How Nobel Prize-winning research unraveled why the immune system doesn't always attack itself

The 2025 Nobel Prize was awarded to scientists who discovered how immune system soldiers are typically stopped from attacking healthy tissue. The work furthered autoimmune understanding and cancer therapies.

Despite the rules, a Nobel Prize in medicine has been awarded posthumously

Ralph Steinman, whose work revealed how dendritic cells activate immune responses, passed away just days before being named a Nobel laureate. Although Nobel Prizes cannot be awarded posthumously, the committee made an exception because they believed he was alive at the time of the decision.

Of the 736 Nobel Prizes in physics, chemistry, physiology or medicine, and economics awarded through 2023, more than 95% come from the same academic family, having been taught by a lineage of previous winners.

Explore a list of Nobel Prize winners supported by National Science Foundation grants

As of 2025, 274 Nobel laureates have received funding from the NSF at some point during their careers, including 49 in physiology or medicine, 82 in physics, and 70 in chemistry. The 73 NSF-funded laureates in economics include every prize winner since 1997.

The Nobel Prize remains science's top honor despite limits and inequities

Each October, a few scientists gain global fame when told they’ve won a Nobel Prize—a century-old award founded by Alfred Nobel to recognize major achievements. While the prizes boost attention and prestige for winners, they exclude many deserving scientists due to rigid rules.

Penicillin’s pioneers were awarded the Nobel Prize in 1945

Alexander Fleming, Howard Florey, and Ernst Chain received the 1945 Nobel Prize in Physiology or Medicine for discovering and developing penicillin.

Only allowing three recipients causes the Nobel Prize to overlook team discoveries

While science has grown more inclusive and collaborative, the Nobel Prize system still struggles with outdated practices, such as secrecy and a rigid limit on awardees. This restriction sidelines many deserving scientists, especially in complex projects like the human genome or gravitational waves.

The Nobel Prizes honor global achievements in science, literature, and peace efforts

Established by Alfred Nobel’s will, the Nobel Prizes have been awarded since 1901 to individuals and organizations making major contributions to humanity. Although often grouped with the five original prizes, the economics award was added later by Sweden’s central bank in 1968 and isn't technically a Nobel Prize.

The 2017 Nobel Prize in physics was awarded to LIGO's founders

Rainer Weiss, Kip Thorne, and Barry Barish won the award for their contributions to the detector a year after the discovery of gravitational waves was announced. Acknowledging the Nobel statutes limited the prize to no more than three people, Thorne stated, "our marvelous discovery is the work of more than a thousand."

Critics say Nobel Prizes need updating to reflect how science and society work today

The rules still favor individuals over teams and may reflect outdated views on who does science. In 2013, the Nobel Prize in physics went to two theorists, even though over 5,000 scientists helped confirm the Higgs boson.

The discovery of insulin led to a controversial Nobel Prize in 1923

For centuries, Type 1 diabetes was fatal. The 1920s "discovery" of insulin netted two of its creators—Frederick Banting and his boss, John Macleod—a Nobel prize. Separately, the German doctor Georg Zuelzer synthesized an effective version of the life-saving drug years earlier but was interrupted by World War I.

Non-Nobel Prize awards recognize topics outside of chemistry, physics and medicine

Established in 2002, the Abel Prize awards $750,000 to a mathematician for pioneering scientific achievements, while the $1M Turing Award honors contributions in computer science. Additional prizes in earth science, engineering, environmental science and policy, astrophysics, nanoscience and neuroscience have also been established.

As of 2025, only five people have won two Nobel Prizes

Marie Curie's awards in physics and chemistry and Linus Pauling's in chemistry and peace are the only pairs in different fields. Awards to Curie's daughter and sons-in-law have made the Curies the most awarded family in history.

The 2018 Nobel Prize in physics was awarded for creating tweezers out of light

At 96, Arthur Ashkin became the oldest person to win a Nobel Prize in Physics for demonstrating how lasers can hold and measure objects, a technique that has since been used to explore microbiological environments. The award was also given to Gérard Mourou and Donna Strickland for developing a method of creating optical pulses.

In 2017, researchers won a Nobel Prize for their work controlling fruit fly circadian rhythms

This detailed circadian rhythm infographic breaks down a day in the biological life of a fly, providing a peek at some of the groundbreaking work that elicited a Nobel Prize in Physiology or Medicine.

Winning a Nobel in economics takes decades of impact and a Swedish stamp of approval

The Nobel Memorial Prize in Economic Sciences isn't one of the original five prizes in Alfred Nobel's will but was added by Sweden's central bank in 1968. Candidates are nominated by top economists, with a focus on lasting academic influence.

Explore the full list of Nobel Prize winners

Since 1901, about 1,000 individuals have been awarded Nobel Prizes. The Nobel Foundation provides biographies of every winner and concise descriptions of their accomplishments, as well as interviews and videos with more recent winners.

Rosalind Franklin’s work led to Nobel Prize-winning discoveries in DNA and virology

Her X-ray diffraction imaging helped uncover the structure of DNA, which earned James Watson, Francis Crick, and Maurice Wilkins a Nobel Prize. The same techniques enabled virus imaging, contributing to Aaron Klug's Nobel Prize in chemistry.

As of 2026, the Pontifical Academy of Sciences, which advises the pope on scientific matters, has included 90 Nobel laureates among its members.

Nobel Prizes in science have heavily favored male, North American, and European scientists

Most science laureates come from established academic institutions, and limited outreach and nomination rules have biased against researchers from low- and middle-income countries. As of 2024, China ranks among the world’s top scientific contributors, but has only won 10 Nobel Prizes in the sciences.

Robert Koch won the Nobel for his tuberculosis work, but he also pioneered cholera research

Koch was one of the first scientists to isolate the bacterium that causes cholera while investigating an outbreak in Egypt in 1883. He went on to advise about rules to control cholera outbreaks, which formed the basis of the disease control approaches and water hygiene techniques still used today.

The Ig Nobel Prizes honor scientific achievements that make people laugh, then think

These prizes show that even seemingly trivial work can gain attention, build momentum, and connect with broader audiences when presented engagingly. Winners include creating a toilet that analyzes your poop and understanding why scientists lick rocks.

The best photos of scientists at work in 2025

The winners of Nature's 2025 photo competition capture the essence of scientific fieldwork in diverse and challenging environments. From a biologist battling waves for whale research to ice core drilling in polar night conditions, this gallery details the research being each winning photo.

Some Nobel laureates have expressed beliefs in pseudoscience after winning

Examples of the phenomenon, known as Nobelitis or Nobel disease, include promoting psychic research, harmful practices like eugenics, and seeing talking raccoons. Increased external pressures after a win and a greater spotlight may contribute to developing or exposing these beliefs.

Why a Nobel Prize winner was awarded 30 years of free beer

Niels Bohr, the Danish physicist who won the Nobel Prize for Physics in 1922, moved into the Carlsberg Honorary Residence in 1932 and was entitled to free delivery of Carlsberg beer for as long as he lived there. He did so until he died in 1962.

Why some nations reach economic success and others don’t

The 2024 Nobel Prize in Economics winners, Daron Acemoglu, Simon Johnson, and James A. Robinson, were honored for their compelling research on the factors that influence a nation’s prosperity. Spanning two decades, their work presents insights into how societal organization can explain the income discrepancies between different countries. In general, their research shows that economic success favors more free and open societies. Listen for more fascinating insights.

The Pius XI Medal—named after the pope who rebranded the Pontifical Academy of Sciences in 1936—has been awarded every two years to a promising scientist under 45.

Drs. Jennifer Doudna and Emmanuelle Charpentier discuss CRISPR

Jennifer Doudna and Emmanuelle Charpentier's were awarded the 2020 Nobel Prize for research focused on understanding and adapting the CRISPR-Cas9 system to precisely edit DNA sequences in other organisms. Doudna has indicated that the system can potentially treat genetic forms of blindness and high cholesterol.

X-rays earned the very first Nobel Prize in physics for revealing hidden worlds

In 1895, Wilhelm Conrad Röntgen discovered X-rays, which could pass through solid objects and make unseen structures visible. Today’s X-ray tools continue to advance science and medicine, including capturing real-time images of proteins.

Experience games that explore Nobel Prize-winning work

Inspired by the educators who set laureates on their path, the Nobel Foundation has created a library of interactive activities for the general public. These allow users to make groundbreaking discoveries, showing that such work is accessible to all.

A French Army surgeon discovered that malaria is a parasitic disease in 1880—but scientists were initially skeptical.

Marie Curie's research in radioactivity made her the first woman to win a Nobel Prize

Overcoming social and academic barriers, Curie's realization that radiation resulted from an intrinsic property of atoms reframed scientific understanding of the phenomenon. Her subsequent work in discovering two new elements—polonium and radium—earned her a second Nobel Prize.

How scientists earned themselves a Nobel Prize by discovering what destroyed ozone

In 1974, chemists Mario Molina and F. Sherwood Rowland showed that chlorofluorocarbons—then used as aerosol propellants, refrigerants, and industrial solvents—rise into the stratosphere and, upon being struck by ultraviolet radiation, release chlorine atoms, which break apart ozone molecules. Their work earned them the Nobel Prize in chemistry in 1995.

Each Nobel committee sends nomination requests to 3,000 leading academics annually

Each Nobel selection committee consults with experts to create a shortlist of finalists from the hundreds of nominations, which is then sent to the Royal Swedish Academy of Sciences. The literature and peace awards also involve nominations from "qualified persons," such as university professors.

Joel Mokyr won the 2025 Economics Nobel as a historian of scientific ideas

Many Nobel Prizes for Economics go to economists for their sophisticated quantification and large-scale studies and surveys. And while Northwestern's Mokyr has conducted such studies, his published works are more traditional history, where he argues for the significance of ideas to the development of material economics.

Oxford scientists turned Fleming’s mold discovery into medicine

In 1939, a team at Oxford—including Howard Florey, Ernst Chain, and Norman Heatley—revived Fleming’s forgotten discovery. Using makeshift equipment like bedpans and milk churns, they purified enough penicillin to prove it could treat deadly infections.

Gender bias in science’s past still echoes in today’s Nobel Prize tallies

Although women make up half the global population, they’ve won only 49 out of 923 Nobel Prizes from 1901 to 2022. Nobel committee members say historical gender bias has limited female representation, but they plan to promote more diverse nominations.

The 2008 Nobel Prize in chemistry was awarded for discovering and developing uses for green fluorescent protein—a biomolecule found in Aequorea victoria, a jellyfish native to the Pacific Northwest.

A Nobel laureate discuss whether stem cells can extend lifespan

Listen to Nobel laureate Shinya Yamanaka discuss the potential of induced pluripotent stem cells to extend human lifespan. By reprogramming adult cells into embryonic-like stem cells, scientists might be able to rejuvenate tissues and treat age-related diseases—though ethical and safety concerns remain.