Diabetes is a chronic disease caused by either a lack of the hormone insulin or problems processing it, which leads to persistently high blood sugar.

Almost 90 to 95% of people with diabetes have Type 2 diabetes, occuring when the pancreas doesn't make enough insulin or the insulin fails to work correctly. Insulin malfunction causes the pancreas to crank out increasingly high amounts of the blood sugar-regulating hormone, leading to overwork and reductions in production.

Glucose, the brain's preferred energy source, enters the bloodstream when the body breaks down consumed carbohydrates. To manage this increase in readily available energy, the body releases the hormone insulin, which allows glucose to enter and fuel our cells. Without insulin, glucose remains in the blood, causing health issues.

Globally, pregnant people are increasingly at risk to develop gestational diabetes due to rising maternal ages and obesity rates. The condition is associated with heavier fetal weight, congenital abnormalities, and perinatal mortality, which includes stillbirths and deaths of babies younger than 7 days old.

High blood sugar levels in untreated diabetes roughen artery walls, increasing plaque buildup, heart disease, and high blood pressure risk. High levels also cause acid to build up in the bloodstream, potentially making the brain swell, the lungs fill with fluid, and the heart to beat arrhythmically—all fatal complications.

Treatments for diabetes depend on the type of condition a patient has. Gestational diabetes typically goes away after birth, and those with Type 2 diabetes may be able to reverse their condition through diet, exercise, and blood sugar management. Type 1 diabetes has no cure, but can be successfully managed.

Clinically referred to as latent autoimmune diabetes in adults, or LADA, this condition is often diagnosed as Type 2 diabetes. However, it’s an autoimmune disease that eventually requires insulin, just like Type 1 diabetes. Misdiagnosis can result in uncontrolled high blood sugar and a slew of other serious health issues.

Diabetes treatment became truly effective after the advent of insulin injections in the early 1900s. Diabetes is becoming increasingly common. Current trends estimate one in three Americans will have diabetes by 2050. This overview explores two centuries of diabetes treatment—starting in 1812—and outline potential challenges to treatment and prevention.

Blood sugar levels increase after a meal when the body starts turning food into usable fuel—sugars, proteins, and more—which are absorbed into the bloodstream through the intestines. Blood sugar levels rise, releasing insulin, and letting sugar in the blood be absorbed into hungry cells, thereby dropping blood sugar levels.

It remains contentious if something inherent about the disease or antipsychotics' side effects (weight gain) are mostly to blame. Some newly diagnosed schizophrenia patients already have insulin resistance, raising questions about if patients' brains are getting enough energy from glucose, and if dietary changes—like a high-fat, low-carbohydrate, moderate-protein diet—may help alleviate symptoms.

Type 2 diabetics in the US risk dying from low blood sugar, an epidemic traced to a decades-old, multi-million-dollar drug industry campaign encouraging an average blood sugar level below 7%. Contemporary research correlated such levels with reduced risk of eye, nerve, and kidney damage and increased hypoglycemia risk.

It's generally accepted that sugar rushes are a myth, and that hyperactivity is a more psychological experience. However, there is real science behind the rare sugar crash that primarily impacts those with diabetes. Read this article to understand how historical and cultural factors have shaped sugar perceptions, and how low blood sugar can trigger shakiness, fatigue, weakness, and more in diabetes patients.

Across the Pacific archipelago of Fiji, diabetes often avoids diagnosis until amputation or death is imminent. Fiji's government has said nearly 30% of its population has diabetes, and, in 2019, related amputations accounted for 40% of the country's hospital operations. This "sugar disease" may have such a stronghold on the archipelago, which has a physically active culture that prizes locally sourced foods, due to cost, with processed foods being much cheaper than alternatives.

For centuries, Type 1 diabetes was fatal. The 1920s "discovery" of insulin netted two of its creators—Frederick Banting and his boss, John Macleod—a Nobel prize. Separately, the German doctor Georg Zuelzer synthesized an effective version of the life-saving drug years earlier but was interrupted by World War I.

Texas has some of the highest rates of diabetes-related amputations in the country. Towering over the rest of the Longhorn state is the city of San Antonio, where men are nearly three times as likely to lose a limb to diabetes than women. This article explains how men in this majority Mexican American city are genetically and culturally at risk of Type 2 diabetes, a disease involving issues with the blood sugar-regulating hormone insulin.

The pancreas weighs about the same as a deck of cards and is smaller than the average adult human hand. This lopsided glandular organ controls blood sugar levels through insulin production and helps the body digest food by creating a neutralizing tonic filled with digestive enzymes.

Scientists Daniel and Kelly talk with researcher Dr. Katrine Whiteson about diabetes, the history of insulin production, and Dr. Lydia Villa-Komaroff—an essential member of the team who discovered that bacteria could be induced to produce insulin. Listen to discover interesting facts about the life-saving medicine and how it works in the human body.

Over time, this cellular defense system can inadvertently damage cells and tissues when it's in this heightened alarm mode over a prolonged period. This occurs because, when immune cells are sent somewhere without a true target, they may attack healthy cells and tissues.

Humanity's ancestors evolved to wring more calories from sugary fruits by storing excess sugar as fat, an adaption that's culminated in many peoples' palettes preferring calorie-rich sweet. Now, the desire for sugar has both contributed to a widespread health crisis and been at the center of atrocities around the world.

New meta-analysis shows blood pressure reductions with ACE inhibitors and ARBs are associated with a lower diabetes risk, but other types of antihypertensive agents have the opposite effect.

In this video, a physician claims that he reversed a patient's Type 2 diabetes in six weeks by addressing inflammation drivers such as diet. More broadly, he argues that society needs to better consider and address numerous disease factors that are modulated by inflammation, such as stress, sleep, diet, and movement.

Prolonged inactivity, like sitting for long periods, slows metabolism, weakens muscles and bones, and impairs insulin function. When these negative changes persist over time, the cumulative result is an increased risk of cardiovascular disease, diabetes, and many cancers.

The world is trending toward weight gain, a development that comes with a corresponding rise in risk for health conditions, including diabetes and heart disease. This article explores how meal timing has become a factor in nutrition and weight maintenance.

The FDA approved Ozempic to help patients with diabetes, but the popularity of semaglutide as a weight loss drug led doctors to prescribe Ozempic to nondiabetic patients who needed to lose weight. Ozempic became so popular that manufacturers could not keep pace with demand, posing risks for Ozempic-users with diabetes.

Stress is our body’s internal mechanism to deal with changes in our internal balance. As such, the stress response affects nearly every organ system through a cascade of both fast and slow hormonal changes. While short-term stress can be adaptive, long-term stress may cause serious health issues.

Read this primer about Alzheimer's disease and learn what factors increase the risk of this form of dementia, including genetics, being a woman, and health conditions, including high blood pressure.

Autoantibodies—which attack the body—may be detectable in the body years before a patient develops symptoms, but some people may have detectable levels yet never go on to develop an autoimmune disease. This video discusses this and other unsolved mysteries with autoimmune disease.

Frederick Banting and his graduate student Charles Best were the first to isolate the peptide insulin from dogs. They induced diabetes in the animals and then treated them with this peptide.

Around 75% of prescriptions for GLP-1 drugs are used to treat diabetes, while the remainder is used for weight loss. This overview from GoodRX includes a list and overview of currently available options along with prices for each.

Researchers theorize that environmental factors, including shifts to less healthy diets, air pollution, infections, stress, climate change, and exposures to xenobiotics—substances like pesticides, plastics, and toxins that incite immune responses—may all be fueling epigenetic changes to our bodies that make people's immune responses go awry.

Dr. David Kessler, former FDA Commissioner and public health leader, explores how these drugs override the brain’s reward-driven eating habits but have notable side effects. These include developing eating disorders, muscle loss, and intestinal obstruction.

Lactose intolerance can develop in adulthood and can be influenced by genetic factors, culture, and dietary practices. Times of famine may have favored those who could digest dairy, naturally selecting them more, resulting in lactase persistence.

How often would you say you struggle to stay or fall asleep? If it's more than three times per week (and has been going on for at least one month), then you might have one of the most common sleep disorders: insomnia.

Lactose intolerance is a digestive condition that occurs when the small intestine has difficulty breaking down lactose, a sugar found in products like milk or cheese, leading to symptoms such as diarrhea or bloating. Almost 70% of the world’s population may have lactose processing issues, particularly in Asia and Africa. This is different from a condition called cow's milk protein allergy—an immune system disorder that can cause hives and anaphylaxis.

Although Alzheimer's disease is sometimes thought of synonymously with dementia, there are multiple types of dementia, which manifest in memory loss and other symptoms that make it challenging to perform daily tasks. These types include Lewy Body dementia, vascular dementia, and frontotemporal dementia. Parkinson's disease is not a form of dementia, but this movement disorder can sometimes develop into issues with memory and a formal diagnosis of dementia.

It's well-established that drugs which mimic the hormone GLP-1 can help people lose weight and control blood sugar levels, primarily through appetite reduction. This technical review provides an overview of how both natural and therapeutic GLP-1 interacts with the gut and brain to produce its effects.

GLP-1 drugs popularity for weight loss and treating diabetes, led to a significant supply shortage and the rise of compound pharmacies, which produce customized drug formulations but lack formal approval from regulators. The drugs are ostensibly the same, but manufacturing methods lead to variations in concentration, filler compounds, and more.

This episode interviews researchers and patients who have used semaglutide to explore some of the potential risks associated with using the drug to lose weight. These include insurance challenges, health scares related to counterfeit versions of these drugs, and some users lose their ability to enjoy food.