Dr. Henry Heimlich, famous for his anti-choking technique from the 1970s, was a proponent of controversial and discredited approaches, including infecting cancer and HIV patients with malaria to try to trigger a heightened immune response.

Abdominal thrusts, also known as the Heimlich maneuver, can save a life if someone is choking.

A scientist successfully treated her own breast cancer by injecting the tumor with lab-grown viruses.

Maryland required cholera researchers to fly a yellow warning flag—signifying quarantine dangers in the 1970s

University of Maryland Hospital researchers intentionally infected volunteers with the cholera bacterium in the late 1970s to further their understanding of the disease. They proceeded with this work following the recommendation of a US government panel. (Some users may encounter a paywall.)

Robert Koch won the Nobel for his tuberculosis work, but he also pioneered cholera research

Koch was one of the first scientists to isolate the bacterium that causes cholera while investigating an outbreak in Egypt in 1883. He went on to advise about rules to control cholera outbreaks, which formed the basis of the disease control approaches and water hygiene techniques still used today.

In 1892, two scientists purposefully infected themselves with cholera bacteria

When they became ill—one with mild diarrhea and the other with severe cholera—researchers pointed to that as proof that the pathogen caused the disease.

Six of history's most unethical human experiments, from deliberate flu exposure to withholding syphilis treatment

Some of the progress made in mental health treatment, vaccines, blood transfusions, and more came about before the advent of consent and ethics committees, resulting in serious physical and psychological harm that participants in studies were not even anticipating.

The US military, concerned about potential deployments worldwide, has long funded experimental hantavirus vaccines and therapies.

Collaborations between the military, biotech, and academic researchers led to an experimental antibody treatment for the Andes hantavirus strain—the one that more readily passes between humans. As of spring 2026, it had only been tested in animals. The US Army has also tested a potential hantavirus vaccine in people. It published early findings in 2023 that seemed promising, eliciting some immune system response. (Some users may encounter a paywall.)

Without the option of modern blood transfusions, some doctors in the mid-1800s tried to help save cholera patients by injecting them with cow's milk, hoping it would boost their nutrition and hydration.

Hippocratic doctors treated severe mental illness with the poisonous plant hellebore

Since symptoms like hallucinations were believed be due to an imbalance of black bile, yellow bile, blood, and phlegm, the treatment at the time was to bring those humors back into balance. That meant standard treatments could include bleeding a patient or using substances like hellebore to induce vomiting or diarrhea.

Watch a histotripsy procedure, a novel noninvasive cancer treatment approach used to destroy tumors with high-intensity sound waves.

Hookworm infection, though risky, may help fight certain health conditions.

How fecal transplants work

1,700 years ago, Chinese alchemist Ge Hong was renowned for his soup that could cure diarrhea-stricken patients. It had a surprising secret ingredient: feces. While it might seem unwise to consume feces, exciting new research suggests that taking...

The iron lung—a simple mechanical ventilator—was first used to treat polio

These breathing devices, developed in the late 1920s at Harvard, were used to treat polio patients with breathing difficulties. Watch this video describing how these negative pressure devices work.

The cholera bacteria was first isolated in 1854—but the discovery was largely ignored

The pathogen was isolated by the Italian physician Filippo Pacini in Florence, Italy, though his discovery was largely ignored in favor of the popular miasma—bad air—theory of disease at the time. The pathogen was separately isolated about three decades later by German microbiologist Robert Koch.

Fecal transplants can help treat infections by transplanting healthy gut bacteria from a donor into a patient's gastrointestinal tract using samples of human waste, which are turned into a liquid mixture and often delivered via a colonoscopy procedure.

Pneumonia was once a leading killer before penicillin treatments

In the early 20th century, pneumonia was a top cause of death worldwide, often fatal without effective treatment. Penicillin turned a once deadly infection into one of the most treatable bacterial diseases.

Using mosquitoes to vaccinate bats could curb the spread of deadly diseases.

Watch an expert's take on the rare disease hantavirus—and why it's not of great concern to the general population

This rare zoonotic disease, transmitted to humans primarily through infected rodent droppings, urine, or saliva, is rarely spread between people. The disease was of particular concern in spring 2026, when an outbreak occurred on a 150-person cruise ship, prompting a flurry of action, including contact tracing for passengers in their home countries. The disease can be fatal. But early care—primarily oxygen support—can help patients survive.

Steve Jobs tried to treat his cancer with alternative medicine

After Steve Jobs was diagnosed with pancreatic cancer, he reportedly restricted his diet to just fruits or just fruits and vegetables, tried out hydrotherapy, and consulted psychics. There’s compelling evidence about the impact of alternative medicine on cancer patients.

The history of germ theory, which explains that illnesses are caused by microorganisms

For centuries, the miasma theory, which held that illnesses were caused by clouds of "bad air" produced by decaying organic matter, was the accepted explanation for the spread of disease. The development of microscopes and the subsequent technology to isolate bacteria and test disease spread in mice greatly contributed to contagionists overturning miasmatists.

Listen to how the 1902 'poison squad' experiments changed food safety in America

As part of government research, a group of young men were paid to eat standard American food—replete with food additives like borax and formaldehyde—which revealed the dangers of unregulated food. The work was led by the first FDA commissioner, Harvey Wiley, who helped end the "century of the great stomachache."

Diphtheria was once a leading childhood killer before antibiotics and vaccines

In 18th- and 19th-century outbreaks, some New England families lost as many as eight children to diphtheria, and fatality rates in hospitals often topped 60%. The invention of antitoxins, penicillin, and vaccines dramatically reduced deaths.

When was the first blood transfusion?

In the 1600s, an English doctor transferred the blood from one dog to another via quills. The procedure ended when one of the dogs died. This article details the early days of blood transfusions, which turned toward humans shortly after the 1666 dog experiment and involved putting the blood of a sheep into a human recipient (who reportedly survived the encounter).

Dr. Bernard Fisher pioneered lumpectomy in the 1970s as a treatment for breast cancer.

Pooping or puking out pathogens is sometimes recommended with food poisoning

Sometimes stopping food poisoning-linked diarrhea with over-the-counter medications is a bad idea because it may prolong illness. Doctors can advise you if your diarrhea or vomiting is severe about what medications to take and when, but generally doctors recommend trying to stay hydrated during a bout of food poisoning and letting the body naturally remove pathogens from the body via vomiting or diarrhea, as needed.

Jonas Salk developed the first successful polio vaccine—and tested it on himself

The American medical researcher developed the inactivated virus vaccine from 1952 to 1955 and proved that it could prevent disease. He tested the virus on himself and his family in 1954 and then carried out formal clinical trials on more than 1.3 million children.

A malaria case in Maryland stumped doctors in 2023—leading to the wrong treatment and underscoring the challenge of physicians being mindful of tropical diseases in our interconnected world.

History's weirdest weight loss fads, fact-checked

Nothing catches popular attention more than a claim to have found a quick weight-loss technique. History shows us such claims are often unfounded. Dr. Michael Mosley explores extreme weight-loss tips from history, from tapeworms to vinegar diets.

How a government chemist founded the FDA—by poisoning people

The Poison Squad tells the story of government chemist Dr. Harvey Wiley who, determined to banish these dangerous substances from dinner tables, took on the powerful food manufacturers and their allies.

Michael Phelps used cupping at the 2016 Olympics, a traditional Chinese medicine approach thought to bring blood to the skin to boost muscle recovery.

Dr. Martin Luther King Jr. survived a near-fatal assassination attempt in 1958

In 1958, Dr. King was stabbed in the chest by a woman at a Harlem book signing. The blade lodged near his aorta, requiring emergency surgery to save his life.

Before launching his cereal company, John Harvey Kellogg promoted a eugenics-inspired natural food regimen.

The American Veterinary Medical Association advocates for vaccinations for pets to extend their lives

The American Animal Hospital Association provides guidelines, while many states legally require certain vaccines, such as rabies. Vaccinating healthy pets—even indoor-only pets—prevents outbreaks and protects other vulnerable animals, and adverse effects, such as allergic reactions and injection-site irritation, are rare. (Some readers may experience a paywall.)

Experience a century of America's healthcare advances with this medical visualization, tracing a sampling of healthcare innovations from head to toe.

60 years after seeing Henrietta Lacks as a patient, her doctor still remembered the unique cervical tumor that gave rise to the 'immortal' cell line now commonly used in biomedical research—it was purple, shiny, and soft—an appearance he said is very different from a typical tumor.

Although rare, HFMD can spreads in pools due to poor bathroom hygiene

In pools with inadequate levels of chlorine, this disease can spread via the poop-to-mouth route, though this isn't one of the most common ways the disease is transmitted. People can become infected by swallowing contaminated pool water after little kids (or their parents) don't do an adequate job removing virus-laden feces from the child before the child enters the water.

A fake vaccine campaign was used to locate Osama bin Laden, fueling vaccine distrust

As part of the intelligence operation to find bin Laden in Pakistan, the US Central Intelligence Agency recruited a Pakistani doctor who ran a fake hepatitis B vaccine campaign and obtained DNA samples from bin Laden. News of this fake campaign fueled further distrust of healthcare workers, attacks on them, and stymied efforts to vaccinate against polio in the region.

Oral rehydration solution was developed in the 1960s in response to cholera deaths.

Harvard drowned rats for this?

Harvard's 1950s rat study was ethically questionable, but scientifically profound. One rescue attempt made rats swim 40x longer. The finding: hope isn't poetic, it's biological.

With no textbooks or antibiotics, this WWI surgeon pioneered facial reconstruction

New Zealand surgeon Dr. Harold Gillies made extraordinary advances in the field of reconstructive surgery during World War I and after. This 36-minute NPR podcast interviews historian Lindsey Fitzharris, author of Gillie's biography, The Facemaker, charting how the good doctor reconstructed the faces of numerous soldiers in an age before antibiotics and plastic surgery as we know it today.

How to think yourself into health

Can the right thoughts lead to a stronger immune system? Neuroimmunologists like Hai Qi study how drugs targeting the brain, as well as thought exercises, can prompt stronger immune responses to infection. This six-minute video investigates the radical claims.

Probiotics, which are living bacteria and yeasts, are not recommended for most patients.

Using psychedelics to manage a cancer diagnosis

Dr. Roland Griffiths helped lead the revival of psychedelic research, often prescribing the use of psilocybin to address severe depression or anxiety in patients. This podcast explores how Griffiths leaned on his own career after being diagnosed with cancer and facing the prospect of death.

Surgery before the dawn of anesthesia

The arc toward anesthetics was painfully slow, with early pain mitigation offerings ranging from analgesics—drugs that dim pain but don't block it—and numbing surgical sites with cold water to gassing patients with carbon dioxide or bashing or bleeding them unconscious. Such treatments and the torturous surgery they preceded led many to avoid even life-saving procedures, and those who survived often kept silent about the trauma.

'Immortal' HeLa cells—cancerous cells widely used in biomedical research after they were nonconsensually taken from a Black woman named Henrietta Lacks—proliferate easily, causing millions of dollars of damage annually by contaminating lab cell cultures.

In 2012, a virus that causes HFMD may have killed dozens of kids in Asia

More than 50 young children in Cambodia died in spring 2012 for unknown reasons, but laboratory testing of samples available from a limited number of those children came back positive for Enterovirus 71. That virus, which can cause HFMD, is known to cause severe complications among some people who contract the disease. But health officials concluded that poor baseline health and then incorrect treatment using steroids helped exacerbate their condition, helping lead to the deaths.

The medical profession has a dark history of 'body snatching' for education

This term originally referred to secretly removing corpses from graves for sale—usually to medical schools where they were used for education. The practice dates back at least to the 1300s but still—much more rarely—persists today.

Oxford scientists turned Fleming’s mold discovery into medicine

In 1939, a team at Oxford—including Howard Florey, Ernst Chain, and Norman Heatley—revived Fleming’s forgotten discovery. Using makeshift equipment like bedpans and milk churns, they purified enough penicillin to prove it could treat deadly infections.

Dr. William Gorgas eradicated yellow fever in Panama, crucial to canal construction

The disease was one of the factors hampering the French effort to build the canal. Gorgas' experience elsewhere in the Caribbean had taught him that good drainage and quaranting patients were essential, and he would eventually apply mosquito prevention tactics on a mass scale.

Reduced inflammation from cold plunges lacks scientific support

The cold water triggers immediate cold shock, increasing heart rate and blood pressure, and prolonged exposure can lead to cold-water incapacitation and hypothermia. Plungers are encouraged to enter the water slowly and manage their breathing to reduce the risk of shock. Warm baths post-plunge are discouraged, and exercise is generally better for recovery.