ergotism, a form of poisoning with symptoms—including headaches, hallucinations, gangrene, and convulsions—varying by season and geography. This grain was used for medicinal purposes as early as the 1500s.

LSD-like drugs may inspire new antidepressants

LSD and psilocybin have shown promise as antidepressants. Using a virtual library of similar chemical compounds, researchers determined via animal studies that two molecules inspired by LSD have antidepressant effects without any associated hallucinogenic experience. These molecules were found to be 40 times more potent than the common antidepressant fluoxetine, also known as Prozac, with antidepressant effects lasting up to 21 days.

The International Olympic Committee banned ibogaine decades ago

Beyond use by athletes as a stimulant before the ban, the drug has a long history. The psychoactive substance was also mass produced in the mid-20th century by a French pharmaceutical company as a product called Lambarène, which was marketed as a cure for conditions including depression and lethargy. Production halted in 1966, however, when ibogaine-containing products became illegal in France.

Only a fraction of LSD reaches the brain, but it concentrates in key regions

When taken, LSD is absorbed quickly (often within an hour of ingestion) and exerts its effects primarily by binding to serotonin receptors. While only a small amount enters the brain, it's active in regions controlling the visual and auditory senses, potentially driving its psychedelic effects. The drug doesn't linger in the body, and is typically undetectable within a day.

Physiological changes to the brain on LSD can be captured via MRI

Psychedelics like LSD often take users on novel experiences that can result in lasting shifts in perspective and behavior. See how LSD affects brain activity in this video that details how scientists visually captured the psychedelic's effect for the first time.

Mental health applications of psychedelics

Scientists are investigating psilocybin, ketamine, LSD, and MDMA (also known as ecstasy) as potential treatments for mental health issues. These drugs enable an altered state of consciousness, which can have beneficial or harmful impacts depending on the nature of the experience. Research suggests these drugs can be effective in treating substance use disorders, mental health conditions, including depression and anxiety, and psychiatric disorders, including schizophrenia.

A psychedelic hamburger led one member of the Manson Family, the murderous cult led by Charles Manson, to testify against the group's leader.

Check out a list of the top 100 players in baseball history, from Barry Larkin to Babe Ruth.

Widespread use of LSD sparked a counter-cultural artistic movement in the 1960s

The trippy visuals often associated with LSD flourished in the 1960s as the drug became more widespread. Psychedelic design, defined by its undulating text and graphics, ultimately grew beyond just visuals, spawning psychedelia, a term that includes art, music, and cultural experiences based on psychedelic experiences.

Psychedelics are being fast-tracked for research after a 2026 executive order

Many such compounds (including LSD, psilocybin, and more) are classified as Schedule I drugs—illegal to possess and federally regarded as having no medical use. Researchers say such restrictions have created significant hurdles for formal clinical trials. With this executive order, the FDA will enable work particularly focused on depression, PTSD, and alcohol use disorder.

The story behind one infamous World Series moment

“The Bartman Incident” during Game 6 of the 2003 NLCS forever changed the life of Cubs fan Steve Bartman, who quickly descended into anonymity. This 2005 ESPN story attempts to find answers behind the notorious Bartman.

An overview of modern clinical research on LSD

Researchers have determined that LSD, taken in a medical setting, decreases anxiety related to "life-threatening disease," reduces brain reactivity to fearful faces, increases the meaning and emotional response derived from music, and more. No complications of LSD administration have been observed in medical settings, though acute adverse effects, including exhaustion, nausea, and difficulty concentrating.

How pitcher Pedro Martinez helped reverse the curse of the Red Sox

The team had not won a World Series for nearly 100 years—while their rivals, the Yankees, had won 26. The Dominican pitcher joined the club in 1997 and helped lead the team to reverse the curse.

MLB 2023 rules changes were the most dramatic alterations in decades, drastically speeding up the game.

Little League sensation Danny Almonte was two years older than his competitors

The New York pitcher was a hotshot pitcher in the 2001 Little League World Series, catapulting his Bronx team to a third-place finish thanks to a no-hitter and a perfect game. Sports Illustrated eventually reported that Almonte was 14, not 12, and that his coach and father had knowingly misled Little League. They were both banned, though Almonte himself was cleared of all wrongdoing.

Merck developed MDMA in the early 1900s as part of its effort to create a blood clotting drug

The company's chemists were attempting to synthesize a substance that could compete with an existing patent for the best clot medicine of that time, hydrastinine. MDMA was the byproduct of that effort.

In July 1979, tens of thousands of people rioted on the Chicago White Sox field during 'Disco Demolition Night,' a promotional event that advertised the public burning of the genre's hit records.