Hyperbaric Oxygen Therapy involves breathing pure oxygen under elevated pressure in a specialized chamber and is being explored as a potential long COVID treatment with mixed results.

Long-haul COVID: What doctors want patients to know

Long COVID continues to be a medical mystery, but some parts of the puzzle are falling into place. Learn more from intensivist Devang Sanghavi, MD.

Based on its varied symptoms, scientists think that long COVID is not a single disease, but rather a group of different conditions triggered by COVID-19 infection.

How specialized oxygen mixtures like heliox enable deep diving without feeling drunk

Beyond a depth of about 30 meters (98 feet), if divers are breathing surface air, which is about 78% nitrogen, underwater pressure forces more nitrogen into the bloodstream and induces nitrogen narcosis, whose symptoms resemble alcohol intoxication. Through saturation diving, where nitrogen is replaced with helium—an inert gas—deep divers can maintain cognitive function while working for extended periods.

Olfactory training, a widely recommended treatment for people with long-term loss of smell after a viral infection like COVID, can be performed at home using bottles of essential oils—often lemon, rose, clove, and eucalyptus—to help reorganize neural connections in the brain.

Some claim breathwork can improve mental health, help process trauma, and more

Research shows people who practice breathing exercises see a decrease in depression and stress levels, and that such exercises are about as effective at treating PTSD as conventional approaches. Even something as simple as extending exhales can slow one's heart rate and activate the parasympathetic nervous system.

Michael Phelps used cupping at the 2016 Olympics, a traditional Chinese medicine approach thought to bring blood to the skin to boost muscle recovery.

This 1440 Original video dives into what the science says about phototherapy and its various potential applications.

Biohacking to boost personal health has become a concept that encompasses everything from vitamin regimens and cryochambers to brain implants and red light therapy.

High-powered red light therapy—delivered directly to nerve fibers via a fiber optic needle—has been used in recent experimental research to suppress pain.

Research advances suggest death takes much longer than we realized

Recent research indicates that organs, including the brain, are better at handling a lack of oxygen after the heart stops beating than previously known. Such findings may open up possibilities that include someday reversing certain death processes and expanding the availability of organs available for organ donations. (Some users may experience a paywall.)

Reduced inflammation from cold plunges lacks scientific support

The cold water triggers immediate cold shock, increasing heart rate and blood pressure, and prolonged exposure can lead to cold-water incapacitation and hypothermia. Plungers are encouraged to enter the water slowly and manage their breathing to reduce the risk of shock. Warm baths post-plunge are discouraged, and exercise is generally better for recovery.

Brain death is a uniquely modern problem stemming from modern ventilators.

DBS effectiveness in treating addiction remains uncertain amid inconsistent results

Critics argue that deep brain stimulation should be considered a last resort and not a scalable solution, given its high costs and trials limited to small samples. However, it has helped some patients manage severe opioid use disorder when conventional methods didn’t work.

The iron lung—a simple mechanical ventilator—was first used to treat polio

These breathing devices, developed in the late 1920s at Harvard, were used to treat polio patients with breathing difficulties. Watch this video describing how these negative pressure devices work.

Red light therapy—a treatment harnessing a specific form of energy that penetrates the top layers of skin—is marketed for skincare and wellness, but has its roots in NASA plant growth research.

Watch a histotripsy procedure, a novel noninvasive cancer treatment approach used to destroy tumors with high-intensity sound waves.

Veterans reported single dose of ibogaine improved TBI, PTSD, anxiety, and depression

Research published in 2024 on the Central African plant-derived drug included 30 male combat vets who received ibogaine treatment in Mexico. It reported significant reductions in multiple mental health conditions and no serious side effects. Other work, however, has shown the substance can cause fatal cardiac arrhythmias, killing at least 19 people between 1990 and 2008. (Some users may encounter a paywall.)

Post-treatment Lyme disease syndrome may be caused by bacterial remnants in the liver

PTLDS, which refers to lingering symptoms of Lyme after antibiotic treatment, is an area of active research. Rodent research published in 2025 suggests that these ongoing symptoms may potentially be due to the body's inflammatory response to lingering cellular components from the bacteria that cause Lyme, Borrelia burgdorferi. In rodents, components of the bacteria's cellular wall may remain in the liver after the bacteria were eliminated with antibiotics.

COVID accelerated antibiotic resistance

The COVID-19 pandemic was caused by a virus, and viruses can’t be treated with antibiotics. But recent research finds that COVID patients were given a tremendous amount of antibiotics, contributing to the problem of antibiotic-resistant bacteria. Why? This NPR feature sheds light on an unexpected side effect of the pandemic.

The body's response to cardiac arrest has been linked to near-death experiences.

Brain activity sometimes goes into overdrive around the point of death according to researchers' recent analysis of patients' brains before and after they were taken off their ventilators.

A scientist successfully treated her own breast cancer by injecting the tumor with lab-grown viruses.

The potential of virtual reality in healthcare

Virtual reality (VR) is carving new frontiers in healthcare, from aiding in stroke recovery to training medical professionals. This article in Time Magazine highlights the innovative uses of VR in medical settings, including its potential and current limitations.

My experience with biohacking

A general approach that employs technology to enhance the functioning of the human body, biohacking enthusiasts are continuously seeking new ways to optimize their performance. Martin Kremmer, an entrepreneur who became interested in the topic after experiencing burnout, explores his own experiences in biohacking his own diet and lifestyle in pursuit of a longer, healthier life.

'Bibliotherapy' is of increasing interest as a way to improve mental health and help navigate complex life situations—with people immersing themselves in the experiences of fictional characters or nonfiction and self-help books to find relief and gain personal insights.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Deep brain stimulation helps manage movement in patients with neurological disorders

DBS is a surgical procedure that uses implanted electrodes to send electrical signals to targeted areas in the brain, interrupting abnormal neural activity. It may be implemented when medications lose effectiveness or cause disruptive side effects.

Links between long-term caregiving and chronic stress

This Cleveland Clinic overview suggests that around 60% of people caring for family or loved ones with health conditions will experience burnout. Caregivers prepare meals, help with transportation, administer medications, and perform daily tasks for others, all while managing their own lives. This guide may help readers overcome the guilt or frustration of long-term caregiving to seek alternative options.

Heatstroke treatment guidelines were built almost exclusively on research in men

Protocols for the standard treatment recommendation for heatstroke—whole-body cold water immersion—were built based on studies almost entirely in men. The research wasn't replicated in women, who typically cool faster than men during cold water immersion, raising questions about standard protocol safety for women, due to the risk of overcooling.

Stem cell therapy has shown promise in treating spinal injuries in an early-stage clinical trial.

The main criticism of a recent neurophysiological explanation for near-death experiences is that these events are too complex to be explained as a neurochemical response to an oxygen-deprived brain.

Tinnitus is a rare side effect of COVID-19

The infection can affect inner ear cells, and a review of the literature across multiple studies concluded that hearing loss occurred in 3.1% of patients with the virus and tinnitus in 4.5%.

Watch an expert's take on the rare disease hantavirus—and why it's not of great concern to the general population

This rare zoonotic disease, transmitted to humans primarily through infected rodent droppings, urine, or saliva, is rarely spread between people. The disease was of particular concern in spring 2026, when an outbreak occurred on a 150-person cruise ship, prompting a flurry of action, including contact tracing for passengers in their home countries. The disease can be fatal. But early care—primarily oxygen support—can help patients survive.

Why helium mixtures are used in respiratory medicine

Unlike the air near Earth's surface, which is primarily composed of oxygen and nitrogen, heliox is composed entirely of oxygen and helium. Because helium is lighter than nitrogen, the lungs do not have to work as hard to push air, easing the uptake of oxygen via a ventilator, mask, or nasal tube.

Dr. Henry Heimlich, famous for his antichoking technique from the 1970s, was a proponent of controversial and discredited approaches, including infecting cancer and HIV patients with malaria to try to trigger a heightened immune response.

Bears may have evolved natural mechanisms to prevent blood clots during hibernation, an important development, since inactivity typically leads to blood clots in other animals.

9/11 first responders still deal with significant mental and physical impairments.

Biohacking: The effort to optimize health and extend life through technology

Biohacking seeks to optimize human health and performance through everything from simple lifestyle adjustments to more radical interventions like body modifications and experimental technology. At its core, biohacking covers a wide spectrum—ranging from improving sleep and focus to implanting devices that integrate technology with the human body.

Can humans delay or reverse old age?

We're not sure yet. Researchers at the University of California San Francisco are studying why some conditions and behaviors, such as low-oxygen environments and exercise, benefit the aging process, hoping to reveal potential health applications. Some of this research focuses on klotho, a naturally occurring age-regulating hormone named after the Greek Fate Clotho. Animal studies on klotho brain injections found subjects had improved memory recall and age-related degeneration resistance.

Ibogaine is being investigated for treating mental health issues and substance abuse

This compound, which is illegal to use in the US, has had promising results for patients who have tried it in other countries for substance abuse and mental health concerns. This psychoactive substance is not without risks, however; this TED talk points out it's also caused fatal cardiac arrhythmias and shouldn't be taken without medical supervision.

Oxygen is produced in the International Space Station from recycled water, which is split into hydrogen and oxygen gases using an electric current.

Chronic lyme isn't a medically recognized diagnosis in conventional medicine

It describes a constellation of symptoms attributed to a persistent Lyme infection—meaning the bacteria have remained present even after antibiotics. It often occurs among people who have never received a positive test for Lyme. Doctors do recognize "post-treatment Lyme disease syndrome," however, which can include muscle and joint pain, fatigue, and cognitive difficulties after treatment for confirmed Lyme.

There's a new (contested) physiological explanation for near-death experiences based on analysis of the brains of resuscitated coma and cardiac arrest patients.

Supplements ahead of exertional heatstroke helped protect mice against brain damage

In the lab, mice dosed with probiotics prior to inducing exertional heatstroke, had better cognitive outcomes. This evidence underscores the links between the gut microbiome and the brain, at least in rodents.

Exercise improves brain blood flow, stimulates neural growth, and more.

What is biohacking? An overview

Biohacking is a broad collection of self-improvement techniques meant to enhance a human's health, lifespan, or ability. There are basic biohacks, like the use of caffeine, and more extreme ones, like under-the-skin implants. The difference between biohacking and standard medicine is that biohacking is primarily a do-it-yourself approach and is mostly unregulated.

The US military, concerned about potential deployments worldwide, has long funded experimental hantavirus vaccines and therapies.

Collaborations between the military, biotech, and academic researchers led to an experimental antibody treatment for the Andes hantavirus strain—the one that more readily passes between humans. As of spring 2026, it had only been tested in animals. The US Army has also tested a potential hantavirus vaccine in people. It published early findings in 2023 that seemed promising, eliciting some immune system response. (Some users may encounter a paywall.)

To survive underwater hibernation, some freshwater turtles perform cloacal breathing—blood vessels absorb dissolved oxygen from water drawn into the organism's cloaca, or rear orifice.

Hookworm infection, though risky, may help fight certain health conditions.

Donated hearts remain viable three times longer now with new tech

Advances in organ perfusion systems have significantly lengthened the amount of time donated hearts can remain viable for transplant, expanding the possibilities for donor organs to wider geographic areas. "Heart in a box" devices, developed in recent years, enable effective oxygen flow in the donor heart during transport, which means that hearts can now travel farther to potential recipients and still be in good condition.