Cyanoacrylate, or superglue, was discovered by accident during World War II when researchers tried to create a clear plastic for precision gunsights.

Sticky notes became associated with canary yellow because, during prototyping, the lab adjacent to the inventors had only yellow scrap paper available.

Teflon was an accidental discovery by a DuPont scientist in the 1930s resulting from efforts to create a safe refrigerant.

How nylon was created

Nylon, one of the most ubiquitous materials in the world, was invented in 1935. Chemist Wallace Carothers was hired by American conglomerate DuPont to perform research. After seven years of work he produced nylon, the first wholly synthetic fabric. Carothers’ life ended tragically, but his contributions revolutionized everything from military equipment to women’s fashion.

Multiple sugar substitutes were accidental discoveries when lab workers didn't wash their hands.

Lasers have been used to create natural adhesives for paper

German researchers at four Fraunhofer institutes have developed a method to seal paper packaging using a carbon monoxide laser. Without the need for glue or plastic adhesives, the Papure project is expected to improve the recyclability of paper. (Some readers may experience a paywall.)

Strands of DNA can act as biochemical Velcro and fasten two molecules together because the complementary bases that make up DNA strands bond together consistently.

A breakdown of gelling agents used to modify a liquid's texture

Gelatin, agar, and other substances form a structural network that traps liquid, making it appear solid and enabling chefs to create stable layers in pastries and confectionery products. In different concentrations, they can also be used to thicken liquids into gels or encase them in gelatinous spheres.

Plastic's history began with an inventor seeking a $10,000 prize offer

In 1869, the first synthetic polymer—celluloid—was created as a substitute for ivory in billiard balls. It became the historical catalyst for the eventual manufacturing of plastics everywhere as an alternative to the depletion of other natural resources, including tortoiseshell and horns.

The applications and industrial uses of graphene, the single-atom-thick material

Shortly after its discovery in 2004, the strength, flexibility, optical properties, and conductivity of this thin layer of carbon atoms earned it the designation of a "wonder material," but breakthroughs in its use have taken decades of research. As of 2026, graphene-enhanced electronic sensors, optical microchips, concrete, and supercapacitors are available, though scale production challenges remain.

Used since the 1940s, 'forever chemicals' include thousands of different types of substances routinely integrated into industry and consumer products, yet research suggests they can accumulate in the body over time.

Adhesion molecules and intercellular junctions allow cells to connect together

While some organic structures are mostly composed of non-cellular components (e.g., collagen and calcium phosphate minerals in bones), tissues and organs composed of connected cells rely on specialized proteins and connections to create watertight seals that protect cells within the interior from environmental molecules.

Merck developed MDMA in the early 1900s as part of its effort to create a blood clotting drug

The company's chemists were attempting to synthesize a substance that could compete with an existing patent for the best clot medicine of that time, hydrastinine. MDMA was the byproduct of that effort.

Penicillin was discovered by accident

In 1928, Alexander Fleming returned from vacation to find mold contaminating a petri dish of bacteria. Around the mold, the microbes had died—an accidental observation that led to the discovery of penicillin.

Beyond a certain pressure and temperature, matter can become a supercritical fluid—an exotic state of matter that simultaneously exhibits properties of gases and liquids.

LSD (better known as acid) was created in 1938 by Swiss chemist Dr. Albert Hofmann

Lysergic acid diethylamide, better known as LSD or acid, was first developed synthetically in 1938 by Swiss chemist Dr. Albert Hofmann. It's since become a linchpin for an entire aesthetic, fueled a counterculture movement, and is being studied for potential therapeutic uses.

Blacklights can illuminate certain biological materials, including blood, teeth, and fingernails, because they contain fluorophores—molecules that visibly glow immediately after exposure to higher-energy light.

Michael Sveda discovered cyclamate by accident

When this lab researcher brought his hands to his lips to smoke his cigarette in 1937, he tasted something sweet, which he called cyclamate. It was quickly used in diet sodas, but it was banned from the US in 1969 after being linked to rodent bladder cancer in lab experiments.

Aspartame was a surprise discovery from a lab working on gastric ulcers

As with saccharin and cyclamate, the aspartame discovery arose from its discoverer tasting something sweet from his workplace. In 1965, American chemist James Schlatter licked a white powder off his finger as he picked up a piece of paper and was startled to discover it tasted sweet. He applied for a patent for the substance, and received it in 1970. It is now one of the most popular artificial sweeteners. (Some users may experience a paywall.)

The history of chemistry up to World War I, from alchemists seeking gold to probing atomic structure

Those involved in the predecessor of the modern scientific discipline engaged in experimentation to develop recipes that would transform ordinary matter into gold and to create medicines, cosmetics, dyes, and alloys. Over the course of centuries, scientists identified unique elements, organized them based on their properties in the periodic table, and eventually developed the technology to discover the internal structure of atoms.

How silica gel took over the world

Silica gel packets are those sugar packet-like bags that keep packaged foods and more dry and free of mildew. First invented in the early 20th century, they saw great commercial success starting in 1927, being deployed in traded goods across the world. This simple invention allows modern supply chains to extend across the globe by extending the preservation of shipped goods.

LSD was discovered accidentally after its inventor touched his face and hallucinated.

Explore the chemical compounds found in fireworks

Besides the various salts and metals used to produce fireworks colors, shells are also filled with gunpowder and oxidizers to help fuel and accelerate reactions. Chlorates help strengthen colors, while dextrin, a starch, helps hold mixtures together.

Glow sticks feed energy released in chemical reactions to fluorescent dyes

When bent, the glass tube inside the stick breaks, releasing hydrogen peroxide into the surrounding solution. The ensuing reaction creates unstable molecules that decompose and release energy, which is then absorbed by molecular dyes that emit light when their excited electrons return to lower energy states.

How chefs suspend liquid in edible pearls resembling caviar to introduce a new texture to fluids

Through spherification, drops of a solution of sodium alginate and a flavored liquid are placed in a calcium lactate solution, which forms a chemical skin around them. This is because calcium replaces the sodium in the alginate chains, forming a gel around each drop's liquid interior.

The food processing techniques developed for World War II, later repurposed for consumers

Research projects funded or sponsored by the military led to the development of active dry yeast to make bread easier to bake and an improved version of dehydrated cheese, which would be used in powdered cheese snacks. Freeze-drying, which had been used to ease the transport of blood plasma to battlefields, where it would be reconstituted with water, was later used on fruit for cereals.

Shrink-wrap is created through a treatment of plastic with high-speed electrons

Atoms in polyethylene are bonded in long strings called polymer chains, which can be destabilized by removing hydrogen atoms via collisions with electrons. These gaps serve as bonding sites for neighboring chains to bond and undergo cross-linking, strengthening the plastic while making it more malleable.

The history of molecular gastronomy, from thickening yolks with alcohol to making art with food

Before understanding why they worked, humans used scientific principles, including designing solutions and analyzing outcomes, to develop preservation methods like curing meat and fermenting vegetables. By the 20th century, the application of industrialized food preparation to smaller kitchens set the stage for the subdiscipline of food science.

Saccharin was widely used in WWI when sugar was rationed

The substance was discovered by chemists in 1878, but its use became more common during World War I and also afterward as a result of sugar rationing. It had become a typical household item in the US and Europe by 1917. During World War II, the artificial sweetener again saw significant popularity.

Watch 'Last Week Tonight' explore the risks of 'forever chemicals,' a group of human-made chemicals used in everyday products to make them resistant to water, stains, grease, and heat. (Warning: language.)

Stereolithography uses light to fabricate objects in layers via chemical reactions

Specific locations in a tank of light-sensitive liquid resin are exposed to projected light, causing them to cure onto a build platform. The resulting cross-section of hardened plastic is moved slightly away from the light source, exposing it to resin once more, and the process repeats to produce successive layers.

Acrylamide forms naturally during high-heat cooking through the Maillard reaction

While studies have shown it can damage DNA and potentially cause cancer in mice, humans absorb and metabolize acrylamide at different rates, introducing uncertainty in the research's applicability to humans. Some international health agencies have nonetheless recommended avoiding darker roasts when cooking starchy foods.

The unexpected origin story of the snow globe

In 1900, a Vienna tradesman named Erwin Perzy I was attempting to invent an inexpensive way to improve light amplification in hospital operating rooms. After experimenting with a glass globe filled with water, the idea for the snow globe struck. Industrious as well as inventive, Perzy eventually turned his idea into a successful business. Read the full article to learn how the invention grew to become recognized globally.

Although PFAS, or forever chemicals, are intentionally designed to be extremely stable and long-lasting because of their strong carbon-fluorine bonds, these bonds can be broken by heat, plasma, and supercritical water.

Research on bacterial cultures used in yogurt production led to CRISPR's discovery

Scientists learned it was a microbial immune system that could be repurposed to protect dairy cultures from viruses. Today, nearly all yogurt is made with CRISPRized bacteria, as are genetically modified crops like herbicide-resistant corn, wheat, and soy.

The history of contact lenses may have begun with Leonardo da Vinci, who developed a concept of vision correction based on placing a substance directly on the eye's surface.

Penicillin was hailed as a 'wonder drug' upon its release

When penicillin became widely available in the 1940s, newspapers and doctors alike celebrated it as a “wonder drug” that could cure infections once considered fatal.

Structures from ancient Rome have endured for millennia because tiny pieces of lime in Roman concrete enabled it to self-heal and prevent cracks from spreading when exposed to water.

Visualization of printing synthetic DNA

Ever wonder how synthetic DNA is made? Discover how GenScript uses innovative technology to synthesize precise, high-quality DNA at a larger scale than ever before.

'Magic ink' is redefining the tattoo

One University of Colorado professor has developed an ink that can be "turned on" with exposure to UV light, and "turned off" with sunlight. While the ink could help those who want to hide their body art from family members or coworkers, there are potential uses for medical procedures.

View a sample of objects surprisingly derived from crude oil, including chewing gum and lipstick

Crude oil processing produces a variety of fuels and the building blocks for plastics, but it also distills out the hydrocarbons used to make aspirin, Teflon, vinyl, crayons, candles, Tupperware, roofing shingles, asphalt pavement, hair dye, anesthetics, food-grade lubricants, polyester, synthetic rubber, and resins for items like dentures.

A deeper (nontechnical) dive into how CRISPR works

Extra crispy? No, it's CRISPR, but this gene-editing technology is "extra" in the sense of being momentous and destined to change everything. Through CRISPR, scientist exploit a quirk in bacteria immune systems, allowing them to potentially, and quickly, control genes, remove undesirable traits, and add preferred ones. The possibilities and applications are endless.

DNA may serve as a flame retardant by self-extinguishing some burning materials

When DNA burns, phosphate groups release phosphoric acid, and nitrogenous bases release ammonia. These molecules, along with the sugar in DNA's backbone, shift the combustion reaction toward the formation of intumescent char. This puffy, carbon-rich layer protects open flames from burning the material beneath.

The pharmaceutical industry evolved, in part, from the discovery of synthetic dyes

In 1856, a chemist accidentally discovered mauveine, the world's first synthetic dye, while trying to make quinine to treat malaria. The synthetic dyes that followed helped reveal germs under microscopes, paving the way for modern imaging techniques and breakthrough treatments, such as antibiotics.

Dsup slightly unwinds DNA and changes shape to better cling to the molecule

The damage suppressor protein, which is exclusively found in tardigrades, has also been modeled as coating DNA and shielding it from radiation and the toxic byproducts of radiation damage. Dsup may become a fundamental ingredient in future DNA storage technologies.

The weakest form of light that is dangerous to humans is ultraviolet

Unlike radio waves, microwave, infrared, and visible light, UV light can produce chemical changes, such as curing adhesives and resins, causing substances to fluoresce, and destroying the genetic material of microorganisms. This makes UV light useful for sterilization, forensics, and quickly drying nail polish.

The history of natural and synthetic plastics

From cheap toys to woolly jumpers, plastic can be found in more products than many people realize. From a chemist's perspective all these things are made of the same class of materials: Polymers. And the distinction between which ones we happen to call "plastics" and which ones we don't is fairly arbitrary.

The five most common chemicals found in modern food

Most modern processed foods rely on a number of preservatives to stay fresh from production to our plates. The most common include citric acid (preservative and flavor), sodium benzoate (preservative), xanthan gum (thickening and stabilizing), carrageenan (thickening), and red dyes 3 and 4 (for color).

The most common type of 3D printer fabricates objects using plastic

At the consumer level, the most common printing method is fused deposition modeling, which builds objects by melting an extruding thermoplastic filament that is deposited in layers. For industrial applications, selective laser sintering, which uses a laser to fuse particles of polymer powder (e.g., nylon), is preferred.

Why bacterial bioremediation may help counter the negative effects of past chemical solutions

Molecules such as DDT, a synthetic insecticide, and PFAS—"forever" chemicals used to make products resistant to heat, water, and grease—have historically been used across various industries but are now known to be harmful. Microbes that can convert some of these substances into nontoxic products, such as water and carbon dioxide, have already been identified, with ongoing research to find others.

Glowing chemicals allow scientists to read DNA like a barcode

The process of determining the order of nitrogenous bases in DNA involves first cutting the DNA into fragments, which are duplicated multiple times using bacteria. Fluorescently labeled terminator bases are added to fragments, which are sorted by length and read via laser to reconstruct the sequence.