An experimental bionic knee has been directly integrated into the user's muscle and bone—not an external socket—marking a significant prosthetic advancement.

Mind-controlled bionic arms use nerve implants to restore sensation and movement

Unlike traditional prosthetics that rely on surface electrodes or mechanical parts, this system uses implanted titanium and nerve-connected electrodes to enable a seamless brain-to-arm connection. Patients train in virtual reality with their implanted signals before using the physical prosthesis.

Listen to how bionic limbs are reshaping what it means to live as an amputee in this award-winning 2022 podcast series covering the stories of two amputees who struggled with shortcomings in prosthetic technology.

Brain implants are restoring movement and communication in early human trials

Several companies developing brain-computer interfaces have begun testing on humans with promising results. These implants have helped reanimate paralyzed limbs and enable communication, though ethical concerns remain about data privacy.

Brain-computer interfaces create a direct link between the brain and external devices

The technology enables users to control prosthetics, computers, or even games using only their thoughts. In 2021, a monkey played table tennis using only its brain, thanks to a Neuralink device, marking a major milestone before human trials began in 2024.

Amputees must navigate the challenging medical and economic aspects of limb support and replacement, but advances in technology and research may reduce these costs.

Neuralink brain implants have enabled a paralyzed person to play video games

As one of twelve test subjects in Neuralink's PRIME study, Rob Greiner's implant translates his brain's activity into digital commands for the 'Battlefield 6' game. He can now also design 3D models and 3D-print objects using his thoughts.

Medical imaging allows 3D printers to create patient-matched devices

With imaging data on a person's anatomy, external prostheses and implants, such as cranial plates or hip joints, can be custom-printed to better match a patient's body. Fabrication of porous structures can promote bone growth, leading to longer-lasting implants.

Interface device implanted into ALS patients restored some of their abilities

Most people with amyotrophic lateral sclerosis, or Lou Gehrig's disease, require assistance with daily life due to loss of motor control. The electrode-coated, stent-like device used motor mapping data and machine learning to translate brain activity into actions.

An essay exploring how living day-to-day with a brain implant helps restore a sense of identity

Companies like Neuralink are experimenting with volunteers who have lost control over their bodies. Many of the program's participants claim the most significant benefit from the tool is the ability to perform simple, mundane tasks, such as playing video games or shaking hands, rather than more obvious milestones like walking or eating. This essay explores what it's like, day to day, to use a brain implant.

Medical professionals have experimented with using mixed reality headsets

Devices like the Apple Vision Pro have helped doctors develop surgical plans for hip and knee replacements using software that provides 3D models and other tools. Virtual screens displayed by mixed reality devices can provide information related to surgical progress, a patient's vitals, and more.

New eye implant clinical trial recruiting in 2026

University of Southern California researchers have launched a phase 2b clinical trial of a stem cell implant designed to restore vision in people with advanced dry macular degeneration. Patients will be randomized to receive the stem cell implant or a simulated procedure and placebo implant. This type of larger, second-stage clinical trial is designed to confirm efficacy and dosing and to look for side effects. It's one of the stages that precedes the US Food & Drug Administration approval of a device.

Hacking the body for a future that didn't happen

Journalist Adi Robertson experimented with one of the most accessible biohacks: magnets. Having a tiny magnet in their right ring finger meant they could sense magnetic fields, attract small metal objects, and more. But magnets weaken over time, eroding this new sense. Such implants do more than offer a new way of interacting with the world, they also pose new complications, such as the inability to get an MRI.

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

The man who turned his leg into a hotspot

Biohacker Michael Laufer recently had a 512GB drive implanted in his leg, which can store data, stream music or movies, and power a hot spot and mesh network. It's called the PegLeg, and WIRED's Daniel Oberhaus spoke with Laufer about the device and the field of biohacking.

Breaking down the knee's anatomy

The human knee is a remarkably complex structure carrying the full weight of the body throughout a person’s life while allowing a number of complex twists, flexes, and extensions. It's also one of the body's biggest weaknesses—the location of chronic pain and replacement surgeries for millions of Americans.

Limb regeneration research may lead to treatments for arthritis

For scientists pursuing the cure for arthritis, the holy grail of discoveries lies in how to regrow healthy cartilage inside human joints. While this feat has so far resisted our best scientific attempts, there are plenty of other human tissues—such as the liver and fingertips—that will successfully regenerate.

As of 2025, perfect synthetic replication of natural organs remains elusive

Advancements such as 3D printing muscles, performing vaginal reconstruction with colon tissue, and growing organs in a lab have shown promise, but artificial options and transplanting substitutions continue to exhibit functional and performance limitations compared to their natural equivalents.

Flexible integrated circuits can be built from carbon nanotubes and elastic materials

Stanford researchers arranged the nanotubes in fishnet-like networks that allow deformation without loss of function. The stretchable ICs have been shown to power micro-LED displays and may be used in smart clothing.

The world's first commercial biological computer combines neurons with silicon

Australian start-up Cortical Labs unveiled CL1, a hybrid chip designed to help scientists study brain function in real-time. The 800,000 lab-grown neurons on the chip are kept viable for six months via a built-in life support system.

After 25 people used virtual reality headsets to practice flying with virtual wings—flapping their arms—their visual cortex responded to the wings almost as if they were real arms, treating them as body parts.

Stem cell therapies show promise in treating spinal injuries

Researchers have long hoped to use stem cells in regenerative medicine to help patients with spinal cord injuries restore sensation and movement. A 2024 clinical trial illustrates how stem cells derived from patients' fat tissue could help spur the creation of new cells in the spinal cord.

See what analysis of one man's amputated leg, donated to The Bone Museum, tells us about his otherwise invisible pain.

What's next for surgical robots?

Since robots were introduced into the operating room in 2001, their patients have seen improved recovery times and decreased risks of infection. This article describes what's next for surgical robots, which, so far, have remained under human...

Particle beams can be used to alter the surface properties of artificial joints

Surface hardening and embedding specific elements or coatings can improve the biocompatibility and bone tissue integration of these implants. Particle accelerators are significant sources of the radioisotopes needed in medical diagnostics, and microwave linear accelerators are used in the majority of cancer irradiation treatments.

Mice were able to regenerate retinal cells in the lab—a breakthrough for mammals

Using gene therapy, a team of Korean researchers has enabled retinal regeneration in mice by blocking the intercellular transfer of a single inhibitory protein. This 2025 finding creates a new potential direction for treating retinal diseases. The work, which is still in animal studies, is projected to enter early-stage clinical trials in the next few years.

How 3D printing inside cells paves the way for microscopic machines

In 2026, scientists in Slovenia developed a method to 3D print a small elephant, several microscopic geometric objects, and barcodes for cell labeling within living human cells, which continued to grow and divide thereafter. The experiment opens the door to fabricating devices within cells to study and manipulate cellular functions.

The Cybathlon is an international competition for assistive technology

The competition pits teams against each other in eight races targeting different innovations, such as arm prostheses, leg prostheses, and vision assistance. Participants in the Cybathlon use it to push the boundaries of technology, including brain implants and assistive software that incorporates AI.

How medical robots could cure cancer

Medical robots are on the verge of being able to be injected into the body, where they will be responsible for semi-autonomous behavior, such as detecting cancer cells and distributing medication. This six-minute video dives into the science of these nanorobots, which are smaller than blood cells. Applications of these nanobots could range from disease discovery and condition monitoring to tissue repair and artificial blood delivery.

Implanted neurotechnology can leave users vulnerable when manufacturers go under

Despite providing relief from neurological conditions, patients are left stranded when the companies that make these devices shut down. The lack of regulation means patients often face technical failure, insurance battles, or risky surgeries to maintain their quality of life.

Eight British children have been born via mitochondrial replacement therapy

In July 2025, a decade after British lawmakers signed off on allowing three-parent IVF, scientists announced that eight healthy babies had already been born using this approach. The news was included in a pair of research articles published in a peer-reviewed journal that noted the oldest kids were already more than two years old, and that they were hitting developmental milestones as expected. (Some users may encounter a paywall.)

A 1992 failed parachute test provided the hardware for the first mixed reality system

The Virtual Fixtures platform was developed to improve human dexterity by merging physical and virtual objects with haptic feedback from an upper-body exoskeleton. Tight budgeting and significant equipment needs nearly canceled the project, were it not for salvaging and repairing cameras and sensors from a smashed experimental parachute rig.

Apple's latest invention

Apple may be working on a robotic smart lamp. Internally called ELEGNT, it's designed to respond to music, display emotion through movement, and even serve up reminders. A new research paper details how it could work—though Apple hasn't officially confirmed a release.

Do wearables help those with chronic disease?

The integration of wearable technology in healthcare has promised significant benefits for chronic disease management, yet the actual impact remains underexplored. This systematic review published in the Journal of Medical Internet Research...

Read why one man agreed to get a pig kidney in 2025 to replace his own failing organ

The 68-year-old New Hampshire man told USA Today that a motivator for the experimental surgery was his belief that he was going to die anyway, and other people suffering from kidney disease could gain valuable insights. Yet the surgery bought him time—he lived 271 days with a pig organ and later received a human kidney transplant. Clinical trials began in 2026 to test the pig xenotransplants in more people.

Using artificial wombs to improve preterm infant health outcomes

Researchers at a hospital in the US have successfully used artificial wombs to care for preterm lambs and are now looking at the possibility of human trials. This nine-minute video includes interviews with the researchers and explains the reasoning...

Prehistoric hunter-gatherers performed amputations and appear to have provided post-op care, according to analysis of a recent fossil discovery from almost 31,000 years ago.

Tech entrepreneur Bryan Johnson's mission to live forever

Johnson has invested millions of dollars into developing a biohacking program he believes will extend his life beyond typical expectations, relying on medical professionals to reduce his "biological age." Most notably, he drew significant public attention with reports of blood-swapping with his teenage son.

Hear about life as an amputee and how mirror box therapy helped.

Palliative care physician BJ Miller describes his phantom limb pain and itching after losing both legs and half an arm in an accident. Mirror box therapy eventually helped him, alongside physical therapy. This podcast also features neuroscientist V.S. Ramachandran who explains how he developed mirror box therapy in the 1990s.

Technological breakthroughs are spurring innovations in the industry

What if you could see your tattoos before they’re embedded in your skin? Or take a virtual visit into a local studio to work out your nerves over a first tattoo? The industry is anticipating some big technological changes, from 3D designs to sci-fi upgrades to more precise tattoo guns.

Kangaroos evolved exceptionally thick knee cartilage to absorb shock

There is significant conflict in the medical field regarding chronic arthritis. Some advocate for keeping the joint as active as possible while others argue progressive overuse leads to worsening arthritis. To settle the score, scientists have looked outside the human population, discovering kangaroos rarely suffer from arthritis in their knees.

A comprehensive review of BPC-157 studies identified no human safety data

This meta-analysis included available studies on this peptide from 1993-2024, and identified 36 studies. It found 35 preclinical (nonhuman) studies and one retrospective study in humans of musculoskeletal pain following injections of BPC-157 for unspecified chronic knee pain. In that one human study, 7 of 12 patients receiving BPC-157 reported relief after the injections (though many had injuries that often heal on their own over time).

Grinding is a body modification subculture focused technological implants

Grinders seek to increase the intensity and range of body modifications to push "beyond the human norm." The movement's roots stretch back to 1998 when cybernetics professor Kevin Warwick installed an RFID chip in his arm that granted him control over external electronics and became, arguably, the world's first cyborg.

Artificial intelligence may improve organ donation systems—and even organ health

Mayo Clinic transplant experts suggest that artificial intelligence could potentially improve organ donation systems in several ways, including better identifying patients most at risk for organ rejection, enhancing donor-recipient matching, and helping to avoid organ transplant needs by identifying health issues earlier.

The origin of cyborgs

The term "cyborg" was coined in a 1960 academic paper discussing what alterations humans would need to undergo to survive in extraterrestrial environments, a venture far "more logical than providing an earthly environment" in space. According to authors Manfred E. Clynes and Nathan S. Kline, Cyborgs with a capital C have incorporated exogenous components that extend their ability to adapt to new environments. Read the paper here.

Genetically modified viruses can help construct battery electrodes

MIT scientists' modifications caused the viruses to attract conductive materials, such as gold ions, which the viruses self-assembled into nanowires that could be used in batteries. These components allow batteries to be thinner and flexible enough to be constructed into new shapes.

Efforts to build touch-enabled machines highlight the complexity of human touch

The challenges that engineers are facing as they try to reproduce a human's ability to touch and also give robots the ability to interpret that kind of sensory flow are furthering our understanding of the myriad intricacies of human touch—and the challenges in emulating it.

Why surgeons implant teeth into eyes

What if the thing that restored your vision… was your own tooth? That’s exactly what happened to Brent Chapman. After 20 years without sight, a bizarre surgery using his tooth as a lens restored his vision.

736,900 cochlear implants had been implanted by 2020 worldwide

In the United States, roughly 118,100 devices had been implanted in adults by that point and 65,000 in children. These estimated figures come from the US Food and Drug Administration, which first approved cochlear implants for adults experiencing hearing loss in the mid-1980s, and collected reports from cochlear implant manufacturers approved for the US market.

Myokines are molecules that facilitate some of the benefits of exercise

When muscles contract, they release ‘hope molecules’ (myokines) such as IL-6 and irisin. These proteins then travel through the bloodstream to reduce inflammation, improve insulin sensitivity, and even support brain repair. This piece illustrates how movement triggers a systemic healing cascade throughout the human body.

'Artificial embryos': The hidden steps in forming a spine

Somitogenesis is the process by which segmented body structures like vertebrae form in embryos. While the process is well understood in animals like mice or zebrafish it is difficult to study in humans. But now, researchers have created a model of somitogenesis, using pluripotent stem cells, called an axioloid.