'Our greatest responsibility is to be good ancestors.'

Jonas Salk developed the first successful polio vaccine—and tested it on himself

The American medical researcher developed the inactivated virus vaccine from 1952 to 1955 and proved that it could prevent disease. He tested the virus on himself and his family in 1954 and then carried out formal clinical trials on more than 1.3 million children.

View this timeline of polio milestones and vaccine development

Polio has a long history in art and medicine, dating back centuries. It includes a representation of an apparent polio survivor with a shriveled leg in ancient Egyptian art. See milestones in the history of polio in this timeline.

Edward Jenner, the father of vaccinations

The British physician was the first to attempt to inoculate someone from smallpox using its milder cousin, cowpox. His innovations and documentations would prove crucial to the deployment of widespread vaccinations.

A quote by scientist Nikola Tesla

"The scientific man does not aim at an immediate result ... His duty is to lay the foundation for those who are to come, and point the way."

Live virus vaccines predated polio—that's how we vaccinate against smallpox

Since 1796, smallpox vaccines have used a live poxvirus related to smallpox. Yellow fever vaccines have used a live weakened form of the virus responsible for yellow fever since 1937.

Improved 19th-century sanitation meant kids encountered polio later, with worse results

Almost all children likely used to contract poliovirus, but scientists suggest that when infants encountered it very early in life—due to poorer conditions and hygiene—they still had some maternal protection from pregnancy or through breastmilk, so the symptoms were more flu-like.

'Few will have the greatness to bend history itself, but each of us can work to change a small portion of events, and in the total of all those acts will be written the history of this generation.'

- Senator Robert F. Kennedy (1925–1968)

How the 1918 pandemic spurred developments in virology and vaccines

This article provides an in-depth historical account of the 1918 Spanish Flu pandemic, including its impact on the global population and how its occurrence spurred significant advancements in the study of viruses—laying the groundwork for the...

Variola: the second-deadliest virus on Earth

Because it was declared eradicated in 1980, many forget smallpox is one of history's deadliest diseases—in its final century, it's estimated to have claimed 500 million lives. This 11-minute video from production studio Kurzgesagt takes a look at...

A history of vaccine rollouts

History tells us the public will tolerate risk of harm from a vaccine if their fear of the disease exceeds their fear of the vaccine.

A quote by Whitney Houston

"I believe that children are our future. Teach them well and let them lead the way. Show them all the beauty they possess inside."

'Too often we participate in the globalization of indifference. May we strive instead to live global solidarity.'

- Pope Francis (1936 - 2025)

Read more about the backstory on the 2025 Nobel Prize for immune system work

A trio of scientists won the Nobel in Physiology or Medicine that year, but they performed their award-worthy work beginning about two decades before winning the prize. This announcement includes details about the science and notes that the three scientists will equally share the 11 million Swedish kronor (almost $1.2M).

Polish chemist and physicist Marie Curie (1867–1934) on learning

“Nothing in life is to be feared; it is only to be understood. Now is the time to understand more, so that we may fear less."

'To live is to choose. But to choose well, you must know who you are and what you stand for, where you want to go and why you want to get there.'

- Diplomat Kofi Annan (1938-2018)

Robert Koch won the Nobel for his tuberculosis work, but he also pioneered cholera research

Koch was one of the first scientists to isolate the bacterium that causes cholera while investigating an outbreak in Egypt in 1883. He went on to advise about rules to control cholera outbreaks, which formed the basis of the disease control approaches and water hygiene techniques still used today.

'When I was a boy and I would see scary things in the news, my mother would say to me, 'Look for the helpers. You will always find people who are helping.''

- Mister Rogers (1928-2003)

'The bounty of nature is also one of the deep needs of man.'

- Lady Bird Johnson (1912-2007)

Beyond DNA, Franklin's legacy extends into modern virology and steel production

While remembered for her critical but under-credited role in uncovering parameters for the structure of DNA, Rosalind Franklin made significant contributions across coal chemistry and virus structure. Her research helped improve fuel efficiency, wartime protective equipment, and foundational knowledge in molecular biology.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

'Pioneering is never done in front of cheerleaders urging on a roaring grandstand of popular approval.'

- "Star Trek" actor George Takei (1937-present)

Six of history's most unethical human experiments, from deliberate flu exposure to withholding syphilis treatment

Some of the progress made in mental health treatment, vaccines, blood transfusions, and more came about before the advent of consent and ethics committees, resulting in serious physical and psychological harm that participants in studies were not even anticipating.

'A life is not important except in the impact it has on other lives.'

- Jackie Robinson, the first Black MLB player (1919-1972)

'We are more fulfilled when we are involved in something bigger than ourselves.'

- Astronaut John Glenn (1921–2016)

Social work pioneer Jane Addams (1860 - 1935) on civilization

"Civilization is a method of living, an attitude of equal respect for all men."

Before Dawkins, other biologists proposed the power of mutating ideas

Nobel Prize winner Jacques Monod proposed, “Ideas have retained some of the properties of organisms. Like them, they tend to perpetuate their structure and to breed; they too can fuse, recombine, segregate their content; indeed they too can evolve, and in this evolution selection must surely play an important role.”

'I attribute my success to this: I never gave or took an excuse.'

- Modern nursing innovator Florence Nightingale (1820-1910)

Listen to how the 1902 'poison squad' experiments changed food safety in America

As part of government research, a group of young men were paid to eat standard American food—replete with food additives like borax and formaldehyde—which revealed the dangers of unregulated food. The work was led by the first FDA commissioner, Harvey Wiley, who helped end the "century of the great stomachache."

J. Robert Oppenheimer’s grandson says his grandfather would back nuclear power

While the "father of the atomic bomb" referred to the bomb as "an evil thing," after the Manhattan Project, he also described nuclear energy’s potential as an environmentally friendly solution to address the world's energy problem.

'Service to others is the rent you pay for your room here on earth.'

- Muhammad Ali (1942-2016)

1978: Thurgood Marshall, commencement address at the University of Virginia

"Where you see wrong or inequality or injustice, speak out, because this is your country. This is your democracy. Make it. Protect it. Pass it on."

'There are only four kinds of people in the world—those who have been caregivers, those who are caregivers, those who will be caregivers, and those who will need caregivers.'

- Former First Lady Rosalynn Carter (1927–2023)

'Knowledge will forever govern ignorance.'

- US President James Madison (1751-1836)

How personalized gene-editing saved a baby's life

KJ Muldoon had a 50% chance of surviving a genetic mutation until doctors developed a one-of-a-kind gene-editing therapy. In an interview with one of the researchers behind the treatment, learn what it will take to make personalized genetic medicine possible for everyone.

'The true measure of all our actions is how long the good in them lasts.'

- Queen Elizabeth II (1926-2022)

Chimpanzees are dying from human colds

For some great apes, the threat of human-borne diseases outweighs poaching or habitat loss. This article details the danger of reverse zoonoses, which refers to diseases that spread from humans to animals.

'When you come to a fork in the road, take it.'

- Baseball great Yogi Berra (1925-2015)

'In my experience, each failure contains the seeds of your next success—if you are willing to learn from it.'

- Microsoft cofounder Paul Allen (1953–2018)

The life of Anthropic's CEO, and how losing his father inspired his vision for AI

In 2006, Riccardo Amodei passed away from a rare illness, four years before a breakthrough treatment made it 95% curable. Seeking to accelerate scientific progress to prevent similar losses, Dario Amodei shifted his graduate studies at Princeton from theoretical physics to biology and has since pursued technological solutions to address complex biological problems.

A quote by Ralph Bunche

"The well-being and the hopes of the peoples of the world can never be served until peace - as well as freedom, honor and self-respect - is secure."

History’s largest intergenerational wealth transfer is happening in the next few decades

The founder of a multifamily office firm offers lessons on how to preserve wealth for generations from a global perspective, like educating younger family members.

'You shouldn't dream your film, you should make it!'

- Filmmaker Steven Spielberg (1946-present)

The quest to find natural ways to extend lifespan

Tales of searching for the Fountain of Youth persist. Our modern-day version is marked by promises of pharmaceutical miracles and a proliferation of viral "biohacking" routines. One doctor’s quest to unlock the keys to longevity stimulated much of this renewed fervor, though his ideas are often taken out of context.

Dr. William Gorgas eradicated yellow fever in Panama, crucial to canal construction

The disease was one of the factors hampering the French effort to build the canal. Gorgas' experience elsewhere in the Caribbean had taught him that good drainage and quaranting patients were essential, and he would eventually apply mosquito prevention tactics on a mass scale.

Svante Pääbo's life work was to discover the Neanderthal in our genes

Geneticist Svante Paabo reconstructed the genome of long-extinct human relatives, showing we have more in common with Neandertals than previously thought. Read up on his research and its impact on the wider scientific community.

Magic Johnson's announcing he had HIV changed public perception of the disease

When Lakers superstar Magic Johnson announced he had HIV in 1991, the disease was highly misunderstood. Commissioner David Stern had behind-the-scenes conversations with Johnson about publicly handling his eventual announcement, leading to the start of the condition's destigmatization.

Pneumonia was once a leading killer before penicillin treatments

In the early 20th century, pneumonia was a top cause of death worldwide, often fatal without effective treatment. Penicillin turned a once deadly infection into one of the most treatable bacterial diseases.

The basics behind mRNA vaccines

In this video, Yale experts Saad Omer, MBBS, MPH, PhD; Onyema Ogbuagu, MBBCh; and Akiko Iwasaki, PhD, explain the science behind COVID-19 mRNA vaccines.

On the role of 'Citizenship In A Republic'

After finishing a Smithsonian-sponsored expedition to East Africa, US President Theodore Roosevelt stopped by Paris and gave a speech about the responsibilities an ordinary citizen has to their republic. Citizens must know there is no effort without error, knowing they "fail while daring greatly" in pursuit of a truly democratic republic. This podcast series on powerful speeches across history is written and narrated by historian and author Jon Meacham.

'Heroes always have their scars. Some you can see, some you read about later on.'

- Boxer George Foreman (1949 - 2025)