LSD was derived from natural compounds produced by the ergot fungus

How to make LSD

Lysergic acid diethylamide, often shortened to LSD, comes from ergot, a parasitic fungus that can be found in grains. Chemists rearrange the fungus' chemical structure or the structure of an ergot derivative through complex chemical reactions, transforming it into the hallucinogenic bicycle-shaped LSD crystal. Due to the partially synthetic drug's criminalization, many of the details of modern LSD crafting honed by "underground chemists" are kept secret.

LSD's molecular structure closely resembles the neurotransmitter serotonin

Lysergic acid diethylamide (C20H25N3O) is a colorless, odorless, and flavorless chemical compound that can induce altered perception, mood, and cognition. One of its roles in the brain is as a serotonin agonist, meaning it enters serotonin receptors and triggers a fraction of the response the neurotransmitter would typically warrant.

In 1951, a small French town was overtaken by the fungus that ultimately led to LSD

During the summer of 1951, the French town of Pont-Saint-Esprit appeared to go mad. Hundreds were treated for hallucinations and delirium, with some reporting ongoing hallucinations a month after the LSD-like symptoms appeared. Some historians argue it was a case of ergotism, better known in the Middle Ages as "burning disease" and "St. Anthony's Fire."

LSD (better known as acid) was created in 1938 by Swiss chemist Dr. Albert Hofmann

Lysergic acid diethylamide, better known as LSD or acid, was first developed synthetically in 1938 by Swiss chemist Dr. Albert Hofmann. It's since become a linchpin for an entire aesthetic, fueled a counterculture movement, and is being studied for potential therapeutic uses.

LSD fueled a countercultural movement before evolving into a potential therapeutic

As the use of recreational psychedelics became common, authorities were quick to claim LSD had lasting adverse effects, criminalizing the drug and halting scientific study for decades. Over time, LSD's reputation shifted from a potential source of enlightenment to a dangerous drug that could dim a person's future, and back to a possible therapeutic compound.

LSD was discovered accidentally after its inventor touched his face and hallucinated

Unlike many drugs, the first time a human ever tripped on acid was recorded first-hand by a scientist. Swiss chemist Albert Hofmann, curious about the "not unpleasant intoxicated-like condition" that overcame him after an accidental exposure, set up a rigorous experiment to test the drug's effects on himself.

Widespread use of LSD sparked a counter-cultural artistic movement in the 1960s

The trippy visuals often associated with LSD flourished in the 1960s as the drug became more widespread. Psychedelic design, defined by its undulating text and graphics, ultimately grew beyond just visuals, spawning psychedelia, a term that includes art, music, and cultural experiences based on psychedelic experiences.

An overview of modern clinical research on LSD

Researchers have determined that LSD, taken in a medical setting, decreases anxiety related to "life-threatening disease," reduces brain reactivity to fearful faces, increases the meaning and emotional response derived from music, and more. No complications of LSD administration have been observed in medical settings, though acute adverse effects, including exhaustion, nausea, and difficulty concentrating.

Only a fraction of LSD reaches the brain, but it concentrates in key regions

When taken, LSD is absorbed quickly (often within an hour of ingestion) and exerts its effects primarily by binding to serotonin receptors. While only a small amount enters the brain, it's active in regions controlling the visual and auditory senses, potentially driving its psychedelic effects. The drug doesn't linger in the body, and is typically undetectable within a day.

LSD-like drugs may inspire new antidepressants

LSD and psilocybin have shown promise as antidepressants. Using a virtual library of similar chemical compounds, researchers determined via animal studies that two molecules inspired by LSD have antidepressant effects without any associated hallucinogenic experience. These molecules were found to be 40 times more potent than the common antidepressant fluoxetine, also known as Prozac, with antidepressant effects lasting up to 21 days.

Merck developed MDMA in the early 1900s as part of its effort to create a blood clotting drug

The company's chemists were attempting to synthesize a substance that could compete with an existing patent for the best clot medicine of that time, hydrastinine. MDMA was the byproduct of that effort.

The 'definitive' history of magic mushrooms

Where did magic mushrooms come from, and how did they get their magical reputation? This article explains the history of the psychedelic fungi from pre-history to now. The earliest concrete evidence of psychedelic mushroom use is 12,000-year-old murals in Northern Australia that portray mushroom iconography. Considering how many species seek out and consume psychoactive substances, such as Siberian reindeer, it's possible human use of these psychedelic mushrooms may predate these murals.

What does LSD have to do with Bicycle Day?

Bicycle Day, generally celebrated on April 19, doesn't have much to do with the two-wheeled, human-powered vehicle as the name would imply. Instead, it's a celebration of the world's first acid trip. On April 19, 1943, Albert Hofmann took an experimental dose of LSD at his lab before trying to return home via bike. This article includes comics from a graphic novel detailing Hofmann's trip.

What do psychedelic plants look like?

Far from the drippy aesthetic often associated with psychedelics, the plants powering naturally occurring psychoactive experiences may not stand out as anything special. This database offers a visual guide to psychoactive plants and fungi. Clicking on the title of a particular plant, such as yerba mate, will bring up a secondary screen with various hyperlinked images, such as the plant itself, related botanical drawings, and molecular structures.

The pharmaceutical industry evolved, in part, from the discovery of synthetic dyes

In 1856, a chemist accidentally discovered mauveine, the world’s first synthetic dye, while trying to make quinine to treat malaria. The synthetic dyes that followed helped reveal germs under microscopes, paving the way for modern imaging techniques and breakthrough treatments, such as antibiotics.

Morphine, heroin, codeine, and more were derived from opium

Opium reached the US at about the time early colonists were itching for ways to soothe aches and pains. The active ingredient in the substance was isolated in the early 19th century, eventually leading to the manufacture and commercial sale of morphine, heroin, and other opium-based drugs.

Psychoactive drugs found in 1,000-year-old bag made of fox noses

Archaeologists in Bolivia have uncovered an ancient bag filled with "amazing goodies" that suggests the owner or owners were well-versed in the properties of psychoactive substances and sourced goods from well-established trade routes. This article details the findings, which shed light on how ancient peoples in the region consumed and obtained psychoactive substances.

Artificial lightning can improve the yield of shiitake mushroom growers

Researchers have found that shockwaves produced from lightning strikes homogenously break internal filaments called hyphae, transitioning the mushrooms from a vegetative growth to a fruiting phase. Repeated minor shocks near mushroom logs mimicked this effect.

Monosodium glutamate is a sodium salt form of a naturally occurring amino acid

Monosodium glutamate myths originate from a 1968 letter to the New England Journal of Medicine, in which unpleasant symptoms after eating Chinese food were dubbed Chinese restaurant syndrome without medical data. Subsequent studies show this savory flavor enhancer—found in tomatoes, mushrooms, and other foods—is safe in moderation.

In 1970, Pittsburgh's Dock Ellis threw a no-hitter on LSD

It was the 174th no-hitter in MLB history, but the only one where the pitcher claimed to be high at the time. This animated video uses Ellis’ own comments from a 2008 NPR interview where he described why he took LSD that morning and the difficulty of pitching while tripping.

Measles evolved from an ancient cattle disease as early as 3,000 years ago

Genetic analysis suggests that the closest modern relative of measles is a livestock virus known as rinderpest, with the viral strains diverging between 2,000 and 3,000 years ago. The timing coincided with the rise of major cities above 250,000 people, offering a novel transmission route for the newly mutated measles virus.

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

A psychedelic hamburger led one member of the Manson Family, the murderous cult led by Charles Manson, to testify against the group's leader.

Cordyceps: the fungi that turn ants into zombies

The hit show (and video game) "Last of Us" was inspired partly by real-life species of fungi that have been known to turn ants into zombies. Spores of the Cordyceps fungi are capable of penetrating the exoskeletons of arthropods, after which they break into enzymes and proliferate within the body. The fungal cells then hack the ant's nervous system and trigger compulsive climbing.

Natural toxins produced on plants or consumed by animals may cause food poisoning

When humans eat plants with certain natural toxins on them—including a family of toxins called aflatoxins that fungi produce on crops like peanuts and corn— they can become ill with food poisoning. Toxins can still harm humans even if animals or plants appear fine to the human eye. The World Health Organization advises that we should throw away moldy or discolored foods, refrain from eating wild plants or mushrooms that aren’t definitively nonpoisonous, and remember that just because something is “natural” it’s not always safe to eat.

In 2011, a mysterious illness spread around LeRoy, New York

A handful of girls were stricken with bizarre twitches, tics, and spasms — all apparently involuntary. Some believed the incident to be conversion disorder, an illness where emotional troubles have physical symptoms.

How fermentation enables the pickling of food and the production of beer

This process occurs when microbes produce lactic acid, ethanol, or carbon dioxide after consuming sugars. The acid helps preserve vegetables in a brine solution during pickling and gives them a sour taste, while ethanol serves as the inebriant in alcoholic beverages. The acid and carbon dioxide give sourdough bread its taste and texture.

Poison ivy's characteristic rash is caused by an allergic response to an oily compound in the plant called urushiol.

In 1892, two scientists purposefully infected themselves with cholera bacteria

When they became ill—one with mild diarrhea and the other with severe cholera—researchers pointed to that as proof that the pathogen caused the disease.

A moldy cantaloupe supercharged penicillin production

In 1943, a moldy cantaloupe found at a market in Peoria, Illinois, yielded a strain that produced six times more penicillin. Though often credited to lab worker “Moldy Mary” Hunt, accounts differ on who actually brought in the fruit.

Wood that changed the color of water was the earliest recorded example of fluorescence

Lignum nephriticum, a tea used to treat kidney and urinary illnesses, was described in the 16th century as derived from white wood that turned water a bluish hue. However, in the 17th century, accounts described the wood as reddish and creating a kaleidoscope of colors in water. In 1915, the sources were identified as two different woods, which absorb UV radiation and emit visible light.

Why is fentanyl poisoning street drugs?

A few grains of fentanyl, a synthetic opioid far more potent than heroin or morphine, is enough to kill a typical adult human. It's made its way into other, less lethal street drugs, where it may be used to increase the highs experienced by unknowing users, increasing their likelihood of addiction and overdose. This 39-minute podcast episode is the first half of a two-part series exploring fentanyl's rise.

Lyme disease is caused by bacteria transmitted through the bite of infected ticks

It's an infectious disease caused by Borrelia burgdorferi bacteria. It's spread through the bite of two species of infected ticks, the Western blacklegged ticks on the West Coast, and Blacklegged ticks found throughout the eastern US. The ticks can transmit the disease at both the nymph and adult stage. It's not known to be transmitted from one person to another via kissing or sex.

Historians theorize Vincent Van Gogh suffered from Ménière's disease or epilepsy

A century after researchers suggested he suffered from epilepsy, some researchers in the 1990s began to support an alternate diagnosis: Ménière's disease, since he had suffered from severe, repeated attacks of disabling vertigo. Still, some researchers remain skeptical of the Ménière's diagnosis. One posits that Van Gogh had temporal epilepsy complicated by his absinthe consumption.

This is the human brain on the world's strongest psychedelic

Within seconds of inhaling a high dose of vaporized synthetic 5-MeO-DMT—a lab-produced substance that otherwise is naturally derived from the glands of the Colorado River toad—it induced slow brain waves. Such waves are typically associated with unconsciousness due to a coma or anesthesia, perhaps explaining why users describe feeling like everything falls away. The compound is currently in clinical trials for treating depression.

Recent research indicates leprosy was present in the Americas before European settlers

New research published in 2025 upended long-held notions that the disease was introduced to the Americas by European colonizers. Evidence of a lesser-known leprosy-causing bacterium was found in ancient human remains that date back 4,000 years.

Fungi make people sick when they invade and survive in otherwise healthy human tissue

We breathe in airborne spores frequently, but they often don't make us sick. This video details how certain concerning fungal changes can occur and discusses the role of mycologists—scientists who study fungi—in helping to improve human health.

How scientists are using molecules found in acidophiles to develop new medical treatments

The Berkeley Pit, an open-pit copper mine in Butte, Montana, that ceased operations in 1982 and is now filled with highly acidic water, is home to various species of fungi and yeast. These extremophiles produce unique compounds that may have anti-inflammatory benefits and have already been used to create an antibiotic for staph infections.

Hippocratic doctors treated severe mental illness with the poisonous plant hellebore

Since symptoms like hallucinations were believed be due to an imbalance of black bile, yellow bile, blood, and phlegm, the treatment at the time was to bring those humors back into balance. That meant standard treatments could include bleeding a patient or using substances like hellebore to induce vomiting or diarrhea.

A 101 on the 'Death Cap,' the world's deadliest mushroom

The Death Cap, also known as amanita phalloides, is the most fatal mushroom on the planet, responsible for roughly 90% of the world's mushroom deaths per year. Ingestion of the mushroom wreaks havoc on the liver and kidneys, frequently leading to...

'Brave New World' author Aldous Huxley turned to LSD on his deathbed

As "Brave New World" author Aldous Huxley lay dying of cancer in 1963, he asked his wife Laura to dose him with the hallucinogen LSD. A month later, Laura Huxley wrote a letter detailing the author's final trip, which she notes ended "so slowly, so gently, like a piece of music just finishing in a sempre piu piano dolcemente."

Budweiser still uses the same yeast lineage derived from the one used in the 1800s

During the late 1800s when Budweiser beers hit the market, darker, all‑malt lagers dominated the US beer market. Budweiser was brewed with a single, consistent yeast strain that gave it a crisp uniform flavor, differentiating it from darker beers.

Rome's herbal panacea may not be as extinct as we thought

Silphion: cure-all, aphrodisiac, birth control, tasty seasoning. Nero allegedly ate the last of this miracle plant. This article details how a researcher may have found more. Seven centuries after the yellow-flowered plant was first documented growing in what's now Libya, it vanished. Historians proposed that the loss of Silphion may have been the first recorded extinction of any species.

GLP-1 drugs, first used to manage diabetes, were derived from Gila monster saliva

Scientists studying the barely-there feeding frequency of the Gila monster found its saliva had a hormone regulating blood sugar and appetite. Further research revealed this hormone resembled a human one known as GLP-1, giving rise to the modern wave of diabetes and weight-management drugs.

The International Olympic Committee banned ibogaine decades ago

Beyond use by athletes as a stimulant before the ban, the drug has a long history. The psychoactive substance was also mass produced in the mid-20th century by a French pharmaceutical company as a product called Lambarène, which was marketed as a cure for conditions including depression and lethargy. Production halted in 1966, however, when ibogaine-containing products became illegal in France.

Random lasers can be created from biomaterials, such as peanuts and birch leaves

Rather than creating a narrow beam of light via amplification in an optical cavity, the random laser produces a red glow by scattering photons created in the natural pores of a peanut kernel after it has been injected with a solution of light-generating carbon dots derived from birch leaves.

Genetic engineering has accelerated millennia of altering various crops' genes

Although farmers have long cross-bred crops to obtain plants with specific colors, sizes, and other characteristics, these processes took significant time. Today, genetic modification in agriculture involves scientists altering an organism's DNA for various purposes, including enhancing pathogen resistance, removing allergens, and delaying spoilage.

Eduard Baltzer encouraged 'natural eating' in the 1860s

Historian Corinna Treitel credits the Protestant minister with inventing the concept of “natural eating” in Nordhausen, Germany, in the 19th century. Baltzer believed that people were consuming excessive amounts of schnapps, sugar, and meat, and that this behavior was having a detrimental impact on their lives. He encouraged a diet mostly of fruits and vegetables, though he was not opposed to food grown with artificial fertilizers.

Michael Sveda discovered cyclamate by accident

When this lab researcher brought his hands to his lips to smoke his cigarette in 1937, he tasted something sweet, which he called cyclamate. It was quickly used in diet sodas, but it was banned from the US in 1969 after being linked to rodent bladder cancer in lab experiments.

Fulgurites are glass sculptures made by lightning vaporizing sand

Sometimes referred to as fossilized lightning, these tube-like structures are formed when high-temperature electrical currents fuse mineral grains into crystals, which can feature branching patterns resembling filaments of current. Their name derives from "fulgur," the Latin word for lightning.