Mosquitoes are the world's deadliest animal, but gene drives could kill them.

What if we killed every mosquito on Earth?

Mosquitoes aren't just annoying, they're deadly. they're also responsible for an estimated 725,000 deaths worldwide, every year. Would it be so bad if we found a way to wipe them out completely? Real scientists have gamed out this hypothetical scenario, concluding it actually wouldn't be that bad. This five-minute video breaks down one way this could happen.

West Nile virus was detected in UK mosquitoes for the first time in 2023

Fragments of the virus were detected in mosquitoes that were being collected in Britain for the first time in 2023, but the UK government considers the overall risk to people to be low. As of spring 2026, there have never been detected locally-acquired cases of the disease.

Researchers are breeding genetically modified mosquitoes to be malaria-resistant.

West Nile virus found in the UK for the first time

The West Nile virus, which mainly spreads between birds and mosquitoes, was detected in the UK for the first time. While no evidence exists for any human infections, climate change may be expanding mosquitoes—and the diseases they carry—farther north.

Mosquitoes top the ranking of the world's deadliest animals.

Some mosquitoes are key pollinators—and eat disease-carrying mosquitoes.

Explore inside a mosquito factory where millions of mosquitoes are bred weekly

In Medellin, Colombia, scientists are infecting Aedes aegypti mosquitoes with Wolbachia, a bacterium that wouldn't otherwise infect the species, but does block its ability to transmit dengue, Zika, yellow fever, and chikungunya. In the wild, infected mosquitoes would breed with wild mosquitoes, pass down Wolbachia, and thus reduce disease transmission.

How we helped make Aedes aegypti mosquitoes such a problem

Mosquito genome sequencing data suggests that Aedes aegypti mosquitoes first started specializing on human blood around 5,000 years ago—when climates shifted and humans started domesticating plants in Africa and stored large amounts of water that may have attracted the bugs.

How Disney World keeps out mosquitos

Disney World may have been built on a swamp, but it's nearly free from the annoyance of mosquitos. That hasn't been an easy task; Disney has worked with engineers and pest specialists on minimizing the invasive bugs through a variety of different methods. This Reader's Digest article breaks down how they've successfully kept the park free from these unwanted guests.

Malaria mosquitoes in a lab were wiped out using CRISPR

Scientists at Imperial College London disabled a gene in female Anopheles gambiae mosquitoes to make them infertile and propagated the infertility mutation at unnaturally high rates using a gene drive. The entire population collapsed within a dozen generations, showing promise for subsequent with mosquitoes in mimicked tropical environments.

Mosquitoes stop flying at wind speeds equivalent to the swishing of a horse's tail.

10 locally acquired malaria cases were reported in the US in 2023—a surprise

The cases, reported in Florida, Texas, Maryland, and Arkansas, broke a 20-year streak since there had been no reported locally acquired mosquito-transmitted malaria in the country since 2003, when there was a case in Florida.

Anopheles mosquitoes are developing resistance to insecticides.

Culicidology is the study of mosquitoes

This deep dive mosquito science podcast states that the word culicidology dates back to the 1970s, and comes from the Latin word for "midge"—a separate, tiny biting insect. It first appeared in a book review about a book called "Mosquitoes of New York."

Wolbachia is also being used to slash mosquito numbers

The naturally occurring bacterium does not naturally infect Aedes aegypti mosquitoes, but communities in locations including California and Texas have released male mosquitoes infected with Wolbachia and reported a significant drop in subsequent mosquitoes: When infected males mate with uninfected wild females, the eggs don't hatch.

Mosquito-borne illnesses have killed two captive orcas at SeaWorld since they became water park attractions.

West Nile Virus is maintained in nature, even without human infections

Mosquitoes pick up the virus when they feed on birds, and then pass it to other birds with their bite, delivering it via virus-laden saliva. Hundreds of different North American bird species can harbor the virus—even if they don't all get sick from it.

Wolbachia: the bacteria that could eliminate dengue fever

Dengue fever, transmitted by mosquitoes, kills more people annually than all types of natural disasters combined. However, mosquitoes that host Wolbachia bacterium have their ability to transmit the virus naturally suppressed, offering a route to eliminating nearly 25,000 deaths annually.

Bedbug problems have been increasing, and some 2023 research suggests the tiny insects may be capable of spreading 'superbug' MRSA.

Mosquitoes drink a maximum of 0.01 milliliters of blood in a single meal.

Invasive species can harm infrastructure and threaten human health

The wildfires in Hawaii in 2022 were made worse by flammable invasive grasses introduced from Africa as livestock pasture, and Zebra mussels native to the Caspian and Black Seas have spread across Europe and the US, where they can clog power plant pipes. Invasive mosquitoes can carry diseases, such as dengue and malaria.

Genetic analysis suggests Anopheles mosquitoes fed on humans some 1.8 million years ago.

Genetic engineering mice is one idea to reduce Lyme disease transmission

Wild white-footed mice are the main carriers of Lyme. A research team is hoping to genetically engineer mice, using CRISPR, to make the animals immune to Lyme. They're proposing a field trial where they would insert a gene with an antibody to Lyme infection to break the disease transmission cycle on a private island and then try it in Nantucket if that goes well. Simply killing the mice isn't an option because it would upend food webs. Unlike traditional vaccines, this "heritable immunization" would pass from one generation of mice to the next.

There may be 500,000 additional malaria deaths by 2050 according to peer-reviewed research published in 2026.

Twin studies helped scientists understand why mosquitoes like some of us more than others

A combination of carbon dioxide output, skin chemistry, genetic factors, hormones, and clothing choice can make us particularly vulnerable to mosquito bites. Watch how mosquitoes responded to one man in the video versus his wife, a research approach typically conducted with identical and fraternal twins to test mosquito attractiveness.

Even in nature reserves, climate change is driving rapid ecological collapse

Studies show a dramatic decline in insect populations, resulting in cascading global biodiversity losses across non-insect species. The balances in tropical ecosystems are the most affected by climate change.

From 1970 to 2017, invasive species have caused $1.28T in damage globally

The costliest species were the Asian tiger and yellow fever mosquitoes ($149B), which arrived in the US from Asia and sub-Saharan Africa, respectively. The bulk of their damage came from their transmission of diseases such as Zika, chikungunya, and dengue. (Some readers may experience a paywall.)

Wolbachia is a naturally occurring bacterium being employed to fight dengue

Scientists are fighting dengue spread in a roundabout way: injecting bacteria into Aedes aegypti mosquito eggs, which blocks the dengue virus from replicating in the tissue of mosquitoes. Researchers hope the bacterium will be passed to future generations, inoculating them against dengue. Wolbachia is also being investigated to combat other mosquito-borne diseases.

At any given time, there are an estimated 10 quintillion individual insects alive on Earth.

Dragonfly migration season is believed to run from August to November

Researchers know much less about dragonfly migrations than they do about bird or whale migrations. However, North America may have up to 18 migratory dragonfly species. A recent study revealed that the species undertakes complex long-distance migrations every year that span generations and seem to be influenced by temperature, making them particularly vulnerable to climate change.

Ticks survived 27 years in a lab, including eight without food

Research published in 2022 set a new record for tick longevity. A group of adult African ticks that are normally found in eastern and southern Africa lived in a laboratory for 27 years, including eight without food. What's more, one of the females laid eggs at least four years after the last male died. Most ticks, on average, reportedly live for six months to three years.

Mosquitoes even have olfactory receptors on their sperm.

More than 20 mosquito-borne and tick-borne diseases are found in the US

Children, older adults, and people with compromised immune systems are at particular risk of poorer health outcomes from these diseases. But dog owners and outdoor enthusiasts are among those at particular risk of contracting these illnesses, which include Lyme disease, Zika, and the condition Alpha-gal Syndrome.

Read the 2012 study about captive orcas and the threat of mosquito-borne illness

Written by orca trainers who went on to become scientists, it states mosquitoes bite orcas at night when the animals hang out close to the surface. What's more, antibiotics used to keep captive orcas healthy also may depress their immune response, boosting the risks of them being unable to fight off diseases like West Nile Virus and encephalitis, which have killed orcas at US water parks.

A malaria case in Maryland stumped doctors in 2023—leading to the wrong treatment and underscoring the challenge of physicians being mindful of tropical diseases in our interconnected world.

Zika virus shocked scientists because the mosquito-borne disease causes birth defects

This revelation, confirmed in 2016, marked the first time that a mosquito-borne disease was known to cause birth defects. Fetuses exposed to the Zika virus during pregnancy sometimes suffer from neurological complications and microcephaly, a small-headed condition associated with neurological development issues and impairment.

Climate change creates conditions for more invasive species

Increasing temperatures shift the conditions native organisms are accustomed to, allowing those from warmer climates to move in with a greater chance of survival. Drought stress can cause invasive plants to absorb less herbicide, limiting the effectiveness of the control method, while melting ice can open new Arctic shipping routes, expanding the transport of species.