The negative effects of cannabis use

LSD fueled a countercultural movement before evolving into a potential therapeutic

As the use of recreational psychedelics became common, authorities were quick to claim LSD had lasting adverse effects, criminalizing the drug and halting scientific study for decades. Over time, LSD's reputation shifted from a potential source of enlightenment to a dangerous drug that could dim a person's future, and back to a possible therapeutic compound.

US states have reported over $25B in tax revenue from recreational cannabis sales and medical marijuana

Colorado and Washington became the first states to allow the sale of cannabis products in 2014. Since then, many more states have legalized marijuana in some capacity—and it's been a boon for state budgets. California now regularly collects more than $1B in marijuana tax revenue each year, for instance.

Chronic drug use can cause neurological changes in the brain

Neuroscientist Judy Grisel breaks down the biology of addiction, examining how drugs hijack the brain’s natural reward system and create lasting neural changes. The physiological and neurological impacts of chronic drug use require a multifaceted treatment approach.

The US war on drugs, explained

The United States has been fighting a global war on drugs for decades. By making drugs more expensive and less available, the US has sought to reduce drug use and inhibit the international drug trade. However, increasing prison populations,...

Words used in cannabis business names

As selling recreational cannabis becomes legal in many states across the US, cannabis dispensaries are increasingly common. While one might expect each of these dispensaries to have vastly different names, one study found that the names have some consistent similarities. Businesses with "beach vibes" or "green" in the name seem particularly common. Explore the full data visual here.

Drugs 101: An interactive guide

What's the difference between opioids and psychedelics? This guide details specific drugs and their various associated effects. Drugs in this wheel fall into seven categories: stimulants, depressants, empathogens, psychedelics, dissociatives, cannabinoids, and opioids.

How to avoid a 'bad trip' advice includes relaxing your mind if you experience scary things and not fighting the feeling

In this video, Michael Pollan, author of "This Is Your Mind On Plants," underscores the gaps in existing understanding about the substances and recommends only taking guided experiences, for safety and help. He tackles how psychedelics work, explains microdosing and psychedelic risks, how the substances could be used to treat addiction, and the history of psychedelic stigma.

How did the pandemic affect mental health?

Read this research brief to learn more about why heightened mental health and substance use concerns persist three years after the outbreak of COVID-19. According to a recent survey, the vast majority of American adults view the nation as facing a...

How a single company hooked the world on herbicides

How harmful are today’s herbicides for us humans, and for the environments they’re seeping into? And do we really need weedkillers to feed the world?

'1440 Explores,' Episode 2: Why We Drink and What It Does to US

Alcohol is the world's most popular drug—a molecule that can calm or excite and bond communities or tear them apart. We trace alcohol's journey from ancient rituals to modern hangovers, uncover how it shaped civilizations, and dive into the neuroscience of how it affects your brain and body. With insights from leading experts, we ask: Given all that we know, why do humans continue to drink?

Alcohol use disorder is the most common addiction in the US

This comprehensive overview from the Addiction Center uses recent data from SAMHSA’s National Survey to examine the 10 most common substance dependencies in the United States. It ranks addictions from alcohol (affecting 28.3 million Americans) to barbiturates, while highlighting key trends, risks, and societal impacts.

Drug trafficking in the MENA

The Middle East and North Africa is a major source, transit point, and consumer of illicit drugs. Despite having some of the harshest penalties for drug-related crimes, the region both influences and is negatively impacted by illicit substance abuse...

Coffee is, generally, good for your health

While overconsumption certainly has its drawbacks—hello, not sleeping until the sun rises—on the whole, coffee is fine, even beneficial, for your health. It can even help prevent serious health conditions, like heart attacks and liver cancer.

A 49-year-old American died at an ibogaine clinic in Mexico, underscoring its risks

The man had sought out the drug to help him overcome his substance abuse disorder. Though anecdotal reports indicate potential promise, there's been no large-scale clinical trials on ibogaine's safety and efficacy. The plant is derived from a root bark named iboga and has been used for centuries by indigenous communities in Gabon, but first entered scientific consciousness in 1901 after its alkaloid was isolated from Iboga.

Alcohol is responsible for 5% of cancer cases and 4% of cancer deaths in the US

Alcohol consumption is linked to at least eight different types of cancer, including liver, breast, and throat. The risk comes from ethanol, which turns into DNA-damaging acetaldehyde. Experts recommend limiting intake or quitting altogether to reduce long-term health risks.

Trauma is a primary risk factor for substance use disorder later in life

Studies indicate 75% of people with substance use disorder have experienced at least one traumatic experience in their life. These experiences alter brain function, leading to heightened stress and emotional pain. Substances offer temporary relief, but this often results in dependency.

Are psychedelics legal in your state?

The answer is usually more complicated than a simple yes or no. This resource includes a state-by-state and international breakdown of current psychedelics legislation and reform. As of November 2023, psychedelics are fully illegal in 18 states, though there still may be religious or medical exemptions depending on the drug in question. Legislation reform and decriminalization efforts are ongoing.

Read this analysis indicating which traditional stevia medical uses have scientific evidence

This research paper investigates the various uses of Stevia rebaudiana leaves and their extracts and concludes that the substances do hold significant potential for improving cardiovascular health and inflammatory disorders in adults, among several other potential applications. Its authors suggest that further research should examine safe dosage questions and chronic disease management approaches.

This is the human brain on the world's strongest psychedelic

Within seconds of inhaling a high dose of vaporized synthetic 5-MeO-DMT—a lab-produced substance that otherwise is naturally derived from the glands of the Colorado River toad—it induced slow brain waves. Such waves are typically associated with unconsciousness due to a coma or anesthesia, perhaps explaining why users describe feeling like everything falls away. The compound is currently in clinical trials for treating depression.

Evidence of opium use dates to as early as 5000 BCE

Archaeological evidence shows the use of the poppy plant for its pain-killing properties likely originated in the Mediterranean before making its way to the East and West via trade. It has since inspired two eponymous wars, and highly addictive derivatives of the naturally occurring substance have led to an ongoing overdose crisis.

Hip-hop has been criticized for obscenity and violence

In 2008, a Pew Research poll found that over 70% of Americans believed the music had a negative societal impact due to its sometimes violent, sexist, and homophobic lyrics. Many rap artists argue they’re not endorsing the lyrics but simply reflecting the world around them.

Why is fentanyl poisoning street drugs?

A few grains of fentanyl, a synthetic opioid far more potent than heroin or morphine, is enough to kill a typical adult human. It's made its way into other, less lethal street drugs, where it may be used to increase the highs experienced by unknowing users, increasing their likelihood of addiction and overdose. This 39-minute podcast episode is the first half of a two-part series exploring fentanyl's rise.

Fantasy sports can have adverse health effects

Experts warn that fantasy sports, including fantasy football, can encourage obsessive use because they offer hits of dopamine. Daily fantasy games, which function more like gambling, are especially problematic.

The security and privacy risks of augmented reality

One of the most serious perceived risks of augmented reality is the loss of privacy. Because AR technology can see what users are doing, user privacy is jeopardized. AR collects far more information about who users are and what they are doing than...

The positives of feeling stressed

Worrying about past events and upcoming challenges is not a pleasant experience, but a reasonable amount of stress can bring a lot of good into our lives. In this episode of "The Happiness Lab" with Dr. Laurie Santos, two psychology experts offer tips for resetting one's relationship with stress. Listen and learn how to make stress a positive tool rather than a debilitating emotion.

Civilians on short-term spaceflights can experience long-term astronaut health impacts

A collection of 44 studies—primarily based on data from a 2021 tourist trip to low Earth orbit—identified immune system disruption and some kidney damage in tourists, with women appearing to recover from space travel faster than men. Return trips from Mars may require human travelers to be on dialysis.

Understanding vaccine side effects

A vaccine is a medical intervention, and as with any medical intervention, may have side effects. This article discusses side effects and adverse events related to vaccination.

More than 130 nations have enacted bans or restrictions on plastic items

Several US states have enacted similar restrictions on plastic bags, straws, food containers, and other single-use plastics, while others have prohibited plastic bans. Despite this, California’s plastic bag ban cut usage by more than 70%, showing the potential of these policies.

The rise of the malicious use of drones

Drones are legally categorized as aircraft, so when homeowners see a drone hovering over their private property, it is illegal to shoot them down. As drones become more commercially available, their illicit use is also increasing. Celebrities have reported incidents of drone privacy invasions and events planners often deploy anti-drone systems to prevent incursions.

Immunosuppressants enable organ transplants, but come with severe side effects

This drug cocktail helps to lower your body's natural response to attack a transplanted organ. Such medications usually need to be taken for a lifetime after receiving an organ and can come with serious side effects including high blood pressure, diabetes, increased risk of some cancers, and high cholesterol, among others.

How to help teens balance social media use and mental healthcare

While initially alluring, excessive social media use is proven to lead to increased feelings of isolation, mental health declines, increased stress, and general dissatisfaction among teens. Conducting digital audits to track screen time, adding friction (or obstacles) to app usage to reduce mindless scrolling, and investing time in offline activities and hobbies may help.

View a map of countries with the safest and most dangerous drinking water

More than a quarter of the world's population lives in water-stressed countries, and a similar number use contaminated drinking water sources, which can lead to widespread disease, according to the World Health Organization. The Environmental Performance Index shows which countries have safe drinking water.

A video showing how drug dealing really works

What motivates people to sell drugs? The “News on Drugs” series asks how people get drawn into the drug trade, unpacking the different goals and aims involved in dealing drugs. While there is a lot of focus on cartels, traffickers, and gangs...

Exercise improves brain blood flow, stimulates neural growth, and more

Exercise has dramatic effects on human biology, including reducing some of the long-term harms associated with chronic stress. Its effects are also pronounced in the brain, including improved memory retention, sleep, cognitive functioning, and more.

The National Institute on Drug Abuse's resource library

The National Institute on Drug Abuse website is an in-depth and highly prolific resource on addiction science. Explore the vast scope of this website to access comprehensive guides, data visualizations, and educational materials on all facets of addiction and its treatment.

Researchers have investigated the benefits of extreme pain rituals, exploring how and why we engage in these events when humans generally naturally avoid pain and perceive it as a negative experience.

What are the human rights issues facing the world today?

This video debates the modern relevance of the UN’s Universal Declaration of Human Rights. The world has seen multiple examples of genocide, war crimes, and crimes against humanity since the document was signed over 70 years ago. Now, many...

Review the health effects of living near oil refineries, including increased respiratory risks

An analysis of 54 studies published between 1977 and 2024 in 15 international regions found evidence that proximity to refineries increased the risks of leukemia, asthma, bronchitis, and respiratory symptoms. Several studies also identified worse cardiovascular function in children and adults living near refineries, alongside other acute and chronic health impacts.

15 facts about the Cali Cartel

The Cali Cartel was a drug cartel based in southern Colombia. Originally founded by the Rodríguez Orejuela brothers in the early 1970s, the cartel changed the structure of drug trafficking, and is often considered “the most powerful crime...

Why is cocaine worth so much?

The global cocaine trade is worth an estimated $100B a year. But, where does that money go, who is spending it, and who is making it? Vice follows the money to understand why the cocaine business functions the way it does. From illicitly growing...

Did people domesticate plants or did plants domesticate us?

Humans rely on plants to survive, and many plants have come to rely on humans. This 14-minute video explores how agriculture was simultaneously a building block of civilization and a trap that captured humanity. Plant types that may not have...

A brief history of Cannes controversies

Cannes is one of the most prestigious festivals in the world, but that hasn’t shielded it from controversies, including inflammatory statements, political protests, and booing audiences.

There's no specific anti-inflammatory diet, but certain foods increase the chance of inflammation

Research suggests humans can reduce inflammation by limiting foods that are already known to be unhealthy for the human body—because they alter gut bacteria and stress the immune system—such as highly-processed foods, deep fried foods, sugary drinks, trans fats, red meats, and foods made with white flour. Foods that help the body include fatty fish such as salmon, legumes, fruits, and vegetables.

The story of Olympian Ryan Wedding's rise and fall as drug kingpin

After a disappointing finish representing Canada in the slalom at the 2002 Winter Olympics, Wedding turned to growing cannabis and selling cocaine. After serving prison time, he upped his game and came to control major drug routes in North America, finding himself on the FBI's 10 Most Wanted List. He was captured in Mexico City in January 2026.

The WHO labeled aspartame as 'possibly carcinogenic' but US regulators consider it safe

The International Agency for Research on Cancer, an arm of the World Health Organization, labeled aspartame—the artificial sweetener in Diet Coke—as one of several hundred possible cancer-causing substances in 2023. The determination was based on animal and human studies and "limited" evidence linking it to liver cancer. The WHO and US Food and Drug Administration both say the substance is safe at moderate levels. The FDA says a person weighing about 132 pounds would need to have 75 packets daily to reach an unsafe level.

Beyond burns, fireworks can harm respiratory, auditory, and visual health

While mishandling fireworks can cause severe burns and loss of appendages, there are also risks for viewers of displays. Released particulate matter can cause the surrounding air to resemble wildfire smoke, and the explosions can cause hearing loss and damage to the corneas.

Kava, kratom, St. John's Wort, and green tea extract present health concerns

Consumer Reports, which tests supplements for safety, urges consumers to avoid these four supplements due to safety warnings from researchers and public health authorities.

The non-alcoholic wine market

A no-nonsense, stats-based exploration of the relatively new market for nonalcoholic wine. Driven by people looking to consume less or no alcohol at all, production of nonalcoholic wine has increased dramatically over the last few years. This report details the basics of nonalcoholic winemaking, as well as the current state of the market and what to expect in the future.

Microplastics are infiltrating the human body with unclear but concerning effects

Scientists have linked microplastics to immune system damage, hormone disruption, inflammatory diseases, and even cancer—yet most of their health impacts remain unknown due to limited research. Studies suggest we ingest about a credit card's worth of plastic weekly.

Within months of a landmark 2002 study that indicated HRT harms, sales dropped by about half

In the early 2000s, Women's Health Initiative studies indicated HRT increased risk of breast cancer, heart disease, and stroke in some women—so many physicians stopped prescribing it to help with menopause symptoms. But further research has concluded that much of the elevated risk was overblown and that it was also disproportionately seen in women in their 70s who had been taking an older HRT formulation.