Watch OpenAI CEO Sam Altman give his first-ever startup pitch in the early 2000s.

Stanford’s archive of lectures about creating a startup includes advice from Y Combinator notables such as former YC president and OpenAI CEO Sam Altman and YC Cofounder Paul Graham.

Prior to Palantir's public listing in 2020, CEO Alex Karp did not give many interviews. In a rare interview from 2009, Karp discussed the dominance of American technology, his academic background, and the founding idea of Silicon Valley entrepreneurs as key players in aiding the fight against terrorism.

Before becoming the head of OpenAI, Sam Altman was the president of Y Combinator—a startup accelerator company that supported companies like Airbnb, DoorDash, and Coinbase. In 2016, Altman interviewed Zuckerberg about creating Facebook and its growth over time. Zuckerberg said that, unlike other companies (think: CourseMatch), Facebook kept growing and adding new features, which prevented the app from becoming obsolete.

Led by CEO Sam Altman, OpenAI's mission is to "ensure artificial general intelligence benefits all of humanity" by making its products open to all users. In 2023, the $86B company behind the chatbot ChatGPT consisted of a for-profit arm under its nonprofit governing board.

Also known as a16z, the firm has invested in companies such as Airbnb, Facebook, and Lyft since its founding in 2009. A podcast episode offers a deep dive into how the firm got started and became the industry disruptor it is today.

Entrepreneur Shaan Puri shares how seven strangers acted as Google’s earliest angel investors. The first gave Google $100K without even putting his equity agreement in writing. The investors on “Shark Tank” use their personal funds to support startups, but they’re often more predatory about terms than typical angels.

Palantir cofounder Joe Lonsdale was an editor of the Stanford Review (which Peter Thiel founded), and Thiel became a mentor to Lonsdale. The two discussed shared sentiments about the importance of developing Palantir to maintain a largely American global order, as well as cultural revolutions.

In March 2005, Y Combinator cofounder Paul Graham announced the program that would become Y Combinator on his website.

Palantir cofounder Joe Lonsdale described the company's driving principle as fighting terrorism in a blog post marking its IPO. Lonsdale also said Palantir's software was developed with a keen focus on privacy, despite many allegations that it enables government surveillance.

Daniel Ha is a venture capitalist who built a suite of AI agents to boost his productivity, both professionally and personally. At his VC firm, a troupe of agents gathers data on startups and analyzes it from competing perspectives to produce a confidence score. When his dad was diagnosed with cancer, Ha used an oncology-trained AI to help him understand the condition.

Mark Zuckerberg became the youngest self-made billionaire in 2006 at 23 years old when Facebook held its initial public offering. In January of 2026, three AI startup founders—Brendan Foody, Adarsh Hiremath, and Surya Midha—broke Zuckerberg's record and became billionaires at 22 years old.

Many of the philosophies that the leaders of Y Combinator have infused into the program’s portfolio companies have become the playbook for building the next big thing, such as its focus on founder personality and more.

AngelList was created to connect startups and angel investors. It’s evolved since its 2010 founding and has been used by companies like Uber and OpenSea.

Polymarket CEO Shayne Coplan started building Polymarket when he was 21. Polymarket has been backed by billionaire investors such as Peter Thiel and Vitalik Buterin.

Airbnb is arguably known as one of the most successful startup stories of all time. But back in 2008, many prominent investors rejected their pitch when they went out to raise money—and Airbnb's founder still has the rejection emails to prove it.

In 2013, the cofounders of DoorDash created a simple, homemade video application to Y Combinator. They didn't know it at the time, but they'd be accepted—and their company would go on to be publicly traded on the NASDAQ.

Palantir was originally founded after the 9/11 attacks as a private-sector solution to the government's growing need for advanced intelligence. One of its earliest investors was In-Q-Tel, the CIA's non-profit venture capital firm.

The venture capital firm that kickstarted an industry.

In one of Paul Graham’s essays on his website, he took the time to explain how and why he and his cofounders (including his girlfriend at the time, and now wife, Jessica Livingston), came up with the idea of and eventually created Y Combinator.

In 2010 when Uber went out to raise money, prominent investors including Mark Cuban and Gary Vaynerchuk passed. Vaynerchuk actually said no twice.

The rapid collapse of FTX, one of the world's largest cryptocurrency exchanges, in late 2022 shocked the world. At the center of the fiasco was Sam Bankman-Fried, a 29-year-old wunderkind who had entranced politicians, journalists, financiers, and others with his melding of altruism and digital currency. The sordid details revealed as the empire fell captured public attention—venture into the death spiral with this in-depth podcast from Bloomberg.

Peter Thiel was Facebook's first big investor. In 2004, he invested $500K into the social network, long before the company owned Instagram or renamed itself "Meta." In 2012, when he sold off most of his stake, he turned that initial $500K investment into more than $1B in cash.

After more than 15 years in business, Palantir held its initial public offering (IPO) via a direct listing—meaning the company didn't rely on underwriters to assess the initial trading price or stock value. Palantir's stock ended the day trading 31% higher than the reference price.

Angel investors leverage their high net worths to fund seed-stage startups. While they could see high returns, investing in such an early company is a risk.

Those programs, such as Y Combinator and Techstars, not only offer expert advice to founders, but also seed funding in exchange for equity. The goal is to help young startups learn from successful companies, making it more likely they attract venture capital.

Radically reducing the cost of rockets and innovating totally new space vehicles originated in the singular force of Elon Musk's vision. In this podcast, Founders creator David Senra shares what he learned reading a book about SpaceX's beginnings, highlighting Musk's audacious refusal to follow industry conventions and promotion of a culture of action and speed. Learn more insights from the founder here.